Christina E Hoei-Hansen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. doi Unexpected marked seizure improvement in paediatric epilepsy surgery candidates
    Christina E Hoei-Hansen
    Department of Paediatrics, University Hospital Rigshospitalet, Copenhagen, Denmark Electronic address
    Seizure 45:70-73. 2016
  2. doi Alternating hemiplegia of childhood in Denmark: clinical manifestations and ATP1A3 mutation status
    Christina E Hoei-Hansen
    Department of Paediatrics, University Hospital Hilleroed, Denmark Electronic address
    Eur J Paediatr Neurol 18:50-4. 2014
  3. doi Application of stem cell markers in search for neoplastic germ cells in dysgenetic gonads, extragonadal tumours, and in semen of infertile men
    Christina E Hoei-Hansen
    Department of Growth and Reproduction, University Hospital of Rigshospitalet, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Treat Rev 34:348-67. 2008
  4. ncbi Current approaches for detection of carcinoma in situ testis
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:398-404; discussion 404-5. 2007
  5. pmc Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers
    Christina E Hoei-Hansen
    University Dept of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Mol Cancer 6:12. 2007
  6. ncbi Towards a non-invasive method for early detection of testicular neoplasia in semen samples by identification of fetal germ cell-specific markers
    C E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 22:167-73. 2007
  7. ncbi New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers
    C E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Pathol 209:25-33. 2006
  8. ncbi A rare diagnosis: testicular dysgenesis with carcinoma in situ detected in a patient with ultrasonic microlithiasis
    Christina E Hoei-Hansen
    Department of Growth and Reproduction, University Hospital of Rigshospitalet, GR5064, Rigshospitalet, 2100 Copenhagen, Denmark
    Asian J Androl 7:445-7. 2005
  9. ncbi Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours
    C E Hoei-Hansen
    University Department of Growth and Reproduction and Department of Pathology, Rigshospitalet, Copenhagen, Denmark
    Histopathology 47:48-56. 2005
  10. ncbi Carcinoma in situ testis, the progenitor of testicular germ cell tumours: a clinical review
    C E Hoei-Hansen
    University Department of Growth, Rigshospitalet, Copenhagen, Denmark
    Ann Oncol 16:863-8. 2005

Collaborators

Detail Information

Publications28

  1. doi Unexpected marked seizure improvement in paediatric epilepsy surgery candidates
    Christina E Hoei-Hansen
    Department of Paediatrics, University Hospital Rigshospitalet, Copenhagen, Denmark Electronic address
    Seizure 45:70-73. 2016
    ..The aim of this study was to describe the number of children withdrawn from an epilepsy surgery programme due to unexpected seizure improvement...
  2. doi Alternating hemiplegia of childhood in Denmark: clinical manifestations and ATP1A3 mutation status
    Christina E Hoei-Hansen
    Department of Paediatrics, University Hospital Hilleroed, Denmark Electronic address
    Eur J Paediatr Neurol 18:50-4. 2014
    ..The patients harboured a wide range of psychomotor difficulties. Patients with no mutation detected tended to be less severely affected. Prevalence was approximately 1 per 100,000 children...
  3. doi Application of stem cell markers in search for neoplastic germ cells in dysgenetic gonads, extragonadal tumours, and in semen of infertile men
    Christina E Hoei-Hansen
    Department of Growth and Reproduction, University Hospital of Rigshospitalet, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Treat Rev 34:348-67. 2008
    ..Many CIS candidate genes are yet uninvestigated, and information from these could increase knowledge about CIS tumour initiation/progression and be used for optimisation of a non-invasive detection method...
  4. ncbi Current approaches for detection of carcinoma in situ testis
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Int J Androl 30:398-404; discussion 404-5. 2007
    ..In conclusion, one difficulty is to determine in which males CIS should be suspected; secondly, there does not as yet exist an optimal noninvasive method of diagnosis that is more acceptable than an open surgical biopsy...
  5. pmc Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers
    Christina E Hoei-Hansen
    University Dept of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Mol Cancer 6:12. 2007
    ..We investigated the origin of malignant OGCTs and underlying molecular events in the development of the various histological subtypes of this neoplasia...
