patrick legembre

Summary

Affiliation: Universite de Rennes-1
Location: Rennes, France
URL: http://www.irset.org/?page_id=366
Summary:
Researcher in Fas signaling

Publications

  1. pmc CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells
    Bryan C Barnhart
    The Ben May Institute for Cancer Research, Committee on Immunology, The University of Chicago, Chicago, IL 60637 5420, USA
    EMBO J 23:3175-85. 2004
  2. pmc CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation
    Nadine Khadra
    Universite Rennes 1, Institut de Recherche sur la Santé, l Environnement et le Travail Equipe Accueil Signalisation et Réponse aux agents infectieux et Chimiques 35043 Rennes, France
    Proc Natl Acad Sci U S A 108:19072-7. 2011
  3. doi CD95-mediated cell signaling in cancer: mutations and post-translational modulations
    Sebastien Tauzin
    université Rennes, France
    Cell Mol Life Sci 69:1261-77. 2012
  4. pmc The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway
    Sebastien Tauzin
    Universite de Rennes 1, Rennes, France
    PLoS Biol 9:e1001090. 2011
  5. doi Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis
    Mathieu Pizon
    CNRS UMR 5164, Bordeaux, France
    Eur J Immunol 41:2368-78. 2011
  6. doi S-nitrosylation of the death receptor fas promotes fas ligand-mediated apoptosis in cancer cells
    Lissbeth Leon-Bollotte
    Ecole Pratique des Hautes Etudes, Tumor Immunology and Immunotherapy Laboratory, Dijon, France
    Gastroenterology 140:2009-18, 2018.e1-4. 2011
  7. doi CD95 engagement mediates actin-independent and -dependent apoptotic signals
    B Chaigne-Delalande
    CNRS UMR 5164, 146 rue Leo Saignat, Bordeaux 33076, France
    Cell Death Differ 16:1654-64. 2009
  8. ncbi The immunosuppressor mycophenolic acid kills activated lymphocytes by inducing a nonclassical actin-dependent necrotic signal
    Benjamin Chaigne-Delalande
    Universite de Bordeaux 2, Bordeaux, France
    J Immunol 181:7630-8. 2008
  9. doi Localization of Fas/CD95 into the lipid rafts on down-modulation of the phosphatidylinositol 3-kinase signaling pathway
    Marie Beneteau
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 5164, 33076 Bordeaux, France
    Mol Cancer Res 6:604-13. 2008
  10. ncbi The HA tag is cleaved and loses immunoreactivity during apoptosis
    Laura Schembri
    Nat Methods 4:107-8. 2007

Collaborators

  • Thomas Ducret
  • Benoit Pinson
  • Patrick Blanco
  • Laure Debure
  • Lixin Zheng
  • Amelie Rebillard
  • Bruno Segui
  • Lionel Couzi
  • Stephane Bouchet
  • Pierre Merville
  • Antonio Martínez-Ruiz
  • Jean Francois Moreau
  • Benjamin Chaigne-Delalande
  • Sebastien Tauzin
  • Sophie Daburon
  • Nadine Khadra
  • Mathieu Pizon
  • Gwendaline Guidicelli
  • Amélie Fouqué
  • Valerie Edmond
  • Aubin Penna
  • Pierre Vacher
  • Lissbeth Leon-Bollotte
  • Jean Luc Taupin
  • Patrick Moreau
  • B Chaigne-Delalande
  • Walid Mahfouf
  • Marie Beneteau
  • Francesca De Giorgi
  • François Ichas
  • Laura Schembri
  • Bryan C Barnhart
  • Pierre van de Weghe
  • Mickaël Jean
  • Benoist Ghali
  • Thierry Levade
  • Josy Reiffers
  • Cécile Contin-Bordes
  • Stéphanie Plenchette-Colas
  • Paul Hofman
  • Olivier Cauvard
  • Catherine Paul
  • Ali Bettaieb
  • Anne Marie Vacher
  • Michel Castroviejo
  • Hariniaina Rampanarivo
  • Laurent Counillon
  • Cindy Godard
  • Laurence Bresson-Bepoldin
  • Michael D Cahalan
  • Jacques Le Seyec
  • Jean Francois Jeannin
  • Selvakumar Subramaniam
  • Eric Selva
  • W Mahfouf
  • Jean Max Pasquet
  • J F Moreau
  • Marie Sarah Dilhuydy
  • S Daburon
  • Francois Xavier Mahon
  • Philippe Pourquier
  • Mathieu Molimard
  • Marie Thérèse Dimanche-Boitrel
  • Renee Dalibart
  • Flora Tomasello
  • Concetta Bubici
  • Eric Pietras
  • Marcus E Peter
  • Guido Franzoso

