Isto Nordback

Summary

Affiliation: Tampere University Hospital
Country: Finland

Publications

  1. ncbi Pancreatico-jejunostomy with a biodegradable pancreatic stent and without stitches through the pancreas
    Isto Nordback
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Hepatogastroenterology 55:319-22. 2008
  2. ncbi Criteria for alcoholic pancreatitis. Results of an international workshop in Tampere, Finland, June 2006
    I Nordback
    Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland
    Pancreatology 7:100-4. 2007
  3. ncbi Obstructed pancreaticojejunostomy partly explains exocrine insufficiency after pancreatic head resection
    Isto Nordback
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 42:263-70. 2007
  4. ncbi Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine
    Hai Tao Jin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, FI 33520 Tampere, Finland
    Pharmacol Rep 63:999-1008. 2011
  5. doi The risk for immediate postoperative complications after pancreaticoduodenectomy is increased by high frequency of acinar cells and decreased by prevalent fibrosis of the cut edge of pancreas
    Matias Laaninen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreas 41:957-61. 2012
  6. doi Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis
    Hai Tao Jin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreatology 11:83-91. 2011
  7. doi A novel radiopaque biodegradable stent for pancreatobiliary applications--the first human phase I trial in the pancreas
    Isto Nordback
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreatology 12:264-71. 2012
  8. doi A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate
    Hai Tao Jin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Surgery 144:49-56. 2008
  9. doi Effects of diameter, number and tightness of sutures on pancreatic injury response
    Teemu Lamsa
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Dig Surg 25:269-77. 2008
  10. doi A novel technique for hepaticojejunostomy for nondilated bile ducts: a purse-string anastomosis with an intra-anastomotic biodegradable biliary stent
    Johanna Laukkarinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, Tampere, Finland
    Am J Surg 200:124-30. 2010

Collaborators

Detail Information

Publications59

  1. ncbi Pancreatico-jejunostomy with a biodegradable pancreatic stent and without stitches through the pancreas
    Isto Nordback
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Hepatogastroenterology 55:319-22. 2008
    ..The initial experiences described herein encourage progression to a phase I safety study, and later possibly to a phase II randomized trial to test the efficacy of the new method...
  2. ncbi Criteria for alcoholic pancreatitis. Results of an international workshop in Tampere, Finland, June 2006
    I Nordback
    Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland
    Pancreatology 7:100-4. 2007
  3. ncbi Obstructed pancreaticojejunostomy partly explains exocrine insufficiency after pancreatic head resection
    Isto Nordback
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 42:263-70. 2007
    ..The objective of this study was to investigate whether this is due to glandular malfunction or obstructed pancreaticojejunal anastomosis...
  4. ncbi Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine
    Hai Tao Jin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, FI 33520 Tampere, Finland
    Pharmacol Rep 63:999-1008. 2011
    ..However, Me(2)Spm could not ameliorate multi-organ injury. Me(2)Spm administration was associated with significant renal toxicity and induced mortality, suggesting that the current dose is too high and needs to be modified...
  5. doi The risk for immediate postoperative complications after pancreaticoduodenectomy is increased by high frequency of acinar cells and decreased by prevalent fibrosis of the cut edge of pancreas
    Matias Laaninen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreas 41:957-61. 2012
    ..The aim was to analyze the proportion of different cell types in the cut edge of pancreas (CEP) in relation to postoperative pancreatitis and other complications after pancreaticoduodenectomy...
  6. doi Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis
    Hai Tao Jin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreatology 11:83-91. 2011
    ..PC has also been observed in experimental taurodeoxycholate pancreatitis. We hypothesized that PC may be a mediator of trypsin activation in taurodeoxycholate pancreatitis...
  7. doi A novel radiopaque biodegradable stent for pancreatobiliary applications--the first human phase I trial in the pancreas
    Isto Nordback
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreatology 12:264-71. 2012
    ..Although routine use of any stent in pancreaticojejunostomy has been under debate, we used this setting to run for the first phase I human clinical trial with a biodegradable stent in a pancreatobiliary application...
