G Pointis

Summary

Country: France

Publications

  1. ncbi request reprint Requirement of gap junctional intercellular communication for human villous trophoblast differentiation
    Laurent Cronier
    Laboratoire de Biomembranes et Signalisation Cellulaire, Universite de Poitiers, 86022 Poitiers Cedex, France
    Biol Reprod 69:1472-80. 2003
  2. ncbi request reprint Opposite regulation of connexin33 and connexin43 by LPS and IL-1alpha in spermatogenesis
    Celine Fiorini
    Faculte de Medecine, INSERM U 670, 28 Ave de Valombrose, 06107 Nice Cedex 2, France
    Am J Physiol Cell Physiol 290:C733-40. 2006
  3. ncbi request reprint The emerging role of connexin 43 in testis pathogenesis
    D Chevallier
    INSERM U 1065, C3M, 151 Route Saint Antoine de Ginestiere, BP 2 3194, 06204 Nice Cedex 3, France
    Curr Mol Med 13:1331-44. 2013
  4. ncbi request reprint Connexins as precocious markers and molecular targets for chemical and pharmacological agents in carcinogenesis
    G Pointis
    INSERM U 670, Faculte de Medecine, 27 avenue de Valombrose, 06107 Nice Cedex 02, France
    Curr Med Chem 14:2288-303. 2007
  5. ncbi request reprint Connexin43: emerging role in erectile function
    Georges Pointis
    INSERM U 670, Faculte de Medecine, IFR 50, 28 Avenue de Valombrose, 06107 Nice Cedex 02, France
    Int J Biochem Cell Biol 38:1642-6. 2006
  6. ncbi request reprint Gap junctional communication in the male reproductive system
    Georges Pointis
    INSERM U 670, Faculte de Medecine, 28 Avenue de Valombrose, 06107 Nice Cedex 02, France
    Biochim Biophys Acta 1719:102-16. 2005
  7. ncbi request reprint Role of connexin-based gap junction channels in testis
    Georges Pointis
    INSERM U 670, Faculte de Medecine, IFR 50, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Trends Endocrinol Metab 16:300-6. 2005
  8. ncbi request reprint Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells
    N Defamie
    INSERM EMI 00-09, IFR 50, , Avenue de Valombrose, 06107 Nice cedex, France
    Carcinogenesis 22:1537-42. 2001
  9. ncbi request reprint Reg I protein in healthy and seminoma human testis
    V Mauro
    INSERM, U895, C3M, University of Nice Sophia Antipolis, UFR Medecine, Nice, France
    Histol Histopathol 23:1195-203. 2008
  10. ncbi request reprint Chemical connexin impairment in the developing gonad associated with offspring infertility
    J Gilleron
    INSERM U 895, University Sophia Antipolis, Team 5 Physiopathology of germ cell control genomic and non genomic mechanisms, C3M, 06204 Nice Cedex 3, France
    Curr Med Chem 18:5145-58. 2011

Collaborators

  • P Fenichel
  • Baharia Mograbi
  • H Tanaka
  • D Czerucka
  • Norah Defamie
  • L Cronier
  • J P Siffroi
  • A Malassine
  • Serge Geribaldi
  • I T Huhtaniemi
  • S Carreau
  • Marc Mesnil
  • Denise Escalier
  • Celine Fiorini
  • D Segretain
  • D Chevallier
  • Dominique Segretain
  • J Gilleron
  • D Carette
  • V Mauro
  • Mireille Starita-Geribaldi
  • C Roger
  • Jerome Gilleron
  • Xavier Decrouy
  • C Batias
  • Corinne Niger
  • J F Michiels
  • Michel Samson
  • Stephan Chevalier
  • Marielle Nebout
  • J Dompierre
  • R Pontier-Bres
  • M Starita-Geribaldi
  • Anne Tilloy
  • Astrid Valette
  • Graziello Geneau
  • F Senegas-Balas
  • Jean Marie Guigonis
  • Diane Carette
  • Silvio Palmero
  • Francoise Senegas-Balas
  • Linda Scarabelli
  • M Nebout
  • A Bouskine
  • S Lambard
  • Anne Tilloy-Ellul
  • Isabelle Bourget
  • Claude Charuel
  • X Decrouy
  • C Fiorini
  • J R Prat
  • Bernard Ferrua
  • Daniel Chevallier
  • Francoise Roux
  • Jerome Garin
  • Nafis Rahman
  • Jim Dompierre
  • S Poggioli
  • J Garin
  • M Zucchini
  • A Lablack
  • D Thepot

