Zoran Ivanovic

Summary

Affiliation: Institut de Veille Sanitaire
Country: France

Publications

  1. ncbi request reprint A clinical-scale expansion of mobilized CD 34+ hematopoietic stem and progenitor cells by use of a new serum-free medium
    Zoran Ivanovic
    French Blood Establishment Aquitaine Limousin, Bordeaux CNRS UMR 5164, University of Bordeaux 2, Bordeaux, France
    Transfusion 46:126-31. 2006
  2. doi request reprint Physiological, ex vivo cell oxygenation is necessary for a true insight into cytokine biology.
    Zoran Ivanovic
    Aquitaine Limousin Branch of the French Blood Institute, Bordeaux, France
    Eur Cytokine Netw 20:7-9. 2009
  3. doi request reprint Stem cell evolutionary paradigm and cell engineering
    Z Ivanovic
    CS21010, Etablissement Français du Sang Aquitaine Limousin, Place Amelie Raba Leon, 33075 Bordeaux cedex, France U1035 INSEM, Universite de Bordeaux, 33076 Bordeaux Cedex, France Electronic address
    Transfus Clin Biol 24:251-255. 2017
  4. doi request reprint Clinical-scale cultures of cord blood CD34(+) cells to amplify committed progenitors and maintain stem cell activity
    Zoran Ivanovic
    Etablissement Français du Sang Aquitaine Limousin, Bordeaux, France
    Cell Transplant 20:1453-63. 2011
  5. doi request reprint CD34+ cells obtained from "good mobilizers" are more activated and exhibit lower ex vivo expansion efficiency than their counterparts from "poor mobilizers"
    Zoran Ivanovic
    Aquitaine Limousin Branch of French Blood Institute and the University Victor Segalen Bordeaux 2, Bordeaux, France
    Transfusion 50:120-7. 2010
  6. doi request reprint Hypoxia or in situ normoxia: The stem cell paradigm
    Zoran Ivanovic
    Aquitaine Limousin Branch of French Blood Institute, Bordeaux, France
    J Cell Physiol 219:271-5. 2009
  7. ncbi request reprint Whole-blood leuko-depletion filters as a source of CD 34+ progenitors potentially usable in cell therapy
    Zoran Ivanovic
    French Blood Establishment Aquitaine Limousin, Bordeaux, France
    Transfusion 46:118-25. 2006
  8. ncbi request reprint Simultaneous maintenance of human cord blood SCID-repopulating cells and expansion of committed progenitors at low O2 concentration (3%)
    Zoran Ivanovic
    Laboratory for Studies on Hematopoiesis Molecular and Functional Aspects, Bordeaux 2 University, France
    Stem Cells 22:716-24. 2004
  9. ncbi request reprint Interleukin-3 and ex vivo maintenance of hematopoietic stem cells: facts and controversies
    Zoran Ivanovic
    Etablissement Français du Sang Aquitaine Limousin, Place Amélie Raba Leon BP24, 33035 Bordeaux Cedex, France
    Eur Cytokine Netw 15:6-13. 2004
  10. doi request reprint Low-oxygen and high-carbon-dioxide atmosphere improves the conservation of hematopoietic progenitors in hypothermia
    Michel Jeanne
    Aquitaine Limousin Branch of French Blood Institute, Bordeaux, France
    Transfusion 49:1738-46. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint A clinical-scale expansion of mobilized CD 34+ hematopoietic stem and progenitor cells by use of a new serum-free medium
    Zoran Ivanovic
    French Blood Establishment Aquitaine Limousin, Bordeaux CNRS UMR 5164, University of Bordeaux 2, Bordeaux, France
    Transfusion 46:126-31. 2006
    ..Because this clinical-grade IS medium is no longer available, a new serum-free medium, Maco Biotech HP 01 (Macopharma), was evaluated...
  2. doi request reprint Physiological, ex vivo cell oxygenation is necessary for a true insight into cytokine biology.