  8. doi A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate
    Hai Tao Jin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Surgery 144:49-56. 2008
    ..We investigated the pathogenetic role of polyamine catabolism by studying the effect of a methylated polyamine analog on taurodeoxycholate-induced acute experimental pancreatitis...
  9. doi Effects of diameter, number and tightness of sutures on pancreatic injury response
    Teemu Lamsa
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Dig Surg 25:269-77. 2008
    ..We have experimental data indicating that the pancreas is easily damaged by any intervention. The present study compared the effects of suture diameter, number of needle passes and suture tightness on rat pancreas...
  10. doi A novel technique for hepaticojejunostomy for nondilated bile ducts: a purse-string anastomosis with an intra-anastomotic biodegradable biliary stent
    Johanna Laukkarinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, Tampere, Finland
    Am J Surg 200:124-30. 2010
    ..05). We conclude that this novel HJ technique is easy and safe to perform, and ensures a well-functioning anastomosis in nondilated bile ducts...
  11. doi Pancreatic damage after the first episode of acute alcoholic pancreatitis and its association with the later recurrence rate
    Hanna Pelli
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreatology 9:245-51. 2009
    ..Changes in pancreatic function and morphology after acute pancreatitis have been characterized previously, but their association with later recurrences has not been adequately studied...
  12. doi A novel biodegradable pancreatic stent for human pancreatic applications: a preclinical safety study in a large animal model
    Johanna Laukkarinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Gastrointest Endosc 67:1106-12. 2008
    ..Endoscopic stenting is one treatment method for pancreatic strictures or pseudocysts in patients with symptomatic chronic pancreatitis. With a biodegradable stent, the later removal of the stent could be avoided...
  13. doi The recurrence of acute alcohol-associated pancreatitis can be reduced: a randomized controlled trial
    Isto Nordback
    Department of Gastroenterology and Alimentary Tract Surgery, Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland
    Gastroenterology 136:848-55. 2009
    ..None of the recent national or international guidelines for treatment include recommendations aimed to decrease recurrences, possibly because of a lack of studies. This study investigated whether AP recurrences can be reduced...
  14. doi Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction
    Jussi Nikkola
    1School of Medicine, University of Tampere, Tampere, Finland
    Alcohol Alcohol 48:483-6. 2013
    ..To determine the recurrence of pancreatitis and subsequent pancreatic function in patients who stop drinking after the first episode of alcohol-associated pancreatitis...
  15. pmc Is alcoholic pancreatitis associated with enteroviral infection?
    Jahangir Khan
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, 33521 Tampere, Finland
    World J Gastroenterol 19:3819-23. 2013
    ..To investigate whether enteroviral infection might trigger acute pancreatitis in patients made susceptible due to high alcohol consumption...
  16. pmc Luminal lactate in acute pancreatitis--validation and relation to disease severity
    Lauri Pynnönen
    Department of Critical Care Medicine, Tampere University Hospital, Teiskontie 35, Tampere 33520, Finland
    BMC Gastroenterol 12:40. 2012
    ..In acute pancreatitis (AP) bacterial translocation is considered as the key event leading to infection of necrotic pancreatic tissue and high severity of illness...
  17. doi Changes in blood polyamine levels in human acute pancreatitis
    Hai Tao Jin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 44:1004-11. 2009
    ..The aim of this human study was to examine the changes in polyamine levels in the RBCs of patients with acute pancreatitis...
  18. doi Pancreatic morphological changes in long-term follow-up after initial episode of acute alcoholic pancreatitis
    Jussi Nikkola
    School of Medicine, University of Tampere, Tampere, Finland
    J Gastrointest Surg 18:164-70; discussion 170-1. 2014
    ..We have previously reported 2-year follow-up results in pancreatic morphology. This study extends the follow-up to 9 years...
