M Duszenko

Summary

Country: Germany

Publications

  1. ncbi request reprint Death of a trypanosome: a selfish altruism
    Michael Duszenko
    Department of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076 Tubingen, Germany
    Trends Parasitol 22:536-42. 2006
  2. ncbi request reprint In vitro translation in a cell-free system from Trypanosoma brucei yields glycosylated and glycosylphosphatidylinositol-anchored proteins
    M Duszenko
    Physiologisch chemisches Institut der Universität Tübingen, Germany
    Eur J Biochem 266:789-97. 1999
  3. ncbi request reprint Troglitazone induces differentiation in Trypanosoma brucei
    Viola Denninger
    Interfakultäres Institut für Biochemie, Universitat Tubingen, Hoppe Seyler Str 4, D 72076 Tubingen, Germany
    Exp Cell Res 313:1805-19. 2007
  4. pmc Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS
    Stefan Mogk
    Interfaculty Institute of Biochemistry, University of Tubingen, Tubingen, Germany
    PLoS ONE 9:e91372. 2014
  5. pmc Late stage infection in sleeping sickness
    Hartwig Wolburg
    Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    PLoS ONE 7:e34304. 2012
  6. ncbi request reprint Drug development against sleeping sickness: old wine in new bottles?
    J Stein
    Interfaculty Institute of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076 Tubingen, Germany
    Curr Med Chem 21:1713-27. 2014
  7. pmc Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death
    Despina Smirlis
    Laboratory of Molecular Parasitology, Department of Microbiology, Hellenic Pasteur Institute, 127 Bas, Sofias Ave, 11521 Athens, Greece
    Parasit Vectors 3:107. 2010
  8. ncbi request reprint Dihydroxyacetone induced autophagy in African trypanosomes
    Nestor L Uzcategui
    Interfaculty Institute of Biochemistry, University of Tubinge, Tubinge, Germany
    Autophagy 3:626-9. 2007
  9. pmc Antiproliferative effect of dihydroxyacetone on Trypanosoma brucei bloodstream forms: cell cycle progression, subcellular alterations, and cell death
    Nestor L Uzcategui
    Interfaculty Institute of Biochemistry, University of Tuebingen, Germany
    Antimicrob Agents Chemother 51:3960-8. 2007
  10. ncbi request reprint Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress
    K Figarella
    Interfaculty Institute of Biochemistry, University of Tuebingen, Germany
    Cell Death Differ 13:1802-14. 2006

Collaborators

  • B K Kubata
  • Florian Lang
  • Susan C Welburn
  • S Fukuzumi
  • Nestor L Uzcategui
  • Michael Lazarus
  • Stefan Mogk
  • Hartwig Wolburg
  • Zakayi Kabututu
  • Yoshihiro Urade
  • Caroline Schönfeld
  • Patrick Merkel
  • J Stein
  • Samuel K Martin
  • Despina Smirlis
  • Alexander Szallies
  • Viola Denninger
  • Wolfgang Voelter
  • Thomas Zeuthen
  • K Figarella
  • Kubata Bruno Kilunga
  • Syed Tasadaque Ali Shah
  • Craig Joe Munday
  • Shin ichiro Kawazu
  • Tomoyoshi Nozaki
  • Tetsuya Okada
  • Lucy W Thuita
  • A Meiwes
  • B P Sommer
  • C N Mudogo
  • A Gray
  • M Huber
  • Xuedong Kang
  • S Mogk
  • M Scholze
  • Ulrich Schraermeyer
  • Swetlana Shtopel
  • Andreas Meiwes
  • Monika Meinert
  • Claudia Frey
  • Sven Acker
  • Ketty Soteriadou
  • Antonio Jiménez Ruiz
  • Effie Scoulica
  • Nicolas Fasel
  • Patrick Bastien
  • Christian Busold
  • Alexander Beck
  • Khalid Muhammad
  • Jörg Hoheisel
  • Stefanie Brems
  • Katherine Figarella
  • Syed Abid Ali
  • A Beck
  • Binghua Wu
  • Joachim E Schultz
  • Jurgen F J Kun
  • Lars M Holm
  • Slavica Pavlovic-Djuranovic
  • C Schoenfeld
  • Eric Beitz
  • Kouji Inaka
  • Hubert Ragge
  • Yousuke Okano
  • Jörg Rademann
  • Yuichi Sumii
  • Hiroyoshi Matsumura
  • Takashi Inui
  • Yasushi Kai
  • Shigeru Sugiyama
  • Yukiko Kusakari
  • Tsuyoshi Inoue
  • Hartmut Echner
  • Marc Rawer