    Zoran Ivanovic
    Aquitaine Limousin Branch of the French Blood Institute, Bordeaux, France
    Eur Cytokine Netw 20:7-9. 2009
  3. doi request reprint Stem cell evolutionary paradigm and cell engineering
    Z Ivanovic
    CS21010, Etablissement Français du Sang Aquitaine Limousin, Place Amelie Raba Leon, 33075 Bordeaux cedex, France U1035 INSEM, Universite de Bordeaux, 33076 Bordeaux Cedex, France Electronic address
    Transfus Clin Biol 24:251-255. 2017
    ..In this review, the basic elements of this paradigm and a possible application in cell engineering were discussed...
  4. doi request reprint Clinical-scale cultures of cord blood CD34(+) cells to amplify committed progenitors and maintain stem cell activity
    Zoran Ivanovic
    Etablissement Français du Sang Aquitaine Limousin, Bordeaux, France
    Cell Transplant 20:1453-63. 2011
    ..This result was enabled by associating antioxidant power of medium with an appropriate cytokine cocktail (i.e., mimicking physiologic effects of a weak oxygenation in hematopoietic environment)...
  5. doi request reprint CD34+ cells obtained from "good mobilizers" are more activated and exhibit lower ex vivo expansion efficiency than their counterparts from "poor mobilizers"
    Zoran Ivanovic
    Aquitaine Limousin Branch of French Blood Institute and the University Victor Segalen Bordeaux 2, Bordeaux, France
    Transfusion 50:120-7. 2010
    ..We hypothesized that, apart from their mobilization from marrow to the blood, the response to G-CSF of CD34+ cells also includes activation of proliferation, metabolic activity, and proliferative capacity...
  6. doi request reprint Hypoxia or in situ normoxia: The stem cell paradigm
    Zoran Ivanovic
    Aquitaine Limousin Branch of French Blood Institute, Bordeaux, France
    J Cell Physiol 219:271-5. 2009
    ..The revision of our knowledge on cell/cytokine physiology, which has been acquired ex vivo at non physiological atmospheric (20-21%) O(2) concentrations representing a hyperoxic state for most primate cells, has thus become imperious...
  7. ncbi request reprint Whole-blood leuko-depletion filters as a source of CD 34+ progenitors potentially usable in cell therapy
    Zoran Ivanovic
    French Blood Establishment Aquitaine Limousin, Bordeaux, France
    Transfusion 46:118-25. 2006
    ....
  8. ncbi request reprint Simultaneous maintenance of human cord blood SCID-repopulating cells and expansion of committed progenitors at low O2 concentration (3%)
    Zoran Ivanovic
    Laboratory for Studies on Hematopoiesis Molecular and Functional Aspects, Bordeaux 2 University, France
    Stem Cells 22:716-24. 2004
    ..This expansion method that avoids stem cell exhaustion could be of paramount interest in hematopoietic transplantation by allowing the use of small-size grafts in adults...
  9. ncbi request reprint Interleukin-3 and ex vivo maintenance of hematopoietic stem cells: facts and controversies
    Zoran Ivanovic
    Etablissement Français du Sang Aquitaine Limousin, Place Amélie Raba Leon BP24, 33035 Bordeaux Cedex, France
    Eur Cytokine Netw 15:6-13. 2004
    ..However, none of the data presently evaluated bring a clear, definitive explanation to this apparent paradox. Those data that appear to be the most informative are presented and discussed in this "technical review"...
  10. doi request reprint Low-oxygen and high-carbon-dioxide atmosphere improves the conservation of hematopoietic progenitors in hypothermia
    Michel Jeanne
    Aquitaine Limousin Branch of French Blood Institute, Bordeaux, France
    Transfusion 49:1738-46. 2009
    ..We hypothesized that physiologic O2 and CO2 concentrations of hematopoietic tissue microenvironment (approx. 3% O2 and approx. 6% CO2) could improve cell viability and functionality during storage at 4°C...