Detail Information

Publications27

  1. ncbi request reprint Requirement of gap junctional intercellular communication for human villous trophoblast differentiation
    Laurent Cronier
    Laboratoire de Biomembranes et Signalisation Cellulaire, Universite de Poitiers, 86022 Poitiers Cedex, France
    Biol Reprod 69:1472-80. 2003
    ..These data suggest that the molecular exchanges through gap junctions preceding cellular fusion are essential for trophoblast differentiation generating the multifunctional syncytiotrophoblast...
  2. ncbi request reprint Opposite regulation of connexin33 and connexin43 by LPS and IL-1alpha in spermatogenesis
    Celine Fiorini
    Faculte de Medecine, INSERM U 670, 28 Ave de Valombrose, 06107 Nice Cedex 2, France
    Am J Physiol Cell Physiol 290:C733-40. 2006
    ..These data reveal that Cx33 and Cx43 genes are controlled differently within the testis and suggest that these two Cxs may exert opposite and complementary effects on spermatogenesis...
  3. ncbi request reprint The emerging role of connexin 43 in testis pathogenesis
    D Chevallier
    INSERM U 1065, C3M, 151 Route Saint Antoine de Ginestiere, BP 2 3194, 06204 Nice Cedex 3, France
    Curr Mol Med 13:1331-44. 2013
    ..This review proposes the gap junction protein connexin 43 as a new potential cancer diagnostic and prognostic marker, as well as a promising therapeutic target for testicular diseases. ..
  4. ncbi request reprint Connexins as precocious markers and molecular targets for chemical and pharmacological agents in carcinogenesis
    G Pointis
    INSERM U 670, Faculte de Medecine, 27 avenue de Valombrose, 06107 Nice Cedex 02, France
    Curr Med Chem 14:2288-303. 2007
    ....
  5. ncbi request reprint Connexin43: emerging role in erectile function
    Georges Pointis
    INSERM U 670, Faculte de Medecine, IFR 50, 28 Avenue de Valombrose, 06107 Nice Cedex 02, France
    Int J Biochem Cell Biol 38:1642-6. 2006
    ..The present review highlights the emerging role of connexin43, one of these membranous proteins, in the physiology and physiopathology of human erectile function and its possible medical application...
  6. ncbi request reprint Gap junctional communication in the male reproductive system
    Georges Pointis
    INSERM U 670, Faculte de Medecine, 28 Avenue de Valombrose, 06107 Nice Cedex 02, France
    Biochim Biophys Acta 1719:102-16. 2005
    ..Their potential dysfunctions in some testis (spermatogenic arrest, seminoma) and prostate (benign hyperplasia, adenocarcinoma) diseases and in the physiopathology of the human erectile function are also discussed...
  7. ncbi request reprint Role of connexin-based gap junction channels in testis
    Georges Pointis
    INSERM U 670, Faculte de Medecine, IFR 50, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Trends Endocrinol Metab 16:300-6. 2005
    ..The implication of connexin-based gap junctions in testicular physiology and in pathological disorders of spermatogenesis (spermatogenic arrest and testis cancer) is also discussed...
  8. ncbi request reprint Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells
    N Defamie
    INSERM EMI 00-09, IFR 50, , Avenue de Valombrose, 06107 Nice cedex, France
    Carcinogenesis 22:1537-42. 2001
    ..The alterations in gap junctions induced by lindane in 42GPA9 Sertoli cells are similar to those observed in tumour cells and may be involved in the pathogenesis of neoplastic seminomal proliferation...
  9. ncbi request reprint Reg I protein in healthy and seminoma human testis
    V Mauro
    INSERM, U895, C3M, University of Nice Sophia Antipolis, UFR Medecine, Nice, France
    Histol Histopathol 23:1195-203. 2008
    ..These data showing for the first time the weak presence of Reg I in the normal testis and its strong expression in the testis cancer suggest a potential role of Reg I in normal and neoplastic germ cell proliferation...
