Mohamed A Farag

Summary

Publications

  1. doi request reprint Comparative metabolite profiling and fingerprinting of genus Passiflora leaves using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, Cairo, P B 11562, Egypt
    Anal Bioanal Chem 408:3125-43. 2016
  2. ncbi request reprint Metabolite profiling in Trigonella seeds via UPLC-MS and GC-MS analyzed using multivariate data analyses
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, Cairo, 11562, Egypt
    Anal Bioanal Chem 408:8065-8078. 2016
  3. doi request reprint Anti-acetylcholinesterase potential and metabolome classification of 4 Ocimum species as determined via UPLC/qTOF/MS and chemometric tools
    M A Farag
    Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt Electronic address
    J Pharm Biomed Anal 125:292-302. 2016
  4. doi request reprint Phytochemical, antioxidant and antidiabetic evaluation of eight Bauhinia L. species from Egypt using UHPLC-PDA-qTOF-MS and chemometrics
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, 11562 Cairo, Egypt Electronic address
    Phytochemistry 119:41-50. 2015
  5. doi request reprint Mechanistic evidence of Passiflora edulis (Passifloraceae) anxiolytic activity in relation to its metabolite fingerprint as revealed via LC-MS and chemometrics
    Asmaa Otify
    Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
    Food Funct 6:3807-17. 2015
  6. doi request reprint Integrated comparative metabolite profiling via MS and NMR techniques for Senna drug quality control analysis
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, P B 11562, Cairo, Egypt
    Anal Bioanal Chem 407:1937-49. 2015
  7. ncbi request reprint Comparative mass spectrometry & nuclear magnetic resonance metabolomic approaches for nutraceuticals quality control analysis: a brief review
    Mohamed A Farag
    Kasr El Aini St, P B 11562, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    Recent Pat Biotechnol 8:17-24. 2014
  8. doi request reprint Metabolomics driven analysis of six Nigella species seeds via UPLC-qTOF-MS and GC-MS coupled to chemometrics
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, P B 11562, Cairo, Egypt Electronic address
    Food Chem 151:333-42. 2014
  9. doi request reprint Metabolomics driven analysis of artichoke leaf and its commercial products via UHPLC-q-TOF-MS and chemometrics
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Cairo, Egypt Electronic address
    Phytochemistry 95:177-87. 2013
  10. doi request reprint Comparative study of the chemical composition and biological activities of Magnolia grandiflora and Magnolia virginiana flower essential oils
    Mohamed A Farag
    Chemistry Department, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, 529 S Jackson St, Louisville, KY 40202, USA
    Nat Prod Res 27:1091-7. 2013

