Ondrej Slaby

Summary

Affiliation: Masaryk Memorial Cancer Institute
Country: Czech Republic

Publications

  1. doi request reprint MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma
    Martina Redova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic
    Tumour Biol 34:481-91. 2013
  2. pmc Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer
    Ondrej Slaby
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    J Cell Mol Med 16:8-21. 2012
  3. pmc Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy
    Ondrej Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, Czech Republic
    J Exp Clin Cancer Res 29:90. 2010
  4. doi request reprint Gene expression of somatostatin receptor 4 predicts clinical outcome of patients with metastatic neuroendocrine tumors treated with somatostatin analogs
    Ondrej Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Cancer Biother Radiopharm 25:237-43. 2010
  5. ncbi request reprint MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients
    O Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Neoplasma 57:264-9. 2010
  6. doi request reprint Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer
    O Slaby
    Departments of Clinical and Experimental Pathology, Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czech Republic
    Oncology 72:397-402. 2007
  7. pmc MicroRNAs in colorectal cancer: translation of molecular biology into clinical application
    Ondrej Slaby
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    Mol Cancer 8:102. 2009
  8. ncbi request reprint [DNA and microRNA microarray technologies in diagnostics and prediction for patients with renal cell carcinoma]
    O Slaby
    klinika komplexní onkologické péce, Masarykův onkologický ujstav, Brno
    Klin Onkol 22:202-9. 2009
  9. ncbi request reprint [Involvement of microRNAs in cancer biology and possibilities of their application to diagnostic and predictive oncology]
    O Slaby
    Oddelení klinické a experimentální patologie, Masarykův Onkologický ústav, Brno
    Cas Lek Cesk 147:25-31. 2008
  10. ncbi request reprint Significant overexpression of Hsp110 gene during colorectal cancer progression
    O Slaby
    Masaryk Memorial Cancer Institute, Department of Oncological and Experimental Pathology, 656 53 Brno, Czech Republic
    Oncol Rep 21:1235-41. 2009

Collaborators

Detail Information

Publications67

  1. doi request reprint MiR-210 expression in tumor tissue and in vitro effects of its silencing in renal cell carcinoma
    Martina Redova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic
    Tumour Biol 34:481-91. 2013
    ..To our knowledge, this is the first report to show miR-210 regulatory effects on cell migration, invasive potential, and HIF1a protein in RCC cells...
  2. pmc Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer
    Ondrej Slaby
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    J Cell Mol Med 16:8-21. 2012
    ..In this review, we provide a comprehensive list of potentially functional miRNA-related SNPs and summarize their importance as candidate cancer biomarkers...
  3. pmc Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy
    Ondrej Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, Czech Republic
    J Exp Clin Cancer Res 29:90. 2010
    ..MicroRNAs are endogenously expressed regulatory noncoding RNAs. Previous studies have shown altered expression levels of several microRNAs in renal cell carcinoma...
  4. doi request reprint Gene expression of somatostatin receptor 4 predicts clinical outcome of patients with metastatic neuroendocrine tumors treated with somatostatin analogs
    Ondrej Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Cancer Biother Radiopharm 25:237-43. 2010
    ..0357). These levels correlated with time to progression (p = 0.0015) and overall survival (p = 0.0017) in NET patients...
  5. ncbi request reprint MicroRNA-181 family predicts response to concomitant chemoradiotherapy with temozolomide in glioblastoma patients
    O Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Neoplasma 57:264-9. 2010
    ..Our data indicate for the first time that expression levels of miR-181b and miR-181c could serve as a predictive marker of response to RT/TMZ therapy in glioblastoma patients...
  6. doi request reprint Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer
    O Slaby
    Departments of Clinical and Experimental Pathology, Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czech Republic
    Oncology 72:397-402. 2007
    ..MicroRNAs (miRNAs) are endogenously expressed regulatory noncoding RNAs. Previous, mainly preclinical studies showed altered expression levels of several miRNAs in CRC...
