Stanislav Filip

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. doi request reprint Splenectomy influences homing of transplanted stem cells in bone marrow-ablated mice
    Stanislav Filip
    Department of Oncology and Radiotherapy, Faculty of Medicine and Teaching Hospital, Charles University in Prague, Hradec Kralove, Czech Republic
    Stem Cells Dev 21:702-9. 2012
  2. ncbi request reprint The transplantation of neural stem cells and predictive factors in hematopoietic recovery in irradiated mice
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, 50005 Hradec Kralove, Czech Republic
    Transfus Apher Sci 32:157-66. 2005
  3. ncbi request reprint Stem cell plasticity and issues of stem cell therapy
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, Hradec Kralove, Czech Republic
    Folia Biol (Praha) 51:180-7. 2005
  4. ncbi request reprint Issues in stem cell plasticity
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, Sokolska Street 480, 500 05 Hradec Kralove, Czech Republic
    J Cell Mol Med 8:572-7. 2004
  5. ncbi request reprint Stem cell plasticity and carcinogenesis
    S Filip
    Department of Oncology and Radiotherapy, Faculty of Medicine Charles University and University Hospital, 50005 Hradec Kralove, Czech Republic
    Neoplasma 53:87-91. 2006
  6. ncbi request reprint Local environmental factors determine hematopoietic differentiation of neural stem cells
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, 500 05 Hradec Kralove, Czech Republic
    Stem Cells Dev 13:113-20. 2004
  7. ncbi request reprint Adult stem cells and their importance in cell therapy
    S Filip
    Department of Oncology and Radiotherapy, Charles University, Medical Faculty, Hradec Kralove, Czech Republic
    Folia Biol (Praha) 49:9-14. 2003
  8. ncbi request reprint Myeloid differentiation and maturation of SCF+IL-3+IL-11 expanded AC133+/CD34+ cells selected from high-risk breast cancer patients
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, Czech Republic
    Neoplasma 47:73-80. 2000
  9. ncbi request reprint [Outpatient clinic of palliative care in oncology]
    Stanislav Filip
    Univerzita Karlova v Praze, Lékarská fakulta Hradec Králové, Klinika onkologie a radioterapie FN
    Cas Lek Cesk 150:169-72. 2011
  10. doi request reprint Homing of lin(-)/CD117(+) hematopoietic stem cells
    Stanislav Filip
    Department of Oncology and Radiotherapy, Charles University in Prague, Faculty of Medicine and Teaching Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
    Transfus Apher Sci 41:183-90. 2009

Collaborators

Detail Information

Publications50

  1. doi request reprint Splenectomy influences homing of transplanted stem cells in bone marrow-ablated mice
    Stanislav Filip
    Department of Oncology and Radiotherapy, Faculty of Medicine and Teaching Hospital, Charles University in Prague, Hradec Kralove, Czech Republic
    Stem Cells Dev 21:702-9. 2012
    ....
  2. ncbi request reprint The transplantation of neural stem cells and predictive factors in hematopoietic recovery in irradiated mice
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, 50005 Hradec Kralove, Czech Republic
    Transfus Apher Sci 32:157-66. 2005
    ..This result is important for the determination of predictive factors for hemopoiesis recovery, for stem cell plasticity and for their use in the cell therapy...
  3. ncbi request reprint Stem cell plasticity and issues of stem cell therapy
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, Hradec Kralove, Czech Republic
    Folia Biol (Praha) 51:180-7. 2005
    ..Many experiments are needed before at least some of these questions may be answered and cell therapy become an important method for the benefit of our patients...
  4. ncbi request reprint Issues in stem cell plasticity
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, Sokolska Street 480, 500 05 Hradec Kralove, Czech Republic
    J Cell Mol Med 8:572-7. 2004
    ....
  5. ncbi request reprint Stem cell plasticity and carcinogenesis
    S Filip
    Department of Oncology and Radiotherapy, Faculty of Medicine Charles University and University Hospital, 50005 Hradec Kralove, Czech Republic
    Neoplasma 53:87-91. 2006
    ..Stimulation of stem cell activation may lead to prophylactic approaches for therapy and prevention in carcinogenesis...
  6. ncbi request reprint Local environmental factors determine hematopoietic differentiation of neural stem cells
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, 500 05 Hradec Kralove, Czech Republic
    Stem Cells Dev 13:113-20. 2004
    ..We also conclude that the bone marrow does not provide an environment supportive of hematopoietic differentiation by neural stem cells...
