Laurence Malandrin

Summary

Country: France

Publications

  1. ncbi Isolation of Babesia divergens from carrier cattle blood using in vitro culture
    Laurence Malandrin
    UMR ENVN INRA 1034, Host Parasite Environment Interactions, Ecole Nationale Veterinaire de Nantes, Atlanpole La Chantrerie, BP 40706, 44307 Nantes Cedex 03, France
    Vet Res 35:131-9. 2004
  2. pmc Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission
    Alain Chauvin
    Ecole Nationale Veterinaire, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Res 40:37. 2009
  3. pmc Natural transmission of Zoonotic Babesia spp. by Ixodes ricinus ticks
    Claire A M Becker
    Institut National de la Recherche Agronomique, Nantes, France
    Emerg Infect Dis 15:320-2. 2009
  4. ncbi Development of a microtitre-based spectrophotometric method to monitor Babesia divergens growth in vitro
    Laurence Malandrin
    UMR ENVN INRA 1034, Host Parasite Environment Interactions, Ecole Nationale Veterinaire de Nantes, Atlanpole La Chantrerie, BP 40706, Nantes Cedex 03 44307, France
    J Microbiol Methods 58:303-12. 2004
  5. pmc Individual heterogeneity in erythrocyte susceptibility to Babesia divergens is a critical factor for the outcome of experimental spleen-intact sheep infections
    Laurence Malandrin
    INRA, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Res 40:25. 2009
  6. doi Redescription of Babesia capreoli (Enigk and Friedhoff, 1962) from roe deer (Capreolus capreolus): isolation, cultivation, host specificity, molecular characterisation and differentiation from Babesia divergens
    Laurence Malandrin
    INRA, UMR1300 Bio agression, Epidémiologie et Analyse de Risque, F 44307 Nantes, France
    Int J Parasitol 40:277-84. 2010
  7. doi Babesia divergens experimental infection of spleen-intact sheep results in long-lasting parasitemia despite a strong humoral response: preliminary results
    Emmanuelle Moreau
    Ecole Nationale Veterinaire, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Parasitol 166:205-11. 2009
  8. doi Modelling bovine babesiosis: a tool to simulate scenarios for pathogen spread and to test control measures for the disease
    Thierry Hoch
    INRA, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, Nantes, F 44307, France
    Prev Vet Med 106:136-42. 2012
  9. pmc The invasion process of bovine erythrocyte by Babesia divergens: knowledge from an in vitro assay
    Yi Sun
    ONIRIS, UMR1300, Biologie, Epidémiologie et Analyse de Risque en santé animale, Route de Gachet, La Chantrerie, BP 40706, F 44307 Nantes, France
    Vet Res 42:62. 2011
  10. doi Validation of BdCCp2 as a marker for Babesia divergens sexual stages in ticks
    Claire A M Becker
    UMR INRA ONIRIS 1300 BioEpAR, Nantes, France
    Exp Parasitol 133:51-6. 2013