  7. pmc MicroRNAs in colorectal cancer: translation of molecular biology into clinical application
    Ondrej Slaby
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    Mol Cancer 8:102. 2009
    ..In this review, we summarize the knowledge regarding miRNAs' functioning in CRC while emphasizing their significance in pathogenetic signaling pathways and their potential to serve as disease biomarkers and novel therapeutic targets...
  8. ncbi request reprint [DNA and microRNA microarray technologies in diagnostics and prediction for patients with renal cell carcinoma]
    O Slaby
    klinika komplexní onkologické péce, Masarykův onkologický ujstav, Brno
    Klin Onkol 22:202-9. 2009
    ..The aim of this review is to summarize the results from microarray studies of renal cell carcinoma realized to date and to present their potential usage in diagnostic and therapeutic protocols...
  9. ncbi request reprint [Involvement of microRNAs in cancer biology and possibilities of their application to diagnostic and predictive oncology]
    O Slaby
    Oddelení klinické a experimentální patologie, Masarykův Onkologický ústav, Brno
    Cas Lek Cesk 147:25-31. 2008
    ..In this review we attempt to introduce basic knowledge of miRNAs biogenesis and biological functions and in particular summarise reports focused on miRNAs in oncology research area...
  10. ncbi request reprint Significant overexpression of Hsp110 gene during colorectal cancer progression
    O Slaby
    Masaryk Memorial Cancer Institute, Department of Oncological and Experimental Pathology, 656 53 Brno, Czech Republic
    Oncol Rep 21:1235-41. 2009
    ..031) and negative trend of HSP110 gene expression and overall survival of CRC patients. We suggest that HSP110 gene is a promising molecular predictor in CRC...
  11. pmc Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population
    Renata Hezova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Eur J Med Res 17:17. 2012
    ..Glutathione S-transferases could act as attractive susceptibility genes for CRC, as they are directly involved in conjugation between glutathione and chemotherapeutics, environmental pollutants and a wide spectrum of xenobiotics...
  12. doi request reprint MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients
    Radek Lakomy
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Cancer Sci 102:2186-90. 2011
    ..Above all, we suggest that the combination of miR-181c and miR-21 could be a very sensitive and specific test to identify patients at high risk of early progression after surgery...
  13. doi request reprint Identification of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer
    Ondrej Slaby
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    Nutr Cancer 65:247-54. 2013
    ..072). This study showed that miRNAs could be involved in chemoprotective effects of natural agents; their function alteration through SNPs in their binding sites and flanking regions presents a new class of CRC risk factors...
  14. doi request reprint Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients
    Ondrej Slaby
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Genes Chromosomes Cancer 51:707-16. 2012
    ..If further validated, we suggest that identified miRNAs might be used for identification of RCC patients at high risk of early relapse after nephrectomy in clinical practice...
  15. pmc Identification and functional screening of microRNAs highly deregulated in colorectal cancer
    Petra Faltejskova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute MMCI, Brno, Czech Republic
    J Cell Mol Med 16:2655-66. 2012
    ..These findings indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumour suppressors, whereas miR-135b functions as an oncogene; both groups of miRNA contribute to CRC pathogenesis...
  16. pmc MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients
    Marek Svoboda
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, 656 53, Czech Republic
    Radiat Oncol 7:195. 2012
    ..MicroRNAs (miRNAs) are small non-coding RNAs playing significant roles in the pathogenesis of many cancers including rectal cancer. MiRNAs could present the new predictive biomarkers for rectal cancer patients...
  17. pmc Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
    Renata Hezova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech
    World J Gastroenterol 18:2827-31. 2012
    ..To investigate whether selected single nucleotide polymorphisms (SNPs) in miR-196a2, miR-27a and miR-146a genes are associated with sporadic colorectal cancer (CRC)...
