Pascal Kintz

Summary

Affiliation: X-Pertise
Location: Oberhausbergen, France
URL: http://www.x-pertise.com
Summary:
forensic analyses
toxicology
hair testing
blood and urine testing
drug facilitated sexual assault case
doping cases

Publications

  1. ncbi Fly larvae: a new toxicological method of investigation in forensic medicine
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Forensic Sci 35:204-7. 1990
  2. ncbi Testing for zopiclone in hair application to drug-facilitated crimes
    M Villain
    Institut de Medecine Legale, 11 rue Humann, 67000 Strasbourg, France
    Forensic Sci Int 145:117-21. 2004
  3. ncbi A fatality involving secobarbital, nitrazepam, and codeine
    A Tracqui
    Institute of Legal Medicine, Strasbourg, France
    Am J Forensic Med Pathol 10:130-3. 1989
  4. ncbi Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens
    V Cirimele
    Laboratoire de Toxicologie, Institut de Medecine Legale, 11 rue Humann, F 67085 Strasbourg, France
    Forensic Sci Int 143:153-6. 2004
  5. ncbi Windows of detection of zolpidem in urine and hair: application to two drug facilitated sexual assaults
    M Villain
    Institut de Medecine Legale, 11, rue Humann, 67000 Strasbourg, France
    Forensic Sci Int 143:157-61. 2004
  6. ncbi Fatal meprobamate self-poisoning
    P Kintz
    Institute of Legal Medicine, Faculty of Pharmacy, Strasbourg, France
    Am J Forensic Med Pathol 9:139-40. 1988
  7. ncbi A fatal dothiepin overdose
    V Cirimele
    Institut de Medecine Legale, Strasbourg, France
    Forensic Sci Int 76:205-9. 1995
  8. ncbi Hair analysis for nordiazepam and oxazepam by gas chromatography--negative-ion chemical ionization mass spectrometry
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Chromatogr B Biomed Appl 677:241-4. 1996
  9. ncbi [Acute poisoning during substitution therapy based on high-dosage buprenorphine. 29 clinical cases--20 fatal cases]
    A Tracqui
    Institut de Medecine Legale, Strasbourg
    Presse Med 27:557-61. 1998
  10. ncbi Testing of the anabolic stanozolol in human hair by gas chromatography-negative ion chemical ionization mass spectrometry
    V Cirimele
    Institut de Medecine Legale, Strasbourg, France
    J Chromatogr B Biomed Sci Appl 740:265-71. 2000

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi Fly larvae: a new toxicological method of investigation in forensic medicine
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Forensic Sci 35:204-7. 1990
    ..Five drugs (triazolam, oxazepam, phenobarbital, alimemazine, and clomipramine) were identified and assayed in some tissues of a putrefied cadaver and in the maggots found on and in the body...
  2. ncbi Testing for zopiclone in hair application to drug-facilitated crimes
    M Villain
    Institut de Medecine Legale, 11 rue Humann, 67000 Strasbourg, France
    Forensic Sci Int 145:117-21. 2004
    ..2 pg/mg, in accordance with a single exposure to the drug. In the other expertise, zopiclone was detected in the two segments analyzed, at 21.3 and 21.5 pg/mg, making unlikely the hypothetical single exposure to zopiclone...
  3. ncbi A fatality involving secobarbital, nitrazepam, and codeine
    A Tracqui
    Institute of Legal Medicine, Strasbourg, France
    Am J Forensic Med Pathol 10:130-3. 1989
    ..The blood concentrations of secobarbital, nitrazepam, and codeine were found to be 11.48, 1.72, and 0.036 microgram/ml, respectively. Results are discussed in the light of the existing literature...
  4. ncbi Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens
    V Cirimele
    Laboratoire de Toxicologie, Institut de Medecine Legale, 11 rue Humann, F 67085 Strasbourg, France
    Forensic Sci Int 143:153-6. 2004
    ..3-15.6 ng/mL), did not cause a false negative response by the immunoassay...
  5. ncbi Windows of detection of zolpidem in urine and hair: application to two drug facilitated sexual assaults
    M Villain
    Institut de Medecine Legale, 11, rue Humann, 67000 Strasbourg, France
    Forensic Sci Int 143:157-61. 2004
    ..4 pg/mg. In the other case, zolpidem was detected in all the segments analyzed, demonstrating likely previous drug use in addition to recent exposure associated with a positive blood result...
  6. ncbi Fatal meprobamate self-poisoning
    P Kintz
    Institute of Legal Medicine, Faculty of Pharmacy, Strasbourg, France
    Am J Forensic Med Pathol 9:139-40. 1988
    ..While the blood level was 204.6 micrograms/ml, the maximum concentration was found in the heart (708 micrograms/g), confirming the cardiac toxicity of meprobamate. Other drugs were not detected...
  7. ncbi A fatal dothiepin overdose
    V Cirimele
    Institut de Medecine Legale, Strasbourg, France
    Forensic Sci Int 76:205-9. 1995
    ..The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concentration of 1.89 ng/mg hair. Results are discussed in the light of the existing literature...
