Jan O Friedrich

Summary

Publications

  1. doi request reprint Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis
    Karen E A Burns
    St Michael s Hospital and the Keenan Research Centre Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Crit Care 21:127. 2017
  2. pmc Should dual antiplatelet therapy be used in patients following coronary artery bypass surgery? A meta-analysis of randomized controlled trials
    Subodh Verma
    Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, M5B 1W8, Canada
    BMC Surg 15:112. 2015
  3. pmc Colchicine in cardiac disease: a systematic review and meta-analysis of randomized controlled trials
    Subodh Verma
    Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
    BMC Cardiovasc Disord 15:96. 2015
  4. ncbi request reprint Surrogate decision makers' attitudes towards research decision making for critically ill patients
    Kali A Barrett
    Internal Medicine Programme, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 38:1616-23. 2012
  5. pmc Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis
    Sachin Sud
    Institute for Better Health and Division of Critical Care S Sud, Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont Interdepartmental Division of Critical Care S Sud, Friedrich, Adhikari, University of Toronto, Toronto, Ont Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute Friedrich, St Michael s Hospital, Toronto, Ont Dipartimento di Anestesia e Rianimazione Taccone, Gattinoni, Polli, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy Istituto di Anestesiologia e Rianimazione Polli, Gattinoni, Universita degli Studi di Milano, Milan, Italy Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti Gattinoni, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy Department of Critical Care Medicine Adhikari, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont Department of Cardiovascular Research Latini, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Dipartimento di Medicina Perioperatoria e Terapie Intensive Pesenti, Azienda Ospedaliera San Gerardo, Monza, Italy Dipartimento di Medicina Sperimentale Pesenti, Universita degli Studi di Milano Bicocca, USA
    CMAJ 186:E381-90. 2014
  6. doi request reprint Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study
    Orla M Smith
    Critical Care Department, St Michael s Hospital, Toronto, Canada
    PLoS ONE 12:e0179207. 2017
  7. pmc Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study
    Abhijat Kitchlu
    Department of Medicine, Division of Nephrology, University of Toronto, Toronto, ON, Canada
    BMC Nephrol 16:127. 2015
  8. doi request reprint Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: a population-based cohort study
    Ron Wald
    Division of Nephrology, St Michael s Hospital and University of Toronto, Toronto, ON, Canada Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada Institute for Clinical Evaluative Sciences Kidney, Dialysis and Transplantation Program, London, ON, Canada Electronic address
    Am J Kidney Dis 65:870-7. 2015
  9. doi request reprint High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
    Sachin Sud
    Critical Care Medicine Program, Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto, ON, Canada, M5G 2N2
    BMJ 340:c2327. 2010
  10. doi request reprint The association between renal replacement therapy modality and long-term outcomes among critically ill adults with acute kidney injury: a retrospective cohort study*
    Ron Wald
    1Division of Nephrology, St Michael s Hospital and University of Toronto, Toronto, ON, Canada 2Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada 3Institute for Clinical Evaluative Sciences, Toronto, ON, Canada 4Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 5Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada 6Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada 7Departments of Critical Care and Medicine, St Michael s Hospital, Toronto, ON, Canada 8Division of Nephrology, London Health Sciences Centre, London, ON, Canada 9Division of General Internal Medicine, St Michael s Hospital, Toronto, ON, Canada
    Crit Care Med 42:868-77. 2014

Collaborators

Detail Information

Publications44

  1. doi request reprint Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis
    Karen E A Burns
    St Michael s Hospital and the Keenan Research Centre Li Ka Shing Knowledge Institute, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Crit Care 21:127. 2017
    ..The effect of alternative spontaneous breathing trial (SBT) techniques on extubation success and other clinically important outcomes is uncertain...
  2. pmc Should dual antiplatelet therapy be used in patients following coronary artery bypass surgery? A meta-analysis of randomized controlled trials
    Subodh Verma
    Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, M5B 1W8, Canada
    BMC Surg 15:112. 2015
    ..We assessed the effectiveness of dual antiplatelet therapy (DAPT) post elective or urgent (i.e., post acute coronary syndrome [ACS]) coronary artery bypass graft surgery (CABG)...
  3. pmc Colchicine in cardiac disease: a systematic review and meta-analysis of randomized controlled trials
    Subodh Verma
    Division of Cardiac Surgery, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
    BMC Cardiovasc Disord 15:96. 2015
    ..Colchicine has unique anti-inflammatory properties that may be beneficial in various cardiovascular conditions. This systematic review and meta-analysis of randomized controlled trials (RCTs) examines this issue...