  19. doi Pancreatic injury response is different depending on the method of resecting the parenchyma
    Teemu Lamsa
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    J Surg Res 154:203-11. 2009
    ..The present study was performed to compare the pancreatic injury response on the parenchymal resection either with ultrasonic scissors, electrocautery, or surgical scalpel...
  20. ncbi Increased prevalence of subclinical hypothyroidism in common bile duct stone patients
    Johanna Laukkarinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere FIN 33520, Finland
    J Clin Endocrinol Metab 92:4260-4. 2007
    ....
  21. ncbi A novel biodegradable biliary stent in the endoscopic treatment of cystic-duct leakage after cholecystectomy
    Johanna Laukkarinen
    Department of Gastroenterology and Alimentary Tract Surgery, Institute of Biomaterials, Tampere University of Technology, Tampere, and Department of Pathology, Helsinki University Hospital, Helsinki, Finland
    Gastrointest Endosc 65:1063-8. 2007
    ..A bile leak is a common complication after a cholecystectomy...
  22. doi Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis
    Hai Tao Jin
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreatology 8:15-24. 2008
    ..We investigated whether there is a relationship in polyamine levels between pancreas and blood, and whether pancreatic and blood polyamine levels change according to the severity of pancreatitis...
  23. doi Risk factors for recurrent acute alcohol-associated pancreatitis: a prospective analysis
    Hanna Pelli
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 43:614-21. 2008
    ..The aim of this prospective follow-up study was to determine the risk factors associated with recurrences...
  24. pmc Validation of intraluminal and intraperitoneal microdialysis in ischemic small intestine
    Lauri Pynnönen
    Critical Care Medicine Research Group, Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland
    BMC Gastroenterol 13:170. 2013
    ..We hypothesized that IL as opposed to IP microdialysis detects small intestinal ischemia with higher sensitivity and specificity...
  25. doi Serum lipid levels are associated with the severity of acute pancreatitis
    Jahangir Khan
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Digestion 87:223-8. 2013
    ..Serum lipid concentrations react during acute disease. We sought to measure changes in the serum lipid profile during acute pancreatitis and ascertain whether these changes were associated with the severity of the disease...
  26. ncbi Biocompatibility of a new bioabsorbable radiopaque stent material (BaSO4 containing poly-L,D-lactide) in the rat pancreas
    Teemu Lamsa
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreatology 6:301-5. 2006
    ..In developing pancreatic stents before long-term experiments, the acute toxicity to the pancreas of a bioabsorbable, radiopaque polylactide (PLA 96-barium sulfate, BaSO4) stent material was investigated...
  27. doi Alcohol consumption in the country and hospitalizations for acute alcohol pancreatitis and liver cirrhosis during a 20-year period
    Juhani Sand
    Department of Gastroenterology and Alimentary Tract Surgery, Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland
    Alcohol Alcohol 44:321-5. 2009
    ..During the1990s there was a temporary decrease in alcohol consumption. We examined the trends in the amount of alcohol consumed in Finland and the incidence of hospital admissions for acute alcoholic pancreatitis and liver cirrhosis...
  28. doi The Long-term Prospective Follow-up of Pancreatic Function After the First Episode of Acute Alcoholic Pancreatitis: Recurrence Predisposes One to Pancreatic Dysfunction and Pancreatogenic Diabetes
    Jussi Nikkola
    Departments of Gastroenterology and Alimentary Tract Surgery Internal Medicine, Tampere University Hospital, Tampere, Finland
    J Clin Gastroenterol 51:183-190. 2017
    ..Our aim was to evaluate the natural course of endocrine and exocrine pancreatic function in the long-term follow-up after the first episode of acute alcoholic pancreatitis (AAP)...
  29. ncbi Tumor-like Chronic Pancreatitis Is Often Autoimmune Pancreatitis
    Sari Raty
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Anticancer Res 35:6163-6. 2015
    ..Our aim was to evaluate the incidence of autoimmune pancreatitis (AIP) among patients operated on for a pancreatic mass with a final histology of CP...