  11. doi request reprint Combination of low O(2) concentration and mesenchymal stromal cells during culture of cord blood CD34(+) cells improves the maintenance and proliferative capacity of hematopoietic stem cells
    Mohammad Hammoud
    Aquitaine Limousin Branch of French Blood Institute Etablissement Français du Sang, Aquitaine Limousin, EFS AL, Bordeaux, France
    J Cell Physiol 227:2750-8. 2012
    ....
  12. ncbi request reprint Very low O2 concentration (0.1%) favors G0 return of dividing CD34+ cells
    Francis Hermitte
    CNRS UMR 5164, Universite de Bordeaux 2, 33076 Bordeaux Cedex, France
    Stem Cells 24:65-73. 2006
    ..1% O2 concentrations but lower than at T0. In conclusion, a low O2 concentration, close to those found in bone marrow stem cell niches, induces the G0 return of CD34+ cells without impairing their functional capacity...
  13. doi request reprint Thrombopoietin to replace megakaryocyte-derived growth factor: impact on stem and progenitor cells during ex vivo expansion of CD34+ cells mobilized in peripheral blood
    Pascale Duchez
    Aquitaine Limousin Branch of French Blood Institute, Bordeaux, France
    Transfusion 51:313-8. 2011
    ..Since the clinical-grade molecule MGDF is no longer available on the market, we evaluated its substitution by thrombopoietin (TPO)...
  14. pmc Busulfan administration flexibility increases the applicability of scid repopulating cell assay in NSG mouse model
    Jean Chevaleyre
    Etablissement Français du Sang Aquitaine Limousin EFS AqLi, Bordeaux, France CNRS UMR 5164, Bordeaux, France Université Bordeaux Segalen UMR 5164, Bordeaux, France
    PLoS ONE 8:e74361. 2013
    ..Recently, the development of busulfan pre-conditioning of animals improved the flexibility of experimentation in comparison with irradiation...
  15. doi request reprint Low oxygen concentration as a general physiologic regulator of erythropoiesis beyond the EPO-related downstream tuning and a tool for the optimization of red blood cell production ex vivo
    Marija Vlaski
    Aquitaine Limousin Branch of French Blood Institute, Bordeaux, France
    Exp Hematol 37:573-84. 2009
    ..However, hypoxia seems to influence erythropoiesis beyond this well-known mechanism. The aim of our study is to test this hypothesis adapting the oxygenation level to each stage of erythropoiesis...
  16. doi request reprint Definitive setup of clinical scale procedure for ex vivo expansion of cord blood hematopoietic cells for transplantation
    Pascale Duchez
    Etablissement Français du Sang Aquitaine Limousin, 5 place Amélie Raba Léon, Bordeaux, France
    Cell Transplant 21:2517-21. 2012
    ..These are the ultimate preclinical modifications of a clinical grade expansion protocol, which is already employed in an ongoing clinical trial...
  17. doi request reprint Functional stability (at +4°C) of hematopoietic stem and progenitor cells amplified ex vivo from cord blood CD34+ cells
    Pascale Duchez
    Etablissement Français du Sang, Aquitaine Limousin, Bordeaux, France
    Cell Transplant 22:1501-6. 2013
    ..These data point to the possibility of the maintenance of the full functional capacity of expanded grafts for 2 days, the time allowing for its transportation to any transplantation center worldwide...
  18. doi request reprint Cryopreservation of hematopoietic stem and progenitor cells amplified ex vivo from cord blood CD34+ cells
    Pascale Duchez
    Etablissement Français du Sang Aquitaine Limousin, Bordeaux, France
    Transfusion 53:2012-9. 2013
    ..Here, we investigated whether it is possible to maintain the functional HSC and CP properties after freezing and thawing of expanded cells...