Collaborators

Detail Information

Publications18

  1. ncbi Isolation of Babesia divergens from carrier cattle blood using in vitro culture
    Laurence Malandrin
    UMR ENVN INRA 1034, Host Parasite Environment Interactions, Ecole Nationale Veterinaire de Nantes, Atlanpole La Chantrerie, BP 40706, 44307 Nantes Cedex 03, France
    Vet Res 35:131-9. 2004
    ..The in vitro isolation of B. divergens from asymptomatic carrier cattle was achieved and will allow the analysis of parasite diversity within cattle herds...
  2. pmc Babesia and its hosts: adaptation to long-lasting interactions as a way to achieve efficient transmission
    Alain Chauvin
    Ecole Nationale Veterinaire, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Res 40:37. 2009
    ..The molecular bases of these adaptations in vertebrate hosts are partially known but few of the tick-host interaction mechanisms have been elucidated...
  3. pmc Natural transmission of Zoonotic Babesia spp. by Ixodes ricinus ticks
    Claire A M Becker
    Institut National de la Recherche Agronomique, Nantes, France
    Emerg Infect Dis 15:320-2. 2009
    ..We found that I. ricinus is a competent vector for EU1 and that their sporozoites directly invade erythrocytes. We conclude that EU1 is naturally transmitted by I. ricinus...
  4. ncbi Development of a microtitre-based spectrophotometric method to monitor Babesia divergens growth in vitro
    Laurence Malandrin
    UMR ENVN INRA 1034, Host Parasite Environment Interactions, Ecole Nationale Veterinaire de Nantes, Atlanpole La Chantrerie, BP 40706, Nantes Cedex 03 44307, France
    J Microbiol Methods 58:303-12. 2004
    ..Generation times of three different B. divergens strains were then determined by the protocol described here and varied between 8 h 36 min and 13 h 8 min...
  5. pmc Individual heterogeneity in erythrocyte susceptibility to Babesia divergens is a critical factor for the outcome of experimental spleen-intact sheep infections
    Laurence Malandrin
    INRA, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Res 40:25. 2009
    ..Only a low percentage (13%) of the sheep population tested possessed susceptible erythrocytes and the potential role of sheep as a natural host or reservoir of B. divergens is discussed...
  6. doi Redescription of Babesia capreoli (Enigk and Friedhoff, 1962) from roe deer (Capreolus capreolus): isolation, cultivation, host specificity, molecular characterisation and differentiation from Babesia divergens
    Laurence Malandrin
    INRA, UMR1300 Bio agression, Epidémiologie et Analyse de Risque, F 44307 Nantes, France
    Int J Parasitol 40:277-84. 2010
    ..An integrated description is given of the host range, geographical distribution, biological and molecular characterisation of B. capreoli, and reference materials have been deposited at the Museum d'Histoire Naturelle de Paris...
  7. doi Babesia divergens experimental infection of spleen-intact sheep results in long-lasting parasitemia despite a strong humoral response: preliminary results
    Emmanuelle Moreau
    Ecole Nationale Veterinaire, UMR 1300 BioEpAR, ENVN, Atlanpole La Chantrerie, BP 40706, F 44307 Nantes Cedex 03, France
    Vet Parasitol 166:205-11. 2009
    ..The use of spleen-intact sheep to study the immune response to B. divergens is discussed...
  8. doi Modelling bovine babesiosis: a tool to simulate scenarios for pathogen spread and to test control measures for the disease
    Thierry Hoch
    INRA, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, Nantes, F 44307, France
    Prev Vet Med 106:136-42. 2012
    ..Regular use of acaricides produces a reduction in pathogen prevalence in cattle. This model could be adapted to other tick-borne diseases...
  9. pmc The invasion process of bovine erythrocyte by Babesia divergens: knowledge from an in vitro assay
    Yi Sun
    ONIRIS, UMR1300, Biologie, Epidémiologie et Analyse de Risque en santé animale, Route de Gachet, La Chantrerie, BP 40706, F 44307 Nantes, France
    Vet Res 42:62. 2011
    ..The dose-dependent, inhibitory effects of these sera on B. divergens invasion suggest that these proteins might be involved in the invasion process. Further investigations are required for their characterisation...
  10. doi Validation of BdCCp2 as a marker for Babesia divergens sexual stages in ticks
    Claire A M Becker
    UMR INRA ONIRIS 1300 BioEpAR, Nantes, France