  30. doi Tissue adhesives and the pancreas: biocompatibility and adhesive properties of 6 preparations
    Teemu Lamsa
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreas 36:261-6. 2008
    ..The aim of this study was to investigate biocompatibility and adhesive properties of 6 tissue adhesives available, when applied between the pancreas and jejunum in an experimental model...
  31. ncbi Postoperative acute pancreatitis as a major determinant of postoperative delayed gastric emptying after pancreaticoduodenectomy
    Sari Raty
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    J Gastrointest Surg 10:1131-9. 2006
    ..Preoperative coronary artery disease and soft texture of the pancreas are significant risk factors for postoperative CT-detected pancreatitis...
  32. ncbi Is it long-term continuous drinking or the post-drinking withdrawal period that triggers the first acute alcoholic pancreatitis?
    Isto Nordback
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Finland
    Scand J Gastroenterol 40:1235-9. 2005
    ..The aim of this study was to investigate the role of withdrawal in triggering acute alcoholic pancreatitis by studying the time-course of development of the first symptoms of the first acute alcoholic pancreatitis...
  33. doi Acute pancreatitis: risk of recurrence and late consequences of the disease
    Juhani Sand
    Division of Surgery, Gastroenterology and Oncology, Tampere University Hospital, Tampere, Finland
    Nat Rev Gastroenterol Hepatol 6:470-7. 2009
    ..This Review focuses on data from studies that investigated the risk factors for recurrent attacks of acute pancreatitis, and discusses the late consequences of this disease...
  34. doi Bile duct stone procedures are more frequent in patients with hypothyroidism. A large, registry-based, cohort study in Finland
    Johanna Laukkarinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 45:70-4. 2010
    ..The aim of this large registry-based study was to investigate the prevalence of CBDS in patients with diagnosed hypothyroidism compared to age-, sex- and living area-adjusted glaucoma (control) patients...
  35. ncbi Perioperative Hydrocortisone Reduces Major Complications After Pancreaticoduodenectomy: A Randomized Controlled Trial
    Matias Laaninen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland Department of Pathology, Tampere University Hospital, Tampere, Finland
    Ann Surg 264:696-702. 2016
    ..The aim of this study was to study whether post-pancreaticoduodenectomy complications (PPDC) in high-risk patients can be reduced with hydrocortisone...
  36. doi Biodegradable biliary stents have a different effect than covered metal stents on the expression of proteins associated with tissue healing in benign biliary strictures
    Antti Siiki
    a Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 51:880-5. 2016
    ..The aim was to assess the expression of proteins related to tissue healing in BBS compared with the intact bile duct (BD), and to study the protein expression after therapy with CSEMS or BDBS...
  37. doi Serum lipid and fatty acid profiles are highly changed in patients with alcohol induced acute pancreatitis
    Jahangir Khan
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Pancreatology 12:44-8. 2012
    ..We hypothesized that these changes may explain individual susceptibility of developing acute pancreatitis. We compared lipid and fatty acid profiles of patients with acute alcoholic pancreatitis and alcoholic controls...
  38. ncbi Screening for human cationic trypsinogen (PRSS1) and trypsinogen inhibitor gene (SPINK1) mutations in a Finnish family with hereditary pancreatitis
    Sari Raty
    Departments of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol 42:1000-5. 2007
    ..The purpose of this study was to report on the incidence of PRSS1 and SPINK1 mutations in a Finnish family with HP and to correlate the findings to the clinical symptoms...
  39. ncbi Ultra thin needle histology may have impact in diagnosing chronic pancreatitis
    Juhani Sand
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, FIN 33521 Tampere, Finland
    Scand J Gastroenterol 42:508-12. 2007
    ....
  40. ncbi Complications of palliative hepaticojejunostomy and gastrojejunostomy in unresectable periampullary cancer: patient- and disease-related risk factors
    Sari Raty
    Department of Surgery, Tampere University Hospital, Finland
    Hepatogastroenterology 53:133-7. 2006
    ....