  4. ncbi request reprint Surrogate decision makers' attitudes towards research decision making for critically ill patients
    Kali A Barrett
    Internal Medicine Programme, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 38:1616-23. 2012
    ..To examine the attitudes and preferences of surrogate decision makers (SDMs) regarding their involvement in the consent to research process for ICU patients...
  5. pmc Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome: a systematic review and meta-analysis
    Sachin Sud
    Institute for Better Health and Division of Critical Care S Sud, Department of Medicine, Trillium Health Partners, University of Toronto, Mississauga, Ont Interdepartmental Division of Critical Care S Sud, Friedrich, Adhikari, University of Toronto, Toronto, Ont Departments of Critical Care and Medicine, and Li Ka Shing Knowledge Institute Friedrich, St Michael s Hospital, Toronto, Ont Dipartimento di Anestesia e Rianimazione Taccone, Gattinoni, Polli, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy Istituto di Anestesiologia e Rianimazione Polli, Gattinoni, Universita degli Studi di Milano, Milan, Italy Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti Gattinoni, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Universita degli Studi di Milano, Milan, Italy Department of Critical Care Medicine Adhikari, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, Ont Department of Cardiovascular Research Latini, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy Dipartimento di Medicina Perioperatoria e Terapie Intensive Pesenti, Azienda Ospedaliera San Gerardo, Monza, Italy Dipartimento di Medicina Sperimentale Pesenti, Universita degli Studi di Milano Bicocca, USA
    CMAJ 186:E381-90. 2014
    ..We sought to determine the effect of prone positioning on mortality among patients with ARDS receiving protective lung ventilation...
  6. doi request reprint Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study
    Orla M Smith
    Critical Care Department, St Michael s Hospital, Toronto, Canada
    PLoS ONE 12:e0179207. 2017
    ..Little is known about homeless patients in intensive care units (ICUs)...
  7. pmc Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study
    Abhijat Kitchlu
    Department of Medicine, Division of Nephrology, University of Toronto, Toronto, ON, Canada
    BMC Nephrol 16:127. 2015
    ..SLED may reduce the hemodynamic perturbations of intermittent hemodialysis, while obviating the resource demands of CRRT. Although SLED is being increasingly used, few studies have evaluated its impact on clinical outcomes...
  8. doi request reprint Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: a population-based cohort study
    Ron Wald
    Division of Nephrology, St Michael s Hospital and University of Toronto, Toronto, ON, Canada Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada Institute for Clinical Evaluative Sciences Kidney, Dialysis and Transplantation Program, London, ON, Canada Electronic address
    Am J Kidney Dis 65:870-7. 2015
    ..Dialysis-requiring acute kidney injury (AKI) is common among critically ill patients, but little is known about trends in the incidence and outcomes of this condition over time...
  9. doi request reprint High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis
    Sachin Sud
    Critical Care Medicine Program, Interdepartmental Division of Critical Care, University of Toronto, Toronto General Hospital, 585 University Ave, Toronto, ON, Canada, M5G 2N2
    BMJ 340:c2327. 2010
    ..To determine clinical and physiological effects of high frequency oscillation compared with conventional ventilation in patients with acute lung injury/acute respiratory distress syndrome (ARDS)...
  10. doi request reprint The association between renal replacement therapy modality and long-term outcomes among critically ill adults with acute kidney injury: a retrospective cohort study*
    Ron Wald
    1Division of Nephrology, St Michael s Hospital and University of Toronto, Toronto, ON, Canada 2Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada 3Institute for Clinical Evaluative Sciences, Toronto, ON, Canada 4Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 5Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada 6Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada 7Departments of Critical Care and Medicine, St Michael s Hospital, Toronto, ON, Canada 8Division of Nephrology, London Health Sciences Centre, London, ON, Canada 9Division of General Internal Medicine, St Michael s Hospital, Toronto, ON, Canada
    Crit Care Med 42:868-77. 2014
    ..Our objective was to determine whether continuous renal replacement therapy was associated with a lower risk of chronic dialysis as compared with intermittent hemodialysis, among survivors of acute kidney injury...
