Cor de Wit

Summary

Country: Germany

Publications

  1. doi request reprint Keep calm and carry on: miR-1298 prevents up-regulation of Cx43 and secures a quiescent vascular smooth muscle cell.
    Kjestine Schmidt
    Institut f r Physiologie, Universit t zu L beck, Ratzeburger Allee 160, L beck 23562, Germany Deutsches Zentrum f r Herz Kreislauf Forschung DZHK e V German Center for Cardiovascular Research, Partner Site Hamburg Kiel L beck, L beck, Germany
    Cardiovasc Res 107:407-9. 2015
  2. doi request reprint Signaling across myoendothelial gap junctions--fact or fiction?
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
    Cell Commun Adhes 15:231-45. 2008
  3. doi request reprint Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Pflugers Arch 459:897-914. 2010
  4. doi request reprint Different pathways with distinct properties conduct dilations in the microcirculation in vivo
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck 23538, Germany
    Cardiovasc Res 85:604-13. 2010
  5. ncbi request reprint EDHF and gap junctions: important regulators of vascular tone within the microcirculation
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Germany
    Curr Pharm Biotechnol 8:11-25. 2007
  6. ncbi request reprint Connexin-dependent communication within the vascular wall: contribution to the control of arteriolar diameter
    Cor de Wit
    Institut fur Physiologie, Universitat Lubeck, Lubeck, Germany
    Adv Cardiol 42:268-83. 2006
  7. ncbi request reprint Endothelial mediators and communication through vascular gap junctions
    Cor de Wit
    Institut fur Physiologie, Universitat Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Biol Chem 387:3-9. 2006
  8. doi request reprint Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension
    Alexander Jobs
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
    Hypertension 60:1422-9. 2012
  9. ncbi request reprint Connexin45 cannot replace the function of connexin40 in conducting endothelium-dependent dilations along arterioles
    Stephanie E Wölfle
    Institut fur Physiologie, Universitat zu Lubeck, Germany
    Circ Res 101:1292-9. 2007
  10. ncbi request reprint Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo
    Daniel Siegl
    Physiologisches Institut, Universitat Lubeck, Lubeck, Germany
    Circ Res 97:781-8. 2005