  41. ncbi [Successful endoscopic examination of gallbladder and pancreatic ducts of outpatients]
    Juhani Sand
    TAYS, gastroenterologian vastuualue, Tampere
    Duodecim 121:763-7. 2005
  42. ncbi Cutting down substance abuse--present state and visions among surgeons and nurses
    Riitta Lappalainen-Lehto
    Department of Surgery, Tampere University Hospital, Finland
    Addict Behav 30:1013-8. 2005
    ..The aim of the present study was to assess surgeons' and nurses' activity in screening substance abuse among their patients and obstacles concerning intervention of patients with substance abuse...
  43. ncbi Impaired gallbladder function in patients after total gastrectomy
    Tuula Tyrväinen
    a Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    Scand J Gastroenterol . 2016
    ..Here, we investigate the changes in gallbladder and biliary tract functions by cholescintygraphy and monitored changes in cholecystokinin (CCK) release in long-term survivors after total gastrectomy for gastric carcinoma...
  44. doi A novel 2-step culture model for long-term in vitro maintenance of human pancreatic acinar cells
    Merja Bläuer
    From the Department of Gastroenterology and Alimentary Tract Surgery and Tampere Pancreas Laboratory, Tampere University Hospital, Tampere, Finland
    Pancreas 43:762-7. 2014
    ..We recently described a method for long-term cultivation of mouse acinar cells. Here, we introduce a novel 2-step culture system for human pancreatic acinar cells...
  45. pmc Is Roux-Y binding pancreaticojejunal anastomosis feasible for patients undergoing left pancreatectomy? Results from a prospective randomized trial
    Anne Antila
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, P O Box 2000, 33521 Tampere, Finland
    Biomed Res Int 2014:508714. 2014
    ..Our aim was to investigate whether FBPJ is feasible and prevents the risk for POPF even after left pancreatectomy (LP)...
  46. doi Quality of life in the long-term survivors after total gastrectomy for gastric carcinoma
    Tuula Tyrväinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland
    J Surg Oncol 97:121-4. 2008
    ..Several studies report the health-related quality of life (HRQoL) after total gastrectomy in short term but long-term results have been less published...
  47. ncbi Cyst fluid tumor-associated trypsin inhibitor may be helpful in the differentiation of cystic pancreatic lesions
    Sari Raty
    Department of Surgery, Tampere University Hospital, Tampere, Finland
    J Gastrointest Surg 8:569-74. 2004
    ..It appears to be a potential marker in the differential diagnosis of benign from malignant cystic pancreatic lesions...
  48. ncbi Plasma Level of Soluble Urokinase-type Plasminogen Activator Receptor Predicts the Severity of Acute Alcohol Pancreatitis
    Anssi Nikkola
    From the Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital University of Tampere, School of Medicine Fimlab Laboratories and Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Pancreas . 2016
    ..We investigated the activation and prognostic value of plasma suPAR (P-suPAR) in patients experiencing their first acute alcohol pancreatitis (AAP)...
  49. doi Can Laparoscopic Cholecystectomy Prevent Recurrent Idiopathic Acute Pancreatitis?: A Prospective Randomized Multicenter Trial
    Sari Raty
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland Department of Surgery, Kuopio University Hospital, Kuopio, Finland Department of Surgery, Vaasa Central Hospital, Vaasa, Finland Division of Digestive Surgery and Urology, Turku University Hospital, Turku, Finland Department of Surgery, Seinajoki Central Hospital, Seinajoki, Finland Department of Surgery, Kanta Hame Central Hospital, Hameenlinna, Finland Department of Surgery, Kuopio University Hospital and University of Eastern Finland
    Ann Surg 262:736-41. 2015
    ..The aim of the present trial was to ascertain whether laparoscopic cholecystectomy (LCC) can prevent recurrent attacks of idiopathic acute pancreatitis (IAP)...
