Mart Krupovic

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc A Novel Type of Polyhedral Viruses Infecting Hyperthermophilic Archaea.
    Ying Liu
    J Virol 91:. 2017
  2. doi request reprint Genomoviridae: a new family of widespread single-stranded DNA viruses
    Mart Krupovic
    Unite de Biologie Moleculaire du Gene chez les Extremophiles, Department of Microbiology, Institut Pasteur, Paris, France
    Arch Virol 161:2633-43. 2016
  3. pmc Self-synthesizing transposons: unexpected key players in the evolution of viruses and defense systems
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France Electronic address
    Curr Opin Microbiol 31:25-33. 2016
  4. pmc Recent Mobility of Casposons, Self-Synthesizing Transposons at the Origin of the CRISPR-Cas Immunity
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France
    Genome Biol Evol 8:375-86. 2016
  5. pmc Evolution of an archaeal virus nucleocapsid protein from the CRISPR-associated Cas4 nuclease
    Mart Krupovic
    Department of Microbiology, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, Paris, 75015, France
    Biol Direct 10:65. 2015
  6. doi request reprint A classification system for virophages and satellite viruses
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France
    Arch Virol 161:233-47. 2016
  7. pmc Plant viruses of the Amalgaviridae family evolved via recombination between viruses with double-stranded and negative-strand RNA genomes
    Mart Krupovic
    Department of Microbiology, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, Paris, 75015, France
    Biol Direct 10:12. 2015
  8. pmc Multiple layers of chimerism in a single-stranded DNA virus discovered by deep sequencing
    Mart Krupovic
    Department of Microbiology, Institut Pasteur, Paris, France
    Genome Biol Evol 7:993-1001. 2015
  9. pmc Casposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, 25 rue du Docteur Roux, 75015 Paris, France
    BMC Biol 12:36. 2014
  10. pmc Conservation of major and minor jelly-roll capsid proteins in Polinton (Maverick) transposons suggests that they are bona fide viruses
    Mart Krupovic
    Department of Microbiology, Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Paris 75015, France
    Biol Direct 9:6. 2014

Collaborators

Detail Information

Publications38

  1. pmc A Novel Type of Polyhedral Viruses Infecting Hyperthermophilic Archaea.
    Ying Liu
    J Virol 91:. 2017
    ..Due to the original genomic and architectural features of SPV1, the virus should be considered a representative of a new viral family, "Portogloboviridae."..
  2. doi request reprint Genomoviridae: a new family of widespread single-stranded DNA viruses
    Mart Krupovic
    Unite de Biologie Moleculaire du Gene chez les Extremophiles, Department of Microbiology, Institut Pasteur, Paris, France
    Arch Virol 161:2633-43. 2016
    ....
  3. pmc Self-synthesizing transposons: unexpected key players in the evolution of viruses and defense systems
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France Electronic address
    Curr Opin Microbiol 31:25-33. 2016
    ..The casposons are thought to have played a pivotal role in the origin of the prokaryotic adaptive immunity, giving rise to the adaptation module of the CRISPR-Cas systems. ..
  4. pmc Recent Mobility of Casposons, Self-Synthesizing Transposons at the Origin of the CRISPR-Cas Immunity
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France
    Genome Biol Evol 8:375-86. 2016
    ..Finally, besides identifying additional representatives in each of the three originally defined families, we describe a new, fourth, family of casposons. ..
  5. pmc Evolution of an archaeal virus nucleocapsid protein from the CRISPR-associated Cas4 nuclease
    Mart Krupovic
    Department of Microbiology, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, Paris, 75015, France
    Biol Direct 10:65. 2015
    ..To our knowledge, this is the first described case of exaptation of an enzyme for a virus capsid protein function...
  6. doi request reprint A classification system for virophages and satellite viruses
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France
    Arch Virol 161:233-47. 2016
    ..For double-stranded DNA virophages, we propose to establish the family Lavidaviridae, including two genera, Sputnikvirus and Mavirus. ..
