Ian Findlay

Summary

Country: France

Publications

  1. pmc Voltage- and cation-dependent inactivation of L-type Ca2+ channel currents in guinea-pig ventricular myocytes
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, France
    J Physiol 541:731-40. 2002
  2. ncbi request reprint High efficiency activation of L-type Ca2+ current by 5-HT in human atrial myocytes
    Emmanuella Di Scala
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, France
    Receptors Channels 10:159-65. 2004
  3. pmc Physiological modulation of inactivation in L-type Ca2+ channels: one switch
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, Parc de Grandmont, 37200 Tours, France
    J Physiol 554:275-83. 2004
  4. pmc Beta-adrenergic and muscarinic agonists modulate inactivation of L-type Ca2+ channel currents in guinea-pig ventricular myocytes
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, Parc de Grandmont, France
    J Physiol 545:375-88. 2002
  5. ncbi request reprint Is there an A-type K+ current in guinea pig ventricular myocytes?
    Ian Findlay
    Faculte des Sciences, Centre National de la Recherche Scientifique UMR 6542, Universite de Tours, France
    Am J Physiol Heart Circ Physiol 284:H598-604. 2003
  6. pmc beta-Adrenergic stimulation modulates Ca2+- and voltage-dependent inactivation of L-type Ca2+ channel currents in guinea-pig ventricular myocytes
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, France
    J Physiol 541:741-51. 2002
  7. pmc Voltage-dependent inactivation of L-type Ca2+ currents in guinea-pig ventricular myocytes
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, Parc de Grandmont, France
    J Physiol 545:389-97. 2002
  8. doi request reprint Catecholaminergic automatic activity in the rat pulmonary vein: electrophysiological differences between cardiac muscle in the left atrium and pulmonary vein
    Nicolas Doisne
    Centre National de la Recherche Scientifique FRE 3092, Faculte des Sciences, Universite Francois Rabelais, Tours, France
    Am J Physiol Heart Circ Physiol 297:H102-8. 2009
  9. ncbi request reprint Intracellular Cs+ activates the PKA pathway, revealing a fast, reversible, Ca2+-dependent inactivation of L-type Ca2+ current
    Fabien Brette
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 6542, Universite de Tours, France
    Am J Physiol Cell Physiol 285:C310-8. 2003
  10. ncbi request reprint Contractile and relaxant properties of rat-isolated pulmonary veins related to localization and histology
    Cécile Bronquard
    Universite Francois Rabelais, CNRS UMR 6542, 31 Avenue Monge, 37200 Tours, France
    Fundam Clin Pharmacol 21:55-65. 2007