  8. ncbi Hair analysis for nordiazepam and oxazepam by gas chromatography--negative-ion chemical ionization mass spectrometry
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Chromatogr B Biomed Appl 677:241-4. 1996
    ..Among thirty samples obtained from polydrug abusers, thirteen tested positive for nordiazepam, in the range of 0.25-18.87 ng/mg. Five samples were also positive for oxazepam, in the range 0.11-0.50 ng/mg...
  9. ncbi [Acute poisoning during substitution therapy based on high-dosage buprenorphine. 29 clinical cases--20 fatal cases]
    A Tracqui
    Institut de Medecine Legale, Strasbourg
    Presse Med 27:557-61. 1998
    ..Buprenorphine has been an important advance in care for drug abusers, but the toxic risk may be fatal. We report here two original series of buprenorphine poisoning in opiate abusers on substitution therapy...
  10. ncbi Testing of the anabolic stanozolol in human hair by gas chromatography-negative ion chemical ionization mass spectrometry
    V Cirimele
    Institut de Medecine Legale, Strasbourg, France
    J Chromatogr B Biomed Sci Appl 740:265-71. 2000
    ..1%, respectively. The analysis of a 3-cm long hair strand, obtained from a young bodybuilder (27 year old) assuming to be a regular user of Winstrol (stanozolol, 2 mg), revealed the presence of stanozolol at the concentration of 15 pg/mg...
  11. ncbi Simultaneous determination of opiates, cocaine and major metabolites of cocaine in human hair by gas chromotography/mass spectrometry (GC/MS)
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Forensic Sci Int 73:93-100. 1995
    ..4-78.4 ng/mg (COC), 0.0-36.3 ng/mg (BZE), 0.0-1.6 ng/mg (EME), 0.0-2.1 ng/mg (CE), 0.0-84.3 ng/mg (6-MAM), 0.2-27.1 ng/mg (MOR) and 0.1-19.6 ng/mg (COD). An application in forensic sciences, involving multi-sectional analysis, is given...
  12. ncbi Characterization of dextromoramide (Palfium) abuse by hair analysis in a denied case
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Int J Legal Med 107:269-72. 1995
    ..5 cm, corresponding to a growth period of 2 months. Concentrations were 1.09, 1.93 and 1.48 ng/mg from the root to the end, respectively. This is the first report on dextromoramide testing in human hair...
  13. ncbi Testing human hair for Cannabis. III. rapid screening procedure for the simultaneous identification of delta 9-tetrahydrocannabinol, cannabinol, and cannabidiol
    V Cirimele
    Institute of Legal Medicine, Strasbourg, France
    J Anal Toxicol 20:13-6. 1996
    ..13 ng/mg), and from 0.1 to 0.29 ng/mg hair (mean, 0.15 ng/mg) for CBD, CBN, and THC, respectively. These results show that this new screening procedure is suitable for the detection of CBD and CBN in the hair of cannabis abusers...
  14. ncbi Tissue distribution of dextromoramide in the rat
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Fundam Clin Pharmacol 4:163-7. 1990
    ..2 mg/kg of the drug. The pattern of distribution was similar at 15, 30, 60 and 90 min, with the highest concentrations being found in the liver and the myocardium, while other organs were not able to concentrate dextromoramide...
  15. ncbi Pharmacological studies on meprobamate incorporation in human beard hair
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Int J Legal Med 105:283-7. 1993
    ..Meprobamate appeared in beard hair approximately 4-5 days after administration and peaked during the 7-9th day. Drug levels in beard hair appeared to be dose-related...
  16. ncbi Are cannabinoids detected in hair after washing with Cannabio shampoo?
    V Cirimele
    Institut de Medecine Legale, Strasbourg, France
    J Anal Toxicol 23:349-51. 1999
    ..02 ng/mg after decontamination). In all cases, THC was never detected. Extensive but unrealistic use of Cannabio shampoo can cause drug-free hair to test positive for CBD and CBN but not for the primary psychoactive drug THC...
  17. ncbi Enzyme immunoassay validation for the detection of buprenorphine in urine
    V Cirimele
    Institut de Medecine Legale, Laboratoire de Toxicologie, 11, rue Humann, 67085 Strasbourg, France
    J Anal Toxicol 27:103-5. 2003
    ..The results of this study support the concept that the Singlestep ELISA for buprenorphine determination in urine should be considered as a new, valided screening procedure...
  18. ncbi Testing for kavain in human hair using gas chromatography-tandem mass spectrometry
    M Villain
    Institut de Medecine Legale, 11 rue Humann, F 67000 Strasbourg, France
    J Chromatogr B Analyt Technol Biomed Life Sci 798:351-4. 2003
    ..7%. The analysis of a segment of hair, obtained from an occasional consumer, revealed the presence of kavain at the concentration of 418 pg/mg. A higher concentration (1708 pg/mg) was detected in the corresponding pubic hair...
  19. ncbi GC-MS procedure for the analysis of zipeprol
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Pharm Biomed Anal 11:335-8. 1993
    ..The minimum detectable quantities are 0.6 and 0.4 ng ml-1, for zipeprol in plasma and urine, respectively. Relative standard deviations for within-run data are less than 6%...
  20. ncbi Fatal intoxication by dextromoramide: a report on two cases
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Anal Toxicol 13:238-9. 1989
    ..The whole blood dextromoramide concentrations were 984.3 ng/mL for case 1 and 871.1 ng/mL for case 2. No correlations could be established with the postmortem levels in blood and in bile...