  19. doi request reprint Slow-cycling/quiescence balance of hematopoietic stem cells is related to physiological gradient of oxygen
    Amélie V Guitart
    Bordeaux University, Bordeaux, France
    Exp Hematol 38:847-51. 2010
    ..This brief review utilizes the article of Eliasson and colleagues in this Journal to summarize the major results and questions about the relationships between O(2) and hematopoiesis...
  20. doi request reprint Long-term repopulating hematopoietic stem cells and "side population" in human steady state peripheral blood
    Philippe Brunet de la Grange
    Etablissement Français du Sang Aquitaine Limousin, 33035 Bordeaux, France
    Stem Cell Res 11:625-33. 2013
    ..Our results open a perspective to set up new therapeutic protocols using expanded LRFs-recovered CD34(+) cells as a source of HSCs for autologous or allogeneic transplantation...
  21. ncbi request reprint Hypoxia modifies proliferation and differentiation of CD34(+) CML cells
    Vanessa Desplat
    Laboratoire de Greffe de Moelle, Universite Bordeaux 2, Bordeaux, France
    Stem Cells 20:347-54. 2002
    ..These effects could be linked to inhibition by hypoxia of the tyrosine hyperphosphorylation of cellular proteins, a major hallmark of CML cells...
  22. doi request reprint A novel procedure to improve functional preservation of hematopoietic stem and progenitor cells in cord blood stored at +4°c before cryopreservation
    Jean Chevaleyre
    1 Etablissement Français du Sang Aquitaine Limousin, Bordeaux, France
    Stem Cells Dev 23:1820-30. 2014
    ....
  23. doi request reprint Obtaining of CD34+ cells from healthy blood donors: development of a rapid and efficient procedure using leukoreduction filters
    Yann Peytour
    CNRS UMR 5164, University of Bordeaux 2, Etablissement Français du Sang Aquitaine Limousin, Laboratoire d Hematologie, CHU of Bordeaux, Bordeaux, France
    Transfusion 50:2152-7. 2010
    ..The CD34+ cell concentration in healthy donor blood is low (1×10(3) -4×10(3) /mL), but their number trapped in one LRF after filtration of 400 to 450mL of blood is high (0.4×10(6) -1.6×10(6) )...
  24. ncbi request reprint Hypoxia maintains and interleukin-3 reduces the pre-colony-forming cell potential of dividing CD34(+) murine bone marrow cells
    Zoran Ivanovic
    Laboratoire Universitaire d Hématologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Exp Hematol 30:67-73. 2002
    ..The effects of interleukin-3 (IL-3) on the cycling and CFC-generation potential of pre-CFC also was investigated...
  25. doi request reprint Interleukin-6 enhances the activity of in vivo long-term reconstituting hematopoietic stem cells in "hypoxic-like" expansion cultures ex vivo
    Pascale Duchez
    Etablissement Français du Sang Aquitaine Limousin and UMR 5164 CNRS Université de Bordeaux, Bordeaux, France
    Transfusion 55:2684-91. 2015
    ....
  26. doi request reprint Hypoxia/hypercapnia-induced adaptation maintains functional capacity of cord blood stem and progenitor cells at 4°C
    Marija Vlaski
    Etablissement Français du Sang Aquitaine Limousin, Bordeaux, France UMR 5164 CNRS Université Bordeaux Segalen, Bordeaux, France
    J Cell Physiol 229:2153-65. 2014
    ..Among them are some protein families known to be implicated in the prolonged survival of hibernating animals in hypothermia. These findings suggest a way to optimize short-term cell conservation without freezing...
  27. ncbi request reprint Comparison of CD34+ cell collection on the CS-3000+ and Amicus blood cell separators
    Michel Jeanne
    French Blood Establishment Aquitaine Limousin, Bordeaux, France
    Transfusion 43:1423-7. 2003
    ..The CD34+ cell collection efficiencies of two cell separators (CS-3000+ and Amicus, Baxter) were tested on two comparable groups of oncology patients...