  18. doi request reprint MiR-205 functions as a tumor suppressor in adenocarcinoma and an oncogene in squamous cell carcinoma of esophagus
    Renata Hezova
    Central European Institute of Technology CEITEC, Masaryk University, Brno, Czech Republic
    Tumour Biol 37:8007-18. 2016
    ..Our results suggest that miR-205 could serve as biomarker in esophageal cancer and acts as a tumor suppressor in esophageal adenocarcinoma and oncogene in esophageal squamous cell carcinoma. ..
  19. pmc Decreased expression levels of PIWIL1, PIWIL2, and PIWIL4 are associated with worse survival in renal cell carcinoma patients
    Robert Iliev
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Onco Targets Ther 9:217-22. 2016
    ..Our results suggest the involvement of PIWIL genes and piR-823 in RCC pathogenesis, and indicate PIWIL1, PIWIL2, and PIWIL4 as potential prognostic biomarkers in patients with RCC. ..
  20. pmc HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma
    Leos Kren
    Department of Pathology, Faculty of Medicine, University Hospital Brno, Masaryk University, Jihlavska 20, Brno 625 00, Czech Republic
    Diagn Pathol 7:58. 2012
    ..A prognostic significance of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not characterized at all...
  21. doi request reprint Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells
    Petra Faltejskova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53 Brno, Czech Republic
    Int J Colorectal Dis 27:1401-8. 2012
    ..MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer (CRC) patients; however, only a little is known about its functional role in CRC...
  22. pmc Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma
    Martina Redova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, Czech Republic
    J Transl Med 10:55. 2012
    ..Our aim was to identify miRNA signature that can distinguish the blood serum of RCC patients and matched healthy controls and validate identified miRNAs as potential biomarkers for RCC...
  23. ncbi request reprint Expression Levels of PIWI-interacting RNA, piR-823, Are Deregulated in Tumor Tissue, Blood Serum and Urine of Patients with Renal Cell Carcinoma
    Robert Iliev
    Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Anticancer Res 36:6419-6423. 2016
    ..There were preliminary data published indicating that piR-823 expression is deregulated in circulating tumor cells and tumor tissue in gastric and kidney cancer, respectively...
  24. doi request reprint Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: Evidence against their usage as biomarkers in colorectal cancer
    Petra Faltejskova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Cancer Biomark 12:199-204. 2012
    ..Therefore, there is a high demand for cost-effective and non-invasive biomarkers that would enable an early detection of asymptomatic and curable disease with high sensitivity and specificity...
  25. pmc Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab
    Peter Grell
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic
    Int J Oncol 41:1204-12. 2012
    ..009; HR 0.45). This study is the first to prove the significance of Akt kinase isoform, activity and compartmentalization for the prediction of response to trastuzumab-based therapy in patients with HER2-positive metastatic breast cancer...
  26. doi request reprint MicroRNAs involved in chemo- and radioresistance of high-grade gliomas
    Andrej Besse
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic
    Tumour Biol 34:1969-78. 2013
    ..In this review, we summarize the current knowledge of the functional role of miRNAs in gliomas resistance to chemo- and radiotherapy. ..
  27. doi request reprint Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer
    Petra Vychytilova-Faltejskova
    Centre for Molecular Medicine, Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic, Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk Memorial Cancer Institute, Masaryk University, Zluty kopec 7, 656 53 Brno, Czech Republic and
    Carcinogenesis 37:941-50. 2016
    ..30; 95% CI 1.44-3.66; P < 0.0004). In summary, highly sensitive signatures of circulating microRNAs enabling non-invasive early detection and prognosis prediction of colon cancer were identified. ..
  28. doi request reprint MiR-338-5p sensitizes glioblastoma cells to radiation through regulation of genes involved in DNA damage response
    Andrej Besse
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Tumour Biol 37:7719-27. 2016
    ..To our knowledge, this is the first study to describe the role of miR-338-5p in GBM and its potential to improve the sensitivity of GBM to radiation. ..
