Jan Krejsek

Summary

Affiliation: Charles University
Country: Czech Republic

Publications

  1. doi request reprint RANK/RANKL Expression Is Induced by Cardiac Surgical Operation
    Jan Krejsek
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Department of Clinical Immunology and Allergology, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:149-153. 2009
  2. pmc Pentraxin 3(PTX 3): an endogenous modulator of the inflammatory response
    P Kunes
    Department of Cardiac Surgery, University Hospital and Medical School of Hradec Kralove, Charles University in Prague, 12843 Prague, Czech Republic
    Mediators Inflamm 2012:920517. 2012
  3. ncbi request reprint TLR2 and TLR4 expression on blood monocytes and granulocytes of cardiac surgical patients is not affected by the use of cardiopulmonary bypass
    Jan Krejsek
    Department of Clinical Immunology, Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 56:57-66. 2013
  4. doi request reprint The role of autoimmunity in gastroenterology
    Jan Krejsek
    Department of Clinical Immunology, Faculty of Medicine, University Hospital, Charles University in Prague, Hradec Kralove, Czech Republic
    Dig Dis 30:208-11. 2012
  5. doi request reprint Impact of methylprednisolone in priming solution of cardiopulmonary bypass on anti-inflammatory CD163 receptor during cardiac surgery
    J Krejsek
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Perfusion 27:284-91. 2012
  6. ncbi request reprint [Autophagy and its role in protective and damaging inflammatory response]
    Krejsek Jan
    Univerzita Karlova v Praze, Lekarska fakulta v Hradci Kralove, Ustav klinické imunologie a alergologie FN
    Cas Lek Cesk 151:128-34. 2012
  7. ncbi request reprint [Innate immunity, receptors for exogenous and endogenous danger patterns in immunopathogenesis of atherosclerosis--part II: TLR receptors, significance of genetic polymorphism of danger signals receptors]
    J Krejsek
    Ustav klinické imunologie a alergologie LF UK a FN, Hradec Kralove
    Cas Lek Cesk 144:790-4. 2005
  8. doi request reprint Expression of CD200/CD200R regulatory molecules on granulocytes and monocytes is modulated by cardiac surgical operation
    Jan Krejsek
    Department of Clinical Immunology and Allergy, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Perfusion 25:389-97. 2010
  9. ncbi request reprint [Innate immunity, receptors for exogenous and endogenous danger patterns in immunopathogenesis of atherosclerosis--part 1: identification of danger signals by innate immunity]
    J Krejsek
    Ustav klinické imunologie a alergologie LF UK a FN, Hradec Kralove
    Cas Lek Cesk 144:785-9. 2005
  10. ncbi request reprint [Mucosal immunity with emphasis on urinary tract immunity and diabetes]
    J Krejsek
    Ustav klinické imunologie a alergologie Lékarské fakulty UK a FN Hradec Králové
    Vnitr Lek 54:478-81. 2008

Collaborators

Detail Information

Publications86

  1. doi request reprint RANK/RANKL Expression Is Induced by Cardiac Surgical Operation
    Jan Krejsek
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Department of Clinical Immunology and Allergology, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:149-153. 2009
    ..Cardiac surgery provokes a systemic inflammatory response in any patient. This complex body reaction involves also RANK/RANKL molecules which have been recently identified as principal regulators of bone metabolism...
  2. pmc Pentraxin 3(PTX 3): an endogenous modulator of the inflammatory response
    P Kunes
    Department of Cardiac Surgery, University Hospital and Medical School of Hradec Kralove, Charles University in Prague, 12843 Prague, Czech Republic
    Mediators Inflamm 2012:920517. 2012
    ....
  3. ncbi request reprint TLR2 and TLR4 expression on blood monocytes and granulocytes of cardiac surgical patients is not affected by the use of cardiopulmonary bypass
    Jan Krejsek
    Department of Clinical Immunology, Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 56:57-66. 2013
    ..The very surgical trauma is responsible for TLR2 and TLR4 modulation. Surprisingly, cardiopulmonary bypass itself was little contributing to the modulation of TLR2 and TLR4 expression...
  4. doi request reprint The role of autoimmunity in gastroenterology
    Jan Krejsek
    Department of Clinical Immunology, Faculty of Medicine, University Hospital, Charles University in Prague, Hradec Kralove, Czech Republic
    Dig Dis 30:208-11. 2012
    ..These defects together with the failure to induce autophagy lead to lack of bacterial clearance and subsequently to mucosal immunopathology...
  5. doi request reprint Impact of methylprednisolone in priming solution of cardiopulmonary bypass on anti-inflammatory CD163 receptor during cardiac surgery
    J Krejsek
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Perfusion 27:284-91. 2012
    ..001). We concluded that the expression of hemoglobin scavenger receptor CD163 on monocytes of cardiac surgical patients is induced by methylprednisolone present in cardiopulmonary bypass fluid...