  11. ncbi request reprint Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort study
    Ayodele Odutayo
    Division of Nephrology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
    Can J Anaesth 59:934-42. 2012
    ..We undertook this study to characterize the epidemiology of acute kidney injury (AKI) in Canadian critical care units. We aimed to identify predictors of mortality for patients diagnosed with AKI...
  12. doi request reprint Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: a systematic review and meta-analysis of observational studies
    Clarence Chant
    Leslie Dan Faculty of Pharmacy, University of Toronto and Pharmacy Department, St Michael s Hospital, Toronto, Canada
    Crit Care Med 39:1167-73. 2011
    ..To determine whether catheter-associated urinary tract infections are associated with increased morbidity and mortality in critically ill patients...
  13. doi request reprint High-frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome
    Sachin Sud
    Division of Critical Care, Department of Medicine, Trillium Health Center, University of Toronto, Mississauga, ON, Canada
    Cochrane Database Syst Rev 4:CD004085. 2016
    ..This review was originally published in 2004 and was updated in 2013 and again in 2015...
  14. doi request reprint Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis
    Neill K J Adhikari
    1Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada 2Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, Camden, NJ 3Department of Anesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden 4Department of Critical Care and Anesthesiology and SAMU, Hopital Lariboisiere, Universite Paris 7 Denis Diderot, Paris, France 5Department of Anesthesiology and Intensive Care Medicine, University Hospital of Lille, Lille, France 6Departments for Anesthesia, Intensive Care Medicine, and Pain Management, Vivantes Klinikum Neukoelln, Berlin, Germany 7Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, South Korea 8Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto ON, Canada 9The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto ON, Canada 10Departments of Critical Care and Medicine, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital and University of Toronto, Toronto, ON, Canada
    Crit Care Med 42:404-12. 2014
    ....
  15. doi request reprint High-frequency oscillation in adults: a utilization review
    Neill K J Adhikari
    Department of Critical Care Medicine and the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada
    Crit Care Med 39:2631-44. 2011
    ..Given the uncertain benefits, our objective was to describe contemporary patient selection, high-frequency oscillation utilization, and outcomes...
  16. doi request reprint Coenrollment in a randomized trial of high-frequency oscillation: prevalence, patterns, predictors, and outcomes*
    Deborah J Cook
    1Department of Medicine, McMaster University, Hamilton, ON, Canada 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada 3Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada 4Department of Medicine, University of Toronto, Toronto, ON, Canada 5Department of Physiology, University of Toronto, Toronto, ON, Canada 6Division of Respirology, Department of Medicine, University Health Network, University of Toronto, Toronto, ON, Canada 7Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada 8Department of Critical Care Medicine, Sunnybrook Health Science Centre, Toronto, ON, Canada 9Department of Critical Care Medicine, Orlando Regional Medical Center, Orlando, FL 10Department of Critical Care, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia 11Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada 12Adult Critical Care Department, University Hospital of Wales, Cardiff, United Kingdom 13Department of Critical Care, University of British Columbia, Vancouver
    Crit Care Med 43:328-38. 2015
    ....
  17. doi request reprint Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults
    Karen E A Burns
    Interdepartmental Division of Critical Care, Keenan Research Centre Li Ka Shing Knowledge Institute, University of Toronto, 30 Bond Street, Rm 4 045 Queen Wing, Toronto, ON, Canada, M5B 1WB
    Cochrane Database Syst Rev 9:CD008638. 2014
    ....
  18. doi request reprint Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury
    Ron Wald
    Division of Nephrology, St Michael s Hospital and University of Toronto, Toronto, Ontario, Canada
    Kidney Int 88:897-904. 2015
    ..No safety signal was evident in either arm. Our findings can inform the design of a large-scale effectiveness randomized control trial...
  19. pmc Risk factors for mortality in patients admitted to intensive care units with pneumonia
    Guowei Li
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 501 25 Charlton Avenue East, Hamilton, ON, L8N 1Y2, Canada
    Respir Res 17:80. 2016
    ..Despite the high mortality in patients with pneumonia admitted to an ICU, data on risk factors for death remain limited...
