Edith Heard

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. ncbi request reprint Recent advances in X-chromosome inactivation
    Edith Heard
    CNRS UMR 218, Curie Institute, 26 Rue d Ulm, Paris 75005, France
    Curr Opin Cell Biol 16:247-55. 2004
  2. doi request reprint Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation
    Anne Valerie Gendrel
    Mammalian Developmental Epigenetics Group, Genetics and Developmental Biology Unit, Institut Curie, 75248 Paris, France email
    Annu Rev Cell Dev Biol 30:561-80. 2014
  3. pmc Transgenerational epigenetic inheritance: myths and mechanisms
    Edith Heard
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934, 26 Rue d Ulm, 75248 Paris Cedex 05, France Collège de France, 11 place Marcelin Berthelot, Paris 75005, France Electronic address
    Cell 157:95-109. 2014
  4. pmc Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation
    Constance Ciaudo
    CNRS UPR2357 Institut de Biologie Moléculaire des Plantes, Universite de Strasbourg, Strasbourg, France
    PLoS Genet 5:e1000620. 2009
  5. ncbi request reprint Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome
    Edith Heard
    CNRS UMR 218, Curie Institute, 26 Rue d Ulm, Paris 75005, France
    Curr Opin Genet Dev 15:482-9. 2005
  6. ncbi request reprint Mammalian X-chromosome inactivation: an epigenetics paradigm
    E Heard
    Mammalian Developmental Epigenetics Group, CNRS UMR218, Curie Institute, 75248 Paris Cedex 05, France
    Cold Spring Harb Symp Quant Biol 69:89-102. 2004
  7. pmc Function of the sex chromosomes in mammalian fertility
    Edith Heard
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR3215 INSERM U934, 75248 Paris Cedex 05, France
    Cold Spring Harb Perspect Biol 3:a002675. 2011
  8. ncbi request reprint Dosage compensation in mammals: fine-tuning the expression of the X chromosome
    Edith Heard
    CNRS UMR218, Curie Institute, Paris, France
    Genes Dev 20:1848-67. 2006
  9. doi request reprint Chromosome structural proteins and RNA-mediated epigenetic silencing
    Edith Heard
    CNRS UMR 218, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Dev Cell 14:813-4. 2008
  10. pmc Ten years of genetics and genomics: what have we achieved and where are we heading?
    Edith Heard
    INSERM U CNRS UMR, Institut Curie Centre de Recherche, Paris, France
    Nat Rev Genet 11:723-33. 2010

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Recent advances in X-chromosome inactivation
    Edith Heard
    CNRS UMR 218, Curie Institute, 26 Rue d Ulm, Paris 75005, France
    Curr Opin Cell Biol 16:247-55. 2004
    ..The paternal X chromosome is initially inactivated in all cells of cleavage-stage embryos and then selectively reactivated in the subset of cells that will form the embryo, with random X inactivation occurring thereafter...
  2. doi request reprint Noncoding RNAs and epigenetic mechanisms during X-chromosome inactivation
    Anne Valerie Gendrel
    Mammalian Developmental Epigenetics Group, Genetics and Developmental Biology Unit, Institut Curie, 75248 Paris, France email
    Annu Rev Cell Dev Biol 30:561-80. 2014
    ....
  3. pmc Transgenerational epigenetic inheritance: myths and mechanisms
    Edith Heard
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934, 26 Rue d Ulm, 75248 Paris Cedex 05, France Collège de France, 11 place Marcelin Berthelot, Paris 75005, France Electronic address
    Cell 157:95-109. 2014
    ..Although the inheritance of epigenetic characters can certainly occur-particularly in plants-how much is due to the environment and the extent to which it happens in humans remain unclear. ..
  4. pmc Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation
    Constance Ciaudo
    CNRS UPR2357 Institut de Biologie Moléculaire des Plantes, Universite de Strasbourg, Strasbourg, France
    PLoS Genet 5:e1000620. 2009
    ....