  7. pmc Plant viruses of the Amalgaviridae family evolved via recombination between viruses with double-stranded and negative-strand RNA genomes
    Mart Krupovic
    Department of Microbiology, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, Paris, 75015, France
    Biol Direct 10:12. 2015
    ..The chimeric genomes of amalgaviruses are a testament to the effectively limitless gene exchange between viruses that shaped the evolution of the virosphere...
  8. pmc Multiple layers of chimerism in a single-stranded DNA virus discovered by deep sequencing
    Mart Krupovic
    Department of Microbiology, Institut Pasteur, Paris, France
    Genome Biol Evol 7:993-1001. 2015
    ..Our results underscore the importance of horizontal gene transfer in the evolution of ssDNA viruses and the role of genetic recombination in the emergence of novel virus groups. ..
  9. pmc Casposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, 25 rue du Docteur Roux, 75015 Paris, France
    BMC Biol 12:36. 2014
    ..With the growth in the number and diversity of sequenced genomes, previously unnoticed mobile elements continue to be discovered...
  10. pmc Conservation of major and minor jelly-roll capsid proteins in Polinton (Maverick) transposons suggests that they are bona fide viruses
    Mart Krupovic
    Department of Microbiology, Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Paris 75015, France
    Biol Direct 9:6. 2014
    ..We propose the name 'Polintoviruses' to denote these putative viruses that could have played a central role in the evolution of several groups of DNA viruses of eukaryotes...
  11. doi request reprint Networks of evolutionary interactions underlying the polyphyletic origin of ssDNA viruses
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Departement de Microbiologie, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France Electronic address
    Curr Opin Virol 3:578-86. 2013
    ..This scenario places structurally related viruses with DNA and RNA genomes into an evolutionary continuum and highlights general evolutionary trends in the virosphere. ..
  12. doi request reprint Recombination between RNA viruses and plasmids might have played a central role in the origin and evolution of small DNA viruses
    Mart Krupovic
    Department of Microbiology, Institut Pasteur, Molecular Biology of the Gene in Extremophiles Unit, Paris, France
    Bioessays 34:867-70. 2012
    ..It also substantiates the hypothesis that certain groups of DNA viruses could have emerged from plasmids via acquisition of capsid protein-coding genes from RNA viruses...
  13. doi request reprint Double-stranded DNA viruses: 20 families and only five different architectural principles for virion assembly
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Paris, France
    Curr Opin Virol 1:118-24. 2011
    ..We note that viruses belonging to 20 different families fall into only five distinct structural groups, suggesting that optimal virus classification approach should equally rely on both sequence and structural information...
  14. doi request reprint A thaumarchaeal provirus testifies for an ancient association of tailed viruses with archaea
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, 28 rue du Dr Roux, 75015 Paris, France
    Biochem Soc Trans 39:82-8. 2011
    ....
  15. pmc Microviridae goes temperate: microvirus-related proviruses reside in the genomes of Bacteroidetes
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France
    PLoS ONE 6:e19893. 2011
    ....
  16. ncbi request reprint Virophages or satellite viruses?
    Mart Krupovic
    Institut Pasteur, Department of Microbiology, 25 rue du Dr Roux, 75015 Paris, France
    Nat Rev Microbiol 9:762-3. 2011
    ..However, Mart Krupovic and Virginija Cvirkaite-Krupovic argue here that these smaller viruses should be classified with the satellite ..
  17. pmc Genomics of bacterial and archaeal viruses: dynamics within the prokaryotic virosphere
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Departement de Microbiologie, 25 rue du Dr Roux, 75015 Paris, France
    Microbiol Mol Biol Rev 75:610-35. 2011
    ..We also point out that horizontal gene transfer is not equally prevalent in different virus families and is not uniformly unrestricted for diverse viral functions...
  18. pmc Unification of the globally distributed spindle-shaped viruses of the Archaea
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Departement de Microbiologie, Paris, France
    J Virol 88:2354-8. 2014
    ..Our results illuminate the utility of structure-based virus classification and bring additional order to the virosphere. ..
