Philippe Delerive

Summary

Publications

  1. ncbi request reprint Identification of Reverb(alpha) as a novel ROR(alpha) target gene
    Philippe Delerive
    Department of Gene Regulation, Bone and Inflammation Research, Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:35013-8. 2002
  2. ncbi request reprint Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1
    Yifei Wu
    Gene Regulation, Bone, and Inflammation Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:8898-905. 2002
  3. ncbi request reprint PGC-1 functions as a transcriptional coactivator for the retinoid X receptors
    Philippe Delerive
    Department of Gene Regulation, Bone, and Inflammation Research, Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:3913-7. 2002
  4. ncbi request reprint Regulation of anti-atherogenic apolipoprotein M gene expression by the orphan nuclear receptor LRH-1
    Nicolas Venteclef
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis, France
    J Biol Chem 283:3694-701. 2008
  5. ncbi request reprint Interleukin-1 receptor antagonist induction as an additional mechanism for liver receptor homolog-1 to negatively regulate the hepatic acute phase response
    Nicolas Venteclef
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis, France
    J Biol Chem 282:4393-9. 2007
  6. ncbi request reprint Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, UK
    J Med Chem 49:6652-5. 2006
  7. pmc Liver receptor homolog 1 is a negative regulator of the hepatic acute-phase response
    Nicolas Venteclef
    GlaxoSmithKline R and D, CVU CEDD, 25 Avenue du Quebec, 91951 Les Ulis, France
    Mol Cell Biol 26:6799-807. 2006
  8. ncbi request reprint Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription
    Philippe Delerive
    GlaxoSmithKline, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, 91951 Les Ulis, France
    Mol Endocrinol 18:2378-87. 2004
  9. ncbi request reprint A paradigm for gene regulation: inflammation, NF-kappaB and PPAR
    Wim Vanden Berghe
    University of Gent, Department of Molecular Biology, KL Ledeganckstraat 35, 9000 Gent, Belgium
    Adv Exp Med Biol 544:181-96. 2003
  10. ncbi request reprint DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha
    Philippe Delerive
    Institut National de la Santé et de la Recherche Médicale U 545, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
    Mol Endocrinol 16:1029-39. 2002

Collaborators

  • Timothy M Willson
  • Bryan Goodwin
  • Nicolas Venteclef
  • Bart Staels
  • Jean Jacques Tousaint
  • Sophie Colin
  • Richard J Whitby
  • Wim Vanden Berghe
  • Yifei Wu
  • Nassirah Khandoudi
  • Jean Marc A Lobaccaro
  • Anna Haroniti
  • Stephane Huet
  • Francoise Caira
  • Sophie Lestavel
  • Iannis Talianidis
  • Anne Benedicte Boullay
  • Elodie Bourguignon
  • Derek J Parks
  • Patrick R Maloney
  • Sally Dixon
  • Jason C Smith
  • Karolien De Bosscher
  • Linda Vermeulen
  • Guy Haegeman
  • Isabelle Berrebi-Bertrand
  • William W Chin
  • Robin E Buckingham
  • Thomas P Burris
  • Antoine Bril

Detail Information

Publications12

  1. ncbi request reprint Identification of Reverb(alpha) as a novel ROR(alpha) target gene
    Philippe Delerive
    Department of Gene Regulation, Bone and Inflammation Research, Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:35013-8. 2002
    ..Together, our results identify Reverb(alpha) as a novel target gene for ROR(alpha)...
  2. ncbi request reprint Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1
    Yifei Wu
    Gene Regulation, Bone, and Inflammation Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:8898-905. 2002
    ..Taken together, these results support the notion that PGC-1 is a bona fide TR coactivator and that PGC-1 modulates TR activity via a mechanism different from that utilized with peroxisome proliferator activator receptor-gamma...
  3. ncbi request reprint PGC-1 functions as a transcriptional coactivator for the retinoid X receptors
    Philippe Delerive
    Department of Gene Regulation, Bone, and Inflammation Research, Eli Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 277:3913-7. 2002
    ..Finally, PGC-1 and TIF2 synergistically enhance ligand-activated RXRalpha transcriptional activity. Taken together, these results indicate that PGC-1 is a bona fide coactivator for RXRalpha...
  4. ncbi request reprint Regulation of anti-atherogenic apolipoprotein M gene expression by the orphan nuclear receptor LRH-1
    Nicolas Venteclef
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis, France
    J Biol Chem 283:3694-701. 2008
    ..Taken together, our results demonstrate that LRH-1 is a novel regulator of APOM transcription and further extend the role of this orphan nuclear receptor in lipoprotein metabolism and cholesterol homeostasis...
  5. ncbi request reprint Interleukin-1 receptor antagonist induction as an additional mechanism for liver receptor homolog-1 to negatively regulate the hepatic acute phase response
    Nicolas Venteclef
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis, France
    J Biol Chem 282:4393-9. 2007
    ..Taken together, these results lead to the identification of IL-1RA as a novel LRH-1 target gene and demonstrate the existence of multiple mechanisms contributing to the overall anti-inflammatory properties of LRH-1 in hepatic cells...
  6. ncbi request reprint Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1
    Richard J Whitby
    School of Chemistry, University of Southampton, Southampton, Hants, SO17 1BJ, UK
    J Med Chem 49:6652-5. 2006
    ..Synthesis of analogues modified at three positions led to the development of compounds with functional selectivity between LRH-1 and SF-1...
  7. pmc Liver receptor homolog 1 is a negative regulator of the hepatic acute-phase response
    Nicolas Venteclef
    GlaxoSmithKline R and D, CVU CEDD, 25 Avenue du Quebec, 91951 Les Ulis, France
    Mol Cell Biol 26:6799-807. 2006
    ..Taken together, our results outline an unexpected role for LRH-1 in the modulation of the hepatic acute-phase response...
  8. ncbi request reprint Identification of liver receptor homolog-1 as a novel regulator of apolipoprotein AI gene transcription
    Philippe Delerive
    GlaxoSmithKline, Cardiovascular and Urogenital Center of Excellence for Drug Discovery, 91951 Les Ulis, France
    Mol Endocrinol 18:2378-87. 2004
    ..Taken together, our results demonstrate that LRH-1 is a novel regulator of APOAI transcription and underscore the role of this receptor in cholesterol homeostasis...
  9. ncbi request reprint A paradigm for gene regulation: inflammation, NF-kappaB and PPAR
    Wim Vanden Berghe
    University of Gent, Department of Molecular Biology, KL Ledeganckstraat 35, 9000 Gent, Belgium
    Adv Exp Med Biol 544:181-96. 2003
    ....
  10. ncbi request reprint DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha
    Philippe Delerive
    Institut National de la Santé et de la Recherche Médicale U 545, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
    Mol Endocrinol 16:1029-39. 2002
    ....
  11. ncbi request reprint Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injury
    Nassirah Khandoudi
    Cardiovascular and Urogenital Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    Diabetes 51:1507-14. 2002
    ..Furthermore, rosiglitazone also inhibited activating protein-1 DNA-binding activity. These data, demonstrating that rosiglitazone limits postischemic injury in isolated hearts, suggest an important function for PPAR-gamma in the heart...
  12. doi request reprint Intestine-specific regulation of PPARalpha gene transcription by liver X receptors
    Sophie Colin
    Institut Pasteur de Lille, Departement d Atherosclerose, Unité 545, Lille, France
    Endocrinology 149:5128-35. 2008
    ..Taken together, these results demonstrate that PPARalpha is an intestine-specific LXR target gene and suggest the existence of a transcriptional cross talk between those members of the nuclear receptor superfamily...