  5. ncbi request reprint Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome
    Edith Heard
    CNRS UMR 218, Curie Institute, 26 Rue d Ulm, Paris 75005, France
    Curr Opin Genet Dev 15:482-9. 2005
    ..Lineage-specific differences provide a glimpse into the developmental complexity of the epigenetic marks that ensure the inactive state...
  6. ncbi request reprint Mammalian X-chromosome inactivation: an epigenetics paradigm
    E Heard
    Mammalian Developmental Epigenetics Group, CNRS UMR218, Curie Institute, 75248 Paris Cedex 05, France
    Cold Spring Harb Symp Quant Biol 69:89-102. 2004
  7. pmc Function of the sex chromosomes in mammalian fertility
    Edith Heard
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR3215 INSERM U934, 75248 Paris Cedex 05, France
    Cold Spring Harb Perspect Biol 3:a002675. 2011
    ..We also present working models for how perturbations in sex chromosome inactivation or reactivation result in subfertility in the major classes of sex chromosome abnormalities...
  8. ncbi request reprint Dosage compensation in mammals: fine-tuning the expression of the X chromosome
    Edith Heard
    CNRS UMR218, Curie Institute, Paris, France
    Genes Dev 20:1848-67. 2006
    ..We also review the discovery and possible implications of a second form of dosage compensation in mammals that deals with the unique, potentially haploinsufficient, status of the X chromosome with respect to autosomal gene expression...
  9. doi request reprint Chromosome structural proteins and RNA-mediated epigenetic silencing
    Edith Heard
    CNRS UMR 218, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Dev Cell 14:813-4. 2008
    ..Two papers in Nature Genetics now show that SMC-like proteins also participate in epigenetic processes such as X inactivation in mammals and RNA-directed DNA methylation in plants...
  10. pmc Ten years of genetics and genomics: what have we achieved and where are we heading?
    Edith Heard
    INSERM U CNRS UMR, Institut Curie Centre de Recherche, Paris, France
    Nat Rev Genet 11:723-33. 2010
    ..The way ahead looks similarly exciting as we address questions such as how cells function as systems and how complex interactions among genetics, epigenetics and the environment combine to shape phenotypes...
  11. ncbi request reprint Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation
    E Heard
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell 107:727-38. 2001
    ..We also identify a unique "hotspot" of H3 Lys-9 methylation 5' to Xist, and we propose that this acts as a nucleation center for Xist RNA-dependent spread of inactivation along the X chromosome via H3 Lys-9 methylation...
  12. ncbi request reprint Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice
    Ikuhiro Okamoto
    CNRS UMR218, Curie Institute, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nature 438:369-73. 2005
    ..We propose that expression of the paternal Xist gene at zygotic gene activation is sufficient to trigger cis-inactivation of the X chromosome, or of an autosome carrying a Xist transgene...
  13. pmc A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced
    Julie Chaumeil
    Mammalian Developmental Epigenetic Group, UMR 218, Curie Institute, 75248 Paris Cedex 05, France
    Genes Dev 20:2223-37. 2006
    ....
  14. pmc RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells
    Constance Ciaudo
    Swiss Federal Institute of Technology Zurich, Department of Biology, Chair of RNA Biology, Zurich, Switzerland Institut Curie, CNRS UMR3215, Paris, France
    PLoS Genet 9:e1003791. 2013
    ..These results shed new light on L1 biology, uncover defensive, in addition to regulatory roles for RNAi, and raise questions on the differentiation defects of Dicer(-/-) mESCs. ..
  15. doi request reprint Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells
    Catherine Corbel
    Unité de génétique et biologie du développement, Institut Curie, CNRS UMR 3215, INSERM U934, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Development 140:861-72. 2013
    ..This unusual combination of silent and active features is likely to reflect, and might underlie, the partial activity of the X chromosome in TGCs...
  16. pmc Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice
    Catherine Patrat
    Mammalian Developmental Epigenetics Group, Institut Curie, Centre National Research Scientifique Unité Mixte de Recherche 3215, Institut National de la Santé et de la Recherche Médicale U934, 75248 Paris, France
    Proc Natl Acad Sci U S A 106:5198-203. 2009
    ..These results reveal that imprinted X inactivation in mice is far less concerted than previously thought and highlight the epigenetic diversity underlying the dosage compensation process during early mammalian development...