  20. doi request reprint Knowledge translation interventions for critically ill patients: a systematic review*
    Tasnim Sinuff
    1Department of Critical Care Medicine, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 2Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada 3Department of Medicine, Queen s University, Kingston, ON, Canada 4Clinical Evaluation Research Unit, Kingston General Hospital, Kingston, ON, Canada 5Department of Critical Care Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada 6Department of Medicine, University of Calgary and Alberta Health Services, Calgary, AB, Canada 7Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada 8Institute of Public Health, University of Calgary, Calgary, AB, Canada 9Center for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada 10Department of Medicine, Providence Health Care and University of British Columbia, Vancouver, BC, Canada 11Department of Medicine, McMaster University, Hamilton, ON, Canada 12Department of Clinical Epidemiology and Biostatistics, Japan
    Crit Care Med 41:2627-40. 2013
    ..We systematically reviewed ICU-based knowledge translation studies to assess the impact of knowledge translation interventions on processes and outcomes of care...
  21. doi request reprint Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study
    Edward Clark
    Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
    Can J Anaesth 59:861-70. 2012
    ..Defining current practice is necessary to design interventional trials. We describe the current Canadian practice regarding the timing of RRT initiation for AKI...
  22. doi request reprint Nurse- vs nomogram-directed glucose control in a cardiovascular intensive care unit
    Clarence Chant
    Pharmacy Department, Critical Care Department at St Michael s Hospital, Toronto, Canada
    Am J Crit Care 21:270-8. 2012
    ..Paper-based nomograms are reasonably effective for achieving glycemic control but have low adherence and are less adaptive than nurses' judgment...
  23. doi request reprint Pressure-Controlled vs Volume-Controlled Ventilation in Acute Respiratory Failure: A Physiology-Based Narrative and Systematic Review.
    Nuttapol Rittayamai
    Li Ka Shing Knowledge Institute and Critical Care Department, St Michael s Hospital, Toronto, ON, Canada Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada Division of Respiratory Diseases and Tuberculosis, Department of Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand
    Chest 148:340-355. 2015
    ..However, included trials were small and varied considerably in quality. These data should help to open the choice of ventilation of patients with acute respiratory failure...
  24. ncbi request reprint The Postcardiac Arrest Consult Team: Impact on Hospital Care Processes for Out-of-Hospital Cardiac Arrest Patients
    Steven C Brooks
    1Department of Emergency Medicine, Queen s University, Kingston, ON, Canada 2Rescu, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario Canada 3Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada 4Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada 5Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON 6Critical Care Department, St Michael s Hospital, Toronto, ON, Canada 7Department of Emergency Medicine, St Michael s Hospital, Toronto, ON, Canada 8Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada 9Heart and Vascular Program, St Michael s Hospital, Toronto, ON, Canada 10Division of Cardiology, Department of Medicine, University of Toronto, Toronto, ON, Canada 11Department of Anesthesia, St Michael s Hospital, Toronto, ON, Canada 12Division of Cardiology, Imperial College London
    Crit Care Med 44:2037-2044. 2016
    ..To evaluate whether a Post-Arrest Consult Team improved care and outcomes for patients with out-of-hospital cardiac arrest...
  25. doi request reprint Implementing a bedside assessment of respiratory mechanics in patients with acute respiratory distress syndrome.
    Lu Chen
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
    Crit Care 21:84. 2017
    ..The present study involves data from our ongoing registry for respiratory mechanics (ClinicalTrials.gov identifier: NCT02623192 . Registered 30 July 2015)...
  26. pmc The hemodynamic tolerability and feasibility of sustained low efficiency dialysis in the management of critically ill patients with acute kidney injury
    Heather E Fieghen
    Department of Medicine, University of Toronto, Toronto, ON, Canada
    BMC Nephrol 11:32. 2010
    ..We also compared the feasibility of SLED administration with that of CRRT and intermittent hemodialysis (IHD)...
  27. doi request reprint Ratio of means for analyzing continuous outcomes in meta-analysis performed as well as mean difference methods
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Epidemiol 64:556-64. 2011
    ..Ratio of means (RoM) is an alternative effect measure that performs comparably in simulation. We compared treatment effects and heterogeneity for RoM, MD, and SMD using empiric data...
  28. pmc Rosiglitazone: can meta-analysis accurately estimate excess cardiovascular risk given the available data? Re-analysis of randomized trials using various methodologic approaches
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Res Notes 2:5. 2009
    ..The objective of this study was to assess the robustness of the rosiglitazone results by using alternative reasonable methodologic approaches and by analyzing additional related outcomes...
  29. doi request reprint Patients' preferences for enrolment into critical-care trials
    Damon C Scales
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
    Intensive Care Med 35:1703-12. 2009
    ..Most critically ill patients are incapable of providing informed consent for research...
