R Bruzzone

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint The cellular Internet: on-line with connexins
    R Bruzzone
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, Paris, France
    Bioessays 18:709-18. 1996
  2. ncbi request reprint Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes
    Roberto Bruzzone
    Department of Neuroscience, Institut Pasteur, Paris, France
    J Neurochem 92:1033-43. 2005
  3. ncbi request reprint Functional analysis of a dominant mutation of human connexin26 associated with nonsyndromic deafness
    R Bruzzone
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, Paris, France
    Cell Commun Adhes 8:425-31. 2001
  4. pmc Learning the language of cell-cell communication through connexin channels
    R Bruzzone
    Institut Pasteur, Unité de Neurovirologie et Régénération du Système Nerveux, 75015 Paris, France
    Genome Biol 2:REPORTS4027. 2001
  5. ncbi request reprint Connexins, gap junctions and cell-cell signalling in the nervous system
    R Bruzzone
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, Paris, France
    Eur J Neurosci 9:1-6. 1997
  6. ncbi request reprint Loss-of-function and residual channel activity of connexin26 mutations associated with non-syndromic deafness
    R Bruzzone
    Departement of Neuroscience, Institut Pasteur, 75015, Paris
    FEBS Lett 533:79-88. 2003
  7. ncbi request reprint Connexin32 mutations associated with X-linked Charcot-Marie-Tooth disease show two distinct behaviors: loss of function and altered gating properties
    C Ressot
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, F 75724 Paris Cedex 15, France
    J Neurosci 18:4063-75. 1998
  8. ncbi request reprint Altered gene expression in Schwann cells of connexin32 knockout animals
    S M Nicholson
    , Institut Pasteur, Paris, France
    J Neurosci Res 66:23-36. 2001
  9. ncbi request reprint Gap junctions: getting the message through
    S M Nicholson
    Institut Pasteur, 25 rue du Docteur Roux, F 75724, Paris, Cedex 15, France
    Curr Biol 7:R340-4. 1997
  10. ncbi request reprint Modulation of perch connexin35 hemi-channels by cyclic AMP requires a protein kinase A phosphorylation site
    Georgia Mitropoulou
    Department of Neuroscience, Institut Pasteur, Paris, France
    J Neurosci Res 72:147-57. 2003

Collaborators

  • T W White
  • Marc Mesnil
  • Pauline Phelan
  • J C Herve
  • Feliksas Bukauskas
  • H Ripps
  • D Weil
  • Roger J Thompson
  • M Srinivas
  • Rolf Dermietzel
  • Alessandra Calabrese
  • Martine Cohen-Salmon
  • Massimiliano Bicego
  • Paola D'Andrea
  • Michael T Barbe
  • Georgia Mitropoulou
  • S M Nicholson
  • Charles P K Lai
  • Fabio Mammano
  • Salvatore Melchionda
  • Georg Zoidl
  • Leopoldo Zelante
  • Guilherme Munhoz Essenfelder
  • Paolo Meda
  • Guy Tran van Nhieu
  • Nathalie Duval
  • John F Bechberger
  • Christian C Naus
  • Brian A MacVicar
  • Massimo Carella
  • Edoardo Arslan
  • Elona Cama
  • Sergio Pantano
  • Victor H Hernandez
  • Valeria Piazza
  • Hannah Monyer
  • Sabina Morassutto
  • Martina Beltramello
  • C Ressot
  • Marcello Morgutti
  • Marian Kremer
  • Gilles Waksman
  • Svenja Weickert
  • Jérôme Lamartine
  • Christiane Zoidl
  • David C Spray
  • Anne Charollais
  • Claudine Blanchet-Bardon
  • Caroline Clair
  • Philippe Sansonetti
  • Laurent Combettes
  • Paolo Gasparini
  • Valentina Veronesi
  • Enzo Di Iorio
  • Viviane Calaora
  • Danielle Gomès
  • D Gomes
  • D Pham-Dinh
  • A Dautigny