  17. doi request reprint Combined immunofluorescence, RNA fluorescent in situ hybridization, and DNA fluorescent in situ hybridization to study chromatin changes, transcriptional activity, nuclear organization, and X-chromosome inactivation
    Julie Chaumeil
    Mammalian Developmental Epigenetics Group, CNRS UMR 218, Curie Institute, Paris, France
    Methods Mol Biol 463:297-308. 2008
    ....
  18. doi request reprint LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation
    Jennifer C Chow
    Institut Curie, Paris F 75248, France
    Cell 141:956-69. 2010
    ....
  19. doi request reprint Developmental dynamics and disease potential of random monoallelic gene expression
    Anne Valerie Gendrel
    Institut Curie, 26 Rue d Ulm, Paris 75248, France Genetics and Developmental Biology Unit, INSERM U934 CNRS UMR3215, Paris 75248, France
    Dev Cell 28:366-80. 2014
    ....
  20. doi request reprint Live-cell imaging combined with immunofluorescence, RNA, or DNA FISH to study the nuclear dynamics and expression of the X-inactivation center
    Tim Pollex
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR3215, INSERM U934, Paris, France
    Methods Mol Biol 1042:13-31. 2013
    ..Furthermore, we will explain how RNA, DNA FISH, or immunofluorescence can be applied following live-cell imaging to correlate gene expression with locus dynamics. ..
  21. pmc Spatial partitioning of the regulatory landscape of the X-inactivation centre
    Elphège P Nora
    Institut Curie, 26 Rue d Ulm, Paris F 75248, France
    Nature 485:381-5. 2012
    ..In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, our study sets the stage for the full genetic dissection of the X-inactivation centre...
  22. ncbi request reprint Epigenetic dynamics of imprinted X inactivation during early mouse development
    Ikuhiro Okamoto
    CNRS UMR218, Curie Institute, 26 Rue d Ulm, Paris 75005, France
    Science 303:644-9. 2004
    ..This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo...
  23. doi request reprint Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development
    Ikuhiro Okamoto
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934, Paris 75248, France
    Nature 472:370-4. 2011
    ..Our study demonstrates the remarkable diversity in XCI regulation and highlights differences between mammals in their requirement for dosage compensation during early embryogenesis...
  24. doi request reprint ncPRO-seq: a tool for annotation and profiling of ncRNAs in sRNA-seq data
    Chong Jian Chen
    Institut Curie, F 75248 Paris, France
    Bioinformatics 28:3147-9. 2012
    ..The ncPRO-seq pipeline can be used to analyze read and alignment data, based on any sequenced genome, including mammals and plants...
  25. pmc Deep-sequencing protocols influence the results obtained in small-RNA sequencing
    Joern Toedling
    Institut Curie, Paris, France
    PLoS ONE 7:e32724. 2012
    ..Thus, when comparing libraries from different biological samples, it is strongly recommended to use the same sequencing platform and protocol in order to ensure the biological relevance of the comparisons...
  26. ncbi request reprint Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    Masashi Narita
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell 113:703-16. 2003
    ..These results provide a molecular explanation for the stability of the senescent state, as well as new insights into the action of Rb as a tumor suppressor...
  27. ncbi request reprint Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells
    J Chaumeil
    Mammalian Developmental Epigenetics Group, CNRS UMR 218, Curie Institute, Paris, France
    Cytogenet Genome Res 99:75-84. 2002
    ..Finally, from an early stage in the X inactivation process, characteristic histone modification patterns can be found on the X chromosome at mitosis, suggesting that they represent true epigenetic marks of the inactive state...
  28. pmc Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods?
    Elphège P Nora
    Institut Curie, Paris, France
    Bioessays 35:818-28. 2013
    ..Finally we suggest a series of experiments to challenge these ideas and provide concrete examples illustrating how they could be practically applied...