  30. doi request reprint Ratio of geometric means to analyze continuous outcomes in meta-analysis: comparison to mean differences and ratio of arithmetic means using empiric data and simulation
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    Stat Med 31:1857-86. 2012
    ....
  31. doi request reprint Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*
    Wendy Lim
    1Department of Medicine, McMaster University, Hamilton, ON, Canada 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada 3Research Center of the CHU de Québec, Population Health and Optimal Health Practices Research Unit, Quebec, QC, Canada 4Division of Critical Care, Department of Medicine, Quebec, QC, Canada 5Section of Critical Care, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 6Section of Hematology Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 7Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada 8Division of Critical Care, Department of Medicine, Centre de Recherche Clinique Étiene Le Bel, Universite de Sherbrooke, Sherbrooke, QC, Canada 9Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St Paul s Hospital and University of British Columbia, Vancouver, BC, Canada 10Department of Critical Care, University of Ottawa, Ottawa, ON, Canada 11Department of Anesthesia, Queen Elizabeth II Health Sciences Centre, 12Department of Critical Care, University of Michigan
    Crit Care Med 43:401-10. 2015
    ..To identify risk factors for failure of anticoagulant thromboprophylaxis in critically ill patients in the ICU...
  32. pmc The use of wireless e-mail to improve healthcare team communication
    Chris O'Connor
    Department of Critical Care Medicine, Room D1 08, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, Canada M4N3M5
    J Am Med Inform Assoc 16:705-13. 2009
    ..To assess the impact of using wireless e-mail for clinical communication in an intensive care unit (ICU)...
  33. pmc Does intensive insulin therapy really reduce mortality in critically ill surgical patients? A reanalysis of meta-analytic data
    Jan O Friedrich
    Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, R, Fraser Elliot Building, 3rd Floor, South Wing, 3S 805, 190 Elizabeth Street, Toronto, Ontario, Canada
    Crit Care 14:324. 2010
    ..Further insights may come from individual patient data meta-analyses or from future large multicenter RCTs in more narrowly defined subgroups of surgical patients...
  34. doi request reprint High-dose renal replacement therapy for acute kidney injury: Systematic review and meta-analysis
    Ryan Van Wert
    Department of Medicine, University of Toronto, Toronto, Canada
    Crit Care Med 38:1360-9. 2010
    ..To determine the effect of renal replacement therapy dose on mortality and dialysis dependence in patients with acute kidney injury...
  35. doi request reprint Has mortality from acute respiratory distress syndrome decreased over time?: A systematic review
    Jason Phua
    F R C P C, Toronto Western Hospital, 399 Bathurst Street, 2MCL 411M, Toronto, ON M5T 2S8, Canada
    Am J Respir Crit Care Med 179:220-7. 2009
    ..It is commonly stated that mortality from acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) is decreasing...
  36. doi request reprint A study protocol for an observational cohort investigating COGnitive outcomes and WELLness in survivors of critical illness: the COGWELL study
    M Elizabeth Wilcox
    Department of Medicine Critical Care Medicine, University of Toronto, University Health Network, Toronto, Canada
    BMJ Open 7:e015600. 2017
    ....
  37. doi request reprint Automated weaning and spontaneous breathing trial systems versus non-automated weaning strategies for discontinuation time in invasively ventilated postoperative adults
    Karen E A Burns
    Interdepartmental Division of Critical Care and the University of Toronto, Keenan Research Centre Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Rm 4 045 Queen Wing, Toronto, Ontario, Canada, M5B 1WB
    Cochrane Database Syst Rev 2:CD008639. 2014
    ....
  38. pmc Do clinicians understand the size of treatment effects? A randomized survey across 8 countries
    Bradley C Johnston
    Department of Anesthesia and Pain Medicine Johnston, Crawford, The Hospital for Sick Children, University of Toronto, Toronto, Ont Institute of Health Policy, Management and Evaluation Johnston, Dalla Lana School of Public Health, University of Toronto, Toronto, Ont Child Health Evaluative Sciences Johnston, The Hospital for Sick Children Research Institute, Toronto, Ont Iberoamerican Cochrane Center Alonso Coello, Dalmau, Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain Departments of Critical Care and Medicine Friedrich, St Michael s Hospital, Toronto, Ont Department of Medicine and Interdepartmental Division of Critical Care Friedrich, University of Toronto, Toronto, Ont Departments of Medicine and Biomedical and Health Informatics Mustafa, University of Missouri Kansas City, Kansas City, Mo Department of Clinical Epidemiology and Biostatistics Mustafa, Tikkinen, Neumann, AKL, Thabane, Guyatt, McMaster University, Hamilton, Ont Departments of Urology and Public Health Tikkinen, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland Department of Internal Medicine Neumann, Pontificia Universidad Catolica de Chile, France
    CMAJ 188:25-32. 2016
    ....