  7. ncbi request reprint Adult stem cells and their importance in cell therapy
    S Filip
    Department of Oncology and Radiotherapy, Charles University, Medical Faculty, Hradec Kralove, Czech Republic
    Folia Biol (Praha) 49:9-14. 2003
    ..Much research is to be done and verified in practice and, at the same time, ethical problems must be resolved...
  8. ncbi request reprint Myeloid differentiation and maturation of SCF+IL-3+IL-11 expanded AC133+/CD34+ cells selected from high-risk breast cancer patients
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, Czech Republic
    Neoplasma 47:73-80. 2000
    ....
  9. ncbi request reprint [Outpatient clinic of palliative care in oncology]
    Stanislav Filip
    Univerzita Karlova v Praze, Lékarská fakulta Hradec Králové, Klinika onkologie a radioterapie FN
    Cas Lek Cesk 150:169-72. 2011
    ....
  10. doi request reprint Homing of lin(-)/CD117(+) hematopoietic stem cells
    Stanislav Filip
    Department of Oncology and Radiotherapy, Charles University in Prague, Faculty of Medicine and Teaching Hospital, Sokolska 581, 500 05 Hradec Kralove, Czech Republic
    Transfus Apher Sci 41:183-90. 2009
    ..Hematopoietic stem cell transplantation led not only to recovery of hematopoietic and lymphoid tissues but also facilitated recovery of the small intestinal mucosa, which was significantly damaged by ionizing radiation...
  11. ncbi request reprint Peripheral progenitor cells (PBPC) in supportive care after high-dose chemotherapy in breast cancer
    S Filip
    Dept of Oncology and Radiotherapy, Charles University Hospital, Hradec Kralove, Czech Republic
    Neoplasma 48:39-47. 2001
    ..At present it has been used also in our patients. The results show that enriched whole blood can be used as sufficient substitution for support in intensive cyclic chemotherapy in breast cancer patients...
  12. ncbi request reprint The current look at high-dose chemotherapy in breast cancer minireview
    S Filip
    Department of Oncology and Radiotherapy, Charles University Hospital, Hradec Krdlove, Czech Republic
    Neoplasma 47:261-8. 2000
    ..Still some believe that different modifications of therapeutic regimens or new, less toxic drugs should be tested which may lead to more effective and safer HDC...
  13. ncbi request reprint [Present view on the stem cell plasticity and cell therapy]
    S Filip
    Onkologická a radioterapeutická klinika FN, Hradec Kralove
    Cas Lek Cesk 144:779-83; discussion 783-4. 2005
    ..Recent experimental results indicate that stem cells may have a key role in stem cell therapy. This review is an introductory discussion on the stem cell plasticity and stem cell therapy...
  14. ncbi request reprint Hematopoietic recovery after transplantation CD117+B220- (LACZ*) bone marrow cells in lethally irradiated mice
    Miroslav Hodek
    Department of Oncology and Radiotherapy, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 51:37-41. 2008
    ....
  15. ncbi request reprint Intensive cyclic chemotherapy with unprocessed whole blood support in advanced breast cancer
    J Vanasek
    Department of Oncology and Radiotherapy, Charles University Hospital, Hradec Kralove, Czech Republic
    Neoplasma 48:34-8. 2001
    ..The yields of CD34+ cells in 450 ml of whole blood were 1.8 x 10(6)/kg, which is not sufficient for optimal hemopoietic recovery...
  16. doi request reprint Irradiated stem cells and ageing of the haematopoietic system
    Jirina Vavrova
    Department of Radiobiology, Faculty of Health Sciences, University of Defence in Brno, Hradec Kralove, Czech Republic
    Radiat Environ Biophys 51:205-13. 2012
    ..In the group exposed to 7 Gy, the numbers of thrombocytes significantly increased, and on the contrary, the numbers of erythrocytes, the amount of haemoglobin, and haematocrit significantly decreased...
  17. doi request reprint Irradiation of adult human dental pulp stem cells provokes activation of p53, cell cycle arrest, and senescence but not apoptosis
    Darina Muthna
    Department of Medical Biochemistry, Charles University, Prague, Czech Republic
    Stem Cells Dev 19:1855-62. 2010
    ..We conclude that DPSCs respond to IR-induced damage by permanent cell cycle arrest in the G2 phase and by stress-induced premature senescence...
  18. ncbi request reprint Expression of intermediate filament nestin in blood vessels of neural and non-neural tissues
    Jaroslav Mokry
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Department of Histology and Embryology, Czech Republic
    Acta Medica (Hradec Kralove) 51:173-9. 2008
    ..Elevation of nestin expression likely corresponds to reorganization of intermediate filament network in the cytoskeleton of endothelial cells in the course of their maturation or adaptation to changes in growing tissues...