  29. doi request reprint Dynamic changes in microRNA expression profiles reflect progression of Barrett's esophagus to esophageal adenocarcinoma
    Ondrej Slaby
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Masaryk University, Faculty of Medicine, 656 53 Brno, Czech Republic, Central European Institute of Technology, Molecular Oncology II, Masaryk University, 625 00 Brno, Czech Republic
    Carcinogenesis 36:521-7. 2015
    ..We suggest that miRNA expression profiling expands current knowledge in molecular pathology of Barrett's-based carcinogenesis and enables identification of molecular biomarkers for early detection of BE dysplasia and progression to EAC. ..
  30. pmc Epithelial-mesenchymal transition-associated microRNA/mRNA signature is linked to metastasis and prognosis in clear-cell renal cell carcinoma
    Hana Mlcochova
    Masaryk University, Central European Institute of Technology CEITEC, Kamenice 5, 625 00, Brno, Czech Republic
    Sci Rep 6:31852. 2016
    ..Finally, we confirmed involvement of miR-429 in EMT regulation in RCC cells in vitro. ..
  31. ncbi request reprint MiR-429 is linked to metastasis and poor prognosis in renal cell carcinoma by affecting epithelial-mesenchymal transition
    Tana Machackova
    Central European Institute of Technology CEITEC, Masaryk University, University Campus Bohunice, Building A35, Room 217, Kamenice 5, 625 00, Brno, Czech Republic
    Tumour Biol 37:14653-14658. 2016
    ..We further suggest that miR-429 has a capacity to inhibit loss of E-cadherin in RCC cells undergoing EMT and consequently attenuate their motility...
  32. doi request reprint Risk Score based on microRNA expression signature is independent prognostic classifier of glioblastoma patients
    Jiri Sana
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno 65653, Czech Republic, Faculty of Medicine, Masaryk University, Brno 62500, Czech Republic, Central European Institute of Technology, Masaryk University, Brno 62500, Czech Republic
    Carcinogenesis 35:2756-62. 2014
    ..We suggest that the Risk Score presents promising prognostic algorithm with potential for individualized treatment decisions in clinical management of GBM patients. ..
  33. pmc MiR-34b is associated with clinical outcome in triple-negative breast cancer patients
    Marek Svoboda
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno 656 53, The Czech Republic
    Diagn Pathol 7:31. 2012
    ..Therefore, miRNAs are also potential prognostic and/or predictive biomarkers in triple-negative breast cancer patients...
  34. ncbi request reprint Overexpression of long non-coding RNA TUG1 predicts poor prognosis and promotes cancer cell proliferation and migration in high-grade muscle-invasive bladder cancer
    Robert Iliev
    Central European Institute of Technology CEITEC, Masaryk University, University Campus Bohunice, Building A35, Room 217, Kamenice 5, 625 00, Brno, Czech Republic
    Tumour Biol 37:13385-13390. 2016
    ..Together with in vitro observations, these data suggest an oncogenic role of TUG1 and its potential usage as biomarker or therapeutic target in MIBC...
  35. pmc Diagnostic and prognostic potential of miR-21, miR-29c, miR-148 and miR-203 in adenocarcinoma and squamous cell carcinoma of esophagus
    Renata Hezova
    Molecular Oncology II Solid Cancers, Molecular Medicine Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Diagn Pathol 10:42. 2015
    ..The aim of this study was to examine the expression levels of candidate microRNAs in esophageal cancer and evaluate their diagnostic and prognostic potential...
  36. doi request reprint Efficacy of Sunitinib in Elderly Patients with Metastatic Renal Cell Carcinoma: Data from Real-World Clinical Practice
    Alexandr Poprach
    Department of Comprehensive Cancer Care and Faculty of Medicine, Masaryk Memorial Cancer Institute and Masaryk University, Brno, Czech Republic
    Drugs Aging 33:655-63. 2016
    ..The aim of the present retrospective registry-based study was to analyse efficacy and toxicity of sunitinib as the first-line targeted therapy of elderly mRCC patients...