  28. doi request reprint Neonatal sex and weight influence CD34(+) cell concentration in umbilical cord blood but not stromal cell-derived factor 1-3'A polymorphism
    Fontanet Bijou
    Etablissement Français du Sang Aquitaine Limousin, Bordeaux, France Electronic address
    Cytotherapy 17:68-72. 2015
    ..Umbilical cord blood (UCB) has been used as an alternative source of donor hematopoietic stem cells for hematologic transplant setting over the past decade. This study attempted to evaluate potential predictors of cord blood quality...
  29. ncbi request reprint Large-scale expansion and transplantation of CD34(+) hematopoietic cells: in vitro and in vivo confirmation of neutropenia abrogation related to the expansion process without impairment of the long-term engraftment capacity
    Jean Michel Boiron
    CHU Bordeaux, Pessac, France
    Transfusion 46:1934-42. 2006
    ..Herein are reported the results obtained in all multiple myeloma patients transplanted with peripheral blood hematopoietic progenitor cells submitted to ex vivo expansion...
  30. doi request reprint HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress
    Kevin Rouault-Pierre
    Haematopoietic Stem Cell Laboratory, London Research Institute, Cancer Research UK, WC2A 3LY, London, UK INSERM U 1035, Bordeaux, F 33076 France Université Bordeaux Segalen, Bordeaux, F 33076 France
    Cell Stem Cell 13:549-63. 2013
    ..Overall, our data demonstrate a key role for HIF-2α in the maintenance of human HSPCs and in the survival of primary AML cells. ..
  31. doi request reprint Clinical-scale validation of a new efficient procedure for cryopreservation of ex vivo expanded cord blood hematopoietic stem and progenitor cells
    Pascale Duchez
    Etablissement Français du Sang Aquitaine Limousin, Bordeaux, France U1035 INSERM Université de Bordeaux, France
    Cytotherapy 18:1543-1547. 2016
    ..It allows cryopreservation of the whole ex vivo expanded culture content, conserving full short- and long-term HSC activity...
  32. doi request reprint A new clinical-scale serum-free xeno-free medium efficient in ex vivo amplification of mesenchymal stromal cells does not support mesenchymal stem cells
    Sandie Gerby
    Etablissement Français du Sang Aquitaine Limousin, Bordeaux, France
    Transfusion . 2016
    ....
  33. ncbi request reprint Angiotensin II that reduces the colony-forming ability of hematopoietic progenitors in serum free medium has an inverse effect in serum-supplemented medium
    Philippe Brunet de la Grange
    Stem Cells 20:269-71. 2002
  34. ncbi request reprint An efficient large-scale thawing procedure for cord blood cells destined for selection and ex vivo expansion of CD34+ cells
    Pascale Duchez
    J Hematother Stem Cell Res 12:587-9. 2003
  35. ncbi request reprint Cord blood processing by using a standard manual technique and automated closed system "Sepax" (Kit CS-530)
    Bernard Dazey
    Stem Cells Dev 14:6-10. 2005
  36. ncbi request reprint Oxygen concentration influences mRNA processing and expression of the cd34 gene
    Philippe Brunet de la Grange
    Universite Victor Segalen Bordeaux 2, France
    J Cell Biochem 97:135-44. 2006
    ..We suggest that this phenomenon is related to the better maintenance of primitive stem cells in hypoxia...
  37. ncbi request reprint In vivo MR imaging of intravascularly injected magnetically labeled mesenchymal stem cells in rat kidney and liver
    Clemens Bos
    Laboratoire d Imagerie Moléculaire et Fonctionnelle, Equipes de Recherche Technologique, Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, Case 117, 33076 Bordeaux, France
    Radiology 233:781-9. 2004
    ..To evaluate in vivo magnetic resonance (MR) imaging with a conventional 1.5-T system for depiction and tracking of intravascularly injected superparamagnetic iron oxide (SPIO)-labeled mesenchymal stem cells (MSCs)...