  19. doi request reprint A new proposed taxon for double-stranded DNA viruses, the order "Ligamenvirales"
    David Prangishvili
    Department of Microbiology, Institut Pasteur, 25 rue du Dr Roux, 75015, Paris, France
    Arch Virol 157:791-5. 2012
    ..To acknowledge this relationship we propose to unify the two families into the new taxonomic order "Ligamenvirales"...
  20. pmc Insights into dynamics of mobile genetic elements in hyperthermophilic environments from five new Thermococcus plasmids
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Departement de Microbiologie, Institut Pasteur, Paris, France
    PLoS ONE 8:e49044. 2013
    ..Finally, the plasmids described here might prove to be useful in developing new genetic tools for hyperthermophiles...
  21. pmc First insights into the entry process of hyperthermophilic archaeal viruses
    Emmanuelle R J Quemin
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Departement de Microbiologie, Paris, France
    J Virol 87:13379-85. 2013
    ..Finally, we also show that SIRV2 establishes superinfection exclusion, a phenomenon not previously described for archaeal viruses. ..
  22. pmc Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon
    Carole Jaubert
    Departement de Microbiologie, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, Paris, France
    Open Biol 3:130010. 2013
    ..Thus, LAL14/1 is a promising model to study virus-host interactions and the CRISPR/Cas defence mechanism in Archaea...
  23. doi request reprint Postcards from the edge: structural genomics of archaeal viruses
    Mart Krupovic
    Department of Microbiology, Institut Pasteur, Molecular Biology of the Gene in Extremophiles Unit, Paris, France
    Adv Virus Res 82:33-62. 2012
    ..Structural studies, discussed here, have advanced our understanding of the archaeal virosphere and provided precious information on different aspects of biology of archaeal viruses and evolution of viruses in general...
  24. pmc A highly divergent archaeo-eukaryotic primase from the Thermococcus nautilus plasmid, pTN2
    Sukhvinder Gill
    Institut Pasteur Unité Biologie Moléculaire du Gène chez les Extrêmophiles, 25 rue du Docteur Roux, 75015 Paris, France, CNRS UMR 7138 Systématique, Adaptation, Evolution, Université Paris 6 quai Saint Bernard, 75252 Paris Cedex 05, France and Univ Paris Sud Institut de Génétique et Microbiologie, CNRS UMR 8621, Orsay 91406, France
    Nucleic Acids Res 42:3707-19. 2014
    ..Surprisingly, the N-terminal domain possesses reverse transcriptase activity. We speculate that this activity could reflect an ancestral function of AEP proteins in the transition from the RNA to the DNA world. ..
  25. doi request reprint Genomics and biology of Rudiviruses, a model for the study of virus-host interactions in Archaea
    David Prangishvili
    Institut Pasteur, Department of Microbiology, 25 rue du Dr Roux, Paris 75015, France
    Biochem Soc Trans 41:443-50. 2013
    ..Future studies on archaeal viruses, combined with the knowledge on viruses of bacteria and eukaryotes, should lead to a better global understanding of the diversity and evolution of virus-host interactions in the viral world...
  26. pmc Archaeal virus with exceptional virion architecture and the largest single-stranded DNA genome
    Tomohiro Mochizuki
    Unite de Biologie Moleculaire du Gene chez les Extremophiles, Departement de Microbiologie, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 109:13386-91. 2012
    ..pernix growth. The genome content of ACV is in line with its unique morphology and confirms that ACV is not closely related to any known virus...
  27. pmc Sulfolobus Spindle-Shaped Virus 1 Contains Glycosylated Capsid Proteins, a Cellular Chromatin Protein, and Host-Derived Lipids
    Emmanuelle R J Quemin
    Institut Pasteur, Unite de Biologie Moleculaire du Gene chez les Extremophiles, Departement de Microbiologie, Paris, France
    J Virol 89:11681-91. 2015
    ..A comparison of the contents of lipids isolated from the virus and its host cell suggests that GDGTs are acquired by the virus in a selective manner from the host cytoplasmic membrane, likely during progeny egress...