  6. ncbi request reprint [Autophagy and its role in protective and damaging inflammatory response]
    Krejsek Jan
    Univerzita Karlova v Praze, Lekarska fakulta v Hradci Kralove, Ustav klinické imunologie a alergologie FN
    Cas Lek Cesk 151:128-34. 2012
    ..Autophagy can enhance the survival of autoreactive T cells in multiple sclerosis patients thus contributing to the disease induction and progression...
  7. ncbi request reprint [Innate immunity, receptors for exogenous and endogenous danger patterns in immunopathogenesis of atherosclerosis--part II: TLR receptors, significance of genetic polymorphism of danger signals receptors]
    J Krejsek
    Ustav klinické imunologie a alergologie LF UK a FN, Hradec Kralove
    Cas Lek Cesk 144:790-4. 2005
    ..The differences in an individual immune reactivity are probably responsible for individual susceptibility or resistance to the development of immunopathological reactivity, which is involved in the immunopathogenesis of atherosclerosis...
  8. doi request reprint Expression of CD200/CD200R regulatory molecules on granulocytes and monocytes is modulated by cardiac surgical operation
    Jan Krejsek
    Department of Clinical Immunology and Allergy, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Perfusion 25:389-97. 2010
    ..We followed the changes in the expression of CD200/CD200R regulatory molecules on monocytes and granulocyte of cardiac surgical patients operated on using either standard (OP) or modified "mini-invasive" cardiopulmonary bypass (MOP)...
  9. ncbi request reprint [Innate immunity, receptors for exogenous and endogenous danger patterns in immunopathogenesis of atherosclerosis--part 1: identification of danger signals by innate immunity]
    J Krejsek
    Ustav klinické imunologie a alergologie LF UK a FN, Hradec Kralove
    Cas Lek Cesk 144:785-9. 2005
    ..Among them the TLR receptors family which is associated with intracellular signaling pathway NF-kappaB is one of the most important. The inflammatory response is induced via activated NF-kappaB transcription factor...
  10. ncbi request reprint [Mucosal immunity with emphasis on urinary tract immunity and diabetes]
    J Krejsek
    Ustav klinické imunologie a alergologie Lékarské fakulty UK a FN Hradec Králové
    Vnitr Lek 54:478-81. 2008
    ..Inflammatory response characterised by the acumulation ofgranulocytes is followed. Both protective and harm characteristics of inflammatory response are inseparable linked and delineated by gene polymorphisms in PRR receptors...
  11. doi request reprint Expression of Toll-like receptors 2 and 4 on innate immunity cells modulated by cardiac surgical operation
    Jan Krejsek
    Department of Clinical Immunology and Allergology, Faculty of Medicine, Charles University in Prague, University Hospital in Hradec Kralove, Czech Republic
    Scand J Clin Lab Invest 68:749-58. 2008
    ..This study aimed to follow-up on the changes in the expression of Toll-like receptors (TLRs) on monocytes and granulocytes in venous blood of patients undergoing cardiac surgical operation...
  12. ncbi request reprint RANK/RANKL expression is induced by cardiac surgical operation
    Jan Krejsek
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:149-53. 2009
    ..Cardiac surgery provokes a systemic inflammatory response in any patient. This complex body reaction involves also RANK/RANKL molecules which have been recently identified as principal regulators of bone metabolism...
  13. doi request reprint Serum level of sCD163, a soluble receptor for hemoglobin, is influenced by cardiac surgery
    Martina Kolackova
    Department of Clinical Immunology and Allergy, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, 500 05 Hradec Kralove, Czech Republic
    Perfusion 24:263-9. 2009
    ..The scavenger receptor for complexes hemoglobin-haptoglobin (CD163), which is expressed on monocytes/ macrophages, is shed to the body fluids in a soluble form (sCD163)...
  14. doi request reprint Serum levels of the pro-inflammatory cytokine interleukin-12 and the anti-inflammatory cytokine interleukin-10 in patients with psoriasis treated by the Goeckerman regimen
    Lenka Borska
    Institute of Pathological Physiology, Charles University in Prague, Faculty of Medicine, University Hospital, Hradec Kralove, Czech Republic
    Int J Dermatol 47:800-5. 2008
    ..This study describes the changes in the serum levels of the pro-inflammatory cytokine interleukin-12 (IL-12) and the anti-inflammatory cytokine IL-10 in patients with psoriasis (n = 55) treated with GR...
  15. pmc Lipopolysaccharide binding protein and sCD14 are not produced as acute phase proteins in cardiac surgery
    Manuela Kudlova
    Institute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Kralove, 500 05 Hradec Kralove, Czech Republic
    Mediators Inflamm 2007:72356. 2007
    ..The changes in the serum levels of lipopolysaccharide binding protein (LBP) and sCD14 during cardiac surgery were followed in this study...