    Exp Parasitol 133:51-6. 2013
    ..5-4.5 μm in diameter, in the gut of partially engorged ticks that were experimentally infected. This molecular marker can then be used in the future to characterize and analyze the biology of B. divergens gametocytes...
  11. ncbi Antibody prevalence and molecular identification of Babesia spp. In roe deer in France
    Suzanne Bastian
    LUNAM Université, ONIRIS, UMR Biologie, Epidémiologie et Analyse de Risque en santé animale, Atlanpole La Chantrerie, BP 40706, Nantes F 44307, France
    J Wildl Dis 48:416-24. 2012
    ..capreoli isolates showed very variable restriction profiles, distinct from those known for Bd37 in B. divergens. Two isolates showed conflicting results, suggestive of mixed infection...
  12. ncbi Sheep as a new experimental host for Babesia divergens
    Alain Chauvin
    UMR ENVN INRA 1034, Interactions Hĵte Parasite Milieu, Ecole Nationale Veterinaire de Nantes, Atlanpole La Chantrerie, France
    Vet Res 33:429-33. 2002
    ..In vitro primary cultures were performed on two of these sheep, demonstrating the parasite persistence at very low parasitaemia in the infected animals. Splenectomized sheep can be used as a new model for B. divergens chronic infection...
  13. doi A Vegetation Index qualifying pasture edges is related to Ixodes ricinus density and to Babesia divergens seroprevalence in dairy cattle herds
    Albert Agoulon
    LUNAM Université, ONIRIS, UMR 1300 Bio Agression, Epidémiologie et Analyse de Risque, Nantes, F 44307, France
    Vet Parasitol 185:101-9. 2012
    ..Given that the Vegetation Index is a steady indicator of the potential I. ricinus density in the biotope, we recommend that the risk of high B. divergens seroprevalence in cows be evaluated using this tool rather than drag samplings...
  14. doi Sequence and organization of the rhoptry-associated-protein-1 (rap-1) locus for the sheep hemoprotozoan Babesia sp. BQ1 Lintan (B. motasi phylogenetic group)
    Qingli Niu
    INRA, UMR1300 Biology, Epidemiology and Risk Analysis in Animal Health, BP 40706, F 44307 Nantes, France LUNAM Université, ONIRIS, UMR BioEpAR, F 44307 Nantes, France
    Vet Parasitol 198:24-38. 2013
    ..bigemina were found and highlight the conservation of synteny at this locus in this phylogenetic clade. ..
  15. doi Rhoptry-associated protein (rap-1) genes in the sheep pathogen Babesia sp. Xinjiang: Multiple transcribed copies differing by 3' end repeated sequences
    Qingli Niu
    INRA, UMR1300 Biology, Epidemiology and Risk Analysis in Animal Health, CS 40706, F 44307 Nantes, France LUNAM Université, ONIRIS, UMR1300 BioEpAR, F 44307 Nantes, France State Key Laboratory of Veterinary Etiological Biology, LVRI, Lanzhou, China Electronic address
    Vet Parasitol 211:158-69. 2015
    ..Even if the nucleotide sequences varied, 6 repeats encoded the same stretch of amino acids. Transcription of at least four α and two β genes was demonstrated by standard RT-PCR...
  16. doi Molecular cloning and genetic polymorphism of Babesia capreoli gene Bcp37/41, an ortholog of Babesia divergens merozoite surface antigen Bd37
    Yi Sun
    INRA, UMR1300, F 44307 Nantes, France
    Vet Parasitol 178:184-91. 2011
    ..capreoli, greater than the one observed for its ortholog Bd37. Such a marker could thus be useful in epidemiological as well as phylogenetic studies...
  17. doi Strong conservation of rhoptry-associated-protein-1 (RAP-1) locus organization and sequence among Babesia isolates infecting sheep from China (Babesia motasi-like phylogenetic group)
    Qingli Niu
    INRA, UMR1300 Biology, Epidemiology and Risk Analysis in Animal Health, CS 40706, F 44307 Nantes, France LUNAM Université, ONIRIS, UMR1300 BioEpAR, F 44307 Nantes, France
    Infect Genet Evol 28:21-32. 2014
    ..7%). The particularities of the rap-1 locus in terms of evolution, phylogeny, diagnosis and vaccine development are discussed...
  18. pmc Stimulation and quantification of Babesia divergens gametocytogenesis
    Marie Jalovecká
    INRA, UMR1300 Biology, Epidemiology and Risk Analysis in Animal Health, CS 40706, F 44307, Nantes, France
    Parasit Vectors 9:439. 2016
    ..Development of Babesia sexual stages in the host blood (gametocytes) plays a decisive role in parasite acquisition by the tick vector. However, the exact mechanism of gametocytogenesis is still unexplained...