  37. pmc miR-155 and miR-484 Are Associated with Time to Progression in Metastatic Renal Cell Carcinoma Treated with Sunitinib
    Jana Merhautova
    Department of Pharmacology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
    Biomed Res Int 2015:941980. 2015
    ..Biological role of miR-484 has to be clarified. Stratification of patients based on miRNA analysis would allow more personalized approach in therapy of metastatic renal cell carcinoma. ..
  38. doi request reprint Extension of microRNA expression pattern associated with high-risk neuroblastoma
    Julie Bienertova-Vasku
    Department of Pediatric Oncology, University Hospital Brno, Brno, Czech Republic
    Tumour Biol 34:2315-9. 2013
    ..We confirm some of the previous observations and we report several new microRNAs associated with aggressive NBL, both being relevant subjects for further translational validation and functional studies...
  39. doi request reprint Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: an unexpected prognostic significance?
    Leos Kren
    Department of Pathology, University Hospital Brno, Brno, Czech Republic
    Neuropathology 31:129-34. 2011
    ..Mechanisms of glioblastoma cell pathophysiology and mechanisms of responses to therapeutic interventions in respect to the expression of these molecules deserves further study...
  40. ncbi request reprint Genome-wide microRNA Expression Profiling in Primary Tumors and Matched Liver Metastasis of Patients with Colorectal Cancer
    Petra Vychytilova-Faltejskova
    Central European Institute of Technology, Masaryk University, Brno, Czech Republic Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Cancer Genomics Proteomics 13:311-6. 2016
    ..MicroRNAs (miRNAs) are small non-coding RNAs that are involved in cancer development and progression, but their role in metastasis has not been extensively investigated...
  41. pmc Mutational analysis of primary and metastatic colorectal cancer samples underlying the resistance to cetuximab-based therapy
    Radim Nēmecek
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Masaryk University, Brno, Czech Republic
    Onco Targets Ther 9:4695-703. 2016
    ..The aim of the present retrospective single-institutional study was to evaluate potential genes responsible for resistance to anti-EGFR therapy in relation to mutational analysis of primary versus metastatic lesions...
  42. pmc MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab
    Jitka Mlcochova
    Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Oncotarget 6:38695-704. 2015
    ..There was no difference in miR-31-5p/3p expression levels in RAS mutated and wild-type tumor samples. MiR-31-5p/3p are promising predictive biomarkers of cetuximab response in wt-RAS mCRC patients. ..
  43. doi request reprint MicroRNAs targeting EGFR signalling pathway in colorectal cancer
    Jitka Mlcochova
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Zluty kopec 7, 656 53, Brno, Czech Republic, Europe
    J Cancer Res Clin Oncol 139:1615-24. 2013
    ..In this review, we summarize current knowledge about miRNAs targeting EGFR signalling pathway, their functioning in CRC pathogenesis and potential usage as biomarkers. ..
  44. doi request reprint Circulating miRNAs as new blood-based biomarkers for solid cancers
    Martina Redova
    Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic
    Future Oncol 9:387-402. 2013
    ....
  45. pmc MicroRNAs and glioblastoma: roles in core signalling pathways and potential clinical implications
    Jiri Sana
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    J Cell Mol Med 15:1636-44. 2011
    ..In this review, we summarize the current knowledge about miRNAs significance in glioblastoma, with special focus on their involvement in core signalling pathways, their roles in drug resistance and potential clinical implications...
  46. ncbi request reprint Expression pattern of HLA class I antigens in renal cell carcinoma and primary cell line cultures: methodological implications for immunotherapy
    Libor Hanak
    University Cell Immunotherapy Center, Masaryk University, Brno, Czech Republic
    Med Sci Monit 15:CR638-43. 2009
    ..In this study both classic and non-classic HLA class I antigens were tested in tumor specimens and established primary cell cultures derived from renal cell carcinoma patients...
  47. ncbi request reprint Efficacy and Toxicity of Panitumumab After Progression on Cetuximab and Predictive Value of MiR-31-5p in Metastatic Wild-type KRAS Colorectal Cancer Patients
    Igor Kiss
    Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Anticancer Res 36:4955-9. 2016
    ..However, few studies have demonstrated that a small subset of mCRC patients may benefit from panitumumab in this setting...