  16. pmc The effect of conventional and mini-invasive cardiopulmonary bypass on neutrophil activation in patients undergoing coronary artery bypass grafting
    Martina Kolackova
    Department of Clinical Immunology, Faculty of Medicine, Charles University, 50005 Hradec Kralove, Czech Republic
    Mediators Inflamm 2012:152895. 2012
    ..While no correlation between IL-10 and IL10R was found, IL-10 was positively correlated with increased percentage of neutrophils at the time points when the level of IL-10 peaked...
  17. ncbi request reprint The effect of cardiac surgery on peripheral blood lymphocyte populations
    Karolina Jankovicova
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 51:25-9. 2008
    ..An alternative approach to cardiac surgery, operating without the use of CPB (i.e. off-pump surgery), seems to display less adverse impacts on the immune response...
  18. doi request reprint Genotoxic hazard and cellular stress in pediatric patients treated for psoriasis with the Goeckerman regimen
    Lenka Borska
    Faculty of Medicine in Hradec Kralove, Institute of Pathological Physiology, Charles University in Prague, Simkova, Hradec Kralove, Czech Republic
    Pediatr Dermatol 26:23-7. 2009
    ..001). Significantly increased CA (p < 0.001) and Hsp70 (p < 0.05) indicated higher genotoxic risk and cellular stress in sensitive pediatric patients, immediately after GR...
  19. pmc Early expression of FcgammaRI (CD64) on monocytes of cardiac surgical patients and higher density of monocyte anti-inflammatory scavenger CD163 receptor in "on-pump" patients
    Martina Kolackova
    Department of Clinical Immunology and Allergy, Medical School in Hradec Králové, Charles University in Prague, Sokolska Street 581, 50005 Hradec Kralove, Czech Republic
    Mediators Inflamm 2008:235461. 2008
    ....
  20. ncbi request reprint The expression of CD38 ADP-ribosyl cyclase ectoenzyme in immune cells of cardiac surgical patients
    Martina Kolackova
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 51:31-5. 2008
    ..This study was aimed at following the changes in the expression of CD38 ADP-ribosyl cyclase ectoenzyme on peripheral blood immune cells of patients undergoing cardiac surgical operations...
  21. ncbi request reprint Essential PTX3 biology (not only) for cardiologists and cardiac surgeons
    Pavel Kunes
    Charles University in Prague, Faculty of Medicine in Hradec Kralove, Department of Cardiac Surgery, Czech Republic
    Acta Medica (Hradec Kralove) 50:29-33. 2007
    ....
  22. ncbi request reprint The number of immunoregulatory T cells is increased in patients with psoriasis after Goeckerman therapy
    Katerina Kondĕlková
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 55:91-5. 2012
    ..0042). In conclusion, this significant increase in Treg count after GT is probably associated with amelioration of inflammation by GT, as disease activity expressed as PASI decreased in our patients by GT (P = 0.0001)...
  23. doi request reprint Genotoxic and apoptotic effects of Goeckerman therapy for psoriasis
    Lenka Borska
    Institute of Pathological Physiology, Charles University in Prague, Faculty of Medicine, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
    Int J Dermatol 49:289-94. 2010
    ..PAH and UVR are mutagenic, carcinogenic and immunotoxic agents that promote apoptosis...
  24. doi request reprint Up-regulation of the Apo/Fas (CD95) complex on neutrophils harvested during cardiac surgery: distinct findings in patients operated on with or without the use of cardiopulmonary bypass
    Pavel Kunes
    Department of Cardiac Surgery, Charles University in Prague, University Hospital and Medical Faculty in Hradec Kralove, Hradec Kralove, Czech Republic
    Perfusion 25:41-6. 2010
    ..In a group of patients undergoing cardiac surgery performed both with ("on-pump") and without the use ("offpump") of cardiopulmonary bypass (CPB), we studied the changes of neutrophil membrane apoptosis-inducing complex Apo/Fas...
  25. ncbi request reprint Serum level of a soluble form of endoglin (CD105) is decreased after Goeckerman's therapy of psoriasis
    David Pohl
    Department of Clinical Immunology and Allergy, Charles University in Prague, Faculty of Medicine, Czech Republic
    Acta Medica (Hradec Kralove) 54:59-62. 2011
    ..The aim of study was to evaluate the influence of GT of psoriasis on proinflammatory and angiogenic activities expressed as changes in levels of endoglin (CD105)...