Collaborators

Detail Information

Publications24

  1. doi request reprint Keep calm and carry on: miR-1298 prevents up-regulation of Cx43 and secures a quiescent vascular smooth muscle cell.
    Kjestine Schmidt
    Institut f r Physiologie, Universit t zu L beck, Ratzeburger Allee 160, L beck 23562, Germany Deutsches Zentrum f r Herz Kreislauf Forschung DZHK e V German Center for Cardiovascular Research, Partner Site Hamburg Kiel L beck, L beck, Germany
    Cardiovasc Res 107:407-9. 2015
  2. doi request reprint Signaling across myoendothelial gap junctions--fact or fiction?
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
    Cell Commun Adhes 15:231-45. 2008
    ..Additionally, MEGJ coupling is possibly tightly controlled in vivo by yet unknown mechanisms that prevent unrestricted direct signaling between endothelial and smooth muscle cells...
  3. doi request reprint Connexins and gap junctions in the EDHF phenomenon and conducted vasomotor responses
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Pflugers Arch 459:897-914. 2010
    ..The present review will focus on the complex interactions between the diverse cellular signaling mechanisms that contribute to these phenomena...
  4. doi request reprint Different pathways with distinct properties conduct dilations in the microcirculation in vivo
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck 23538, Germany
    Cardiovasc Res 85:604-13. 2010
    ..Because distances are quite distinct for different dilators, we hypothesized that separate pathways with distinct properties are involved...
  5. ncbi request reprint EDHF and gap junctions: important regulators of vascular tone within the microcirculation
    Cor de Wit
    Institut fur Physiologie, Universitat zu Lubeck, Germany
    Curr Pharm Biotechnol 8:11-25. 2007
    ..Aside from myoendothelial coupling gap junctions also interconnect endothelial cells thus creating a functional unit, which efficiently synchronizes cellular behavior within the arteriolar tree of the microcirculation...
  6. ncbi request reprint Connexin-dependent communication within the vascular wall: contribution to the control of arteriolar diameter
    Cor de Wit
    Institut fur Physiologie, Universitat Lubeck, Lubeck, Germany
    Adv Cardiol 42:268-83. 2006
    ..While the role of other connexins is less well established, an abundance of experimental data has proven the necessity of gap junctional communication to coordinate vascular behavior during adaptive blood flow regulation...
  7. ncbi request reprint Endothelial mediators and communication through vascular gap junctions
    Cor de Wit
    Institut fur Physiologie, Universitat Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Biol Chem 387:3-9. 2006
    ..While the role of other connexins is less well established, an abundance of data has proven the necessity of GJ communication to coordinate vascular behaviour during blood flow regulation...
  8. doi request reprint Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension
    Alexander Jobs
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
    Hypertension 60:1422-9. 2012
    ..These functions are unaltered by long-lasting hypertension. In the presence of a nonconducting Cx40, Cx37 is present but cannot support the conduction highlighting the importance of endothelial Cx40...
  9. ncbi request reprint Connexin45 cannot replace the function of connexin40 in conducting endothelium-dependent dilations along arterioles
    Stephanie E Wölfle
    Institut fur Physiologie, Universitat zu Lubeck, Germany
    Circ Res 101:1292-9. 2007
    ..Therefore, unique properties of Cx40 are required for endothelial signal conduction, whereas nonspecific restoration of communication maintains additional functions related to blood pressure control...
  10. ncbi request reprint Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo
    Daniel Siegl
    Physiologisches Institut, Universitat Lubeck, Lubeck, Germany
    Circ Res 97:781-8. 2005
    ..Because tight myoendothelial coupling was found in vitro in previous studies, we suggest that it is differentially regulated between vascular beds and/or by mechanisms acting in vivo...
  11. doi request reprint Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo
    Stephanie E Wölfle
    Department of Physiology, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Cardiovasc Res 82:476-83. 2009
    ..Although EDHF is the main mediator of acetylcholine (ACh)-induced dilation in the murine skeletal microcirculation, the differential contribution of KCa3.1 and KCa2.3 is not known...
  12. doi request reprint Crucial importance of the endothelial K+ channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction
    Malte Milkau
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    FASEB J 24:3572-9. 2010
    ..The differential impact of SK3- and IK1-deficiency on dilations to distinct stimuli suggests stimulus-dependent activation of these endothelial channels...
  13. ncbi request reprint Intact endothelium-dependent dilation and conducted responses in resistance vessels of hypercholesterolemic mice in vivo
    Stephanie E Wölfle
    Physiologisches Institut, Universitat Lubeck, Lubeck, Germany
    J Vasc Res 42:475-82. 2005
    ..This conclusion is confirmed by an intact conducted response since EDHF is a prerequisite for this response. The intact conduction also suggests that gap-junctional communication is functionally preserved in these models...
  14. ncbi request reprint Gap junctions synchronize vascular tone within the microcirculation
    Volker J Schmidt
    Institut fur Physiologie, Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Pharmacol Rep 60:68-74. 2008
    ..In this review, we will summarize physiologic function of connexins in arterioles and briefly address their role in the kidney with respect to renin secretion...
  15. pmc Amplification of EDHF-type vasodilatations in TRPC1-deficient mice
    Kjestine Schmidt
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
    Br J Pharmacol 161:1722-33. 2010
    ....
  16. pmc Connexin45 is expressed in vascular smooth muscle but its function remains elusive
    Volker J Schmidt
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
    PLoS ONE 7:e42287. 2012
    ..Possibly, other Cx functionally replace the lack of Cx45 in VSM. The reported role of Cx45 in renin secretion does not seem to alter arterial pressure in freely moving mice...
  17. doi request reprint Distinct endothelium-derived hyperpolarizing factors emerge in vitro and in vivo and are mediated in part via connexin 40-dependent myoendothelial coupling
    Markus Boettcher
    Physiologie Institut, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Hypertension 57:802-8. 2011
    ..We suggest that distinct EDHFs (even in the same artery) explain partially the controversy on the role of myoendothelial gap junctions in EDHF signaling...
  18. ncbi request reprint Endogenous and exogenous NO attenuates conduction of vasoconstrictions along arterioles in the microcirculation
    Barbara Rodenwaldt
    Physiologisches Institut, Universitat Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Am J Physiol Heart Circ Physiol 292:H2341-8. 2007
    ..This mechanism may support the dilatory potency of NO by preventing the conduction of remote vasoconstrictions into areas with basal or activated NO release...
  19. ncbi request reprint Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion
    Cor de Wit
    Physiologisches Institut, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    Physiol Genomics 13:169-77. 2003
    ..It is also not related to an altered efficacy of NO or other endothelial dilators. However, the observed irregular vasomotion suggests that peripheral vascular resistance is affected...
  20. ncbi request reprint EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles
    Bernd Hoepfl
    Physiologisches Institut, Ludwig Maximilians Universitat, 80336 Munich, Germany
    Am J Physiol Heart Circ Physiol 283:H996-H1004. 2002
    ....
  21. ncbi request reprint cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo
    Michael Koeppen
    Physiologisches Institut, Universitat Lubeck, Germany
    Hypertension 44:952-5. 2004
    ..However, the NO/cGMP/cGKI pathway is not essential for ACh-induced dilation of arterioles and for basal blood pressure regulation in mice...
  22. ncbi request reprint Connexins pave the way for vascular communication
    Cor de Wit
    Institut fur Physiologie, Universitat Lubeck, 23538 Lubeck, Germany
    News Physiol Sci 19:148-53. 2004
    ..Mounting evidence indicates that gap-junctional communication contributes to the control of vascular tone...
  23. pmc Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice
    Josephine Radtke
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany DZHK German Centre for Cardiovascular Research, partner site Hamburg Kiel Lübeck, Lubeck, Germany
    Br J Pharmacol 170:293-303. 2013
    ..1 dilates skeletal muscle arterioles and whether myoendothelial gap junctions formed by connexin40 (Cx40) are required for EDH-type dilatations and pressure depressor responses in vivo...
  24. doi request reprint Semiautomatic quantification of angiogenesis
    Markus Boettcher
    Institut fur Physiologie, Universitat zu Lubeck, Lubeck, Germany
    J Surg Res 162:132-9. 2010
    ....