  10. ncbi request reprint Chemical connexin impairment in the developing gonad associated with offspring infertility
    J Gilleron
    INSERM U 895, University Sophia Antipolis, Team 5 Physiopathology of germ cell control genomic and non genomic mechanisms, C3M, 06204 Nice Cedex 3, France
    Curr Med Chem 18:5145-58. 2011
    ..Moreover, we underline the impact of maternal chemical exposure on connexin expression during fetal gonad development and we link this effect to future offspring fertility...
  11. ncbi request reprint Estrogen-induced growth inhibition of human seminoma cells expressing estrogen receptor beta and aromatase
    C Roger
    INSERM U 670, 28 Avenue de Valombrose, Faculte de Medecine, 06102 Nice Cedex 2, France
    J Mol Endocrinol 35:191-9. 2005
    ..Whether this estrogen control, however, involves an ERbeta-mediated stimulation of cell apoptosis and/or an ERbeta-mediated inhibition of cell proliferation, remains to be further determined...
  12. ncbi request reprint Connexin43 gene expression and regulation in the rodent seminiferous epithelium
    C Batias
    INSERM CJF 95 04, EA 1760, IFR 50, Faculte de Medecine, Nice, France
    J Histochem Cytochem 48:793-805. 2000
    ..Moreover, they suggest that retinoids, through the RXRbeta receptors, could be involved in the control of Cx43 gene expression in Sertoli cells...
  13. ncbi request reprint A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway
    D Segretain
    INSERM EMI 00 09, IFR 50, Universite Paris V, 45, rue des Saint Pères, 75006 Paris, France
    Biochimie 86:241-4. 2004
    ..These data strongly support a novel role for ZO-1 in the turnover of Cx43 during gap junction plaque endocytosis...
  14. ncbi request reprint Dominant negative effect of connexin33 on gap junctional communication is mediated by connexin43 sequestration
    Celine Fiorini
    INSERM EMI 00 09, IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    J Cell Sci 117:4665-72. 2004
    ..In the testis, connexin33 could exert a specific role on germ cell proliferation by suppressing the regulatory effect of connexin43...
  15. doi request reprint The anti-mitotic drug griseofulvin induces apoptosis of human germ cell tumor cells through a connexin 43-dependent molecular mechanism
    V Mauro
    INSERM U 1065, Centre Méditerranéen de Médecine Moléculaire, 06204 Nice Cedex 3, France
    Apoptosis 18:480-91. 2013
    ..Altogether, these results described a new molecular mechanism connexin 43-dependent targeted by griseofulvin leading to apoptosis of human germ cell tumor cells...
  16. ncbi request reprint Modified expression of testicular gap-junction connexin 43 during normal spermatogenic cycle and in altered spermatogenesis
    C Batias
    INSERM CJF 95 04, EA 1760, IFR 50, Faculte de Medecine, Nice, France
    Cell Tissue Res 298:113-21. 1999
    ..The present study represents one of the first in vivo examples of alteration of seminiferous tubule Cx43 in testes with impaired spermatogenesis...
  17. ncbi request reprint Mapping of seminal plasma proteins by two-dimensional gel electrophoresis in men with normal and impaired spermatogenesis
    M Starita-Geribaldi
    INSERM EMI 00 09 Groupe de Recherche en Endocrinologie et Reproduction, IFR 50, UFR de Medecine, Avenue de Valombrose, 06107 Nice Cedex 2, France
    Mol Hum Reprod 7:715-22. 2001
    ....
  18. ncbi request reprint Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway
    Baharia Mograbi
    INSERM EMI 00 09, IFR 50, Faculte de Medecine, Avenue de Valombrose, F 06107 Nice Cedex 02, France
    Carcinogenesis 24:1415-23. 2003
    ..Such inappropriate activation of the mitogenic MAPK pathway and inactivation of the tumor suppressor Cx43 by Lindane may participate in the promotion of neoplastic cell growth...
  19. ncbi request reprint Development of narrow immobilized pH gradients covering one pH unit for human seminal plasma proteomic analysis