Detail Information

Publications25

  1. ncbi request reprint The cellular Internet: on-line with connexins
    R Bruzzone
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, Paris, France
    Bioessays 18:709-18. 1996
    ....
  2. ncbi request reprint Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes
    Roberto Bruzzone
    Department of Neuroscience, Institut Pasteur, Paris, France
    J Neurochem 92:1033-43. 2005
    ..The opposite was true in the case of connexin46 (Cx46), thus indicating that gap junction blockers are able to selectively modulate pannexin and connexin channels...
  3. ncbi request reprint Functional analysis of a dominant mutation of human connexin26 associated with nonsyndromic deafness
    R Bruzzone
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, Paris, France
    Cell Commun Adhes 8:425-31. 2001
    ....
  4. pmc Learning the language of cell-cell communication through connexin channels
    R Bruzzone
    Institut Pasteur, Unité de Neurovirologie et Régénération du Système Nerveux, 75015 Paris, France
    Genome Biol 2:REPORTS4027. 2001
    ..A report on the Ninth International Gap Junction Conference, Honolulu, USA, 4-9 August 2001...
  5. ncbi request reprint Connexins, gap junctions and cell-cell signalling in the nervous system
    R Bruzzone
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, Paris, France
    Eur J Neurosci 9:1-6. 1997
    ..These findings raise new questions on the significance of connexin diversity and on their functional role in the nervous system...
  6. ncbi request reprint Loss-of-function and residual channel activity of connexin26 mutations associated with non-syndromic deafness
    R Bruzzone
    Departement of Neuroscience, Institut Pasteur, 75015, Paris
    FEBS Lett 533:79-88. 2003
    ....
  7. ncbi request reprint Connexin32 mutations associated with X-linked Charcot-Marie-Tooth disease show two distinct behaviors: loss of function and altered gating properties
    C Ressot
    Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, F 75724 Paris Cedex 15, France
    J Neurosci 18:4063-75. 1998
    ..The presence of a functional group of mutations suggests that a selective deficit of Cx32 channels may be sufficient to impair the homeostasis of Schwann cells and lead to the development of CMTX...
  8. ncbi request reprint Altered gene expression in Schwann cells of connexin32 knockout animals
    S M Nicholson
    , Institut Pasteur, Paris, France
    J Neurosci Res 66:23-36. 2001
    ..Identifying the relationship between increased GFAP expression and the absence of Cx32 could lead to the definition of specific roles for Cx32 in the control of myelin homeostasis and in the development of CMTX...
  9. ncbi request reprint Gap junctions: getting the message through
    S M Nicholson
    Institut Pasteur, 25 rue du Docteur Roux, F 75724, Paris, Cedex 15, France
    Curr Biol 7:R340-4. 1997
    ..Studies of mice lacking connexin genes have demonstrated the need for intercellular transfer of messenger molecules and are uncovering the specific functions of each connexin...
  10. ncbi request reprint Modulation of perch connexin35 hemi-channels by cyclic AMP requires a protein kinase A phosphorylation site
    Georgia Mitropoulou
    Department of Neuroscience, Institut Pasteur, Paris, France
    J Neurosci Res 72:147-57. 2003
    ..These studies demonstrate that perch Cx35 is a target of the cAMP/PKA signaling pathway and identify a consensus PKA phosphorylation site that is required for channel gating...
  11. ncbi request reprint Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells
    Nathalie Duval
    Institut Pasteur, Unité de Neurovirologie et Régénération du Système Nerveux, 75015 Paris, France
    J Cell Sci 115:3241-51. 2002
    ..These results point to a major role of cell-to-cell communication and Cx43 during the differentiation of neural progenitor cells in vitro...
  12. ncbi request reprint Structure and function of gap junctions in the developing brain
    Roberto Bruzzone
    Department of Neuroscience, Institut Pasteur, 75015 Paris, France
    Cell Tissue Res 326:239-48. 2006
    ....
  13. ncbi request reprint Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells
    Guy Tran van Nhieu