  29. pmc Evolutionary diversity and developmental regulation of X-chromosome inactivation
    Martín Escamilla-Del-Arenal
    Mammalian Developmental Epigenetics Group, Unit of Genetics and Developmental Biology, Institut Curie, CNRS UMR3215, INSERM U934, 75248 Paris, France
    Hum Genet 130:307-27. 2011
    ....
  30. pmc Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription
    Luca Giorgetti
    Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France CNRS UMR3215, 75248 Paris Cedex 05, France INSERM U934, 75248 Paris Cedex 05, France
    Cell 157:950-63. 2014
    ....
  31. pmc HiTC: exploration of high-throughput 'C' experiments
    Nicolas Servant
    Institut Curie, F 75248 Paris, France
    Bioinformatics 28:2843-4. 2012
    ..The package operates within the Bioconductor framework and thus offers new opportunities for future development in this field...
  32. pmc HiC-Pro: an optimized and flexible pipeline for Hi-C data processing
    Nicolas Servant
    Institut Curie, Paris, France
    Genome Biol 16:259. 2015
    ..We applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time. Source code and documentation are available at http://github.com/nservant/HiC-Pro . ..
  33. doi request reprint Regulation of X-chromosome inactivation by the X-inactivation centre
    Sandrine Augui
    1 Mammalian Developmental Epigenetics Group, Unit of Genetics and Developmental Biology, Institut Curie, CNRS UMR3215, INSERM U934, Paris F 75248, France 2
    Nat Rev Genet 12:429-42. 2011
    ..The recent discovery of the plasticity of the inactive state during early development, or during cloning, and induced pluripotency have also contributed to the X chromosome becoming a gold standard in reprogramming studies...
  34. pmc Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation
    Osamu Masui
    Institut Curie, Paris, France
    Cell 145:447-58. 2011
    ....
  35. doi request reprint Lessons from comparative analysis of X-chromosome inactivation in mammals
    Ikuhiro Okamoto
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR3215 INSERM U934, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Chromosome Res 17:659-69. 2009
    ....
  36. ncbi request reprint X-chromosome inactivation in mouse embryonic stem cells: analysis of histone modifications and transcriptional activity using immunofluorescence and FISH
    Julie Chaumeil
    Mammalian Developmental Epigenetics Group, UMR 218 Nuclear Dynamics and Genome Plasticity, Curie Institute Research Section, Paris, France
    Methods Enzymol 376:405-19. 2004
  37. doi request reprint The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network
    Edda G Schulz
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934, Paris 75248, France Electronic address
    Cell Stem Cell 14:203-16. 2014
    ..We propose that double X dosage interferes with differentiation, thus ensuring a tight coupling between X chromosome dosage compensation and development. ..
  38. doi request reprint [Establishing transcriptional silencing of the X chromosome during early embryogenesis]
    Elphège P Nora
    Epigenese et developpement des mammiferes, Institut Curie, Paris, France
    Biol Aujourdhui 204:199-204. 2010
    ..Recent findings have revealed that young, active LINE-1 retrotransposons are expressed from the inactive X chromosome and may facilitate X inactivation, particularly in regions of the X that would otherwise be prone to escape...
  39. ncbi request reprint The dynamics of imprinted X inactivation during preimplantation development in mice
    I Okamoto
    CNRS UMR218, Curie Institute, Paris, France
    Cytogenet Genome Res 113:318-24. 2006
    ..Furthermore, the Xp becomes inactivated in all cells of cleavage-stage embryos and then reactivated in the cells of the inner cell mass (ICM) that form the epiblast, where random XCI ensues...
  40. pmc Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation
    Katia Ancelin
    Institut Curie, Paris, France
    elife 5:. 2016
    ....
  41. doi request reprint Role and control of X chromosome dosage in mammalian development
    Edda G Schulz
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR 3215, INSERM U934, Paris 75248, France
    Curr Opin Genet Dev 23:109-15. 2013
    ..In this review, we discuss the evolution of dosage compensation and how it is controlled during embryogenesis of mammals. In addition we will summarize evidence on the potential role of X chromosome number during early development...
