Frederic Bringaud

Summary

Country: France

Publications

  1. pmc Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids: pyruvate, phosphate dikinase
    F Bringaud
    Laboratoire de Parasitologie Moleculaire, Université Victor Ségalène de Bordeaux II, France
    Proc Natl Acad Sci U S A 95:7963-8. 1998
  2. doi Role of transposable elements in trypanosomatids
    Frederic Bringaud
    Laboratoire de Résonance Magnétique des Systèmes Biologiques, Universite Victor Segalen Bordeaux 2, UMR 5536 CNRS, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Microbes Infect 10:575-81. 2008
  3. pmc Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    PLoS Pathog 3:1291-307. 2007
  4. ncbi Energy metabolism of trypanosomatids: adaptation to available carbon sources
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, UMR 5162 CNRS, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Mol Biochem Parasitol 149:1-9. 2006
  5. ncbi The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    Mol Biol Evol 23:411-20. 2006
  6. ncbi Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, UMR 5162 CNRS, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Mol Biochem Parasitol 145:158-70. 2006
  7. ncbi The ingi and RIME non-LTR retrotransposons are not randomly distributed in the genome of Trypanosoma brucei
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 CNRS, Université Victor Segalen Bordeaux II, Bordeaux, France
    Mol Biol Evol 21:520-8. 2004
  8. ncbi Conserved organization of genes in trypanosomatids
    F Bringaud
    Laboratoire de Parasitologie Moleculaire, Université Victor Ségolène de Bordeaux II, France
    Mol Biochem Parasitol 94:249-64. 1998
  9. ncbi Characterization and disruption of a new Trypanosoma brucei repetitive flagellum protein, using double-stranded RNA inhibition
    F Bringaud
    Laboratoire de Parasitologie Moleculaire, université Victor Segalen de Bordeaux II, UMR 5016 CNRS, Bordeaux, France
    Mol Biochem Parasitol 111:283-97. 2000
  10. ncbi Identification of non-autonomous non-LTR retrotransposons in the genome of Trypanosoma cruzi
    Frederic Bringaud
    Laboratoire de Parasitologie Moleculaire, Université Victor Segalen Bordeaux II, UMR 5016 CNRS, 146 rue Leo Saignat, Bordeaux, France
    Mol Biochem Parasitol 124:73-8. 2002