  26. ncbi request reprint The inflammatory response in cardiac surgery. An up-to-date overview with the emphasis on the role of heat shock proteins (HSPs) 60 and 70
    Pavel Kunes
    Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine, University Hospital in Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 50:93-9. 2007
    ..This review article presents some new data regarding its biological importance, along with an insight into the recently discovered role played by heat shock proteins 60 and 70...
  27. ncbi request reprint Pentraxin 3 and other inflammatory biomarkers related to atrial fibrillation in cardiac surgery
    Zdenka Holubcová
    Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
    Perfusion . 2016
    ..The aim was to evaluate the association between perioperative inflammatory biomarkers and atrial fibrillation (AF) in cardiac surgical patients...
  28. ncbi request reprint The long pentraxin 3 in cardiac surgery: distinct responses in "on-pump" and "off-pump" patients
    Pavel Kunes
    Department of Cardiac Surgery, Charles University in Prague, University Hospital and Faculty of Medicine in Hradec Králové, Czech Republic
    Scand Cardiovasc J 41:171-9. 2007
    ..The purpose of this study was to assess the kinetics of release of PTX3 in cardiac surgical patients, operated on either with or without the use of cardiopulmonary bypass (CPB)...
  29. doi request reprint Expression of urokinase plasminogen activator receptor on monocytes and granulocytes is modulated by cardiac surgery
    Jan Krejsek
    Department of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Perfusion 26:115-21. 2011
    ..We followed the modulation of urokinase plasminogen activator receptor uPAR (CD87) separately for monocytes and granulocytes in blood of cardiac surgery patients...
  30. doi request reprint Significant change in ZAP-70 expression during the course of chronic lymphocytic leukemia
    Vladimira Vroblova
    Institute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Eur J Haematol 84:513-7. 2010
    ..However, data supporting this notion are surprisingly scarce. Therefore, we assessed expression of ZAP-70 in serial samples taken during the course of the disease...
  31. ncbi request reprint Expression of an activated form of integrin beta2 chain CD18 in cardiac surgical operations
    Manuela Kudlova
    Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Czech Republic
    Acta Medica (Hradec Kralove) 50:187-93. 2007
    ..It is supposed that this activation is more profound in patients operated with cardiopulmonary bypass (CPB) ("on-pump") in comparison with patients operated without CPB ("off-pump")...
  32. pmc Oxidative damage to nucleic acids and benzo(a)pyrene-7,8-diol-9,10-epoxide-DNA adducts and chromosomal aberration in children with psoriasis repeatedly exposed to crude coal tar ointment and UV radiation
    Lenka Borska
    Institute of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, 50038 Hradec Kralove, Czech Republic
    Oxid Med Cell Longev 2014:302528. 2014
    ..The study confirmed good effectiveness of the GT (significantly decreased PASI score). ..
  33. ncbi request reprint CD200/CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; Part I: CD200/CD200R structure, activation, and function
    Drahomíra Holmannová
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kriálové, Czech Republic
    Acta Medica (Hradec Kralove) 55:12-7. 2012
    ..Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss...
  34. ncbi request reprint CC and CXC chemokines patterns in psoriasis determined by protein array method were influenced by Goeckerman's therapy
    David Pohl
    Department of Clinical Immunology and Allergy, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:9-13. 2009
    ..It could be the cause for decreased proangiogenic activity which is described after GT of psoriasis...
  35. ncbi request reprint Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression
    Drahomíra Holmannová
    Department of Clinical Immunology, Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic
    Perfusion . 2016
    ..We evaluated the impact of cardiac surgery on the expression of CD162, CD166, CD195 molecules and their association with the type of CPB used...
  36. doi request reprint Biological Prognostic Markers in Chronic Lymphocytic Leukemia
    Vladimira Vroblova
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Institute of Clinical Immunology and Allergology, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:3-8. 2009
    ..Molecules regulating the process of angiogenesis are also considered as promising markers. The purpose of this review is to summarize in detail the specific role of these prognostic factors in chronic lymphocytic leukemia...
  37. pmc Selected Inflammatory and Metabolic Markers in Psoriatic Patients Treated with Goeckerman Therapy
    Katerina Kondĕlková
    Institute of Clinical Immunology and Allergology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Sokolska 581, 50005 Hradec Kralove, Czech Republic
    Mediators Inflamm 2015:979526. 2015
    ..However, the levels of proinflammatory CRP and leptin remained significantly higher in the patients than in the control group. ..
  38. doi request reprint Could pentraxin 3 be a new diagnostic marker for excessive inflammatory response in cardiac surgery?
    Zdenka Holubcová
    Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
    Thorac Cardiovasc Surg 62:670-6. 2014
    ....
  39. doi request reprint Membrane and soluble Toll-like receptor 2 in patients with psoriasis treated by Goeckerman therapy
    Katerina Kondĕlková
    Department of Clinical Immunology and Allergology, University Hospital Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    Int J Dermatol 53:e512-7. 2014
    ....