  19. doi request reprint The importance of rheological parameters in the therapy of the dry form of age-related macular degeneration with rheohaemapheresis
    Milan Blaha
    IInd Department of Internal Medicine, Haematology, Charles University, Hradec Kralove, Czech Republic
    Clin Hemorheol Microcirc 50:245-55. 2012
    ..Our modification of rheohaemapheresis is safe (5.4% of patients experienced clinically insignificant side effects)...
  20. doi request reprint Stem cells and the phenomena of plasticity and diversity: a limiting property of carcinogenesis
    Stanislav Filip
    Department of Oncology and Radiotherapy, Charles University in Prague, Faculty of Medicine and Teaching Hospital, Hradec Kralove, Czech Republic fi
    Stem Cells Dev 17:1031-8. 2008
    ..We view this situation in a manner similar to the principle of indefiniteness; cells must choose either plasticity or diversity, as both are not possible at the same time...
  21. ncbi request reprint Program of palliative cancer care--our experience
    Iva Slanska
    Department of Clinical Oncology and Radiotherapy, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 56:29-32. 2013
    ..The purpose of the so called program of palliative cancer care is to guide a patient in palliative cancer care and to improve the cooperation among health care providers...
  22. pmc The peripheral chimerism of bone marrow-derived stem cells after transplantation: regeneration of gastrointestinal tissues in lethally irradiated mice
    Stanislav Filip
    Department of Oncology and Radiotherapy, Faculty of Medicine and Teaching Hospital, Charles University in Prague, Hradec Kralove, Czech Republic
    J Cell Mol Med 18:832-43. 2014
    ....
  23. doi request reprint Experience with extracorporeal elimination therapy in myasthenia gravis
    Milan Blaha
    2nd Department of Internal Medicine, Charles University, Faculty of Medicine and Teaching Hospital, 500 05 Hradec Kralove, Czech Republic
    Transfus Apher Sci 45:251-6. 2011
    ..Extracorporeal elimination therapy through PE or immunoadsorption is effective and sometimes life saving and is safe in the hands of an experienced team (6% complication rate)...
  24. ncbi request reprint Hepatic arterial infusion chemotherapy in sarcoma liver metastases: a report of 6 cases
    Bohuslav Melichar
    Department of Oncology and Radiotherapy, Charles University Medical School Teaching Hospital, Hradec Kralove, Czech Republic
    Tumori 91:19-23. 2005
    ..Liver metastases in patients with sarcoma are rare and associated with a poor prognosis. The experience with liver-directed therapies, eg hepatic arterial infusion, in these patients is limited...
  25. ncbi request reprint Weekly paclitaxel combined with local hyperthermia in the therapy of breast cancer locally recurrent after mastectomy--a pilot experience
    Z Zoul
    Department of Oncology and Radiotherapy, Charles University Medical School Teaching Hospital, Hradec Kralove, Czech Republic
    Onkologie 27:385-8. 2004
    ..In the present report we evaluate the efficacy and toxicity of a combination of weekly paclitaxel combined with local hyperthermia in breast cancer...
  26. ncbi request reprint Endovascular brachytherapy potentiated by hyperthermia in the prevention of vascular restenosis. A case report
    J Dvorak
    Department of Radiotherapy and Oncology, Charles University Hospital, 50005 Hradec Kralove, Czech Republic
    Cardiovasc Radiat Med 2:205-7. 2001
    ..The combination of hyperthermia and radiotherapy has additive or synergistic effects. This combination has been studied extensively in radiation oncology, but not in the prevention of vascular restenosis...
  27. ncbi request reprint The role of chemotherapy in prostate cancer. Minireview
    K Odrazka
    Department of Oncology and Radiotherapy, Charles University Hospital, Hradec Kralove, Czech Republic
    Neoplasma 47:197-203. 2000
    ....
  28. ncbi request reprint Clinical results of intensity-modulated radiation therapy (IMRT) for tumors of the head and neck region
    K Odrazka
    Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, 50011 Hradec Kralove, Czech Republic
    Neoplasma 52:85-94. 2005
    ..In perspective, the potential of IMRT should be explored in conjunction with altered fractionation regimens, including simultaneous integrated boost (SIB). Particularly, studies with dose escalation are desirable...
  29. ncbi request reprint Management of inoperable carcinoma of the breast by curative radiotherapy and chemo-hormonotherapy
    J Petera
    Department of Oncology and Radiotherapy, Charles University Medical School Teaching Hospital, CR 50005 Hradec Králové, Czech Republic
    Onkologie 24:263-6. 2001
    ..The aim of this study was to evaluate local control and its relation to survival in patients with locally advanced breast cancer treated with curative irradiation and systemic therapy...