Collaborators

Detail Information

Publications29

  1. pmc Functional and molecular characterization of a glycosomal PPi-dependent enzyme in trypanosomatids: pyruvate, phosphate dikinase
    F Bringaud
    Laboratoire de Parasitologie Moleculaire, Université Victor Ségalène de Bordeaux II, France
    Proc Natl Acad Sci U S A 95:7963-8. 1998
    ..The precise role of PPDK in trypanosomatid carbohydrate metabolism remains to be clarified...
  2. doi Role of transposable elements in trypanosomatids
    Frederic Bringaud
    Laboratoire de Résonance Magnétique des Systèmes Biologiques, Universite Victor Segalen Bordeaux 2, UMR 5536 CNRS, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Microbes Infect 10:575-81. 2008
    ..In this review, we highlight the remarkable role extinct transposable elements can play as the source of potential new functions...
  3. pmc Members of a large retroposon family are determinants of post-transcriptional gene expression in Leishmania
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    PLoS Pathog 3:1291-307. 2007
    ..To our knowledge, this is the first example in eukaryotes of the domestication and expansion of a family of mobile elements that have evolved to fulfill a critical cellular function...
  4. ncbi Energy metabolism of trypanosomatids: adaptation to available carbon sources
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, UMR 5162 CNRS, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Mol Biochem Parasitol 149:1-9. 2006
    ....
  5. ncbi The Trypanosoma cruzi L1Tc and NARTc non-LTR retrotransposons show relative site specificity for insertion
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    Mol Biol Evol 23:411-20. 2006
    ..This analysis clearly indicates that the L1Tc and NARTc elements display relative site specificity for insertion, which suggests that the APE activity is not responsible for first-strand cleavage of the target site...
  6. ncbi Evolution of non-LTR retrotransposons in the trypanosomatid genomes: Leishmania major has lost the active elements
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, UMR 5162 CNRS, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Mol Biochem Parasitol 145:158-70. 2006
    ....
  7. ncbi The ingi and RIME non-LTR retrotransposons are not randomly distributed in the genome of Trypanosoma brucei
    Frederic Bringaud
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 CNRS, Université Victor Segalen Bordeaux II, Bordeaux, France
    Mol Biol Evol 21:520-8. 2004
    ..In conclusion, the ingi and RIME retroelements are not randomly distributed in the genome of T. brucei and are preceded by a conserved sequence, which may be the recognition site of the ingi-encoded endonuclease...
  8. ncbi Conserved organization of genes in trypanosomatids
    F Bringaud
    Laboratoire de Parasitologie Moleculaire, Université Victor Ségolène de Bordeaux II, France
    Mol Biochem Parasitol 94:249-64. 1998
    ..vivax within Salivarian trypanosomes. On the basis of gene organization, biochemical characteristics of isoforms and phylogeny, we discuss the genesis of the glucose transporter multigene family in Salivarian trypanosomes...
  9. ncbi Characterization and disruption of a new Trypanosoma brucei repetitive flagellum protein, using double-stranded RNA inhibition
    F Bringaud
    Laboratoire de Parasitologie Moleculaire, université Victor Segalen de Bordeaux II, UMR 5016 CNRS, Bordeaux, France
    Mol Biochem Parasitol 111:283-97. 2000
    ..hrucei. Molecular ablation of FTZC does not generate any obvious phenotype such as, lethality, modification of growth rate or cellular shape, in the growth conditions used...
  10. ncbi Identification of non-autonomous non-LTR retrotransposons in the genome of Trypanosoma cruzi
    Frederic Bringaud
    Laboratoire de Parasitologie Moleculaire, Université Victor Segalen Bordeaux II, UMR 5016 CNRS, 146 rue Leo Saignat, Bordeaux, France
    Mol Biochem Parasitol 124:73-8. 2002
    ..In addition, the genome of Leishmania major contains the same conserved motif present in the trypanosome retroelements, whicle no transposable elements have been detected so far in Leishmania sp...
  11. pmc A new, expressed multigene family containing a hot spot for insertion of retroelements is associated with polymorphic subtelomeric regions of Trypanosoma brucei
    Frederic Bringaud
    Laboratoire de Parasitologie Moleculaire, Université Victor Segalen Bordeaux II, UMR 5016 CNRS, 33076 Bordeaux, France
    Eukaryot Cell 1:137-51. 2002
    ..brucei strain TREU927/4 GUTat10.1. RHS genes comprise the remaining sequence of the size-polymorphic "repetitive region" described for T. brucei chromosome I, and a homologous gene family is present in the Trypanosoma cruzi genome...
  12. ncbi A mitochondrial NADH-dependent fumarate reductase involved in the production of succinate excreted by procyclic Trypanosoma brucei
    Virginie Coustou
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 CNRS, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    J Biol Chem 280:16559-70. 2005
    ..We propose that FRDm1 is involved in the maintenance of the redox balance in the mitochondrion, as proposed for the ancestral soluble FRD presumably present in primitive anaerobic cells...
  13. pmc Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability
    Muriel Mazet
    Centre de Résonance Magnétique des Systèmes Biologiques RMSB, UMR5536, Université Bordeaux Segalen, CNRS, Bordeaux, France
    PLoS Negl Trop Dis 7:e2587. 2013
    ..brucei...
  14. pmc The threonine degradation pathway of the Trypanosoma brucei procyclic form: the main carbon source for lipid biosynthesis is under metabolic control
    Yoann Millerioux
    Centre de Résonance Magnétique des Systèmes Biologiques RMSB, UMR 5536 Université Bordeaux Segalen, CNRS, 146 rue Leo Saignat, 33076, Bordeaux, France
    Mol Microbiol 90:114-29. 2013
    ..We conclude that TDH expression is under control and can be downregulated in response to metabolic perturbations, such as in the PEPCK mutant in which the glycolytic metabolic flux was redirected towards acetate production. ..
  15. ncbi Fumarate is an essential intermediary metabolite produced by the procyclic Trypanosoma brucei
    Virginie Coustou
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 CNRS and Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    J Biol Chem 281:26832-46. 2006
    ..Inaoka, D. K., Osanai, A., Nara, T., Odaka, M., Aoki, T., Inaka, K., Harada, S., and Kita, K. (2002) Mol. Biochem. Parasitol. 122, 189-200)...