  40. doi request reprint Amniotic fluid CD200 levels in pregnancies complicated by preterm prelabor rupture of the membranes
    Marian Kacerovsky
    Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
    J Matern Fetal Neonatal Med 26:1416-24. 2013
    ....
  41. pmc Serum level of antibody against benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA adducts in people dermally exposed to PAHs
    Lenka Borska
    Institute of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, 50038 Hradec Kralove, Czech Republic
    J Immunol Res 2014:834389. 2014
    ..Further studies are needed to reduce interpretation uncertainty of this promising bioindicator. ..
  42. pmc TLR2 in pleural fluid is modulated by talc particles during pleurodesis
    Karolina Jankovicova
    Department of Clinical Immunology and Allergy, Faculty of Medicine and University Hospital in Hradec Kralove, Charles University in Prague, Sokolska Street 581, 500 05 Hradec Kralove, Czech Republic
    Clin Dev Immunol 2012:158287. 2012
    ..Our results proved that patients with favourable prognosis had more than 3-fold higher soluble TLR2 level in pleural fluid early, 2 hours after talc pleurodesis intervention...
  43. ncbi request reprint Regulatory T cells (TREG) and their roles in immune system with respect to immunopathological disorders
    Katerina Kondĕlková
    Charles University in Prague, Faculty of Medicine, Department of Clinical Immunology and Allergology and University Hospital Hradec Králové, Czech Republic
    Acta Medica (Hradec Kralove) 53:73-7. 2010
    ..Therapeutical Treg modulation is considered to be a promising therapeutical approach to treat some selected disorders, such as allergies, and to prevent allograft rejection...
  44. ncbi request reprint CD200/CD200R paired potent inhibitory molecules regulating immune and inflammatory responses; Part II: CD200/CD200R potential clinical applications
    Drahomíra Holmannová
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 55:59-65. 2012
    ..Many research projects are aimed to develop clinically valuable methods being based on the structure and function of these paired molecules. In this review, we would like to introduce CD200/CD200R functions in a clinical context...
  45. ncbi request reprint Selected immunological changes in patients with Goeckerman's therapy TNF-alpha, sE-selectin, sP-selectin, sICAM-1 and IL-8
    L Borska
    Institute of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic
    Physiol Res 55:699-706. 2006
    ..Determination of sE-selectin and sICAM seems to be a promising marker of psoriasis's activity. Chemokine pathway (IL-8) and TNF-alpha activity seem to be modulated by Goeckerman's therapy (polycyclic aromatic hydrocarbons)...
  46. doi request reprint Impact of cardiac surgery on the expression of CD40, CD80, CD86 and HLA-DR on B cells and monocytes
    Drahomíra Holmannová
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Perfusion 31:391-400. 2016
    ....
  47. doi request reprint The Effect of Interferon-γ and Lipopolysaccharide on the Growth of Francisella tularensis LVS in Murine Macrophage-like Cell Line J774
    Monika Holicka
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Department of Clinical Immunology and Allergology, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:101-106. 2009
    ..Francisella tularensis, a causative agent of human tularemia, displaying the ability to proliferate inside the human cells...
  48. doi request reprint The dynamics of selected local inflammatory markers to talc in the treatment of malignant pleural effusions
    Petr Habal
    Department of Cardiac Surgery, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital in Hradec Kralove, Czech Republic
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 157:311-5. 2013
    ..However, markers of inflammatory reactions to extraneous substances like talc are not fully understood. The aim of this study was to assess the course of local inflammatory changes in the pleural cavity after talc insufflation...
  49. ncbi request reprint Scavenger receptor CD163 and its biological functions
    Gabriela Onofre
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:57-61. 2009
    ..It seems apparent from this review that CD163 scavenger receptor can be used as biomarker in different diseases and as a valuable diagnostic parameter for prognosis of many diseases especially inflammatory disorders and sepsis...
  50. ncbi request reprint Immunosuppressive effect of polycyclic aromatic hydrocarbons by induction of apoptosis of pre-B lymphocytes of bone marrow
    Jakub Novosad
    Charles University in Prague, Faculty of Medicine in Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 45:123-8. 2002
    ..Intensity of entire manifestations is also considerably dependent on the presence and intensity of mechanisms of active or passive resistance of cells...
  51. ncbi request reprint The significance of soluble CD138 in diagnosis of monoclonal gammopathies
    V Maisnar
    2nd Department of Medicine Department of Clinical Hematology, Charles University Teaching Hospital, 50005 Hradec Kralove, Czech Republic
    Neoplasma 53:26-9. 2006
    ..029). It seems that determination of sCD138 can be recommended as a helpful and reliable marker for differential diagnosis as well as prognosis of monoclonal gammopathies...