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 75724, Paris, France
    Nat Cell Biol 5:720-6. 2003
    ..These results provide evidence that pathogen-induced opening of connexin channels promotes signalling events that favour bacterial invasion and dissemination...
  14. ncbi request reprint Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina
    Georg Zoidl
    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, University Street 150, D 44801 Bochum, Germany
    J Biol Chem 279:2913-21. 2004
    ....
  15. ncbi request reprint Hearing loss: frequency and functional studies of the most common connexin26 alleles
    Paola D'Andrea
    Dipartimento di Biochimica, Biofisica e Chimica delle, Macromolecole, University of Trieste, Via Licio Giorgieri 1, I 34127 Trieste, Italy
    Biochem Biophys Res Commun 296:685-91. 2002
    ..These data support the hypothesis of a functional role for M34T as a dominant allele and represent a further step towards a complete understanding of the role of GJB2 in causing hearing loss...
  16. pmc Pathogenetic role of the deafness-related M34T mutation of Cx26
    Massimiliano Bicego
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, and Servizio di Genetica Medica, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Hum Mol Genet 15:2569-87. 2006
    ..Our findings are consistent with a structural model, predicting that the mutation leads to a constriction of the channel pore. These data support the view that M34T is a pathological variant of Cx26 associated with hearing impairment...
  17. ncbi request reprint Cell-cell communication beyond connexins: the pannexin channels
    Michael T Barbe
    Department of Clinical Neurobiology and Interdisciplinary Center for Neuroscience, University of Heidelberg, Heidelberg, Germany
    Physiology (Bethesda) 21:103-14. 2006
    ..Of note, pannexin1 can also form Ca2+-activated hemichannels that open at physiological extracellular Ca2+ concentrations and exhibit distinct pharmacological properties...
  18. ncbi request reprint Selective defects in channel permeability associated with Cx32 mutations causing X-linked Charcot-Marie-Tooth disease
    Massimiliano Bicego
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Via Licio Giorgieri 1, 34127 Trieste, Italy
    Neurobiol Dis 21:607-17. 2006
    ..These data reveal that a lower size cutoff distinguishes these functional CMTX variants from wild-type channels and suggest that this defect may be of pathophysiological relevance...
  19. ncbi request reprint Connexins, innexins and pannexins: bridging the communication gap
    Jean Claude Hervé
    Communications Jonctionnelles, UMR CNRS 6187, Universite de Poitiers, 40 Av du Recteur Pineau, 86022 Poitiers, France
    Biochim Biophys Acta 1719:3-5. 2005
  20. ncbi request reprint Virtual cloning, functional expression, and gating analysis of human connexin31.9
    Thomas W White
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661, USA
    Am J Physiol Cell Physiol 283:C960-70. 2002
    ..Thus Cx31.9 is a novel human connexin that forms channels with unique functional properties...
  21. ncbi request reprint Hearing the messenger: Ins(1,4,5)P3 and deafness
    Roberto Bruzzone
    Nat Cell Biol 7:14-6. 2005
  22. ncbi request reprint Connexin30 mutations responsible for hidrotic ectodermal dysplasia cause abnormal hemichannel activity
    Guilherme Munhoz Essenfelder
    Service de Génomique Fonctionnelle, CEA Evry, France
    Hum Mol Genet 13:1703-14. 2004
    ....
  23. pmc Pannexins, a family of gap junction proteins expressed in brain
    Roberto Bruzzone
    Department of Clinical Neurobiology, Interdisciplinary Center for Neurosciences, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 100:13644-9. 2003
    ....
  24. ncbi request reprint [Ins(1,4,5)P3: a messenger for hearing]
    Roberto Bruzzone
    Med Sci (Paris) 21:585-8. 2005
  25. ncbi request reprint Tumor-suppressive effects of pannexin 1 in C6 glioma cells
    Charles P K Lai
    Departments of Cellular and Physiological Sciences and Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 67:1545-54. 2007
    ..Altogether, we conclude that the loss of pannexin expression may participate in the development of C6 gliomas, whereas restoration of Panx1 plays a tumor-suppressive role...