  6. ncbi Towards a non-invasive method for early detection of testicular neoplasia in semen samples by identification of fetal germ cell-specific markers
    C E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Hum Reprod 22:167-73. 2007
    ..Diagnosis at the CIS stage is desirable as it minimizes the necessary treatment. A detailed clinical evaluation of an approach to detect CIS cells in the ejaculate using primordial germ cell/gonocyte markers is presented...
  7. ncbi New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers
    C E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    J Pathol 209:25-33. 2006
    ....
  8. ncbi A rare diagnosis: testicular dysgenesis with carcinoma in situ detected in a patient with ultrasonic microlithiasis
    Christina E Hoei-Hansen
    Department of Growth and Reproduction, University Hospital of Rigshospitalet, GR5064, Rigshospitalet, 2100 Copenhagen, Denmark
    Asian J Androl 7:445-7. 2005
    ..Accordingly, patients with one TDS symptom ought to be examined for the presence of the others, and if more that one is present, extra concern is warranted...
  9. ncbi Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours
    C E Hoei-Hansen
    University Department of Growth and Reproduction and Department of Pathology, Rigshospitalet, Copenhagen, Denmark
    Histopathology 47:48-56. 2005
    ..In the present study we analysed the protein expression of NANOG during normal development of human testis and in a large series of neoplastic/dysgenetic specimens...
  10. ncbi Carcinoma in situ testis, the progenitor of testicular germ cell tumours: a clinical review
    C E Hoei-Hansen
    University Department of Growth, Rigshospitalet, Copenhagen, Denmark
    Ann Oncol 16:863-8. 2005
    ..Further research is warranted to identify causal factors explaining the increasing incidence of TGCT and to obtain a method of non-invasive CIS detection...
  11. ncbi A subfertile patient diagnosed with testicular carcinoma in situ by immunocytological staining for AP-2gamma in semen samples: case report
    C E Hoei-Hansen
    University Department of Growth and Reproduction GR 5064, Rigshospitalet Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Hum Reprod 20:579-82. 2005
    ..The value of this method for diagnostic use in the clinic requires further careful validation in a large series of patients and controls, but the preliminary results are promising...
  12. ncbi Transcription factor AP-2gamma is a developmentally regulated marker of testicular carcinoma in situ and germ cell tumors
    Christina E Hoei-Hansen
    University Department of Growth and Reproduction, Rigshospitalet, Denmark
    Clin Cancer Res 10:8521-30. 2004
    ..In this study we aimed to investigate the expression pattern of AP-2gamma and to shed light on this factor in germ cell differentiation and the pathogenesis of germ cell neoplasia...
  13. ncbi CDH1 (E-cadherin) in testicular germ cell neoplasia: suppressed translation of mRNA in pre-invasive carcinoma in situ but increased protein levels in advanced tumours
    Si B Sonne
    University Department of Growth and Reproduction, Rishospitalet, University Hospital, Copenhagen, Denmark
    APMIS 114:549-58. 2006
    ..In conclusion, despite high mRNA levels, the CDH1 protein is not expressed in CIS, suggesting translational suppression of CDH1 protein expression. CDH1 serum levels may be a serological marker for staging of TGCT patients...
  14. ncbi Genomic and gene expression signature of the pre-invasive testicular carcinoma in situ
    Kristian Almstrup
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Cell Tissue Res 322:159-65. 2005
    ..The gene expression profile of CIS cells has remarkable similarity to that of embryonic stem cells and supports our long-standing hypothesis of an early developmental origin of CIS and testicular germ cell cancer...
  15. ncbi Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling
    Kristian Almstrup
    University Department of Growth and Reproduction, Rigshospitalet, Section GR 5064, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Cancer Res 64:4736-43. 2004
    ..Finally, some of the highly expressed genes identified in this study are promising candidates for new diagnostic markers for CIS and/or TGCTs...
  16. ncbi Identity of M2A (D2-40) antigen and gp36 (Aggrus, T1A-2, podoplanin) in human developing testis, testicular carcinoma in situ and germ-cell tumours
    Si Brask Sonne
    University Department of Growth and Reproduction, Section GR 5064, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Virchows Arch 449:200-6. 2006
    ..Our findings also suggest that podoplanin has a function in developing testis, most likely at the level of cell-cell interactions among pre-meiotic germ cells and immature Sertoli cells...