Detail Information

Publications17

  1. pmc CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells
    Bryan C Barnhart
    The Ben May Institute for Cancer Research, Committee on Immunology, The University of Chicago, Chicago, IL 60637 5420, USA
    EMBO J 23:3175-85. 2004
    ..This could become highly relevant during chemotherapy, which can cause upregulation of CD95 ligand by both tumor and nontumor cells...
  2. pmc CD95 triggers Orai1-mediated localized Ca2+ entry, regulates recruitment of protein kinase C (PKC) β2, and prevents death-inducing signaling complex formation
    Nadine Khadra
    Universite Rennes 1, Institut de Recherche sur la Santé, l Environnement et le Travail Equipe Accueil Signalisation et Réponse aux agents infectieux et Chimiques 35043 Rennes, France
    Proc Natl Acad Sci U S A 108:19072-7. 2011
    ..We suggest that these localized events provide a time of decision to prevent accidental cell death...
  3. doi CD95-mediated cell signaling in cancer: mutations and post-translational modulations
    Sebastien Tauzin
    université Rennes, France
    Cell Mol Life Sci 69:1261-77. 2012
    ..The focus of this review is to discuss these apparent contradictions of the known function(s) of CD95...
  4. pmc The naturally processed CD95L elicits a c-yes/calcium/PI3K-driven cell migration pathway
    Sebastien Tauzin
    Universite de Rennes 1, Rennes, France
    PLoS Biol 9:e1001090. 2011
    ....
  5. doi Actin-independent exclusion of CD95 by PI3K/AKT signalling: implications for apoptosis
    Mathieu Pizon
    CNRS UMR 5164, Bordeaux, France
    Eur J Immunol 41:2368-78. 2011
    ..Overall, these findings highlight that the oncogenic PI3K/Akt signalling pathway participates in maintaining cells in a type II phenotype by excluding CD95 from lipid rafts...
  6. doi S-nitrosylation of the death receptor fas promotes fas ligand-mediated apoptosis in cancer cells
    Lissbeth Leon-Bollotte
    Ecole Pratique des Hautes Etudes, Tumor Immunology and Immunotherapy Laboratory, Dijon, France
    Gastroenterology 140:2009-18, 2018.e1-4. 2011
    ..Many cancer cells express Fas but do not undergo Fas-mediated apoptosis. Nitric oxide reverses this resistance by increasing levels of Fas at the plasma membrane. We studied the mechanisms by which NO affects Fas function...
  7. doi CD95 engagement mediates actin-independent and -dependent apoptotic signals
    B Chaigne-Delalande
    CNRS UMR 5164, 146 rue Leo Saignat, Bordeaux 33076, France
    Cell Death Differ 16:1654-64. 2009
    ..In conclusion, the addition of APO1-3 on type I cells triggers an actin-dependent apoptotic signal, which is absent or marginal in cells (both types I and II) treated with CD95L...
  8. ncbi The immunosuppressor mycophenolic acid kills activated lymphocytes by inducing a nonclassical actin-dependent necrotic signal
    Benjamin Chaigne-Delalande
    Universite de Bordeaux 2, Bordeaux, France
    J Immunol 181:7630-8. 2008
    ..In addition to its medical interest, this study sheds light on a novel and atypical molecular mechanism leading to necrotic cell death...
  9. doi Localization of Fas/CD95 into the lipid rafts on down-modulation of the phosphatidylinositol 3-kinase signaling pathway
    Marie Beneteau
    Centre National de la Recherche Scientifique Unite Mixte de Recherche 5164, 33076 Bordeaux, France
    Mol Cancer Res 6:604-13. 2008
    ..These findings indicate that the antitumoral agent edelfosine down-modulates the PI3K signal to sensitize tumor cells to death through the redistribution of Fas into large platform of membrane rafts...
  10. ncbi The HA tag is cleaved and loses immunoreactivity during apoptosis
    Laura Schembri
    Nat Methods 4:107-8. 2007
  11. ncbi Modulation of Fas-mediated apoptosis by lipid rafts in T lymphocytes
    Patrick Legembre
    Laboratoire Composantes Innées de la Réponse Immunitaire et Différenciation, Centre National de la Recherche Scientifique Unite Mixte de Recherche 5164, University of Bordeaux, France
    J Immunol 176:716-20. 2006
    ..Moreover, our results demonstrate that Fas-induced apoptosis can be controlled at the level of the cytoplasmic membrane...
  12. pmc Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds
    Patrick Legembre
    The Ben May Institute for Cancer Research, University of Chicago, 924 E 57th Street, Chicago, Illinois 60637, USA
    EMBO Rep 5:1084-9. 2004
    ..Mutations in CD95 may eliminate the tumour-suppressive function of CD95, at the same time allowing induction of survival or proliferative pathways, which could contribute to the increased risk for lymphoma seen in ALPS type Ia patients...
  13. ncbi Review of PI3K/mTOR Inhibitors Entering Clinical Trials to Treat Triple Negative Breast Cancers
    Amélie Fouqué
    Centre Eugene Marquis, INSERM ERL440, rue bataille Flandres Dunkerque, 35042 Rennes, France
    Recent Pat Anticancer Drug Discov 11:283-96. 2016
    ..Accordingly, many PI3K and/or mTOR inhibitors have entered clinical trials, and completed studies should soon reveal the efficacy of these new drug families in the treatment of cancer patients...
  14. pmc The necrotic signal induced by mycophenolic acid overcomes apoptosis-resistance in tumor cells
    Gwendaline Guidicelli
    CNRS UMR 5164, Bordeaux, France
    PLoS ONE 4:e5493. 2009
    ..The anti-viral agent ribavirin and the immunosuppressant mycophenolic acid (MPA) are potent inhibitors of IMPDH. We recently showed that IMPDH inhibition led to a necrotic signal requiring the activation of Cdc42...
  15. pmc Precise mapping of the CD95 pre-ligand assembly domain
    Valerie Edmond
    Universite de Rennes 1, Rennes, France
    PLoS ONE 7:e46236. 2012
    ..Interfering with this PLAD may represent a new therapeutic strategy for altering CD95-induced apoptotic and non-apoptotic signals...