D Grimm

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. doi How and why does the proteome respond to microgravity?
    Daniela Grimm
    Department of Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Arhus C, Denmark
    Expert Rev Proteomics 8:13-27. 2011
  2. ncbi Anti-Angiogenic Drugs in the Treatment of Metastatic Renal Cell Carcinoma: Advances in Clinical Application
    Ole H Nielsen
    Institute of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark, Wilhelm Meyers Allé 4, 8000 Aarhus C, Denmark
    Curr Vasc Pharmacol 13:381-91. 2015
  3. pmc Spheroid formation of human thyroid cancer cells under simulated microgravity: a possible role of CTGF and CAV1
    Elisabeth Warnke
    Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Cell Commun Signal 12:32. 2014
  4. pmc Changes in morphology, gene expression and protein content in chondrocytes cultured on a random positioning machine
    Ganna Aleshcheva
    Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University, Magdeburg, Germany
    PLoS ONE 8:e79057. 2013
  5. pmc Interleukin-6 expression under gravitational stress due to vibration and hypergravity in follicular thyroid cancer cells
    Xiao Ma
    Institute of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e68140. 2013
  6. pmc Genomic approach to identify factors that drive the formation of three-dimensional structures by EA.hy926 endothelial cells
    Xiao Ma
    Institute of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e64402. 2013
  7. doi Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space
    Xiao Ma
    1Institute of Biomedicine, Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Aarhus C, Denmark
    FASEB J 28:813-35. 2014
  8. pmc Biomarkers for anti-angiogenic therapy in cancer
    Markus Wehland
    Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Leipziger Str 44, Magdeburg D 39120, Germany
    Int J Mol Sci 14:9338-64. 2013
  9. pmc Interaction of proteins identified in human thyroid cells
    Jessica Pietsch
    Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Clinic, Leipziger Str 44, 39120 Magdeburg, Germany
    Int J Mol Sci 14:1164-78. 2013
  10. doi Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids
    Jirka Grosse
    Department of Nuclear Medicine, University of Regensburg, Regensburg, Germany
    FASEB J 26:5124-40. 2012

Collaborators

  • Johann Bauer
  • Manfred Infanger
  • Mehdi Shakibaei
  • S Baatout
  • Nils E Magnusson
  • Ruth Hemmersbach
  • Markus Braun
  • Jirka Grosse
  • Soroush Sharbati
  • Johann Schoenberger
  • J Eucker
  • Ralf Einspanier
  • Markus Wehland
  • Xiao Ma
  • Jessica Pietsch
  • Peter Kossmehl
  • Marcel Egli
  • Claudia Ulbrich
  • Ganna Aleshcheva
  • Reinhold Kreutz
  • Martin Paul
  • Kriss Westphal
  • Lars Rothermund
  • Ole H Nielsen
  • Johann Schönberger
  • Elisabeth Warnke
  • Katrin Saar
  • Norbert Hubner
  • Kai Waßer
  • Herbert Schulz
  • Jayashree Sahana
  • Jens Hauslage
  • Albert Sickmann
  • Gerhard Weber
  • J Pietsch
  • Gundula Schulze-Tanzil
  • Christoph Eilles
  • Augusto Cogoli
  • Maria Birlem
  • Mark Görög
  • Achim Schwarzwälder
  • Astrid Horn
  • Jürgen Segerer
  • Stefan Riwaldt
  • Ulf Simonsen
  • C Ulbrich
  • P Wise
  • M Egli
  • Mikkel Nissum
  • Robert Wildgruber
  • Henrik D F Winkler
  • Annekatrin Leder
  • Richard Kussian
  • Sonia Vadrucci
  • Burkhard Flick
  • Hanane Derradji
  • Marc Nierhaus
  • Ricarda Ibscher
  • Olaf Fialkowski
  • Susanne Mieschel
  • Florian Freese
  • Rüdiger von Bauer
  • Britta Habighorst
  • Shideh Faramarzi
  • Ekkehard Kurth
  • Francesco Curcio
  • Holger Pickenhahn
  • Sabine Fredersdorf

Detail Information

Publications31

  1. doi How and why does the proteome respond to microgravity?