  21. ncbi Simultaneous determination of mefloquine and chloroquine in biological fluids using high-performance liquid chromatography
    J M Lamant
    Institut de Medecine Legale, Strasbourg
    Ann Biol Clin (Paris) 46:722-4. 1988
    ..The lower detection limits are 3 and 10 micrograms/l for mefloquine and chloroquine, respectively. Thus, this method appears to be simple, rapid, very sensitive and applicable in pharmaco-clinical, toxicological and forensic analyses...
  22. ncbi A fatal case of alimemazine poisoning
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Anal Toxicol 19:591-4. 1995
    ..The blood concentration of alimemazine was 6.52 micrograms/mL. The brain was the major site of drug deposition, and tissue distribution is discussed in light of the existing literature...
  23. ncbi Identification of ten corticosteroids in human hair by liquid chromatography-ionspray mass spectrometry
    V Cirimele
    Institut de Medecine Legale 11, Strasbourg, France
    Forensic Sci Int 107:381-8. 2000
    ..03 to 0.17 ng/mg for a signal-to-noise ratio of 2. The detection of prednisone and beclomethasone in three hair specimens obtained from forensic and clinical cases have documented corticosteroids incorporation into human hair...
  24. ncbi Blood investigation in a fatality involving the veterinary drug T-61
    P Kintz
    Institut de Medecine Legale, Faculte de Medecine, Strasbourg, France
    J Anal Toxicol 26:529-31. 2002
    ..4 and separation on a 5-mm Nucleosil C18 column. Blood concentrations were 43.0, 6.5, and 0.21 mg/L for embutramide, mebezonium, and tetracaine, respectively. No other drugs, including ethanol, were detected...
  25. ncbi HPLC/MS findings in a fatality involving sustained-release verapamil
    A Tracqui
    Institut de Medecine Legale, Faculté de médecine de Strasbourg, 11 rue Humann, 67085 Strasbourg Cedex, France
    Hum Exp Toxicol 22:515-21. 2003
    ..To our knowledge, this is the first report of a verapamil fatality documented by repeated plasma measurements of the drug during the antemortem period...
  26. ncbi Entomotoxicology for the forensic toxicologist: much ado about nothing?
    A Tracqui
    Institut de Medecine Legale, 11 rue Humann, 67085, Strasbourg, France
    Int J Legal Med 118:194-6. 2004
    ..Since drugs identified in maggots are always detectable in the cadaver too, we conclude that larvae analysis is of almost no interest for practical forensic casework...
  27. ncbi Dioxins and furans determination in postmortem blood by gas chromatography--high-resolution mass spectrometry
    V Cirimele
    Laboratoire ChemTox, Parc d Innovation, 3, rue Grüninger, F 67400 Illkirch Graffenstaden, France
    J Anal Toxicol 29:90-4. 2005
    ..Nevertheless, knowledge of dioxin body burden in the French population would be of interest for an accurate interpretation of these results...
  28. ncbi Hair analysis to document a clinical case of TCDD over-exposure
    V Cirimele
    ChemTox, 3 rue Gruninger, F 67400 Illkirch Graffenstaden, France
    Forensic Sci Int 176:51-3. 2008
    ..From the best of our knowledge, this is the first case of over-exposure to Seveso dioxin through hair analysis reported in the literature...
  29. ncbi Use of alternative specimens: drugs of abuse in saliva and doping agents in hair
    Pascal Kintz
    Institut de Medecine Legale, 11 rue Humann, F 67000 Strasbourg, France
    Ther Drug Monit 24:239-46. 2002
    ..Before an extensive review on the detection of anabolics, corticosteroids, and beta-adrenergic stimulants in hair, the place of this specimen in doping control is discussed, with a focus on the potential problems of this new technology...
  30. ncbi Hair to document drug-facilitated crimes: four cases involving bromazepam
    Marion Villain
    Institut de Medecine Legale, 11 rue Humann, 67000 Strasbourg, France
    J Anal Toxicol 28:516-9. 2004
    ....
  31. ncbi Hair analysis for drug detection
    Pascal Kintz
    Laboratoire ChemTox, 3 rue Gruninger, F 67400 Illkirch, France
    Ther Drug Monit 28:442-6. 2006
    ..Hair analysis may be a useful adjunct to conventional drug testing in urine. Methods for evading urinalysis do not affect hair analysis. The aim of this review is to document toxicological applications of hair analysis in drug detection...
  32. ncbi Oral fluid testing for cannabis: on-site OraLine IV s.a.t. device versus GC/MS
    Vincent Cirimele
    Laboratoire ChemTox, Illkirch, France
    Forensic Sci Int 161:180-4. 2006
    ..These preliminary results obtained with the OraLine IV s.a.t. device indicate more encouraging data for the detection of THC using on-site tests than previous evaluations...
  33. ncbi Clenbuterol determination in calf hair by UPLC-MS-MS: case report of a fraudulent use for cattle growth
    Guillaume Salquebre
    Laboratoire ChemTox, 3 rue Gruninger, 67400 Ilkirch, France
    J Anal Toxicol 31:114-8. 2007
    ..The analysis of two hair samples from calves suspected of drug administration showed low clenbuterol concentrations at 3.6 and 4.8 pg/mg...