Collaborators

Detail Information

Publications39

  1. doi request reprint Comparative metabolite profiling and fingerprinting of genus Passiflora leaves using a multiplex approach of UPLC-MS and NMR analyzed by chemometric tools
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, Cairo, P B 11562, Egypt
    Anal Bioanal Chem 408:3125-43. 2016
    ..Novel insight on metabolite candidates to mediate for Passiflora CNS sedative effects is also presented...
  2. ncbi request reprint Metabolite profiling in Trigonella seeds via UPLC-MS and GC-MS analyzed using multivariate data analyses
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, Cairo, 11562, Egypt
    Anal Bioanal Chem 408:8065-8078. 2016
    ..foenum-graecum presents a better source of Trigonella secondary bioactive metabolites...
  3. doi request reprint Anti-acetylcholinesterase potential and metabolome classification of 4 Ocimum species as determined via UPLC/qTOF/MS and chemometric tools
    M A Farag
    Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt Electronic address
    J Pharm Biomed Anal 125:292-302. 2016
    ..5 and 7.9mg/ml respectively, suggesting that HCs are likely to mediate for the anticholinesterase effect in Ocimum extracts. ..
  4. doi request reprint Phytochemical, antioxidant and antidiabetic evaluation of eight Bauhinia L. species from Egypt using UHPLC-PDA-qTOF-MS and chemometrics
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, 11562 Cairo, Egypt Electronic address
    Phytochemistry 119:41-50. 2015
    ..DPPH radical scavenging and α-glucosidase inhibitory assays were also performed to assess selected aspects of the antioxidant and antidiabetic potential for the examined species with respect to metabolite profiles. ..
  5. doi request reprint Mechanistic evidence of Passiflora edulis (Passifloraceae) anxiolytic activity in relation to its metabolite fingerprint as revealed via LC-MS and chemometrics
    Asmaa Otify
    Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
    Food Funct 6:3807-17. 2015
    ....
  6. doi request reprint Integrated comparative metabolite profiling via MS and NMR techniques for Senna drug quality control analysis
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, P B 11562, Cairo, Egypt
    Anal Bioanal Chem 407:1937-49. 2015
    ..To the best of our knowledge, this study provides the first approach utilizing both UPLC-MS and NMR to reveal secondary metabolite compositional differences among Senna species. ..
  7. ncbi request reprint Comparative mass spectrometry & nuclear magnetic resonance metabolomic approaches for nutraceuticals quality control analysis: a brief review
    Mohamed A Farag
    Kasr El Aini St, P B 11562, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    Recent Pat Biotechnol 8:17-24. 2014
    ..Finally I will look at the future developments and perspectives of these two technologies for the quality control of herbal materials. ..
  8. doi request reprint Metabolomics driven analysis of six Nigella species seeds via UPLC-qTOF-MS and GC-MS coupled to chemometrics
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, P B 11562, Cairo, Egypt Electronic address
    Food Chem 151:333-42. 2014
    ..Nevertheless, both GC-MS and UPLC-MS support the remote position of Nigella nigellastrum in relation to the other taxa. ..
  9. doi request reprint Metabolomics driven analysis of artichoke leaf and its commercial products via UHPLC-q-TOF-MS and chemometrics
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Cairo, Egypt Electronic address
    Phytochemistry 95:177-87. 2013
    ..To the best of our knowledge, this study provides the first approach utilizing UHPLC-MS based metabolite fingerprinting to reveal secondary metabolite compositional differences in artichoke leaf extracts...
  10. doi request reprint Comparative study of the chemical composition and biological activities of Magnolia grandiflora and Magnolia virginiana flower essential oils
    Mohamed A Farag
    Chemistry Department, Center for Regulatory and Environmental Analytical Metabolomics, University of Louisville, 529 S Jackson St, Louisville, KY 40202, USA
    Nat Prod Res 27:1091-7. 2013
    ..virginiana displayed a moderate antioxidant activity relative to vitamin E, whereas both essential oils were active against human lung carcinoma and breast carcinoma cell lines, even at concentrations higher than 200 µg mL(-1)...
  11. pmc Dynamic chemical communication between plants and bacteria through airborne signals: induced resistance by bacterial volatiles
    Mohamed A Farag
    Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt
    J Chem Ecol 39:1007-18. 2013
    ..Taken together, these studies provide further insight into the biological and ecological potential of PGPR VOCs for enhancing plant self-immunity and/or adaptation to biotic and abiotic stresses in modern agriculture. ..
  12. doi request reprint Metabolome classification of Brassica napus L. organs via UPLC-QTOF-PDA-MS and their anti-oxidant potential
    Mohamed A Farag
    Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    Phytochem Anal 24:277-87. 2013
    ..In addition to the seed, other organs contain a wide range of phenolic metabolites although they have not been investigated to the same extent as in seeds...
  13. doi request reprint Volatiles profiling in medicinal licorice roots using steam distillation and solid-phase microextraction (SPME) coupled to chemometrics
    Mohamed A Farag
    Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D 06120 Halle Saale, Germany