    Daniela Grimm
    Department of Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Arhus C, Denmark
    Expert Rev Proteomics 8:13-27. 2011
    ..Here, we discuss and speculate how and why the proteome responds to microgravity, focusing on proteomic discoveries and their future potential...
  2. ncbi Anti-Angiogenic Drugs in the Treatment of Metastatic Renal Cell Carcinoma: Advances in Clinical Application
    Ole H Nielsen
    Institute of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark, Wilhelm Meyers Allé 4, 8000 Aarhus C, Denmark
    Curr Vasc Pharmacol 13:381-91. 2015
    ..In this review, current guidelines in mRCC management are summarized and possibilities of future personalized therapies are pointed out. ..
  3. pmc Spheroid formation of human thyroid cancer cells under simulated microgravity: a possible role of CTGF and CAV1
    Elisabeth Warnke
    Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Cell Commun Signal 12:32. 2014
    ..On Earth, these experiments are more cost-efficient and easily performable. However, each GBF might exert device-specific and altered superimposingly gravity-dependent effects on the cells...
  4. pmc Changes in morphology, gene expression and protein content in chondrocytes cultured on a random positioning machine
    Ganna Aleshcheva
    Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University, Magdeburg, Germany
    PLoS ONE 8:e79057. 2013
    ....
  5. pmc Interleukin-6 expression under gravitational stress due to vibration and hypergravity in follicular thyroid cancer cells
    Xiao Ma
    Institute of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e68140. 2013
    ..We conclude that a PKCa-independent mechanism of IL6 gene activation is very sensitive to physical forces in thyroid cells cultured in vitro as monolayers. ..
  6. pmc Genomic approach to identify factors that drive the formation of three-dimensional structures by EA.hy926 endothelial cells
    Xiao Ma
    Institute of Biomedicine, Pharmacology, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e64402. 2013
    ..Thus, the study reveals numerous genes, which mutually influence each other during initiation of 3D growth of endothelial cells...
  7. doi Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space
    Xiao Ma
    1Institute of Biomedicine, Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Aarhus C, Denmark
    FASEB J 28:813-35. 2014
    ..Gene expression during the PFC was often regulated in the opposite direction. In summary, microgravity is an invaluable tool for exploring new targets in anticancer therapy and can be simulated in some aspects in ground-based facilities...
  8. pmc Biomarkers for anti-angiogenic therapy in cancer
    Markus Wehland
    Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Leipziger Str 44, Magdeburg D 39120, Germany
    Int J Mol Sci 14:9338-64. 2013
    ..This review aims to give an overview of the recent developments in this field, focusing on the most prevalent tumor species...
  9. pmc Interaction of proteins identified in human thyroid cells
    Jessica Pietsch
    Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Clinic, Leipziger Str 44, 39120 Magdeburg, Germany
    Int J Mol Sci 14:1164-78. 2013
    ..Analyzing these groups, networks of interaction could be established which show how a punctual influence of simulated microgravity may propagate via various members of interaction chains...
  10. doi Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids
    Jirka Grosse
    Department of Nuclear Medicine, University of Regensburg, Regensburg, Germany
    FASEB J 26:5124-40. 2012
    ..IL-6 protein expression and secretion mirrored its gene expression. Thus, we concluded that the signaling elements IL-6, IL-8, OPN, TLN1, and CTGF are involved with NF-κB p65 in RPM-dependent thyroid carcinoma cell spheroid formation...
  11. ncbi Target-based anti-angiogenic therapy in breast cancer
    Markus Wehland
    Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University Magdeburg, Germany
    Curr Pharm Des 18:4244-57. 2012
    ..This review will compile the knowledge about recently developed anti-angiogenic drugs in the treatment of breast cancer and will provide an overview on currently relevant clinical trials...