  34. ncbi Determination of chronic abuse of the anaesthetic agents midazolam and propofol as demonstrated by hair analysis
    Vincent Cirimele
    Institut de Medecine Legale, Strasbourg, France
    Int J Legal Med 116:54-7. 2002
    ..These compounds were also detected in pubic and axillary hairs. Self-administration of midazolam and propofol without respiratory assistance and medical control certainly contributed to the death...
  35. ncbi Screening method for benzodiazepines and hypnotics in hair at pg/mg level by liquid chromatography-mass spectrometry/mass spectrometry
    Marion Villain
    Laboratoire ChemTox, rue Grüninger, 67400 Illkirch, France
    J Chromatogr B Analyt Technol Biomed Life Sci 825:72-8. 2005
    ..These results were found suitable to screen for 16 benzodiazepines in hair and detect them at very low concentrations, making this method suitable to monitor single dose...
  36. ncbi Doping control for metandienone using hair analyzed by gas chromatography-tandem mass spectrometry
    Marie Bresson
    Laboratoire ChemTox, 3 rue Gruninger, Parc d Innovation, F 67400 Illkirch, France
    J Chromatogr B Analyt Technol Biomed Life Sci 836:124-8. 2006
    ..The analysis of hair, cut into four segments, obtained from an athlete, revealed the presence of metandienone at the concentrations of 78, 7, 10 and 108 pg/mg in each segment of hair (0-1, 1-2, 2-3 and 3 cm to the tip)...
  37. ncbi Bioanalytical procedures for detection of chemical agents in hair in the case of drug-facilitated crimes
    Pascal Kintz
    Laboratoire ChemTox, 3 rue Gruninger, 67400 Illkirch, France
    Anal Bioanal Chem 388:1467-74. 2007
    ..This approach may find useful applications, but the definition of legally defensible cutoff values would require much more data. MS/MS technologies appear as a prerequisite in drug-facilitated cases...
  38. ncbi Evaluation of the IDS One-Step ELISA kits for the detection of illicit drugs in hair
    Marie Laure Pujol
    Laboratoire ChemTox, Illkirch, France
    Forensic Sci Int 170:189-92. 2007
    ..This technology should find interest in workplace drug testing or driving license regranting, especially when many samples have to be tested with a high rate of negative samples, as ELISA is an easy and high-throughput method...
  39. doi Chemical abuse in the elderly: evidence from hair analysis
    Pascal Kintz
    Laboratoire ChemTox, Illkirch, France
    Ther Drug Monit 30:207-11. 2008
    ..Mass spectrometry/mass spectrometry technologies appear to be required for analyses in drug-facilitated cases. The experience of the authors is presented in cases involving the elderly and chemical poisoning...
  40. ncbi Codeine testing in sweat and saliva with the Drugwipe
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Int J Legal Med 111:82-4. 1998
    ..This can be explained by a codeine concentration which was too low to show positive with the Drugwipe, interfering substances may be present in saliva or the sampling procedure is inadequate...
  41. ncbi A single therapeutic treatment with betamethasone is detectable in hair
    Jean Sebastien Raul
    Institut de Medecine Legale, 11, rue Humann, F 67000 Strasbourg, France
    J Anal Toxicol 26:582-3. 2002
  42. ncbi Hair analysis in toxicology
    Marion Villain
    Laboratoire de Toxicologie, Institut de Medecine Legale, Strasbourg, France
    Clin Chem Lab Med 42:1265-72. 2004
    ..The present review aims to summarise the various applications that have been published...
  43. ncbi Hair to document exposure to glibenclamide
    Marion Villain
    ChemTox, 3 rue Gruninger, 67400 Illkirch, France
    J Chromatogr B Analyt Technol Biomed Life Sci 842:111-5. 2006
    ..After a 20 mg/day dose, the hair concentration of a subject under glibenclamide therapy was 650 pg/mg...
  44. doi Heroin markers in hair of a narcotic police officer: active or passive exposure?
    Marion Villain
    Laboratoire ChemTox, Illkirch, France
    Forensic Sci Int 196:128-9. 2010
    ..All the narcotic team tested negative, irrespective of the compound...
  45. ncbi Toxicological findings after fatal dextromoramide injection
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Toxicol Clin Toxicol 27:385-8. 1989
    ..The drug was analyzed in whole blood, bile, stomach contents, kidney, brain and liver. The whole blood concentration was 1526 ng/ml. The results are compared with the existing literature...
  46. ncbi Acute fatal poisoning with dichlorophen
    P Kintz
    Institut de Medecine Legal, Strasbourg, France
    Int J Legal Med 110:95-6. 1997
    ..The blood concentration was 9.77 mg/l and other drugs, including ethanol, were not detected...
  47. ncbi Prednisone concentrations in human hair
    Vincent Cirimele
    Institut de Medecine Legale, Strasbourg, France
    J Anal Toxicol 26:110-2. 2002
  48. ncbi Ultra-rapid procedure to test for gamma-hydroxybutyric acid in blood and urine by gas chromatography-mass spectrometry
    Marion Villain
    Institut de Medecine Legale, Universite Louis Pasteur ULP, 11 rue Humann, 67000 Strasbourg, France
    J Chromatogr B Analyt Technol Biomed Life Sci 792:83-7. 2003
    ..The procedure was linear from 1 to 200 mg/l for both blood and urine. Precisions were in the range 4 to 11%. The method appears simple, specific and rapid as an accurate result can be obtained within 1 h...