    J Food Sci 77:C1179-84. 2012
    ..inflata. Principal component and hierarchical cluster analyses clearly separated G. echinata and G. inflata from G. glabra; with phenolics and aliphatic aldehydes contributing mostly for species segregation...
  14. doi request reprint Metabolome classification of commercial Hypericum perforatum (St. John's Wort) preparations via UPLC-qTOF-MS and chemometrics
    Mohamed A Farag
    Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle Saale, Germany
    Planta Med 78:488-96. 2012
    ..To the best of our knowledge, this study provides the first approach utilizing UPLC-MS-based metabolic fingerprinting to reveal secondary metabolite compositional differences in Hypericum extract...
  15. ncbi request reprint GC-MS SPME profiling of rhizobacterial volatiles reveals prospective inducers of growth promotion and induced systemic resistance in plants
    Mohamed A Farag
    Pharmacognosy Department, Faculty of Pharmacy, Kasr El Aini St, P B 11562, Cairo University, Cairo, Egypt
    Phytochemistry 67:2262-8. 2006
    ..The branched-chain alcohols share a similar functional motif to that of 2,3-butanediol and may afford alternative structural patterns for elicitors from bacterial sources...
  16. doi request reprint Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC-MS, LC-MS and 1D NMR techniques
    Mohamed A Farag
    Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle Saale, Germany
    Phytochemistry 76:60-72. 2012
    ..inflata roots. Both LC-MS and NMR were found effective techniques in sample classification based on genetic and or geographical origin as revealed from derived PCA analysis...
  17. doi request reprint Metabolite profiling in 18 Saudi date palm fruit cultivars and their antioxidant potential via UPLC-qTOF-MS and multivariate data analyses
    Mohamed A Farag
    Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
    Food Funct 7:1077-86. 2016
    ....
  18. doi request reprint Metabolome based volatiles profiling in 13 date palm fruit varieties from Egypt via SPME GC-MS and chemometrics
    Mohammed N A Khalil
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, Cairo P B 11562, Egypt
    Food Chem 217:171-81. 2017
    ..This study provides the most complete map of volatiles in Egyptian date fruit, with Siwi and Sheshi varieties exhibiting the most distinct aroma among studied date varieties. ..
  19. doi request reprint Phytochemical, phylogenetic, and anti-inflammatory evaluation of 43 Urtica accessions (stinging nettle) based on UPLC-Q-TOF-MS metabolomic profiles
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, P B 11562, Cairo, Egypt Leibniz Institute of Plant Biochemistry, Dept Bioorganic Chemistry, Weinberg 3, D 06120Halle Saale, Germany
    Phytochemistry 96:170-83. 2013
    ..dioica-clade). Anti-inflammatory in vitro COX1 enzyme inhibition assays suggest that bioactivity may be predicted by gross metabolic profiling in Urtica. ..
  20. doi request reprint Soft Corals Biodiversity in the Egyptian Red Sea: A Comparative MS and NMR Metabolomics Approach of Wild and Aquarium Grown Species
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr El Aini St, P B 11562, Cairo 12613, Egypt
    J Proteome Res 15:1274-87. 2016
    ..Cyclopropane containing sterols observed in abundance in corals may act as cellular membrane protectant against the action of coral toxins, that is, cembranoids. ..
  21. doi request reprint Phytochemical analysis and anti-inflammatory potential of Hyphaene thebaica L. fruit
    Mohamed A Farag
    Pharmacognosy Dept, Faculty of Pharmacy, Cairo Univ, Cairo 11562, Egypt
    J Food Sci 78:C1503-8. 2013
    ..Fruit organic extracts anti-inflammatory potential was assessed in vitro by cyclooxygenase-1 enzyme inhibition. ..
  22. ncbi request reprint Acylated pregnane glycosides from Caralluma russeliana
    Essam Abdel-Sattar
    Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
    Phytochemistry 68:1459-63. 2007
    ..The structures of the compounds were elucidated using MS, 1H NMR, 13C NMR, 1H-1H COSY, HMQC, NOESY and HMBC experiments...
  23. ncbi request reprint Nor-ent-kaurane diterpenes and hydroxylactones from Antennaria geyeri and Anaphalis margaritacea
    Ahmed A Ahmed
    Department of Chemistry, Faculty of Science, El Minia University, El Minia 61519, Egypt
    Phytochemistry 65:2539-43. 2004
    ..Anaphalis margaritacea afforded two hydroxylactones. The structures were established by one and two dimensional NMR techniques, IR and CIMS...
  24. doi request reprint Structure-Activity Relationships of Antimicrobial Gallic Acid Derivatives from Pomegranate and Acacia Fruit Extracts against Potato Bacterial Wilt Pathogen
    Mohamed A Farag
    Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El Aini St, P B 11562, Cairo, Egypt phone 20 2 23632245 fax 20 2 25320005
    Chem Biodivers 12:955-62. 2015
    ..47 mg/ml. We further performed a structure-activity relationship (SAR) study for the inhibition of R. solanacearum growth by ten natural, structurally related benzoic acids...
  25. doi request reprint Unraveling the active hypoglycemic agent trigonelline in Balanites aegyptiaca date fruit using metabolite fingerprinting by NMR
    Mohamed A Farag
    Pharmacognosy Department, College of Pharmacy, Cairo University, Cairo, Kasr El Aini St, P B 11562, Egypt Electronic address
    J Pharm Biomed Anal 115:383-7. 2015
    ..UPLC-MS of the crude extract additionally revealed the fruit flavonoid pattern showing quercetin/isorhamnetin flavonol conjugates in addition to epicatechin, the latter being present at much lower levels...
