MKOUNGA Pierre

Summary

Affiliation: University of Yaounde I
Location: Yaounde, Cameroon
Summary:
Phytochemical studies of Cameroonian medicinal plants used in careroonian folkloric medicine to cure several deaseases
synthesis of natural products skeleton
anti bacterial and anti biological activities
cytotoxic activities
Grants:
VISITING FELLOW, AUF (Agence universitaire de la Francophonie) July 2009 - Sept. 2009

Laboratory of CNRS of CUSB (College Universitaire Saint Boniface) Winnipeg Canada.
Working under the supervision of Pr Lamine Diop
Investigated the methods of extraction and purification of news insecticides from Canadian plants: Apocynum and Sonchus. Developed purification method to get high yield and purity.
Developed HPLC analytical methods; set up, troubleshooting, and maintenance of HPLC instruments.
Contributed to the formulation procedures for news generations of insecticides development.

VISITING RESEARCHER June-July 2008
University of Manitoba Canada working under the supervision of Pr Philip G. Hultin
Investigation of the methods of extraction purification and synthesis of more bioactive natural product from Pycnanthus angolensis, with application in the industry.
Publications:
1- Globulixanthones A and B : two new cytotoxic xanthones with isoprenoid group from the root bark of Symphonia globulifera.
A.E. Nkengfack, P. Mkounga, Z.T. Fomum, M. Meyer and B. Bodo: J. Nat. Prod. 2002; 65; 736.
2- Globulixanthones C, D and E : tree new prenylated xanthones with antimicrobial properties from the root bark of Symphonia globulifera.
A.E. Nkengfack, P. Mkounga, Z.T. Fomum, M. Meyer and B. Bodo: Phytochemistry. 2002; 61; 181.
3- Globulixanthone F, a new polyoxygenated xanthone with isoprenoid group and two antimicrobial biflavonoids from the stem bark of Symphonia globulifera
P. Mkounga, A.E. Nkengfack, Z.T. Fomum, M. Meyer and B. Bodo: Nat. Prod. Comm. 2009 4(6) 803-8
4- Two new antimicrobial dimeric compounds: febrifuquinone, a vismione-anthraquinone coupled pigment and adamabianthrone, from two Psorospermum species.
Maurice Tsaffack, Jean Robert Nguemeving, Victor Kuete, Basile Le Sage Ndejouong Tchize, Pierre Mkounga, Veronique Penlap Beng, Philip Gregory Hultin, Etienne TSAMO and Augustin Ephrem Nkengfack. Chem. Pharm. Bull. 2009. 57 (10), 1113.
5- Pycnanthulignens A-D, four new antimicrobial cyclolignens from Pycnanthus angolensis.
Eric Carly Nono Nono, Pierre Mkounga, Victor Kuete, kirk Marat, Hultin G. Philip, Augustin Ephrem Nkengfack. J. Nat. Prod. 2010, 73, 213.
6- Tritrpenoid Derivatives from Cylicodiscus gabunensis
Pierre Mkounga; Alembert Tchinda Tiabou; Jacques Kouam. Chem. Pharm. Bull. 2010. 58(8) 1100—1102.
7- Antimicrobial activities of CH2Cl2-CH3OH (1 : 1) extract and compounds from the roots and fruits of Pycnanthus angolensis (Myristicaceae), Nat. Prod. Resp. 2010 Online
Victor Kuete, Eric Carly Nono Nono, Pierre Mkounga, kirk Marat, Hultin G. Philip, Augustin Ephrem Nkengfack.

Publications

  1. ncbi request reprint Globulixanthone F, a new polyoxygenated xanthone with an isoprenoid group and two antimicrobial biflavonoids from the stem bark of Symphonia globulifera
    Pierre Mkounga
    Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P O Box 812, Yaounde, Cameroon
    Nat Prod Commun 4:803-8. 2009

Collaborators

  • Pierre Mkounga
  • Augustin E Nkengfack
  • Zacharias T Fomum
  • Bernard Bodo
  • Michele Meyer

Detail Information

Publications1

  1. ncbi request reprint Globulixanthone F, a new polyoxygenated xanthone with an isoprenoid group and two antimicrobial biflavonoids from the stem bark of Symphonia globulifera
    Pierre Mkounga
    Department of Organic Chemistry, Faculty of Science, University of Yaounde I, P O Box 812, Yaounde, Cameroon
    Nat Prod Commun 4:803-8. 2009
    ..The spectral data of 1 and 2 are reported here for the first time, as well as the antimicrobial activity of globulixanthone F against a range of microorganisms. We also report the total synthesis of the xanthone skeleton...