  52. ncbi request reprint [Resistance of hematologic neoplasm cells to cytostatics. Part II]
    K Kodydková
    Ustav klinické imunologie a alergologie LF UK a FN, Hradec Kralove
    Cas Lek Cesk 139:591-5. 2000
    ..The great effort is now focused on both the detection of mechanisms of the resistance and on the clinical procedures of overcoming the resistance to cytotoxic drugs...
  53. ncbi request reprint [Resistance to cytostatics in hematologic neoplasm cells. Part III]
    K Kodydková
    Ustav klinické imunologie a alergologie LF UK a FN, Hradec Kralove
    Cas Lek Cesk 139:620-2. 2000
    ..The great effort is now focused on both the detection of mechanisms of the resistance and on the clinical procedures of overcoming the resistance to cytotoxic drugs...
  54. ncbi request reprint [Cytoimmunofluorometry in the diagnosis of MALT lymphoma of the gastrointestinal tract]
    J Krejsek
    Univerzita Karlova v Praze, Lékarská fakulta v Hradci Králové Ustav klinické imunologie a alergologie
    Acta Medica (Hradec Kralove) Suppl 44:9-12. 2001
    ..The ultimate evidence of clonality is immunoglobulin light chains either kappa or lambda expression determination...
  55. ncbi request reprint The effect of trimetazidine on C-reactive protein, cytokines and adhesion molecules in the course of acute myocardial infarction
    R Pudil
    2nd Department of Medicine, Charles University, Prague, Faculty of Medicine, Hradec Kralove
    Acta Medica (Hradec Kralove) 44:135-40. 2001
    ....
  56. ncbi request reprint Selectins and monocyte chemotactic peptide as the markers of atherosclerosis activity
    M Blaha
    Department Hematology, Institute of Clinical Immunology and Allergology, Faculty Hospital, Charles University, Hradec Kralove, Czech Republic
    Physiol Res 53:273-8. 2004
    ....
  57. ncbi request reprint [Transcription factor Egr-1 in cardiovascular biology]
    P Kunes
    Kardiochirurgická klinika LF UK a FN, Hradec Kralove
    Cas Lek Cesk 146:466-73. 2007
    ....
  58. doi request reprint Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features
    F Vrbacky
    2nd Department of Internal Medicine, Department of Clinical Hematology, Faculty of Medicine and University Hospital, Charles University, Hradec Kralove, Czech Republic
    Hematology 15:210-4. 2010
    ..Further studies are needed to confirm the results in a larger patient cohort...
  59. ncbi request reprint [Multidrug resistance markers monitoring in acute myeloid leukemia cells]
    K Jankovicova
    Ustav klinické imunologie a alergologie FN, Hradec Kralove
    Cas Lek Cesk 143:471-5. 2004
    ..The aim of this study was to find the relationship between some multidrug resistance markers and some clinical and laboratory parameters. We compare also P-gp expression between acute myeloid leukemia (AML) FAB subgroups M0-M6...
  60. ncbi request reprint [Transcription factor KLF2 (Krüppel-like factor 2) and natural defence of vascular endothelium]
    P Kunes
    Kardiochirurgická klinika FN a LF UK, Hradec Kralove
    Cas Lek Cesk 146:909-15. 2007
    ..This review article offers an insight into basic preventive mechanisms exerted by KLF2, notably those related to atherosclerosis...
  61. doi request reprint Scavenger Receptor CD163 and Its Biological Functions
    Gabriela Onofre
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Department of Clinical Immunology and Allergology, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:57-61. 2009
    ..It seems apparent from this review that CD163 scavenger receptor can be used as biomarker in different diseases and as a valuable diagnostic parameter for prognosis of many diseases especially inflammatory disorders and sepsis...
  62. doi request reprint Increase of Intracellular BAFF in B Cells of Sjögren's Patients Is Not Affected by Decrease of BAFFR
    Jan Krejsek
    Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Department of Clinical Immunology and Allergology, Czech Republic
    Acta Medica (Hradec Kralove) 58:25-31. 2015
    ..The decrease of BAFFR expression in SjS patients suggests that there is the mechanism that attempts to take over in order to balance the high level of BAFF. ..
  63. ncbi request reprint Immunologic changes in TNF-alpha, sE-selectin, sP-selectin, sICAM-1, and IL-8 in pediatric patients treated for psoriasis with the Goeckerman regimen
    Lenka Borska
    Institute of Pathological Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, University Hospital, Hradec Kralove, Czech Republic
    Pediatr Dermatol 24:607-12. 2007
    ..The serum level of IL-8 increased after the Goeckerman regimen. This fact indicates that the chemokine pathway of IL-8 activity could be modulated by this treatment, most likely by polycyclic aromatic hydrocarbons...