  42. ncbi request reprint The ins and outs of gene regulation and chromosome territory organisation
    Edith Heard
    CNRS UMR 218, Curie Institute, 75248 Paris Cedex 05, France
    Curr Opin Cell Biol 19:311-6. 2007
    ..Recent work suggests that chromosome territory reorganisation can be an important step in the gene silencing process...
  43. pmc Nuclear organization and dosage compensation
    Jennifer C Chow
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR3215, INSERM U934, Paris, F 75248 France
    Cold Spring Harb Perspect Biol 2:a000604. 2010
    ....
  44. doi request reprint X chromosome inactivation: when dosage counts
    Elphège P Nora
    Institut Curie, CNRS UMR3215, INSERM U934, 75724 Paris Cedex 05, France
    Cell 139:865-7. 2009
    ..2009) show that Rnf12/RLIM, encoded by the X-linked gene Rnf12, induces X chromosome inactivation only when present above a certain threshold, a condition fulfilled when at least two Xs are active...
  45. doi request reprint X inactivation and the complexities of silencing a sex chromosome
    Jennifer Chow
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR3215, INSERM 934, 26 Rue d Ulm, Paris 75005, France
    Curr Opin Cell Biol 21:359-66. 2009
    ..Recent studies have also revealed surprising diversity in the kinetics and extent of gene silencing across the X chromosome, as well as in the mechanisms of XCI between mammals...
  46. pmc Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist
    B Courtier
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 92:3531-5. 1995
    ..We propose that such a region could be involved in the initial stages of the inactivation process and in particular in the choice of which of the two X chromosomes present in a female cell will be inactivated...
  47. pmc Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation
    Serena Sanulli
    Institut Curie, 26 Rue d Ulm, 75005 Paris, France INSERM U934, 26 Rue d Ulm, 75005 Paris, France CNRS UMR3215, 26 Rue d Ulm, 75005 Paris, France
    Mol Cell 57:769-83. 2015
    ..Our results uncover a regulation loop where Jarid2 methylation fine-tunes PRC2 activity depending on the chromatin context. ..
  48. doi request reprint High-resolution 3D DNA FISH using plasmid probes and computational correction of optical aberrations to study chromatin structure at the sub-megabase scale
    Luca Giorgetti
    Institut Curie, 26 Rue d Ulm, 75248, Paris Cedex 05, France
    Methods Mol Biol 1262:37-53. 2015
    ....
  49. doi request reprint Fifty years of X-inactivation research
    Anne Valerie Gendrel
    Mammalian Developmental Epigenetics Group, Genetics and Developmental Biology Unit, Institut Curie, CNRS UMR3215, INSERM U934, 75248 Paris, France
    Development 138:5049-55. 2011
    ....
  50. doi request reprint Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome
    Simao Teixeira da Rocha
    Curie Institute, CNRS UMR3215, INSERM U934, 26 Rue d Ulm, Paris 75248, France
    Mol Cell 53:301-16. 2014
    ..Jarid2 thus represents an important intermediate between PRC2 and Xist RNA for the initial targeting of the PRC2 complex to the X chromosome during onset of XCI...
  51. doi request reprint Small RNAs derived from structural non-coding RNAs
    Chong Jian Chen
    Institut Curie, 26 Rue d Ulm, F 75248 Paris, France CNRS UMR3215, Paris, France INSERM U934, Paris, France Inserm U900, Paris, France MINES ParisTech, Fontainebleau, France Electronic address
    Methods 63:76-84. 2013
    ..Based on this, we propose the existence of a potential novel small RNA family associated with Sm proteins...
  52. ncbi request reprint X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors
    Anne Vincent-Salomon
    Institut Curie, Centre de Recherche, Paris, France
    Cancer Res 67:5134-40. 2007
    ..Finally, we also show the necessity for combined global and single-cell approaches in the assessment of tumors with such a high degree of heterogeneity...