  48. pmc Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma
    Lenka Besse
    Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic
    PLoS ONE 10:e0137294. 2015
    ..0001). Together, our data suggest connection between lower level of microRNA-130a and extramedullary disease and prompt further work to evaluate this miRNA as a marker of extramedullary disease in multiple myeloma. ..
  49. doi request reprint The role of microRNAs in mitochondria in cancer
    Julie Bienertova-Vasku
    Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Cancer Lett 336:1-7. 2013
    ..Here we summarize current knowledge about miRNAs involved in mitochondrial functioning with focus on cellular energy metabolism, apoptosis and mitophagy...
  50. pmc Novel classes of non-coding RNAs and cancer
    Jiri Sana
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Zluty kopec 7, Brno, Czech Republic, Europe
    J Transl Med 10:103. 2012
    ..In this review, we summarize newly discovered classes of ncRNAs, and highlight their functioning in cancer biology and potential usage as biomarkers or therapeutic targets...
  51. doi request reprint MicroRNAs and their target gene networks in renal cell carcinoma
    Martina Redova
    Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Brno, Czech Republic
    Biochem Biophys Res Commun 405:153-6. 2011
    ..In this review, we summarize the current knowledge of miRNA functions in renal cell carcinoma with an emphasis on miRNAs potential to serve as a powerful biomarker of disease and a novel therapeutic target in oncology...
  52. doi request reprint microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients
    Renata Hezova
    University Cell Immunotherapy Centre, Masaryk University, Brno, Czech Republic Laboratory of Molecular Pathology, Medical Faculty, Palacky University, Olomouc, Czech Republic
    Cell Immunol 260:70-4. 2010
    ..To our knowledge, this is the first study demonstrating changes in miRNA expression profiles occurring in Tregs of T1D patients and a miRNAs signature of adult Tregs...
  53. ncbi request reprint [Possibilities of resistance prediction to neoadjuvant concomitant chemoradiotherapy in the treatment algorithm of patients with rectal carcinoma]
    I Garajova
    Masarykův Onkologický ústav, klinika komplexní onkologické péce, Brno
    Klin Onkol 21:330-7. 2008
    ..It is reported that cca 15 percent of patients with advanced rectal cancer show pCR which is indicative of improved long-term prognosis...
  54. ncbi request reprint [EGFR tyrosine kinase inhibitors as a targeted therapy for bronchioloalveolar carcinoma of the lung: a case report of a clinically prompt and intensive response and literature review]
    M Svoboda
    klinika komplexní onkologické péce, Masarykův Onkologický ústav, Brno
    Klin Onkol 23:224-30. 2010
    ....
  55. ncbi request reprint [Gene expression profiling in prediction of tumor response to neoadjuvant concomitant chemoradiotherapy in patients with locally advanced rectal carcinoma: pilot study]
    I Garajova
    klinika komplexní onkologické péce, Masarykův Onkologický ústav, Brno
    Cas Lek Cesk 147:381-6. 2008
    ..It is based on fluoropyrimidines (5-fluorouracil, capecitabine) with concurrent radiotherapy. The aim of the study was to evaluate the capability of gene expression method to identify nonresponders (NR) pretherapeutically...
  56. pmc MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma
    Petra Vychytilova-Faltejskova
    Molecular Oncology II Solid Cancers, Molecular Medicine, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
    Diagn Pathol 10:38. 2015
    ..The aim of this study was to analyze the expression of selected microRNAs in normal pancreas, chronic pancreatitis and pancreatic ductal adenocarcinoma tissues and evaluate their diagnostic and prognostic potential...
  57. pmc Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer
    Nithyananda Thorenoor
    Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic
    Oncotarget 7:622-37. 2016
    ..However, molecular mechanisms behind these interactions have to be further clarified. ..