  30. ncbi request reprint Differentiation of neural stem cells into cells of oligodendroglial lineage
    Jaroslav Mokry
    Charles University in Prague, Faculty of Medicine in Hradec Kralove, Department of Histology and Embryology, Czech Republic
    Acta Medica (Hradec Kralove) 50:35-41. 2007
    ..The cultivation conditions that supported growth and differentiation of neural stem cells were optimal for in vitro developmental studies and the production of oligodendroglial cells...
  31. doi request reprint WAA apheresis registry in the Czech Republic: two centers experience
    Milan Blaha
    Faculty of Medicine and Faculty Hospital, Charles University, Hradec Kralove, Czech Republic
    Transfus Apher Sci 41:27-31. 2009
    ..In Czech Republic hemaphereses are used in a broad spectrum of indications. Since the year 2004 data on hemaphereses done in Czech Republic have been registered. In this paper we present a survey of our to date recordings...
  32. ncbi request reprint Nestin expression by newly formed human blood vessels
    J Mokry
    Department of Histology and Embryology, Charles University in Prague, Medical Faculty in Hradec Kralove, Czech Republic
    Stem Cells Dev 13:658-64. 2004
    ..Because nestin expression was recognized under all conditions of vascular development, nestin represents a novel and reliable marker of neovascularization...
  33. ncbi request reprint Differentiation potential of murine neural stem cells in vitro and after transplantation
    J Mokry
    Department of Histology and Embryology, Charles University in Prague, Medical Faculty in Hradec Kralove, Czech Republic
    Transplant Proc 37:268-72. 2005
    ..Following intravenous injection of NSCs, the transplanted cells colonized hematopoietic and lymphatic organs, facilitating hematopoiesis in irradiated animals...
  34. ncbi request reprint Antiapoptotic cytokine IL-3 + SCF + FLT3L influence on proliferation of gamma-irradiated AC133+/CD34+ progenitor cells
    J Vavrova
    Institute of Radiobiology and Immunology, Purkyne Military Medical Academy, Hradec Kralove, Czech Republic
    Folia Biol (Praha) 48:51-7. 2002
    ..Under the influence of cytokine combination (SCF + IL-3 + FLT3L), the surviving 20% of cells entered the cell cycle and, similarly to non-irradiated control cells, on 7th day 35% of cells were in S phase...
  35. doi request reprint Plasmafiltration as a possible contributor to kinetic targeting of pegylated liposomal doxorubicin (PLD) in order to prevent organ toxicity and immunosuppression
    Jirina Martinkova
    Department of Oncology and Radiotherapy, Charles University in Prague, Medical Faculty and University Hospital in Hradec Kralove, Hradec Kralove, Czech Republic
    Cancer Chemother Pharmacol 77:429-37. 2016
    ..To examine the removal of pegylated liposomal doxorubicin (PLD) during plasmafiltration (PF) and determine whether the drug could be withheld prior to its organ distribution responsible for mucocutaneous toxicity...
  36. pmc Different solutions used for submucosal injection influenced early healing of gastric endoscopic mucosal resection in a preclinical study in experimental pigs
    Jan Bures
    Second Department of Internal Medicine, Charles University in Praha, Faculty of Medicine at Hradec Kralove, University Teaching Hospital, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
    Surg Endosc 23:2094-101. 2009
    ..The aim of this study was to evaluate histological and immunological changes after EMR in experimental pigs...
  37. pmc Utilizing Autologous Multipotent Mesenchymal Stromal Cells and β-Tricalcium Phosphate Scaffold in Human Bone Defects: A Prospective, Controlled Feasibility Trial
    Pavel Sponer
    Department of Orthopaedic Surgery, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Simkova 870, 500 38 Hradec Kralove, Czech Republic
    Biomed Res Int 2016:2076061. 2016
    ..The clinical trial was registered at the EU Clinical Trials Register before patient recruitment has begun (EudraCT number 2012-005599-33). ..
  38. doi request reprint Human Multipotent Mesenchymal Stromal Cells in the Treatment of Postoperative Temporal Bone Defect: An Animal Model
    Lukas Skoloudik
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
    Cell Transplant 25:1405-14. 2016
    ..00166). Our results proved a beneficial effect of hMSCs on temporal bone formation and provided a promising tool to improve the quality of life of patients after canal wall down mastoidectomy by hMSC implantation. ..
  39. doi request reprint Extracorporeal Elimination of Circulating Pegylated Liposomal Doxorubicin (PLD) to Enhance the Benefit of Cytostatic Therapy in Platinum-Resistant Ovarian Cancer Patients
    Ondřej Kubeček
    Department of Oncology and Radiotherapy, Charles University in Prague, Medical Faculty and University Hospital in Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 58:3-8. 2015
    ..This article intends to review PLD characteristics and the importance of extracorporeal elimination to enhance treatment tolerance and benefits. ..
