Anne Tailleux

Summary

Country: France

Publications

  1. ncbi Apolipoprotein A-II, HDL metabolism and atherosclerosis
    Anne Tailleux
    Faculte de Pharmacie, Département d athérosclérose et INSERM U 545, Institut Pasteur, Universite Lille 2, 1, rue du Professeur Calmette, 59019 Cedex, Lille, France
    Atherosclerosis 164:1-13. 2002
  2. ncbi Increased susceptibility of low-density lipoprotein to ex vivo oxidation in mice transgenic for human apolipoprotein B treated with 1 melatonin-related compound is not associated with atherosclerosis progression
    Anne Tailleux
    Département de Recherches sur l Athérosclérose, INSERM U545, Institut Pasteur de Lille, Lille, France
    J Cardiovasc Pharmacol 46:241-9. 2005
  3. pmc Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development
    Kristiaan Wouters
    Univ Lille Nord de France, Lille, France
    PLoS ONE 7:e32440. 2012
  4. doi Cdkn2a/p16Ink4a regulates fasting-induced hepatic gluconeogenesis through the PKA-CREB-PGC1α pathway
    Kadiombo Bantubungi
    Universite Lille 2, Lille, France INSERM, U1011, Lille, France European Genomic Institute for Diabetes, Lille, France Institut Pasteur de Lille, Lille, France
    Diabetes 63:3199-209. 2014
  5. pmc Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver
    Fanny Lalloyer
    University Lille Nord de France, Lille, France
    Arterioscler Thromb Vasc Biol 29:1488-95. 2009
  6. pmc Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice
    Fanny Lalloyer
    University Lille Nord de France, Lille, France
    Arterioscler Thromb Vasc Biol 31:1573-9. 2011
  7. doi Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    Bart Staels
    Institut Pasteur de Lille, Lille, France INSERM, UMR1011, Lille, France Université Lille Nord de France, Lille, France Université Droit et Santé de Lille, Lille, France
    Hepatology 58:1941-52. 2013
  8. pmc p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages
    Céline Cudejko
    Universite Lille Nord de France, Lille, France
    Blood 118:2556-66. 2011
  9. doi Screening strategy to generate cell specific recombination: a case report with the RIP-Cre mice
    Valeria Spinelli
    European Genomic Institute for Diabetes EGID, FR 3508, 59000, Lille, France
    Transgenic Res 24:803-12. 2015
  10. doi The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice
    Michal Pawlak
    European Genomic Institute for Diabetes, Lille, France INSERM UMR1011, F 59000, Lille, France University Lille 2, Lille, France Institut Pasteur de Lille, Lille, France
    Hepatology 60:1593-606. 2014