  12. ncbi The effects of newer beta-adrenoceptor antagonists on vascular function in cardiovascular disease
    Markus Wehland
    Clinic for Plastic, Aesthetic and Hand Surgery, Otto von Guericke University, Magdeburg, Germany
    Curr Vasc Pharmacol 10:378-90. 2012
    ..Moreover, anti-proliferative, anti-inflammatory, and anti-oxidative properties have been detected for carvedilol and nebivolol, contributing to their additional value in treatment of hypertension and heart failure...
  13. doi Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells
    Jirka Grosse
    Department of Nuclear Medicine, University of Regensburg, Regensburg, Germany
    FASEB J 26:639-55. 2012
    ..Several gravisensitive signaling elements, such as AMPKα1 and integrins, are involved in the reaction of ECs to altered gravity...
  14. ncbi Diagnostic and therapeutic use of membrane proteins in cancer cells
    D Grimm
    Department of Pharmacology, Aarhus University, Wilhelm Meyers Allé 4, DK 8000 Arhus C, Denmark
    Curr Med Chem 18:176-90. 2011
    ..Their function will be explained and their role in tumor biology will be discussed...
  15. ncbi Drugs interfering with apoptosis in breast cancer
    Daniela Grimm
    Department of Pharmacology, Aarhus University, Denmark
    Curr Pharm Des 17:272-83. 2011
    ..Their function will be explained, their role in tumor biology and actual clinical studies will be discussed...
  16. doi Different responsiveness of endothelial cells to vascular endothelial growth factor and basic fibroblast growth factor added to culture media under gravity and simulated microgravity
    Daniela Grimm
    Department of Pharmacology, Aarhus University, Bartholin Building, Wilhelm Meyers Allé 4, Building 1240, DK 8000 Aarhus C, Denmark
    Tissue Eng Part A 16:1559-73. 2010
    ..These findings provide evidence that phosphokinase Calpha plays a key role in tube formation. Improving the interaction of VEGF and/or bFGF with EC under s-microg could enhance the engineering of vascular intimas...
  17. ncbi Blockade of neoangiogenesis, a new and promising technique to control the growth of malignant tumors and their metastases
    Daniela Grimm
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Germany and Department of Pharmacology, Aarhus University, Denmark
    Curr Vasc Pharmacol 7:347-57. 2009
    ..Also the combination of these approaches with conventional chemotherapy or radiotherapy will be discussed...
  18. doi A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness
    Daniela Grimm
    Institute of Clinical Pharmacology and Toxicology, CBF CCM, Charite Universitatsmedizin, Berlin, Berlin, Germany
    Tissue Eng Part A 15:2267-75. 2009
    ..These results suggest that culturing ECs under conditions of modeled gravitational unloading represents a new technique for studying the formation of tubes that resemble vascular intimas...
  19. ncbi The effects of weightlessness on the human organism and mammalian cells
    J Pietsch
    FU Berlin, Division of Biology, Chemistry, Pharmacy, Berlin, Germany
    Curr Mol Med 11:350-64. 2011
    ..Moreover, the latest information on how these changes lead to clinically relevant health problems and current strategies of countermeasures are reviewed...
  20. ncbi Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells
    Daniela Grimm
    Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, Freie Universitat Berlin, Germany
    FASEB J 16:604-6. 2002
    ....
  21. doi Characterization of human chondrocytes exposed to simulated microgravity
    Claudia Ulbrich
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Cell Physiol Biochem 25:551-60. 2010
    ..Tissue engineering is a strategy of cartilage regeneration, but scaffolds, required for 3D growth of chondrocytes, are still a problem...
  22. doi Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity
    Claudia Ulbrich
    Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, CBF CCM, Center of Space Medicine, 14195 Berlin, Germany
    J Cell Biochem 104:1324-41. 2008
    ..bFGF differently changes intracellular signals in ECs depending whether it is applied under microgravity or normal gravity conditions. In microgravity, bFGF contributes to protect the EC from apoptosis...