  49. ncbi Detection of physiological concentrations of cortisol and cortisone in human hair
    Jean Sebastien Raul
    Institut de Medecine Legale, 11 rue Humann, 67085 Strasbourg Cedex, France
    Clin Biochem 37:1105-11. 2004
    ..We have developed a new extraction, purification, and separation technique using liquid chromatography and mass spectrometry for the identification and quantification of two endogenous glucocorticoids: cortisol and cortisone...
  50. doi Suicide by ingestion of caffeine
    Frédéric Aknouche
    Laboratoire Aknouche, 22 avenue Robert Soleau, 06000 Antibes, France
    Egypt J Forensic Sci 7:6. 2017
    ..30 am. At home, an empty plastic bag with a 100 g caffeine label was found. The drug was bought via Internet 6 months earlier. External body examination and autopsy revealed the lack of any traumatic injury...
  51. doi High risk of misinterpreting hair analysis results for children tested for methadone
    Pascal Kintz
    X pertise Consulting, 84 route de Saverne, F 67205 Oberhausbergen, France Institut de Médecine légale, 11 rue Humann, F 67000 Strasbourg, France Electronic address
    Forensic Sci Int 280:176-180. 2017
    ..Practising scientists have the responsibility to inform the child protection authorities, courts, etc about these limitations...
  52. doi Detection of the designer benzodiazepine metizolam in urine and preliminary data on its metabolism
    Pascal Kintz
    X pertise Consulting, Oberhausbergen, France
    Drug Test Anal . 2016
    ..M1, together with its glucuronide (M1-Glu), and M2 were observed in urine at the 8 h mark, whereas only M1 and M1-Glu were still detected in urine at 30 h post administration...
  53. pmc Evidence of 2 populations of mephedrone abusers by hair testing. Application to 4 forensic expertises
    Pascal Kintz
    X pertise Consulting, 84 route de Saverne 67205, Oberhausbergen, France
    Curr Neuropharmacol . 2016
    ..99 ng/mg). Hair testing for new psychoactive substances appears as a good complement to standard urine analyses. This study confirms the increasing diffusion of new drugs among population of abusers...
  54. ncbi [Crime under the influence of psychoactive drugs: the problem of the duration of detection]
    P Kintz
    Institut de Médecine Légale 11 rue Humann F 67000 Strasbourg, France
    Acta Clin Belg 57:24-30. 2002
    ..Use of an ultra-sensitive technique, such as GC/MS/MS/NCI for 7-aminoflunitrazepam; 2. Use of a cumulative specimen, such as sweat for GHB and 3. Use of a metabolite with a long half-life, such as ethyl glucuronide for ethanol...
  55. doi Contribution of in utero drug exposure when interpreting hair results in young children
    P Kintz
    X pertise Consulting, 84 route de Saverne, F 67205 Oberhausbergen, France Institut de Médecine légale, 11 rue Humann, F 67000 Strasbourg, France Electronic address
    Forensic Sci Int 249:314-7. 2015
    ..It is important, when using this cut-off to have at least 3 or 4 segments to be able to observe the variation in drug concentrations, whatever the length of each segment (>1cm)...
  56. doi Testing for ethanol markers in hair: discrepancies after simultaneous quantification of ethyl glucuronide and fatty acid ethyl esters
    P Kintz
    X pertise Consulting, 84 route de Saverne, F 67205 Oberhausbergen, France Electronic address
    Forensic Sci Int 243:44-6. 2014
    ..Four cases (4.1%) were EtG positive and FAEE negative that were attributed to the use of herbal lotions containing EtG. ..
  57. doi Usage criminel de substances psycho-actives : le problème de la durée de détection
    P Kintz
    Institut de Medecine Legale, 11 rue Humann, F 67000 Strasbourg, France, Tél 33 390 24 33 49, E mail
    Acta Clin Belg 57:24-30. 2002
    ..Use of an ultra-sensitive technique, such as GC/MS/MS/NCI for 7-aminoflunitrazepam; 2. Use of a cumulative specimen, such as sweat for GHB and 3. Use of a metabolite with a long half-life, such as ethyl glucuronide for ethanol. ..
  58. ncbi [Norandrostenolone and noretiocholanolone: metabolite markers]
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Acta Clin Belg 53:68-73. 1999
    ..All concentrations were clearly under the proposed positive cut-off level (2 ng/ml) and the concentration of NA was always higher than the concentration of NE...
  59. ncbi Testing for anabolic steroids in hair from two bodybuilders
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Forensic Sci Int 101:209-16. 1999
    ..Although not yet recognized by the International Olympic Committee, hair analysis may be a useful adjunct to conventional drug testing in urine from athletes...
  60. ncbi Physiological concentrations of DHEA in human hair
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Anal Toxicol 23:424-8. 1999
    ..This new technology may find useful applications in anabolic abuse control...
  61. ncbi Testing for alpha-chloralose by headspace-GC/MS. A case report
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Forensic Sci Int 104:59-63. 1999
    ..Peripheral blood concentration was 175.7 mg/l. Alpha-chloralose was quantified in several tissues, indicating kidney sequestration. No other drugs, including ethanol, were detected...