  50. pmc The underlying mechanisms: how hypothyroidism affects the formation of common bile duct stones-a review
    Johanna Laukkarinen
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Teiskontie 35, FIN 33521 Tampere, Finland
    HPB Surg 2012:102825. 2012
    ..The authors conclude that when treating patients with CBD stones or microlithiasis, clinicians should be aware of the possible hypothyroid background...
  51. doi A novel explant outgrowth culture model for mouse pancreatic acinar cells with long-term maintenance of secretory phenotype
    Merja Bläuer
    Department of Gastroenterology and Alimentary Tract Surgery and Tampere Pancreas Laboratory, Tampere University Hospital, Teiskontie 35, FIN 33521 Tampere, Finland
    Eur J Cell Biol 90:1052-60. 2011
    ..01 nM (p=0.049) and 2-fold in 6- to 7-day cultures at 0.1 nM (p=0.003). The present culture model provides a means to obtain functionally competent normal mouse acinar cells for long-term in vitro experimentation...
  52. ncbi Increased wall tension in response to vasoconstrictors in isolated mesenteric arterial rings from patients with high blood pressure
    Anna Tahvanainen
    Department of Internal Medicine, University of Tampere, 33014 University of Tampere, Tampere, Finland
    Basic Clin Pharmacol Toxicol 99:440-9. 2006
    ..Since the mesenteric circulation is an important regulator of peripheral arterial resistance, possible functional alterations in this vascular bed should be further investigated in hypertensive patients...
  53. doi Probiotics in severe acute pancreatitis
    Juhani Sand
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, FIN 33521 Tampere, Finland
    Lancet 371:634-5. 2008
  54. ncbi Is bile flow reduced in patients with hypothyroidism?
    Johanna Laukkarinen
    Department of Surgery, Tampere University Hospital, Tampere, Finland
    Surgery 133:288-93. 2003
    ..The aim of the present study was to investigate human biliary dynamics in relation to altered thyroid gland function...
  55. ncbi Calcium channel antagonists and inhibition of human sphincter of Oddi contractions
    Juhani Sand
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere, Finland
    Scand J Gastroenterol 40:1394-7. 2005
    ..The effects of other calcium channel antagonists on sphincter of Oddi have not been elucidated...
  56. ncbi Pancreatic pseudocystportal vein fistula manifests as residivating oligoarthritis, subcutaneous, bursal and osseal necrosis: a case report and review of literature
    Anne Marja Hammar
    Department of Surgery, Tampere University Hospital, P O Box 2000, 33521 Tampere, Finland
    Hepatogastroenterology 49:273-8. 2002
    ..To diminish the ongoing extrapancreatic manifestations after the closure of the fistula massive corticosteroid treatment may be attempted although the role of this therapy remains controversial...
  57. pmc activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality
    Mervi T Hyvonen
    Department of Biotechnology and Molecular Medicine, A I Virtanen Institute for Molecular Sciences, University of Kuopio, P O Box 1627, FI 70211 Kuopio, Finland
    Am J Pathol 168:115-22. 2006
    ..Our data suggest that activation of polyamine catabolism is a general pathway in the pathogenesis of acute pancreatitis and that experimental disease can be ameliorated with stable polyamine analogues...
  58. ncbi Delayed gastric emptying and intestinal hormones following pancreatoduodenectomy
    Lisa Strömmer
    Center for Surgical Sciences, Stockholm, Sweden
    Pancreatology 5:537-44. 2005
    ..The present study tested the hypothesis that gastrointestinal hormones known to effect gastric emptying contribute to DGE in patients after PD...
  59. ncbi Long-term changes in hepatobiliary physiology after Roux-en-Y hepaticojejunostomy
    Johanna Laukkarinen
    Department of Experimental Surgery, Singapore General Hospital, Singapore, Singapore
    J Surg Res 143:270-5. 2007
    ..The clinical significance of these changes, and the reduced weight gain observed is a topic of further investigations...