    Mireille Starita-Geribaldi
    INSERM EMI 00 09, Groupe de Recherche en Endocrinologie et Reproduction, IFR 50, UFR de Medecine, 28 Avenue de Valombrose, 06107 Nice Cedex 2, France
    Proteomics 3:1611-9. 2003
    ..Therefore, zooming-in on the proteome of human seminal plasma allowed more accurate differential expression analysis of impaired spermatogenesis associated markers...
  20. ncbi request reprint A potential novel mechanism involving connexin 43 gap junction for control of sertoli cell proliferation by thyroid hormones
    Jerome Gilleron
    INSERM U 670, Faculte de Medecine, Université de Paris V René Descartes, Paris, France
    J Cell Physiol 209:153-61. 2006
    ..Based on these data, we propose a working hypothesis in which Cx43 could be an intermediate target for T3 inhibition of neonatal Sertoli cell proliferation...
  21. ncbi request reprint Disrupted traffic of connexin 43 in human testicular seminoma cells: overexpression of Cx43 induces membrane location and cell proliferation decrease
    C Roger
    INSERM EMI 00 09, 28 Avenue de Valombrose, 06102 Nice Cedex 2, France
    J Pathol 202:241-6. 2004
    ..By preventing Cx43 membrane expression, this disrupted traffic may itself participate in tumour promotion...
  22. ncbi request reprint Accelerated internalization of junctional membrane proteins (connexin 43, N-cadherin and ZO-1) within endocytic vacuoles: an early event of DDT carcinogenicity
    Celine Fiorini
    INSERM U 670, Faculte de Medecine, 28 Avenue de Valombrose, 06107 Nice Cedex 02, France
    Biochim Biophys Acta 1778:56-67. 2008
    ..Such an alteration may play a specific role during carcinogenesis...
  23. ncbi request reprint Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants
    Celine Fiorini
    INSERM EMI 00 09, IFR 50, Faculte de Medecine, Avenue de Valombrose, 06107 Nice Cedex 02, France
    Reprod Toxicol 18:413-21. 2004
    ..The SerW3 cell line therefore appears as a useful in vitro model to evaluate molecules with potential anti-reproductive effects...
  24. ncbi request reprint Impaired gap junction connexin43 in Sertoli cells of patients with secretory azoospermia: a marker of undifferentiated Sertoli cells
    Norah Defamie
    INSERM EMI 00 09, IFR 50, Faculte de Medecine, Nice Cedex, France
    Lab Invest 83:449-56. 2003
    ..This defect could be a new functional marker of undifferentiated Sertoli cells and could be related to the increased risk of testicular cancer recently described in the population of infertile men...
  25. ncbi request reprint Modified expression of cytoplasmic isocitrate dehydrogenase electrophoretic isoforms in seminal plasma of men with sertoli-cell-only syndrome and seminoma
    Mireille Starita-Geribaldi
    INSERM U 670, UFR de Medecine, Nice Cedex 2, France
    Mol Carcinog 47:410-4. 2008
    ..These results propose IDPc as a promising SP biomarker of testicular seminoma. Whether IDPc alteration in secretory azoospermia is predictive of testicular seminoma remains to be elucidated...
  26. ncbi request reprint Endothelin-1 inhibits human osteoblastic cell differentiation: influence of connexin-43 expression level
    Corinne Niger
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA
    J Cell Biochem 103:110-22. 2008
    ..Our data also indicate that the gap junctional protein could play a pivotal role in the response of osteoblasts to mitogenic factors implicated in bone pathologies...
  27. ncbi request reprint Sequestration of connexin43 in the early endosomes: an early event of Leydig cell tumor progression
    Dominique Segretain
    INSERM EMI 00 09, Universite Paris V, Paris, France
    Mol Carcinog 38:179-87. 2003
    ..Altogether, this study provides the first evidence that impaired Cx43 trafficking in endosomes is an early event associated with uncontrolled cell proliferation that could serve as a neoplastic marker...