  62. ncbi Determination of "Ecstasy" components in alternative biological specimens
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Chromatogr B Biomed Sci Appl 733:137-43. 1999
    ..Some references, dealing with amphetamine and methamphetamine in alternative specimens are listed in the manuscript to give an overview on the stimulants detection...
  63. ncbi [Drug tests on 198 drivers involved in an accident]
    P Kintz
    Institut de Medecine Legale, Strasbourg
    Presse Med 29:1275-8. 2000
    ....
  64. ncbi The distribution of laudanosine in tissues after death from atracurium injection
    P Kintz
    Institut de Medecine Legale, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg, France
    Int J Legal Med 114:93-5. 2000
    ..The heart blood (917 ng/ml) to peripheral blood (390 ng/ml) ratio was 2.4. No other drugs, including ethanol were detected...
  65. ncbi Doping control for nandrolone using hair analysis
    P Kintz
    Institut de Medecine Legale, Universite Louis Pasteur, 11 rue Humann, F 67000 Strasbourg, France
    J Pharm Biomed Anal 24:1125-30. 2001
    ..2 and 15.1%, respectively, with an extraction recovery of 81.7%. The analysis of three strands of hair, obtained from three bodybuilders, revealed the presence of nandrolone at the concentration of 1, 3.5 and 7.5 pg/mg...
  66. ncbi Deaths involving buprenorphine: a compendium of French cases
    P Kintz
    Institut de Medecine Legale, Universite Louis Pasteur ULP, 11 rue Humann, 67000 Strasbourg, France
    Forensic Sci Int 121:65-9. 2001
    ..In addition, two suicide-related deaths were also observed, with blood buprenorphine concentrations at 144 and 3276ng/ml...
  67. ncbi Doping control for methenolone using hair analysis by gas chromatography-tandem mass spectrometry
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Chromatogr B Analyt Technol Biomed Life Sci 766:161-7. 2002
    ..9-14.1% and 13.7-16.8%, respectively, with an extraction recovery of 97.6%. The analysis of a strand of hair obtained from two bodybuilders, revealed the presence of methenolone at the concentrations of 7.3 and 8.8 pg/mg...
  68. ncbi A new series of 13 buprenorphine-related deaths
    Pascal Kintz
    Institut de Medecine Legale, 11 rue Humann, 67000 Strasbourg, France
    Clin Biochem 35:513-6. 2002
    ..Since this date, numerous deaths were attributed to this drug. This paper reports a new series of 13 fatalities involving buprenorphine observed at the Institute of Legal Medicine of Strasbourg, between August 2000 to October 2001...
  69. ncbi Testing for GHB in hair by GC/MS/MS after a single exposure. Application to document sexual assault
    Pascal Kintz
    Institut de Medecine Legale, 11 rue Humann, F 67000 Strasbourg, France
    J Forensic Sci 48:195-200. 2003
    ..6 to 0.8 ng/mg). This study demonstrates that a single exposure to GHB in a case of sexual assault can be documented by hair analysis when collected about one month after the crime...
  70. ncbi Testing for anabolic steroids in hair: a review
    Pascal Kintz
    Institut de Medecine Legale, 11 rue Humann, F 67000 Strasbourg, France
    Leg Med (Tokyo) 5:S29-33. 2003
    ..Moreover, the window of drug detection is dramatically extended to weeks, months or even years. The aim of this review is to document the current detection of anabolic steroids in hair...
  71. ncbi Buprenorphine in drug-facilitated sexual abuse: a fatal case involving a 14-year-old boy
    Pascal Kintz
    Institut Médecine Légale, Strasbourg, France
    J Anal Toxicol 27:527-9. 2003
    ..The use of buprenorphine as a sedative drug was not challenged by the perpetrator...
  72. ncbi Value of hair analysis in postmortem toxicology
    Pascal Kintz
    Institut de Medecine Legale, 11, rue Humann, F 67000 Strasbourg, France
    Forensic Sci Int 142:127-34. 2004
    ..Moreover, the window of drug detection is dramatically extended to weeks, months or even years. The aim of this review is to document the current status of hair analysis in postmortem toxicology...
  73. ncbi Testing for the undetectable in drug-facilitated sexual assault using hair analyzed by tandem mass spectrometry as evidence
    Pascal Kintz
    Institut de Medecine Legale, F 67000 Strasbourg, France
    Ther Drug Monit 26:211-4. 2004
    ..Hair analysis may be a useful adjunct to conventional drug testing in sexual assault. It should not be considered as an alternative to blood and urine analyses but as a complement. MS/MS technologies appear to be a prerequisite...
  74. ncbi GHB in postmortem toxicology. Discrimination between endogenous production from exposure using multiple specimens
    Pascal Kintz
    Institut de Medecine Legale, 11 rue Humann, F 67000 Strasbourg Cedex, France
    Forensic Sci Int 143:177-81. 2004
    ....
  75. ncbi Windows of detection of lorazepam in urine, oral fluid and hair, with a special focus on drug-facilitated crimes
    Pascal Kintz
    Institut de Medecine Legale, Universite Louis Pasteur ULP, 11 rue Humann, F 67000 Strasbourg, France
    Forensic Sci Int 145:131-5. 2004
    ..Therefore, in case of drug-facilitated crimes involving lorazepam, urine appears as the best specimen to document exposure, particularly if LC-MS/MS is used...