  17. ncbi Environment, testicular dysgenesis and carcinoma in situ testis
    Inge A Olesen
    University Department of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Best Pract Res Clin Endocrinol Metab 21:462-78. 2007
    ..It is of great importance that clinicians in different specialties treating patients with TDS are aware of the association between the different symptoms...
  18. ncbi The emerging phenotype of the testicular carcinoma in situ germ cell
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    APMIS 111:267-78; discussion 278-9. 2003
    ....
  19. ncbi From embryonic stem cells to testicular germ cell cancer-- should we be concerned?
    Kristian Almstrup
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    Int J Androl 29:211-8. 2006
    ....
  20. ncbi Testicular carcinoma in situ in subfertile Danish men
    Inge A Olesen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen
    Int J Androl 30:406-11; discussion 412. 2007
    ....
  21. ncbi Histological evidence of testicular dysgenesis in contralateral biopsies from 218 patients with testicular germ cell cancer
    Christina E Hoei-Hansen
    Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Pathol 200:370-4. 2003
    ..The findings therefore support the hypothesis that this cancer is part of a testicular dysgenesis syndrome. The presence of contralateral carcinoma in situ was higher in the present study than previously reported...
  22. doi From gonocytes to testicular cancer: the role of impaired gonadal development
    Ewa Rajpert-De Meyts
    University Department of Growth and Reproduction, Copenhagen University Hospital Rigshospitalet, DK 2100 Copenhagen, Denmark
    Ann N Y Acad Sci 1120:168-80. 2007
    ..The effects of environmental factors are likely modulated by genomic variation (polymorphisms), thus explaining the individual susceptibility and population-level differences in the incidence of testicular cancer...
  23. pmc Optimizing staining protocols for laser microdissection of specific cell types from the testis including carcinoma in situ
    Si Brask Sonne
    Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 4:e5536. 2009
    ..Both protocols retain a morphology that is compatible with laser microdissection and yield RNA of a quality suitable for PCR and microarray analysis...
  24. ncbi Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle
    Mette Holm
    University Department of Growth and Reproduction, Copenhagen University Hospital, Denmark
    J Urol 170:1163-7. 2003
    ..We compared clinical and histological data regarding the contralateral testicle in a population of men diagnosed with testicular germ cell cancer to find features associated with an increased risk of bilateral neoplasia...
  25. doi Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: implications for the anti-tumor barrier concept and treatment
    Jirina Bartkova
    Danish Cancer Society Research Center, Copenhagen, Denmark Electronic address
    Mol Oncol 8:1667-78. 2014
    ....
  26. doi Recent advances in understanding the etiology and pathogenesis of pediatric germ cell tumors
    Christiane H Mosbech
    Department of Growth and Reproduction Department of Pediatrics, University Hospital of Rigshospitalet, Copenhagen Department of Pediatrics, University Hospital of Hilleroed, Hilleroed, Denmark
    J Pediatr Hematol Oncol 36:263-70. 2014
    ..Although recent advances have identified candidate pathways, further effort is needed to answer central questions of pathogenesis of these fascinating tumors...
  27. pmc Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis
    Sigrid Marie Kraggerud
    Department of Cancer Prevention, Institute for Cancer Research, Oslo University Hospital, N 0310 Oslo, Norway
    Endocr Rev 34:339-76. 2013
    ..This similarity combined with the process of ovary development, explain why mOGCTs present so early in life, and with greater histological complexity, than most somatic solid tumors...
  28. ncbi Immunoexpression of androgen receptor and nine markers of maturation in the testes of adolescent boys with Klinefelter syndrome: evidence for degeneration of germ cells at the onset of meiosis
    Anne M Wikström
    Hospital for Children and Adolescents, Helsinki University Central Hospital, P O Box 281, 00029 Helsinki, Finland
    J Clin Endocrinol Metab 92:714-9. 2007
    ..The pathogenesis and mechanisms behind the degeneration of the seminiferous tubules in testes of subjects with Klinefelter syndrome (KS) are yet unknown...