  40. pmc Signaling involved in hair follicle morphogenesis and development
    Pisal Rishikaysh
    Department of Histology and Embryology, Medical Faculty in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38 Hradec Kralove, Czech Republic
    Int J Mol Sci 15:1647-70. 2014
    ..The dermal Wnt pathway helps in upregulation of epithelial Notch expression. Dysregulation of these pathways leads to certain abnormalities and in some cases even tumor outgrowth. ..
  41. ncbi request reprint Intraluminal high dose rate brachytherapy of tumorous esophageal stenoses
    Josef Dvorak
    Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Kralove, Czech Republic
    Hepatogastroenterology 53:702-4. 2006
    ..The aim of this study was to retrospectively evaluate the effectiveness of intraluminal high dose rate brachytherapy in the palliative treatment of tumorous esophageal stenoses...
  42. ncbi request reprint Safety and tolerability of long lasting LDL-apheresis in familial hyperlipoproteinemia
    Milan Blaha
    Department of Haematology, IInd Internal Clinic, Charles University, Hiradec Králové, Czech Republic
    Ther Apher Dial 11:9-15. 2007
    ..An acceptable procedure duration limit, balancing the possibility to achieve a targeted cholesterol level while still maintaining an acceptable patient tolerance, was confirmed to be 4 hours...
  43. ncbi request reprint Issues and ethical problems of stem cell therapy--where is Hippocrates?
    Lucie Rousková
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Department of Oncology and Radiotherapy, Czech Republic
    Acta Medica (Hradec Kralove) 51:121-6. 2008
    ..In this paper important ethical problems are pointed out in order to find answers to some key problems connected with cell therapy and the use of stem cells...
  44. ncbi request reprint Cancer stem cells--new approach to cancerogenensis and treatment
    Zuzana Macingova
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Department of Oncology and Radiotherapy, Czech Republic
    Acta Medica (Hradec Kralove) 51:139-44. 2008
    ..Thus the biological properties of cancer stem cells are just beginning to be revealed, the continuation of these studies should lead to the development of cancer stem cells target therapies for cancer treatment...
  45. doi request reprint Phenotypic and morphological characterization of in vitro oligodendrogliogenesis
    J Mokry
    Department of Histology and Embryology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, 50038 Hradec Kralove, Czech Republic
    Stem Cells Dev 17:333-41. 2008
    ..These include oligodendrocyte progenitors, preoligodendrocytes, and oligodendrocytes. The highly complex morphology of mature oligodendrocytes was compatible with functional cells...
  46. ncbi request reprint Prevention of infection transmission during stem cell transplantation
    M Blaha
    University Hospital, Medical Faculty, Charles University, Hradec Kralove, Czechia
    Folia Microbiol (Praha) 51:609-13. 2006
    ....
  47. ncbi request reprint Screening for depression in survivors of metastatic ovarian cancer in a programme of palliative cancer care
    L Slovacek
    Clinical Oncology and Radiation Therapy Department, Charles University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic
    Bratisl Lek Listy 110:655-9. 2009
    ..Depression is seen in many cancer patients. It occurs in approximately 25% of palliative care patients...
  48. doi request reprint Re-expression of nestin in the myocardium of postinfarcted patients
    J Mokry
    Department of Histology and Embryology, Medical Faculty in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    Virchows Arch 453:33-41. 2008
    ..These findings document a crucial role of nestin in remodeling cytoskeleton of cells in the human postinfarcted myocardium...
  49. ncbi request reprint Intensive cyclic chemotherapy and transplantation of autologous peripheral blood progenitor cells (PBPC) or whole blood in high-risk breast cancer - follow up at 10 years
    P Cinek
    Department of Clinical Oncology, Central Military Hospital, 169 02 Prague, Czech Republic
    Exp Oncol 29:144-51. 2007
    ..The main aim of our paper is to contribute to objectification of currently widely discussed results of overall survival (OS), disease free survival (DFS) and time from relapse to tumor progression (TTP) in women with breast cancer...
  50. ncbi request reprint [Stem cells, stem cell therapy, and ethical problems of medicine]
    I Hruska
    Ustav filozofie a spolecenských ved, Fakulta humanitních studií, Univerzita Hradec Králové
    Cas Lek Cesk 146:440-3; discussion 443-4. 2007
    ..In this paper some of these questions are discussed and some ways of forming the ethics in therapeutic use of stem cells are presented...