  64. ncbi request reprint The effect of interferon-gamma and lipopolysaccharide on the growth of Francisella tularensis LVS in murine macrophage-like cell line J774
    Monika Holicka
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:101-6. 2009
    ..Francisella tularensis, a causative agent of human tularemia, displaying the ability to proliferate inside the human cells...
  65. ncbi request reprint Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall
    Pavel Kunes
    Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:135-9. 2009
    ..This review article offers recent information concerning activities of Krüppel-like factor 4 in the vascular wall...
  66. ncbi request reprint The counter-regulation of atherogenesis: a role for interleukin-33
    Pavel Kunes
    Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 53:125-9. 2010
    ..IL-33 is a nuclear transcription factor of endothelial cells. As such, it is abundant in nonproliferating vessels. Its down-regulation is required for angiogenesis, which may be profitable in wound healing or deleterious in tumor growth...
  67. ncbi request reprint Inflammatory response to acute myocardial infarction complicated by cardiogenic shock
    R Pudil
    2nd Department of Medicine, Charles University, Prague, Faculty of Medicine, Hradec Kralove
    Acta Medica (Hradec Kralove) 44:149-51. 2001
    ..value 1652 pg/ml, vs. normal value < 30 pg/ml). The soluble adhesion molecule levels (sE-selectin and sICAM 1) were elevated throughout the period of observation without any significant peak...
  68. doi request reprint Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall
    Pavel Kunes
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Department of Cardiac Surgery, Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 52:135-139. 2009
    ..This review article offers recent information concerning activities of Krüppel-like factor 4 in the vascular wall...
  69. doi request reprint Amniotic fluid concentrations of soluble scavenger receptor for hemoglobin (sCD163) in pregnancy complicated by preterm premature rupture of the membranes and histologic chorioamnionitis
    Marian Kacerovsky
    Department of Obstetrics and Gynecology, Charles University in Prague, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Czech Republic
    J Matern Fetal Neonatal Med 24:995-1001. 2011
    ....
  70. ncbi request reprint Biological prognostic markers in chronic lymphocytic leukemia
    Vladimira Vroblova
    Charles University in Prague, Faculty of Medicine and University Hospital Hradec Kralove, Czech Republic, Institute of Clinical Immunology and Allergology
    Acta Medica (Hradec Kralove) 52:3-8. 2009
    ..Molecules regulating the process of angiogenesis are also considered as promising markers. The purpose of this review is to summarize in detail the specific role of these prognostic factors in chronic lymphocytic leukemia...
  71. ncbi request reprint [Cell death and its role in immunopathogenesis of infectious diseases]
    Jakub Novosad
    Department of Clinical Immunology and Allergology, University Hospital, Hradec Kralove, Czech Republic
    Klin Mikrobiol Infekc Lek 17:76-80. 2011
    ..These cell death scenarios are discussed in the context of pathogenesis of infectious diseases...
  72. ncbi request reprint B cell toll-like receptors with respect to the pathogenesis of Sjögren's syndrome
    Irena Berglová
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine, Czech Republic
    Acta Medica (Hradec Kralove) 54:51-7. 2011
    ..This review will focus on the possible role of B cells and TLRs signaling in the pathogenesis of SS...
  73. ncbi request reprint Serum soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and neopterin in patients with Sjögren's syndrome
    C Andrys
    Department of Clinical Immunology and Allergology, University Teaching Hospital, Hradec Kralove
    Acta Medica (Hradec Kralove) 42:97-101. 1999
    ..No statistically significant differences in serum levels of sVCAM-1 were found either in patients with primary or secondary SS compared to control group...
  74. doi request reprint Crohn's disease: a role of gut microbiota and Nod2 gene polymorphisms in disease pathogenesis
    Lucia Hrncirova
    Department of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic
    Acta Medica (Hradec Kralove) 57:89-96. 2014
    ....
  75. ncbi request reprint Health risk of occupational exposure in welding processes II. Immunological effects
    Lenka Borska
    Charles University in Prague, Faculty of Medicine in Hradec Kralove, Institute of Pathological Physiology, Czech Republic
    Acta Medica (Hradec Kralove) 46:31-5. 2003
    ..001) and ceruloplasmin (p < 0.05) were found. Some of these changes were characteristic for the exposed group. They could be considered as precursors of biological markers of effect for given type of exposure...
  76. ncbi request reprint Platelets activation in patients undergoing PTCA and their responsiveness after in vitro stimulation
    Martina Loudová
    Charles University in Prague, Faculty of Medicine in Hradec Králové Department of Clinical Immunology and Allergology, Czech Republic
    Acta Medica (Hradec Kralove) 46:183-8. 2003
    ..98% (in comparison with control group 94.98%), CD31: 87.10% (92.78%), CD36: 87.37% (90.98%), CD41: 88.09% (95.62%), CD42a: 88.54% (94.98%), CD42a: 88.31% (94.13%)...