  39. pmc Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit: a randomized trial
    Christopher S Parshuram
    Department of Critical Care Medicine Parshuram and The Center for Safety Research at Child Health Evaluative Sciences Parshuram, Willan, The Hospital for Sick Children, Toronto, Ont Interdepartmental Division of Critical Care Medicine Parshuram, Amaral, Ferguson, Granton, Mehta, Scales, Friedrich, Institute for Health Policy, Management and Evaluation Baker, Flintoft, Department of Medicine Etchells, Granton, Stewart, Department of Anaesthesia Stewart and Dalla Lana School of Public Health Willan, University of Toronto, Toronto, Ont Department of Critical Care Friedrich and Li Ka Shing Knowledge Institute Friedrich, St Michael s Hospital, Toronto, Ont Sunnybrook Research Institute Amaral, Scales, Department of Critical Care Medicine Amaral, Scales and Division of General Internal Medicine Etchells, Sunnybrook Health Sciences Centre, Toronto, Ont Critical Care Medicine Granton, University Health Network, Toronto, Ont Centre for Education Research and Innovation Lingard and Department of Medicine and Dentistry Lingard, Western University, London, Ont Perelman School of Medicine Kirpalani, University of Pennsylvania, Philadelphia, Tokyo
    CMAJ 187:321-9. 2015
    ..We evaluated the effects of 3 resident schedules in the intensive care unit (ICU) on patient safety, resident well-being and continuity of care...
  40. doi request reprint Vital signs after cardiac arrest following withdrawal of life-sustaining therapy: a multicenter prospective observational study
    Sonny Dhanani
    1Division of Pediatric Critical Care, Children s Hospital of Eastern Ontario, Ottawa, ON, Canada 2Children s Hospital of Eastern Ontario Research Institute, Ottawa, ON, CANADA 3Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada 4Montreal Children s Hospital, McGill University Health Centre, Montreal, QC, Canada 5McGill University Health Centre Research Institute, Montreal, QC, Canada 6Department of Critical Care, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada 7Faculty of Medicine, Interdepartmental Division of Critical Care, University of Toronto, ON, Canada 8Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St Paul s Hospital, Vancouver, BC, Canada 9Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada 10Ingram School of Nursing McGill University, McGill University Health Centre, Montreal, QC, Canada 11Faculty of Medicine Biomedical Ethics Unit, McGill University, Montreal, QC, Canada 12Department of Critical Care Medicine and Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, UK
    Crit Care Med 42:2358-69. 2014
    ..This study assessed the feasibility of conducting a prospective, observational study of continuous monitoring of vital signs for 30 minutes after the clinical determination of death in five Canadian ICUs. Waveform data were analyzed...
  41. doi request reprint Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis
    Sachin Sud
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    Intensive Care Med 36:585-99. 2010
    ..Prone position ventilation for acute hypoxemic respiratory failure (AHRF) improves oxygenation but not survival, except possibly when AHRF is severe...
  42. ncbi request reprint Effort To Breathe With Various Spontaneous Breathing Trial Techniques. A Physiological Meta-analysis
    Michael C Sklar
    St Michael s Hospital, Department of Critical Care Medicine, Toronto, Ontario, Canada
    Am J Respir Crit Care Med . 2016
    ..Conclusion Pressure support reduces respiratory effort compared to T-Piece. CPAP of 0 cm H2O and T-Piece more accurately reflect the physiologic conditions following extubation...
  43. pmc Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis
    Neill K J Adhikari
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
    BMJ 334:779. 2007
    ....
  44. pmc The ratio of means method as an alternative to mean differences for analyzing continuous outcome variables in meta-analysis: a simulation study
    Jan O Friedrich
    Department of Medicine, University of Toronto, Toronto, Canada
    BMC Med Res Methodol 8:32. 2008
    ..SMD and RoM allow pooling of outcomes expressed in different units and comparisons of effect sizes across interventions, but RoM interpretation does not require knowledge of the pooled SD, a quantity generally unknown to clinicians...