  28. doi request reprint The Sulfolobus rod-shaped virus 2 encodes a prominent structural component of the unique virion release system in Archaea
    Tessa E F Quax
    Institut Pasteur, Molecular Biology of the Gene in Extremophiles Unit, 75724 Paris Cedex 15, France
    Virology 404:1-4. 2010
    ....
  29. pmc Eukaryotic-Like Virus Budding in Archaea
    Emmanuelle R J Quemin
    Unite de Biologie Moleculaire du Gene chez les Extremophiles, Departement de Microbiologie, Institut Pasteur, Paris, France
    MBio 7:. 2016
    ....
  30. pmc Casposon integration shows strong target site preference and recapitulates protospacer integration by CRISPR-Cas systems
    Pierre Beguin
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris
    Nucleic Acids Res 44:10367-10376. 2016
    ..These findings reinforce the mechanistic similarities and evolutionary connection between the casposons and the adaptation module of the prokaryotic adaptive immunity systems...
  31. pmc A virus of hyperthermophilic archaea with a unique architecture among DNA viruses
    Elena Ilka Rensen
    Department of Microbiology, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 113:2478-83. 2016
    ..PFV1 is a lytic virus that completely disrupts the host cell membrane at the end of the infection cycle. ..
  32. pmc Abundant Lysine Methylation and N-Terminal Acetylation in Sulfolobus islandicus Revealed by Bottom-Up and Top-Down Proteomics
    Egor A Vorontsov
    From the Structural Mass Spectrometry and Proteomics Unit, Structural Biology and Chemistry Department, Institut Pasteur, 75015 Paris, France
    Mol Cell Proteomics 15:3388-3404. 2016
    ..The data have been deposited to the ProteomeXchange with identifiers PXD003074 and PXD004179...
  33. doi request reprint Cellular domains and viral lineages
    Patrick Forterre
    Institut Pasteur, 25 rue du Dr Roux, 75015, Paris, France Institut de Génétique et Microbiologie, University Paris Sud, Centre National de la Recherche Scientifique CNRS UMR 8621, 91405 Orsay Cedex, France Electronic address
    Trends Microbiol 22:554-8. 2014
    ..We suggest tracing phylogeny of viruses along evolutionary lineages primarily defined by virion architectures and the structures of the major capsid proteins. ..
  34. pmc Archaeal tetrathionate hydrolase goes viral: secretion of a sulfur metabolism enzyme in the form of virus-like particles
    Mart Krupovic
    Institut Pasteur, Department of Microbiology, Molecular Biology of the Gene in Extremophiles Unit, Paris, France
    Appl Environ Microbiol 78:5463-5. 2012
    ..The particles were shown to represent a secreted form of a genuine cellular enzyme, tetrathionate hydrolase, involved in sulfur metabolism...
  35. doi request reprint Mysterious hexagonal pyramids on the surface of Pyrobaculum cells
    Elena Rensen
    Department of Microbiology, Institut Pasteur, 25 rue du Dr Roux, Paris 75015, France
    Biochimie 118:365-7. 2015
    ..When the base of these isosceles triangles reached approximately 200 nm in length, the pyramids opened like flower petals. The origin and function of these mysterious nanostructures remain unknown. ..
  36. doi request reprint Single-stranded DNA viruses employ a variety of mechanisms for integration into host genomes
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Paris, France
    Ann N Y Acad Sci 1341:41-53. 2015
    ....
  37. doi request reprint Polintons: a hotbed of eukaryotic virus, transposon and plasmid evolution
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Paris 75015, France
    Nat Rev Microbiol 13:105-15. 2015
    ..We hypothesize that Polintons were the first group of eukaryotic double-stranded DNA viruses to evolve from bacteriophages and that they gave rise to most large DNA viruses of eukaryotes and various other selfish genetic elements. ..
  38. pmc Evolution of eukaryotic single-stranded DNA viruses of the Bidnaviridae family from genes of four other groups of widely different viruses
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Paris 75015, France
    Sci Rep 4:5347. 2014
    ..The unusual evolutionary history of bidnaviruses emphasizes the key role of horizontal gene transfer, sometimes between viruses with completely different genomes but occupying the same niche, in the emergence of new viral types. ..