  77. ncbi request reprint The multidrug resistance and apoptosis evaluation in acute myeloid leukemia cells after the in vitro doxorubicin treatment
    Karolina Jankovicova
    Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Kralove, Czech Republic Department of Clinical Immunology and Allergology
    Acta Medica (Hradec Kralove) 47:181-5. 2004
    ..The relation between the AML blast in vitro reaction and some clinical parameters such as the age of patient, white blood cell count, and blast percentage was also observed...
  78. ncbi request reprint Abnormalities of tau-protein and beta-amyloid in brain ventricle cerebrospinal fluid
    Radomir Talab
    Department of Neurology, Charles University in Prague, School of Medicine in Hradec Kralove, University Hosptial, Hradec Kralove, Czech Republic
    Neuro Endocrinol Lett 30:647-51. 2009
    ....
  79. doi request reprint Neutrophil apoptosis by Fas/FasL: harmful or advantageous in cardiac surgery?
    P Kunes
    Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital, Hradec Kralove, Czech Republic
    Thorac Cardiovasc Surg 57:1-6. 2009
    ..This review article, aimed preferentially but not exclusively at the cardiac surgeon, presents some new information in support of this viewpoint, which fits in with our own observations...
  80. doi request reprint J774 macrophage-like cell line cytokine and chemokine patterns are modulated by Francisella tularensis LVS strain infection
    M Holicka
    Department of Clinical Immunology and Allergology, University Hospital and School of Medicine in Hradec Kralove, Charles University in Prague, 500 05, Hradec Kralove, Czech Republic
    Folia Microbiol (Praha) 55:191-200. 2010
    ..t. infection did not affect the production of IL-8, IL-6, MCP-5, and RANTES by stimulated macrophages. This showed that F.t. infection modulates the cytokine synthesis by J774 macrophage cell line...
  81. ncbi request reprint Angiogenic activity in patients with psoriasis is significantly decreased by Goeckerman's therapy
    C Andrys
    Department of Clinical Immunology and Allergy, School of Medicine, Charles University in Prague, Hradec Kralove, Czech Republic
    Arch Dermatol Res 298:479-83. 2007
    ..0319). In conclusion, we found that the angiogenic potential which is abnormally increased in patients with psoriasis is significantly alleviated by GT...
  82. ncbi request reprint [Importance of selected laboratory indicators in the differential diagnosis and monitoring of multiple myeloma]
    V Maisnar
    Oddelení klinicke hematologie FN, Hradec Kralove
    Vnitr Lek 48:290-7. 2002
    ..Except of beta 2-microglobulin serum level we did not find statistically significant correlation with activity of multiple myeloma in any of the investigated parameters...
  83. ncbi request reprint [Cytoimunofluorometry and its use in the detection of blood platelet activation]
    M Loudova
    Ustav klinické imunologie a alergologie Fakultní nemocnice, Hradec Kralove
    Vnitr Lek 47:175-80. 2001
    ..Procoagulant microparticles are shedding and the aggregates of platelets with leucocytes are appearing. The activated platelet can be detected by flow cytometry after imunofluorescent staining...
  84. ncbi request reprint [Immunopathogenesis of diabetes mellitus I]
    J Krejsek
    Ustav klinické imunologie a alergologie Lékarské fakulty UK a FN, Hradec Kralove
    Vnitr Lek 50:408-11. 2004
    ..There could be the chance to interrupt this pathogenetic process by manipulation with immune system to achieve induction of tolerance. Such clinical trials are now under progress...
  85. ncbi request reprint [Immunofluorescence determination using flow cytometry of platelet surface antigens in peripheral blood of healthy individuals (pilot study)]
    M Loudova
    Ustav klinické imunologie a alergologie Lékarské fakulty UK a FN, Hradec Kralove
    Vnitr Lek 48:632-7. 2002
    ..97), CD36: 90.98% (+/- 5.25), CD41: 95.62% (+/- 2.23), CD42a: 94.98% (+/- 2.62), CD42b: 94.13% (+/- 2.58), activation molecules CD62P: 0.45% (+/- 0.33), CD63: 0.32% (+/- 0.22). This study is the first report in Czech literature...
  86. ncbi request reprint [Multidrug resistance of leukemia cells to cytostatics--the functional fluorescent dye efflux assay evaluated by flow cytometry]
    K Jankovicova
    Ustav klinické imunologie a alergologie Lékarské fakulty UK a Fakultní nemocnice, Hradec Kralove
    Vnitr Lek 47:25-9. 2001
    ..The cell line K562 with transfected P-glycoprotein gene serves as a model system for the studying of the transport function with the use of the fluorescent substrates and P-glycoprotein inhibitors...