  53. doi request reprint [Inactivation of X chromosome: cells know how to count two X chromosomes]
    Sandrine Augui
    Dynamique Nucléaire et Plasticité du Génome, UMR 218 CNRS, Institut Curie, Paris, France
    Med Sci (Paris) 24:584-5. 2008
  54. ncbi request reprint Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic
    S Augui
    CNRS UMR218, Curie Institute, 26 Rue d Ulm, Paris 75005, France
    Science 318:1632-6. 2007
    ..We propose that homologous associations driven by this novel X-pairing region (Xpr) of the Xic enable a cell to sense that more than one X chromosome is present and coordinate reciprocal Xist/Tsix expression...
  55. ncbi request reprint Molecular correlates of the murine Xce locus
    P Avner
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Genet Res 72:217-24. 1998
    ..Data relating to the specificity and other characteristics of this association are presented...
  56. ncbi request reprint Transgenic mice carrying an Xist-containing YAC
    E Heard
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Hum Mol Genet 5:441-50. 1996
    ....
  57. ncbi request reprint RNA and protein actors in X-chromosome inactivation
    O Masui
    CNRS UMR 218, Institut Curie, Paris, France
    Cold Spring Harb Symp Quant Biol 71:419-28. 2006
    ....
  58. pmc Creation of a deletion series of mouse YACs covering a 500 kb region around Xist
    E Heard
    Unité de Génétique Moléculaire Murine, CNRS URA 1445, Institut Pasteur, Paris, France
    Nucleic Acids Res 22:1830-7. 1994
    ..The use of this series of YACs in a biological assay will help us define the extent of the sequences necessary to bring about X chromosome inactivation...
  59. doi request reprint Random monoallelic expression of genes on autosomes: Parallels with X-chromosome inactivation
    Anne Valerie Gendrel
    Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Mammalian Developmental Epigenetics Group, F 75005 Paris, France Sorbonne Universités, UPMC Univ Paris 6, F 75005 Paris, France Electronic address
    Semin Cell Dev Biol 56:100-10. 2016
    ....
  60. pmc Transcriptional Analysis by Nascent RNA FISH of In Vivo Trophoblast Giant Cells or In Vitro Short-term Cultures of Ectoplacental Cone Explants
    Catherine Corbel
    Unité de génétique et biologie du développement, Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934
    J Vis Exp . 2016
    ..This approach can be applied to detect expression of any gene expressed from autosomes and/or sex chromosomes and can provide important information into developmental mechanisms as well as placental diseases...
  61. doi request reprint X-chromosome inactivation: new insights into cis and trans regulation
    Rafael Galupa
    Mammalian Developmental Epigenetics Group, Institut Curie, PSL University, CNRS UMR3215, INSERM U934, 26, rue d Ulm, 75005 Paris, France
    Curr Opin Genet Dev 31:57-66. 2015
    ....
  62. pmc Girafe--an R/Bioconductor package for functional exploration of aligned next-generation sequencing reads
    Joern Toedling
    Institut Curie, 26 Rue d Ulm, F 75248 Paris, INSERM U900, F 75248 Paris, France
    Bioinformatics 26:2902-3. 2010
    ..Moreover, the package operates within and extends the ever-growing Bioconductor framework and thus enables users to leverage a multitude of methods for their data in order to answer specific research questions...
  63. doi request reprint Recent advances in X-chromosome inactivation research
    Tim Pollex
    Mammalian Developmental Epigenetics Group, Institut Curie, CNRS UMR3215, INSERM U934, 26, rue d Ulm, F 75005 Paris, France
    Curr Opin Cell Biol 24:825-32. 2012
    ..Here, we will describe some of the most recent findings made in X-inactivation research with a special focus on the regulation of Xist and the spatial organization of the Xic...
  64. ncbi request reprint [Cross talk between the Xics]
    Sandrine Augui
    Equipe Epigenèse et Développement des Mammifères, CNRS UMR 218, Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 06, France
    Med Sci (Paris) 22:910-1. 2006
  65. ncbi request reprint Physical mapping and YAC contig analysis of the region surrounding Xist on the mouse X chromosome
    E Heard
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Genomics 15:559-69. 1993
    ....