  76. ncbi Testing for zolpidem in oral fluid by liquid chromatography-tandem mass spectrometry
    Pascal Kintz
    Institut de Medecine Legale, 11 rue Humann, F 67000 Strasbourg, France
    J Chromatogr B Analyt Technol Biomed Life Sci 811:59-63. 2004
    ..4 ng/ml) after 15 min intake. Peak zolpidem concentrations were obtained at 150 min (53.5 ng/ml) and 180 min (75.7 ng/ml), respectively. Oral fluid tested positive for zolpidem for over 8 h (9-15 ng/ml)...
  77. ncbi Drug-facilitated sexual assault and analytical toxicology: the role of LC-MS/MS A case involving zolpidem
    Pascal Kintz
    Institut de Medecine Legale, 11 rue Humann, F 67000 Strasbourg, France
    J Clin Forensic Med 12:36-41. 2005
    ..The drug tested also positive in the corresponding hair segment at 0.75 pg/mg. The requested extraordinary sensitivity of LC-MS/MS appears as a pre-requisite to document any case involving drug-facilitated sexual assault...
  78. ncbi Screening and confirmatory method for benzodiazepines and hypnotics in oral fluid by LC-MS/MS
    Pascal Kintz
    Laboratoire ChemTox, rue Grüninger, F 67400 Illkirch, France
    Forensic Sci Int 150:213-20. 2005
    ..These results were found suitable to screen for 17 benzodiazepines in oral fluid and detect them at very low concentrations, making this method suitable for monitoring subjects under the influence...
  79. ncbi Evidence of addiction by anesthesiologists as documented by hair analysis
    P Kintz
    X pertise Consulting, 3 rue Gruninger, 67400 Illkirch, France
    Forensic Sci Int 153:81-4. 2005
    ..In these cases, the combination of an alternative specimen (hair) and hyphenated analytical techniques (tandem mass spectrometry) appears to be a pre-requisite...
  80. ncbi Identification of alprazolam in hair in two cases of drug-facilitated incidents
    P Kintz
    Institut de Medecine Legale, 11 rue Humann, 67000 Strasbourg, France
    Forensic Sci Int 153:222-6. 2005
    ..In the other case, alprazolam was detected in four consecutive 1cm hair segments at 3.1-0.4 pg/mg, obtained from an adolescent who had been forced to prostitute herself...
  81. ncbi Unusually high concentrations in a fatal GHB case
    Pascal Kintz
    X pertise Consulting, Laboratoire ChemTox, 3 rue Gruninger, F 67400 Illkirch, France
    J Anal Toxicol 29:582-5. 2005
    ..4 to 25.0 ng/mg (in comparison with physiological concentrations < 2 ng/mg). Methylenedioxymethamphetamine was present in femoral blood at 144 ng/mL. These results are consistent with an acute fatal overdose of GHB...
  82. ncbi Methadone as a chemical weapon: two fatal cases involving babies
    Pascal Kintz
    X pertise Consulting, Laboratoire ChemTox, Illkirch, France
    Ther Drug Monit 27:741-3. 2005
    ..The death of the babies was attributed to accidental asphyxia ina situation where methadone was considered as a chemical weapon. The mothers, who were the perpetrators in both cases, did not deny the use of methadone as a sedative drug...
  83. ncbi Detection of cannabis use in drivers with the drugwipe device and by GC-MS after Intercept device collection
    Pascal Kintz
    X pertise Consulting, Laboratoire ChemTox, 3, rue Grüninger, F 67400 Illkirch, France
    J Anal Toxicol 29:724-7. 2005
    ..A current limitation of the use of this specimen for roadside testing is the absence of a suitable immunoassay that detects the parent compound in sufficiently low concentrations...
  84. ncbi Determination of trimeprazine-facilitated sedation in children by hair analysis
    Pascal Kintz
    Laboratoire ChemTox, 3 rue Gruninger, F 67400 Illkirch, France
    J Anal Toxicol 30:400-2. 2006
    ..In the hair of the two subjects, trimeprazine was detected at concentrations in the range 23 to 339 pg/mg. The stepmother, who was the perpetrator in both cases, did not challenge the use of trimeprazine as a sedative drug...
  85. ncbi Testing for atropine and scopolamine in hair by LC-MS-MS after Datura inoxia abuse
    Pascal Kintz
    Laboratoire ChemTox, 3 rue Gruninger, 67400 Illkirch, France
    J Anal Toxicol 30:454-7. 2006
    ..Liquid chromatography-tandem MS appears to be a necessity for testing tropane alkaloids of the Datura group, given the low concentrations to be measured...
  86. ncbi Multi-element screening by ICP-MS of two specimens of Napoleon's hair
    Pascal Kintz
    Laboratoire ChemTox, 3 rue Gruninger, F 67400 Illkirch, France
    J Anal Toxicol 30:621-3. 2006
    ....