  26. doi request reprint Developmental changes in leaf phenolics composition from three artichoke cvs. (Cynara scolymus) as determined via UHPLC-MS and chemometrics
    Amira S El Senousy
    Pharmacognosy Department, College of Pharmacy, Cairo University, Cairo, Egypt
    Phytochemistry 108:67-76. 2014
    ....
  27. doi request reprint Chemical composition, insecticidal and insect repellent activity of Schinus molle L. leaf and fruit essential oils against Trogoderma granarium and Tribolium castaneum
    Essam Abdel-Sattar
    Department of Pharmacognosy, College of Pharmacy, University of Alexandria, Alexandria, Egypt
    Nat Prod Res 24:226-35. 2010
    ..84%, respectively. p-Cymene was identified as a major component in both oils. The high yield and efficacy of S. molle essential oil against T. granarium and T. castaneum suggest that it may provide leads for active insecticidal agents...
  28. doi request reprint The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials
    Mahmoud Fahmi Elsebai
    Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Egypt
    Food Funct 7:3006-16. 2016
    ....
  29. doi request reprint Metabolites profiling reveals for antimicrobial compositional differences and action mechanism in the toothbrushing stick "miswak" Salvadora persica
    Mohamed A Farag
    Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El Aini St, P B 11562, Cairo, Egypt Electronic address
    J Pharm Biomed Anal 133:32-40. 2017
    ..persica extract. This study provides the most complete profile of volatiles, sugars, and organic acids in S. persica organs and more rationalizing its use as a toothbrush...
  30. doi request reprint Metabolite profiling driven analysis of Salsola species and their anti-acetylcholinesterase potential
    Dalia M Rasheed
    a Pharmacognosy Department, Faculty of Pharmacy, October 6 University, Central Axis, Part 1 1, Sixth of October, Egypt
    Nat Prod Res 27:2320-7. 2013
    ..tetrandra versus quercetin in S. vermiculata. The root of S. vermiculata exhibited strong anti-acetylcholinesterase activity relative to eserine standard. ..
  31. doi request reprint Profiling the chemical content of Ficus lyrata extracts via UPLC-PDA-qTOF-MS and chemometrics
    Mohamed A Farag
    a Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El Aini 11562, Egypt
    Nat Prod Res 28:1549-56. 2014
    ..This study provides the most complete map for polyphenol distribution in F. lyrata leaves and fruits and the basis for future investigation of its fruits nutritional value or possible nutraceutical uses. ..
  32. pmc Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
    Teresa W M Fan
    Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA
    Mol Cancer 8:41. 2009
    ..NMR and GC-MS were used for 13C-isotopomer-based metabolomic analysis of the extracts of tissues and blood plasma...
  33. pmc Bacterial volatiles promote growth in Arabidopsis
    Choong Min Ryu
    Department of Entomology and Plant Pathology, Auburn University, 209 Life Sciences Building, Auburn, AL 36849, USA
    Proc Natl Acad Sci U S A 100:4927-32. 2003
    ....
  34. doi request reprint Sub-lethal levels of electric current elicit the biosynthesis of plant secondary metabolites
    Evans Kaimoyo
    Division of Plant Pathology and Microbiology, Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Biotechnol Prog 24:377-84. 2008
    ..On the basis of our results, electric current would appear to be a general elicitor of plant secondary metabolites and to have potential for application in both basic and commercial research...
  35. pmc Metabolomics reveals novel pathways and differential mechanistic and elicitor-specific responses in phenylpropanoid and isoflavonoid biosynthesis in Medicago truncatula cell cultures
    Mohamed A Farag
    Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Physiol 146:387-402. 2008
    ....
  36. ncbi request reprint Rhizobacterial volatile emissions regulate auxin homeostasis and cell expansion in Arabidopsis
    Huiming Zhang
    Department of Chemistry Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
    Planta 226:839-51. 2007
    ..The discovery that bacterial VOCs, devoid of auxin or other known plant hormones regulate auxin homeostasis and cell expansion provides a new paradigm as to how rhizobacteria promote plant growth...
  37. ncbi request reprint Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS
    Mohamed A Farag
    Plant Biology Division, The Samuel Roberts Noble Foundation, P O Box 2180, Ardmore, OK 73401, USA
    Phytochemistry 68:342-54. 2007
    ..Comparative metabolic profiling of Medicago truncatula root and cell cultures was then performed and revealed significant differences in the isoflavonoid composition of these two tissues...
  38. ncbi request reprint Metabolic profiling of Medicago truncatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism
    Corey D Broeckling
    The Samuel Roberts Noble Foundation, Plant Biology, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    J Exp Bot 56:323-36. 2005
    ....
  39. pmc Bacterial volatiles induce systemic resistance in Arabidopsis
    Choong Min Ryu
    Department of Entomology and Plant Pathology, Auburn University, 209 Life Sciences Building, Auburn, Alabama 36849, USA
    Plant Physiol 134:1017-26. 2004
    ..This study provides new insight into the role of bacteria VOCs as initiators of defense responses in plants...