  66. ncbi request reprint X-chromosome inactivation in mammals
    E Heard
    Unité de Génétique Moléculaire Murine, URA CNRS 1968, Institut Pasteur, Paris, France
    Annu Rev Genet 31:571-610. 1997
    ....
  67. ncbi request reprint Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region
    M C Simmler
    CNRS UA 1968, Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Mamm Genome 8:760-6. 1997
    ..BRX is a new potential candidate for one of the X-linked mental retardation syndromes mapped within the pericentromeric region of the human X Chromosome (Chr)...
  68. ncbi request reprint Cloning and localization of the murine Xpct gene: evidence for complex rearrangements during the evolution of the region around the Xist gene
    E Debrand
    Unité de Génétique Moléculaire Murine, CNRS URA 1968, Institut Pasteur, Paris, France
    Genomics 48:296-303. 1998
    ..Consequently, the evolution of the region between human and mouse appears to be highly complex, with structural rearrangements involving a region of up to 600 kb or more around the Xist gene...
  69. ncbi request reprint Role play in X-inactivation
    E Heard
    Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France
    Hum Mol Genet 3:1481-5. 1994
    ..This review explores the recent literature concerning the definition of Xic and its relationship both to Xist and to another genetic entity thought to play a role in the initiation of X-inactivation, the X-controlling element, or Xce...
  70. pmc Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte
    Siqin Bao
    The Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge
    EMBO Rep 6:748-54. 2005
    ..All the epigenetic marks on the X are apparently erased in the epiblast, suggesting that the oocyte and epiblast may have distinct properties for stepwise programming of the genome...
  71. ncbi request reprint Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation
    Christian P Bacher
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, German
    Nat Cell Biol 8:293-9. 2006
    ..We propose that transient colocalization of Xics may be necessary for a cell to determine Xic number and to ensure the correct initiation of X inactivation...
  72. ncbi request reprint Role of histone methyltransferase G9a in CpG methylation of the Prader-Willi syndrome imprinting center
    Zhenghan Xin
    Departments of Biochemistry and Molecular Genetics and Pediatrics, University of Virginia, Charlottesville, Virginia 22908 0733, USA
    J Biol Chem 278:14996-5000. 2003
    ....
  73. pmc Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin
    Emily Bernstein
    Laboratory of Chromatin Biology, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Mol Cell Biol 26:2560-9. 2006
    ....
  74. ncbi request reprint Non-rigid registration of 3D multi-channel microscopy images of cell nuclei
    Siwei Yang
    Biomedical Computer Vision Group, Dept Theoretical Bioinformatics, DKFZ Heidelberg, Germany
    Med Image Comput Comput Assist Interv 9:907-14. 2006
    ..We also describe an extension of our approach which is applied for the registration of 3D+t (4D) image series of moving cell nuclei...
  75. ncbi request reprint Relationship of XIST expression and responses of ovarian cancer to chemotherapy
    Kuan Chun Huang
    Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cancer Ther 1:769-76. 2002
    ..Our data suggest that XIST expression may be a potential marker for chemotherapeutic responses in ovarian cancer...
  76. ncbi request reprint Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
    Tilo Kunath
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Canada
    Development 132:1649-61. 2005
    ..Based on gene expression analysis, chimera studies and imprinted X-inactivation, XEN cell lines are representative of extra-embryonic endoderm and provide a new cell culture model of an early mammalian lineage...
  77. pmc Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome
    Claire Rougeulle
    CNRS URA 2578, Unité de Génétique Moléculaire Murine, Pasteur Institute, Paris 75015, France
    Mol Cell Biol 24:5475-84. 2004
    ..However, analysis of this region in G9a mutant embryonic stem cells shows that these two methyl marks are dependent on different histone methyltransferases...
  78. ncbi request reprint Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
    Barbara A Boggs
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 30:73-6. 2002
    ....
  79. ncbi request reprint Antisense RNA in imprinting: spreading silence through Air
    Claire Rougeulle
    Unité de Génétique Moléculaire Murine, Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France
    Trends Genet 18:434-7. 2002
    ..A recent study provides the first evidence that, at least in one case, a noncoding RNA has a direct role in regulating imprinted gene expression in cis...