Collaborators

Detail Information

Publications13

  1. pmc Voltage- and cation-dependent inactivation of L-type Ca2+ channel currents in guinea-pig ventricular myocytes
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, France
    J Physiol 541:731-40. 2002
    ....
  2. ncbi request reprint High efficiency activation of L-type Ca2+ current by 5-HT in human atrial myocytes
    Emmanuella Di Scala
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, France
    Receptors Channels 10:159-65. 2004
    ..We will show that the effect of 5-HT upon human atrial myocytes is an imbalance between low production of cAMP and maximal activation of ICaL...
  3. pmc Physiological modulation of inactivation in L-type Ca2+ channels: one switch
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, Parc de Grandmont, 37200 Tours, France
    J Physiol 554:275-83. 2004
    ..The physiological implications of these ideas are that under basal conditions the contribution of I(CaL) to the action potential will be determined largely by voltage and by Ca(2+) following Beta-adrenergic stimulation...
  4. pmc Beta-adrenergic and muscarinic agonists modulate inactivation of L-type Ca2+ channel currents in guinea-pig ventricular myocytes
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, Parc de Grandmont, France
    J Physiol 545:375-88. 2002
    ..It is concluded that agonist modulation of rapid voltage-dependent inactivation of L-type Ca(2+) channels involves an 'on-off' switch...
  5. ncbi request reprint Is there an A-type K+ current in guinea pig ventricular myocytes?
    Ian Findlay
    Faculte des Sciences, Centre National de la Recherche Scientifique UMR 6542, Universite de Tours, France
    Am J Physiol Heart Circ Physiol 284:H598-604. 2003
    ..The voltage dependence of inactivation of the outward current was identical to that of the L-type Ca(2+) current. It is concluded that extracellular Ca(2+) does not mask an A-type K(+) current in guinea pig ventricular myocytes...
  6. pmc beta-Adrenergic stimulation modulates Ca2+- and voltage-dependent inactivation of L-type Ca2+ channel currents in guinea-pig ventricular myocytes
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, France
    J Physiol 541:741-51. 2002
    ..It is concluded that, under control conditions Ca2+ channel current decay is largely dominated by rapid voltage-dependent inactivation, while in isoproterenol this is replaced by Ca2+-induced inactivation...
  7. pmc Voltage-dependent inactivation of L-type Ca2+ currents in guinea-pig ventricular myocytes
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite de Tours, Parc de Grandmont, France
    J Physiol 545:389-97. 2002
    ..In basal conditions, voltage accelerated inactivation. In isoproterenol, voltage could also reduce inactivation...
  8. doi request reprint Catecholaminergic automatic activity in the rat pulmonary vein: electrophysiological differences between cardiac muscle in the left atrium and pulmonary vein
    Nicolas Doisne
    Centre National de la Recherche Scientifique FRE 3092, Faculte des Sciences, Universite Francois Rabelais, Tours, France
    Am J Physiol Heart Circ Physiol 297:H102-8. 2009
    ..The differences in membrane potential and reaction to adrenergic stimulation lead to automatic electrical activity occurring specifically in cardiac muscle in the PV...
  9. ncbi request reprint Intracellular Cs+ activates the PKA pathway, revealing a fast, reversible, Ca2+-dependent inactivation of L-type Ca2+ current
    Fabien Brette
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 6542, Universite de Tours, France
    Am J Physiol Cell Physiol 285:C310-8. 2003
    ..Cs+ seems to activate the cAMP-dependent protein kinase pathway when used as a substitute for K+ in the pipette solution...
  10. ncbi request reprint Contractile and relaxant properties of rat-isolated pulmonary veins related to localization and histology
    Cécile Bronquard
    Universite Francois Rabelais, CNRS UMR 6542, 31 Avenue Monge, 37200 Tours, France
    Fundam Clin Pharmacol 21:55-65. 2007
    ....
  11. ncbi request reprint Physiological modulation of voltage-dependent inactivation in the cardiac muscle L-type calcium channel: a modelling study
    Ian Findlay
    CNRS UMR 6542, Faculte des Sciences, Universite Francois Rabelais de Tours, France
    Prog Biophys Mol Biol 96:482-98. 2008
    ..The developed model thus will be useful to estimate the respective roles of VDI and CDI of L-type Ca2+ channels in various physiological and pathological conditions of the heart which would otherwise be difficult to show experimentally...
  12. ncbi request reprint Low-voltage triggering of Ca2+ release from the sarcoplasmic reticulum in cardiac muscle cells
    Fabien Brette
    School of Biomedical Sciences, Univ of Leeds, Leeds LS2 9NQ, UK
    Am J Physiol Cell Physiol 285:C1544-52. 2003
    ..However, L-type Ca2+ currents could be distinguished at voltages as negative as -45 mV. It is concluded that in the presence of isoproterenol, Ca2+ release from the SR at negative potentials is due to activation of L-type Ca2+ channels...
  13. doi request reprint In silico risk assessment for drug-induction of cardiac arrhythmia
    Shingo Suzuki
    Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    Prog Biophys Mol Biol 98:52-60. 2008
    ..This method may be of use to assess the arrhythmogenic risk of various I(Kr)-blockers...