  87. ncbi Hair analysis for diphenhydramine after surreptitious administration to a child
    Pascal Kintz
    Laboratoire ChemTox, 3 rue Gruninger, F 67400 Illkirch, France
    Forensic Sci Int 173:171-4. 2007
    ..2-152.1 and 167.1 and m/z 289.9-154.0 for diphenhydramine and the IS, respectively. In the hair of the child, diphenhydramine was detected at concentrations in the range 33-39 pg/mg, depending on the segment...
  88. ncbi Arsenic speciation of two specimens of Napoleon's hair
    Pascal Kintz
    Laboratoire ChemTox, Illkirch, France
    Forensic Sci Int 170:204-6. 2007
    ..These results prove that more than 97% of the arsenic found in the hair of Napoleon is in inorganic form, which is consistent with a chronic intoxication to arsenic...
  89. ncbi Ethyl glucuronide: unusual distribution between head hair and pubic hair
    Pascal Kintz
    Laboratoire ChemTox, 3 rue Gruninger, 67400 Illkirch, France
    Forensic Sci Int 176:87-90. 2008
    ..It appears, therefore, that it is not possible to document the drinking status of a subject by simply switching from head hair to pubic hair...
  90. doi Evaluation of the Cozart DDSV test for cannabis in oral fluid
    Pascal Kintz
    Laboratoire ChemTox, Illkirch, France
    Ther Drug Monit 31:131-4. 2009
    ..Given the results, the DDSV device was considered as an acceptable tool to detect cannabis abuse in oral fluid within a period of 2-3 hours after smoking...
  91. ncbi Smoking cessation with varenicline: a suicidal fatality
    Pascal Kintz
    Laboratoire ChemTox, 3 rue Gruninger, 67400 Illkirch, France
    J Anal Toxicol 33:118-20. 2009
    ..Because of its potential effects on behavior, the influence of the drug on the mental functioning of the user should be considered in cases of suicide...
  92. ncbi Hair analysis to demonstrate administration of sildenafil to a woman in a case of drug-facilitated sexual assault
    Pascal Kintz
    Laboratoire ChemTox, 67400 Illkirch, France
    J Anal Toxicol 33:553-6. 2009
    ..This was in accord with the victim's claim. In the absence of any controlled studies, it was impossible to put any quantitative interpretation on the measured concentration...
  93. doi Interpretation of hair findings in children after methadone poisoning
    Pascal Kintz
    Laboratoire ChemTox, Illkirch, France
    Forensic Sci Int 196:51-4. 2010
    ..In view of these results we concluded that a single determination should not be used firmly to discriminate long-term exposure to a drug...
  94. doi Segmental hair analysis can demonstrate external contamination in postmortem cases
    Pascal Kintz
    X pertise Consulting, 84 route de Saverne, 67205 Oberhausbergen, France
    Forensic Sci Int 215:73-6. 2012
    ..Nor should the presence of a metabolite be considered as a discrimination tool, as it can also be present in putrefactive material...
  95. ncbi A high endrin concentration in a fatal case
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    Forensic Sci Int 54:177-80. 1992
    ..The blood concentration of endrin was 544.9 mg/l. Results are discussed in the light of the existing literature...
  96. ncbi Determination of meprobamate in human plasma, urine, and hair by gas chromatography and electron impact mass spectrometry
    P Kintz
    Institut de Medecine Legale, Strasbourg, France
    J Anal Toxicol 17:408-10. 1993
    ..Applications in forensic science, particularly for hair analysis, are presented...
  97. ncbi Detection of flunitrazepam and 7-aminoflunitrazepam in oral fluid after controlled administration of rohypnol
    Nele Samyn
    National Institute of Criminalistics and Criminology, Toxicology Section, Brussels, Belgium
    J Anal Toxicol 26:211-5. 2002
    ....
  98. ncbi A new series of hair analyses from Napoleon confirms chronic exposure to arsenic
    Pascal Kintz
    J Anal Toxicol 26:584-5. 2002
  99. ncbi Windows of detection of tetrazepam in urine, oral fluid, beard, and hair, with a special focus on drug-facilitated crimes
    Marta Concheiro
    Instituto de Medicina Legal, C San Francisco s n, Facultad de Medicina, 15782 Santiago de Compostela, Spain
    Ther Drug Monit 27:565-70. 2005
    ..Therefore, in cases of drug-facilitated crimes in which tetrazepam is involved, hair and beard analyses can be an important complement to urine analyses to document exposure, particularly if LC-MS/MS is used...
  100. ncbi Detection of exogenous GHB in blood by gas chromatography-combustion-isotope ratio mass spectrometry: implications in postmortem toxicology
    Christophe Saudan
    Laboratoire Suisse d Analyse du Dopage, Institut Universitaire de Medecine Legale, Rue du Bugnon 21, 1005 Lausanne, Switzerland
    J Anal Toxicol 29:777-81. 2005
    ..2 to -50.2 per thousand. In contrast to the use of cut-off concentrations for positive postmortem blood GHB concentrations, this method should provide an unambiguous indication of the drug origin...
  101. ncbi A case in south-eastern France: a review of drug facilitated sexual assault in European and English-speaking countries
    Anne H Dorandeu
    Department of Forensic Sciences, Hopital Lapeyronie, 371, avenue du Doyen Gaston Giraud, 34295 Montpellier, France
    J Clin Forensic Med 13:253-61. 2006
    ..Prevention is fundamental and is recognised as demonstrated by campaigns in various countries...