  58. doi request reprint Association study of selected genetic polymorphisms and occurrence of venous thromboembolism in patients with multiple myeloma who were treated with thalidomide
    Martina Almasi
    Babak Research Institute, Masaryk University, Brno, Czech Republic
    Clin Lymphoma Myeloma Leuk 11:414-20. 2011
    ..In that study, the researchers built a classification tree that enables prediction of individual risk of VTE in patients with MM...
  59. doi request reprint MicroRNA involvement in glioblastoma pathogenesis
    Jana Novakova
    University Cell Immunotherapy Center, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Biochem Biophys Res Commun 386:1-5. 2009
    ....
  60. ncbi request reprint Doxorubicin and Liposomal Doxorubicin Differentially Affect Expression of miR-208a and let-7g in Rat Ventricles and Atria
    Jan Novak
    Department of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A20, 625 00, Brno, Czech Republic
    Cardiovasc Toxicol . 2016
    ..79 and 14.70% reduction in let-7g expression in the LA (p = 0.015), respectively. Acute administration of DOX/L-DOX alters expression of miR-208a in LV and of let-7g in LA. These changes may partly contribute to the development of AIC...
  61. doi request reprint Urinary microRNAs as a new class of noninvasive biomarkers in oncology, nephrology, and cardiology
    Hana Mlcochova
    Central European Institute of Technology, Masaryk University, Kamenice 5, Brno, Czech Republic
    Methods Mol Biol 1218:439-63. 2015
    ..Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in urologic cancers, nephrology, and cardiology. ..
  62. pmc MicroRNA profiling of activated and tolerogenic human dendritic cells
    Zuzana Stumpfova
    Department of Pharmacology, Faculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic
    Mediators Inflamm 2014:259689. 2014
    ..This work may contribute to identifying specific modulating miRNAs for aDC and tDC, which could in the future serve as therapeutic targets in the treatment of cancer and autoimmune diseases...
  63. pmc MicroRNA-206: a promising theranostic marker
    Jan Novak
    1 International Clinical Research Center, Department of Cardiovascular Diseases, St Anne s University Hospital Brno, Brno, Czech Republic 2 Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic 3 Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
    Theranostics 4:119-33. 2014
    ....
  64. doi request reprint MicroRNAs involved in skeletal muscle development and their roles in rhabdomyosarcoma pathogenesis
    Jan Novak
    Faculty of Medicine, Department of Physiology, Masaryk University, Brno, Czech Republic Faculty of Medicine, Department of Pathological Physiology, Masaryk University, Brno, Czech Republic
    Pediatr Blood Cancer 60:1739-46. 2013
    ..This review summarizes current information about the role of miRs in the development of normal skeletal muscle and their deregulation in RMS...
  65. doi request reprint Individual myeloma-specific T-cell clones eliminate tumour cells and correlate with clinical outcomes in patients with multiple myeloma
    Jaroslav Michalek
    University Cell Immunotherapy Centre, Masaryk University, Kamenice 5, Brno, Czech Republic
    Br J Haematol 148:859-67. 2010
    ..We conclude that the clonotypic assay is the most sensitive tool for immunomonitoring of low-frequency T cells...
  66. doi request reprint Circulating Blood-Borne microRNAs as Biomarkers in Solid Tumors
    Petra Vychytilova-Faltejskova
    Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic
    EXS 106:75-122. 2015
    ..Here, we summarize the tumor-specific profiles of blood-borne microRNAs and discuss their potential utility for personalized medicine of solid tumors. ..
  67. doi request reprint Urine microRNAs as potential noninvasive biomarkers in urologic cancers
    Hana Mlcochova
    Central European Institute of Technology, Masaryk University, Brno, Czech Republic Masaryk Memorial Cancer Institute, Department of Comprehensive Cancer Care, Zluty kopec 7, 656 53 Brno, Czech Republic
    Urol Oncol 32:41.e1-9. 2014
    ..Finally, we summarize the studies focusing on detection and characterization of urinary miRNAs as potential biomarkers in bladder, prostate, and kidney cancers. ..