  16. pmc Trypanosomatid genomes contain several subfamilies of ingi-related retroposons
    Frederic Bringaud
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Eukaryot Cell 8:1532-42. 2009
    ....
  17. ncbi ATP generation in the Trypanosoma brucei procyclic form: cytosolic substrate level is essential, but not oxidative phosphorylation
    Virginie Coustou
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 CNRS, France
    J Biol Chem 278:49625-35. 2003
    ..We conclude that PYK is essential because of its ATP production, which implies that the cytosolic substrate level phosphorylation is essential for the growth of procyclic trypanosomes...
  18. ncbi Succinate secreted by Trypanosoma brucei is produced by a novel and unique glycosomal enzyme, NADH-dependent fumarate reductase
    Sebastien Besteiro
    Laboratoire de Parasitologie Moleculaire, UMR 5016 CNRS, Université Victor Segalen Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    J Biol Chem 277:38001-12. 2002
    ..FRDg may have the characteristics of such an ancestral enzyme and is the only NADH-dependent fumarate reductase characterized to date...
  19. pmc Contribution of pyruvate phosphate dikinase in the maintenance of the glycosomal ATP/ADP balance in the Trypanosoma brucei procyclic form
    Kamel Deramchia
    From the Centre de Résonance Magnétique des Systèmes Biologiques, Universite de Bordeaux, CNRS UMR 5536, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    J Biol Chem 289:17365-78. 2014
    ..This illustrates the key roles played by glycosomal and cytosolic kinases, including PPDK, to maintain the cellular ATP/ADP homeostasis. ..
  20. ncbi Acetyl:succinate CoA-transferase in procyclic Trypanosoma brucei. Gene identification and role in carbohydrate metabolism
    Loïc Rivière
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, UMR 5162 CNRS, Université Victor Segalen Bordeaux II, 33076 Bordeaux Cedex, France
    J Biol Chem 279:45337-46. 2004
    ..These studies show that ASCT is indeed involved in acetate production, but is not essential, as apparently it is not the only enzyme that produces acetate in T. brucei...
  21. pmc ATP synthesis-coupled and -uncoupled acetate production from acetyl-CoA by mitochondrial acetate:succinate CoA-transferase and acetyl-CoA thioesterase in Trypanosoma
    Yoann Millerioux
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, 146 rue Leo Saignat, 33076 Bordeaux, France
    J Biol Chem 287:17186-97. 2012
    ..We concluded that acetate is produced from both ASCT and ACH; however, only ASCT is responsible, together with the F(0)/F(1)-ATP synthase, for ATP production in the mitochondrion...
  22. ncbi A soluble pyrophosphatase, a key enzyme for polyphosphate metabolism in Leishmania
    Benoit Espiau
    Laboratoire de Genomique Fonctionnelle des Trypanosomatides, Universite Victor Segalen Bordeaux 2, UMR CNRS 5162, 146 rue Leo Saignat, 33076 Bordeaux, France
    J Biol Chem 281:1516-23. 2006
    ..These results make the VSP1 enzyme an attractive drug target against trypanosomatid parasites...
  23. doi Combining reverse genetics and nuclear magnetic resonance-based metabolomics unravels trypanosome-specific metabolic pathways
    Frederic Bringaud
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536 Université de Bordeaux, CNRS, 146 rue Leo Saignat, 33076, Bordeaux, France
    Mol Microbiol 96:917-26. 2015
    ....
  24. pmc TSIDER1, a short and non-autonomous Salivarian trypanosome-specific retroposon related to the ingi6 subclade
    Frederic Bringaud
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, 146 rue Leo Saignat, 33076 Bordeaux, France
    Mol Biochem Parasitol 179:30-6. 2011
    ..brucei (22 copies) genomes confirms that trypanosomes have not expanded short transposable elements, which is in contrast to Leishmania spp. (∼2000 copies), where SIDER play a role in the regulation of gene expression...
  25. pmc Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes
    Loïc Rivière
    Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité, Unité Mixte de Recherche 5234 Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Proc Natl Acad Sci U S A 106:12694-9. 2009
    ..To date, Trypanosoma is the only known eukaryotic organism that uses acetate instead of citrate to transfer acetyl groups over the mitochondrial membrane for cytosolic lipid synthesis...
  26. pmc Two related subpellicular cytoskeleton-associated proteins in Trypanosoma brucei stabilize microtubules
    Cécile Vedrenne
    Laboratoire de Parasitologie Moleculaire, université Victor Segalen de Bordeaux II, Unité Mixte Recherche 5016 Centre National de la Recherche Scientifique, 33076 Bordeaux, France
    Mol Biol Cell 13:1058-70. 2002
    ..When overexpressed in T. brucei, both CAP15 and CAP17 cover the whole subpellicular corset and induce morphological disorders, cell cycle-based abnormalities, and subsequent asymmetric cytokinesis...
  27. ncbi Nucleotide sequence of the gyrA gene of Arcobacter species and characterization of human ciprofloxacin-resistant clinical isolates
    Khalil Abdelbaqi
    Universite Victor Segalen Bordeaux 2, Centre national de référence des Campylobacters et Helicobacters, Laboratoire de Bacteriologie, Bordeaux, France
    FEMS Immunol Med Microbiol 49:337-45. 2007
    ..In addition, a Thr-->Ile mutation at amino acid 85 in the quinolone resistance-determining region was associated with ciprofloxacin resistance for two A. butzleri and one A. cryaerophilus ciprofloxacin-resistant strains...
  28. doi Identification and analysis of ingi-related retroposons in the trypanosomatid genomes
    Frederic Bringaud
    Centre de Résonance Magnétique des Systèmes Biologiques RMSB, UMR 5536 CNRS, Universite de Bordeaux, 146, rue Leo Saignat, 33076, Bordeaux, France
    Methods Mol Biol 1201:109-22. 2015
    ..Here, we present an overview of the computational methods used to identify, annotate, and analyze ingi-related retroposons for providing a comprehensive picture of all these TE families in newly available trypanosomatid genome sequences...
  29. ncbi Multiple roles of proline transport and metabolism in trypanosomatids
    Frederic Bringaud
    Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, Bordeaux, France
    Front Biosci (Landmark Ed) 17:349-74. 2012
    ..cruzi. This review focuses on recent progress in understanding the different aspects of proline metabolism in trypanosomatids, with a particular interest on the insect forms...