Affiliation: Institut Pasteur de Lille
- Dumont J, Josse R, Lambert C, Antherieu S, Le Hegarat L, Aninat C, et al. Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells. Toxicol Appl Pharmacol. 2010;245:256-63 pubmed publisher..Our findings highlight the need to investigate interactions between HAA when assessing risks for human health and provide new insights in the mechanisms of interaction between PhIP and MeIQx. ..
- Dumont J, Josse R, Lambert C, Antherieu S, Laurent V, Loyer P, et al. Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010;249:91-100 pubmed publisher..In conclusion, these results identify the AhR gene battery as the preferential target of PhIP and MeIQx in HepaRG cells and further support the hypothesis that intake of HAA in diet might increase human cancer risk. ..