  23. ncbi Simulated weightlessness changes the cytoskeleton and extracellular matrix proteins in papillary thyroid carcinoma cells
    Manfred Infanger
    Department of Trauma and Reconstructive Surgery, Charite University Medical School, Center of Space Medicine, Benjamin Franklin Medical Center, 12200, Berlin, Germany
    Cell Tissue Res 324:267-77. 2006
    ..The amount of E-cadherin was enhanced time-dependently. We suggest that simulated weightlessness rapidly affects the cytoskeleton of papillary thyroid carcinoma cells and increases the amount of ECM proteins in a time-dependent manner...
  24. ncbi Longterm conditions of mimicked weightlessness influences the cytoskeleton in thyroid cells
    Manfred Infanger
    Department of Trauma and Reconstructive Surgery, Charite University Medicine, Berlin, Germany
    J Gravit Physiol 11:P169-72. 2004
    ..Future studies to clarify the pathway that regulate the observed integrin activation and the mechanisms by which they function have to be performed...
  25. ncbi Weightlessness induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways
    Peter Kossmehl
    Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, Freie Universitat Berlin, 14195 Berlin, Germany
    Endocrinology 144:4172-9. 2003
    ..Gravitational unloading affects the mitochondria and thereby may trigger apoptosis in thyroid cells subjected to weightlessness by clinorotation...
  26. doi Application of free-flow IEF to identify protein candidates changing under microgravity conditions
    Jessica Pietsch
    FU Berlin, Division of Biology, Chemistry, Pharmacy, Berlin, Germany
    Proteomics 10:904-13. 2010
    ..Proteins that concentrated differently in such pieces of gel are considered as candidates for further investigations of gravitational sensitivity...
  27. doi Vascular endothelial growth factor induces extracellular matrix proteins and osteopontin in the umbilical artery
    Manfred Infanger
    Department of Trauma and Reconstructive Surgery, Charite Universitatsmedizin, Berlin, Germany
    Ann Vasc Surg 22:273-84. 2008
    ..VEGF initiates vascular remodeling as early as it generates edema, even if the target vessel is not damaged. Osteopontin and ss(1)-integrin, both induced by VEGF, may play an important role in the vascular remodeling process...
  28. ncbi Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy
    Lars Rothermund
    Institut fur Klinische Pharmakologie und Toxikologie, Berlin, Germany
    Am J Hypertens 15:644-52. 2002
    ..The objective of this study was to analyze extracellular matrix protein (ECMP) expression in Ang II-dependent left ventricular (LV) hypertrophy (LVH), LV dysfunction, and to investigate right ventricular changes...
  29. ncbi Genetic low nephron number hypertension is associated with dysregulation of the hepatic and renal insulin-like growth factor system during nephrogenesis
    Lars Rothermund
    Medizinische Klinik IV, Endokrinologie und Nephrologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 24:1857-64. 2006
    ..We tested the hypothesis that low nephron number is already present during fetal development, and the expression pattern of important molecules of the IGF system is altered in MWF rat during the critical period of kidney development...
  30. ncbi Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion
    Peter Kossmehl
    Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, Charite University Medical School, Garystr 5, 14195 Berlin, Germany
    J Mol Med (Berl) 83:626-37. 2005
    ..Moreover, OPN, fibronectin and TGF-beta1 protein and gene expression are elevated after ischemia and reperfusion in the ex vivo working hemoperfused porcine heart model...
  31. ncbi Experimental diabetes and left ventricular hypertrophy: effects of beta-receptor blockade
    Daniela Grimm
    Institute of Clinical Pharmacology and Toxicology, Benjamin Franklin Medical Center, Freie Universitat Berlin, Garystr 5, D 14195 Berlin, Germany
    Cardiovasc Pathol 11:229-37. 2002
    ..Moreover, this study focused on the impact of beta-adrenoceptor blockade with carvedilol (C) on the expression of ECMPs...