Collaborators

Detail Information

Publications22

  1. ncbi Apolipoprotein A-II, HDL metabolism and atherosclerosis
    Anne Tailleux
    Faculte de Pharmacie, Département d athérosclérose et INSERM U 545, Institut Pasteur, Universite Lille 2, 1, rue du Professeur Calmette, 59019 Cedex, Lille, France
    Atherosclerosis 164:1-13. 2002
    ..It can be suggested that apo A-II is not a strong determinant of lipid metabolism, but is rather a modulator of reverse cholesterol transport...
  2. ncbi Increased susceptibility of low-density lipoprotein to ex vivo oxidation in mice transgenic for human apolipoprotein B treated with 1 melatonin-related compound is not associated with atherosclerosis progression
    Anne Tailleux
    Département de Recherches sur l Athérosclérose, INSERM U545, Institut Pasteur de Lille, Lille, France
    J Cardiovasc Pharmacol 46:241-9. 2005
    ..These data confirm that the capacity of molecules to inhibit atherogenic lipoprotein oxidation in vitro offers no prediction of their capacity to inhibit in vivo atherosclerosis development...
  3. pmc Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development
    Kristiaan Wouters
    Univ Lille Nord de France, Lille, France
    PLoS ONE 7:e32440. 2012
    ..Therefore, we investigated the influence of immune cell p16(INK4a) on glucose tolerance and atherosclerosis in mice...
  4. doi Cdkn2a/p16Ink4a regulates fasting-induced hepatic gluconeogenesis through the PKA-CREB-PGC1α pathway
    Kadiombo Bantubungi
    Universite Lille 2, Lille, France INSERM, U1011, Lille, France European Genomic Institute for Diabetes, Lille, France Institut Pasteur de Lille, Lille, France
    Diabetes 63:3199-209. 2014
    ..Taken together, these results provide evidence that p16(Ink4a) controls fasting glucose homeostasis and could as such be involved in T2D development. ..
  5. pmc Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver
    Fanny Lalloyer
    University Lille Nord de France, Lille, France
    Arterioscler Thromb Vasc Biol 29:1488-95. 2009
    ..The most frequent side-effect of bexarotene administration is an increase in plasma triglycerides, an independent risk factor of cardiovascular disease. The molecular mechanism behind this hypertriglyceridemia remains poorly understood...
  6. pmc Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice
    Fanny Lalloyer
    University Lille Nord de France, Lille, France
    Arterioscler Thromb Vasc Biol 31:1573-9. 2011
    ....
  7. doi Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    Bart Staels
    Institut Pasteur de Lille, Lille, France INSERM, UMR1011, Lille, France Université Lille Nord de France, Lille, France Université Droit et Santé de Lille, Lille, France
    Hepatology 58:1941-52. 2013
    ..GFT505 treatment decreased plasma concentrations of alanine aminotransferase, gamma-glutamyl transpeptidase, and alkaline phosphatase...
  8. pmc p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages
    Céline Cudejko
    Universite Lille Nord de France, Lille, France
    Blood 118:2556-66. 2011
    ..These findings identify p16(INK4a) as a modulator of macrophage activation and polarization via the JAK2-STAT1 pathway with possible roles in inflammatory diseases...
  9. doi Screening strategy to generate cell specific recombination: a case report with the RIP-Cre mice
    Valeria Spinelli
    European Genomic Institute for Diabetes EGID, FR 3508, 59000, Lille, France
    Transgenic Res 24:803-12. 2015
    ....
  10. doi The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice
    Michal Pawlak
    European Genomic Institute for Diabetes, Lille, France INSERM UMR1011, F 59000, Lille, France University Lille 2, Lille, France Institut Pasteur de Lille, Lille, France
    Hepatology 60:1593-606. 2014
    ..Pharmacologically activated PPAR-α inhibited hepatic inflammatory responses and the transition from steatosis toward NASH and fibrosis through a direct, anti-inflammatory mechanism independent of its lipid handling properties...
  11. doi Glucose sensing O-GlcNAcylation pathway regulates the nuclear bile acid receptor farnesoid X receptor (FXR)
    Wahiba Berrabah
    European Genomic Institute for Diabetes EGID, Lille, France INSERM UMR1011, Lille, France Univ Lille 2, Lille, France Institut Pasteur de Lille, Lille, France
    Hepatology 59:2022-33. 2014
    ..Finally, in vivo fasting-refeeding experiments show that FXR undergoes O-GlcNAcylation in fed conditions associated with increased direct FXR target gene expression and decreased liver bile acid content...
  12. ncbi Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins
    Stéphanie Bultel-Brienne
    Unité INSERM U 545, Institut Pasteur de Lille, Faculte de Pharmacie, Universite Lille 2, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    J Biol Chem 277:36092-9. 2002
    ..We propose that this direct interaction could modify SR-BI structure in cell membranes and potentiate CE uptake...
  13. pmc Cell-derived microparticles in atherosclerosis: biomarkers and targets for pharmacological modulation?
    Morgane Baron
    Universite Lille Nord de France, Lille, France
    J Cell Mol Med 16:1365-76. 2012
    ....
  14. ncbi The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia
    Fanny Lalloyer
    Institut Pasteur de Lille, Departement d Atherosclerose, Lille, France
    Arterioscler Thromb Vasc Biol 26:2731-7. 2006
    ..Here, we investigated the effect of bexarotene on atherosclerosis progression in a dyslipidemic murine model, the human apolipoprotein E2 knockin mouse, that develops essentially macrophage-laden lesions...
  15. doi Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1
    Olivier Briand
    University Lille, INSERM, Centre hospitalier universitaire CHU de Lille, Institut Pasteur de Lille, U1011 European Genomic Institute for Diabetes, Lille, France
    Gastroenterology 150:650-8. 2016
    ..We aimed to determine whether intestinal LXRs regulate triglyceride absorption...
  16. pmc Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice
    Antoine Leboucher
    Universite Lille Nord de France, Université du Droit et de Santé de Lille, Lille, France
    Diabetes 62:1681-8. 2013
    ..Together, our data demonstrate that DIO worsens τ phosphorylation and learning abilities in τ transgenic mice independently from peripheral/central insulin resistance...
  17. doi Bariatric surgery, lipoprotein metabolism and cardiovascular risk
    Anne Tailleux
    aEuropean Genomic Institute for Diabetes EGID bINSERM UMR1011 cUniv Lille 2 dInstitut Pasteur de Lille, Lille, France eBiomedical Sciences Research Center Alexander Fleming, Vari, Greece fINSERM UMR1190, Lille, France
    Curr Opin Lipidol 26:317-24. 2015
    ..To summarize recent epidemiological, preclinical and clinical studies on the effects of Roux-en-Y-gastric bypass (RYGBP) surgery on cardiovascular risk factors and the underlying mechanisms...
  18. ncbi Daily melatonin supplementation in mice increases atherosclerosis in proximal aorta
    Anne Tailleux
    Departement d Atherosclerose, INSERM U545, Institut Pasteur, 1 rue du Pr Calmette, 59019 Lille, France
    Biochem Biophys Res Commun 293:1114-23. 2002
    ..This study suggests that caution should be taken as regards high melatonin dosage in hypercholesterolemic patients...
  19. pmc Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways
    Giulia Chinetti-Gbaguidi
    Univ Lille Nord de France, Lille, France
    Circ Res 108:985-95. 2011
    ..Macrophages are heterogeneous cells that adapt their response to environmental cytokines. Th1 cytokines promote monocyte differentiation into M1 macrophages, whereas Th2 cytokines trigger an "alternative" M2 phenotype...
  20. ncbi Paradoxical exacerbation of combined hyperlipidemia in human apolipoprotein A-II transgenic mice treated with fenofibrate
    Vicent Ribas
    Servei de Bioquímica i Institut de Recerca, Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain
    Biochim Biophys Acta 1737:130-7. 2005
    ..Therefore, the paradoxical enhancement of hyperlipidemia in fenofibrate-treated apoA-II transgenic mice is mainly due to decreased VLDL catabolism and, also, to a partial impairment in PPARalpha-signaling...
  21. ncbi Host glucose metabolism mediates T4 and IL-7 action on Schistosoma mansoni development
    Pasquine Saule
    UMR 8527 CNRS Institut de Biologie de Lille, Lille, France 59 021
    J Parasitol 91:737-44. 2005
    ..These experiments characterize the elaborate links between parasite and host metabolism and their reciprocal influences...
  22. ncbi Murine models to investigate pharmacological compounds acting as ligands of PPARs in dyslipidemia and atherosclerosis
    Anne Tailleux
    Unité de Recherche INSERM 545, Departement d Atherosclerose, Institut Pasteur de Lille, France
    Trends Pharmacol Sci 24:530-4. 2003