Pasi Kaukinen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi request reprint Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions
    Pasi Kaukinen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Helsinki, Finland
    J Med Virol 85:71-82. 2013
  2. pmc Mapping of the regions involved in homotypic interactions of Tula hantavirus N protein
    Pasi Kaukinen
    Department of Virology, Haartman Institute, FIN 00014 University of Helsinki, Finland
    J Virol 77:10910-6. 2003
  3. ncbi request reprint Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter
    Kirsi M Jääskeläinen
    Department of Virology, Haartman Institute, FIN 00014 University of Helsinki, Finland
    J Med Virol 79:1527-36. 2007
  4. pmc Oligomerization of Hantavirus N protein: C-terminal alpha-helices interact to form a shared hydrophobic space
    Pasi Kaukinen
    Department of Virology, Haartman Institute, P O Box 21, FI 00014 University of Helsinki, Finland
    J Virol 78:13669-77. 2004
  5. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
  6. doi request reprint Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses
    Finny S Varghese
    Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
    Antiviral Res 126:117-24. 2016
  7. ncbi request reprint Non-covalent interaction between nucleocapsid protein of Tula hantavirus and small ubiquitin-related modifier-1, SUMO-1
    Pasi Kaukinen
    Department of Virology, Haartman Institute, PO Box 21, University of Helsinki, FIN 00014, Helsinki, Finland
    Virus Res 92:37-45. 2003
  8. pmc Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection
    Oxana V Denisova
    Institute for Molecular Medicine Finland, FIMM, Helsinki, Finland
    J Biol Chem 287:35324-32. 2012

Collaborators

Detail Information

Publications8

  1. doi request reprint Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions
    Pasi Kaukinen
    Virology Unit, Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare THL, Helsinki, Finland
    J Med Virol 85:71-82. 2013
    ..The present study identified HCV NS2 as a potent interferon antagonist, and describes an explanation of how NS2 downregulates the major signaling pathways involved in the development of host innate antiviral responses...
  2. pmc Mapping of the regions involved in homotypic interactions of Tula hantavirus N protein
    Pasi Kaukinen
    Department of Virology, Haartman Institute, FIN 00014 University of Helsinki, Finland
    J Virol 77:10910-6. 2003
    ..Furthermore, our data suggested a tail-to-tail and head-to-head binding scheme for the N proteins...
  3. ncbi request reprint Tula and Puumala hantavirus NSs ORFs are functional and the products inhibit activation of the interferon-beta promoter
    Kirsi M Jääskeläinen
    Department of Virology, Haartman Institute, FIN 00014 University of Helsinki, Finland
    J Med Virol 79:1527-36. 2007
    ..The findings may explain why the NSs ORF has been preserved in the genome of most hantaviruses during their long evolution and why hantavirus-infected cells secrete relatively low levels of IFNs...
  4. pmc Oligomerization of Hantavirus N protein: C-terminal alpha-helices interact to form a shared hydrophobic space
    Pasi Kaukinen
    Department of Virology, Haartman Institute, P O Box 21, FI 00014 University of Helsinki, Finland
    J Virol 78:13669-77. 2004
    ..N protein trimerization was supported by three-dimensional reconstruction of the N protein by electron microscopy after negative staining. Finally, we discuss how N protein trimerization could occur...
  5. pmc Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
    Pasi Kaukinen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    Virol J 3:66. 2006
    ..Previously, the serine protease NS3/4A was shown to inhibit IFN-beta gene expression by blocking dsRNA-activated retinoic acid-inducible gene I (RIG-I) and Toll-like receptor 3 (TLR3)-mediated signaling pathways...
  6. doi request reprint Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses
    Finny S Varghese
    Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland
    Antiviral Res 126:117-24. 2016
    ..Time of addition experiments also suggested that they act on the replication phase of the viral infectious cycle...
  7. ncbi request reprint Non-covalent interaction between nucleocapsid protein of Tula hantavirus and small ubiquitin-related modifier-1, SUMO-1
    Pasi Kaukinen
    Department of Virology, Haartman Institute, PO Box 21, University of Helsinki, FIN 00014, Helsinki, Finland
    Virus Res 92:37-45. 2003
    ..By using a pepscan assay, two basic amino acid stretches in the N-terminal part of SUMO-1 were shown to be involved in the interaction...
  8. pmc Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection
    Oxana V Denisova
    Institute for Molecular Medicine Finland, FIMM, Helsinki, Finland
    J Biol Chem 287:35324-32. 2012
    ..Altogether, our results suggest that phase II obatoclax, investigational SaliPhe, and FDA/EMEA-approved gemcitabine represent potent antiviral agents...