Detail Information

Publications21

  1. ncbi request reprint Death of a trypanosome: a selfish altruism
    Michael Duszenko
    Department of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076 Tubingen, Germany
    Trends Parasitol 22:536-42. 2006
    ..As we discuss here, the most important point that needs to be addressed is whether a single-celled organism can undertake a process that is considered altruistic...
  2. ncbi request reprint In vitro translation in a cell-free system from Trypanosoma brucei yields glycosylated and glycosylphosphatidylinositol-anchored proteins
    M Duszenko
    Physiologisch chemisches Institut der Universität Tübingen, Germany
    Eur J Biochem 266:789-97. 1999
    ....
  3. ncbi request reprint Troglitazone induces differentiation in Trypanosoma brucei
    Viola Denninger
    Interfakultäres Institut für Biochemie, Universitat Tubingen, Hoppe Seyler Str 4, D 72076 Tubingen, Germany
    Exp Cell Res 313:1805-19. 2007
    ..To further investigate the mechanisms responsible for these changes, microarray analyses were performed, showing an upregulation of expression site associated gene 8 (ESAG8), a potential differentiation regulator...
  4. pmc Cyclical appearance of African trypanosomes in the cerebrospinal fluid: new insights in how trypanosomes enter the CNS
    Stefan Mogk
    Interfaculty Institute of Biochemistry, University of Tubingen, Tubingen, Germany
    PLoS ONE 9:e91372. 2014
    ..We propose a different model of brain infection that is in accordance with our observations and with well-established facts about the development of sleeping sickness. ..
  5. pmc Late stage infection in sleeping sickness
    Hartwig Wolburg
    Institute of Pathology and Neuropathology, University of Tubingen, Tubingen, Germany
    PLoS ONE 7:e34304. 2012
    ..Our data suggest that trypanosomes do not intend to colonize the brain but reside near or within the glia limitans, from where they can re-populate blood vessels and disrupt the sleep wake cycles...
  6. ncbi request reprint Drug development against sleeping sickness: old wine in new bottles?
    J Stein
    Interfaculty Institute of Biochemistry, University of Tubingen, Hoppe Seyler Str 4, 72076 Tubingen, Germany
    Curr Med Chem 21:1713-27. 2014
    ....
  7. pmc Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death
    Despina Smirlis
    Laboratory of Molecular Parasitology, Department of Microbiology, Hellenic Pasteur Institute, 127 Bas, Sofias Ave, 11521 Athens, Greece
    Parasit Vectors 3:107. 2010
    ..This review will be confined to the events known to drive trypanosomatid parasites to apoptosis...
  8. ncbi request reprint Dihydroxyacetone induced autophagy in African trypanosomes
    Nestor L Uzcategui
    Interfaculty Institute of Biochemistry, University of Tubinge, Tubinge, Germany
    Autophagy 3:626-9. 2007
    ..Since autophagy is not well studied in African trypanosomes our work offers a way to investigate the importance of autophagy for trypanosomes not only for stress coping but also for organelle reconstruction during differentiation...
  9. pmc Antiproliferative effect of dihydroxyacetone on Trypanosoma brucei bloodstream forms: cell cycle progression, subcellular alterations, and cell death
    Nestor L Uzcategui
    Interfaculty Institute of Biochemistry, University of Tuebingen, Germany
    Antimicrob Agents Chemother 51:3960-8. 2007
    ..Based on the toxicity of DHA for trypanosomes compared with mammals, we consider DHA a starting point for a rational design of new trypanocidal drugs...
  10. ncbi request reprint Prostaglandin-induced programmed cell death in Trypanosoma brucei involves oxidative stress
    K Figarella
    Interfaculty Institute of Biochemistry, University of Tuebingen, Germany
    Cell Death Differ 13:1802-14. 2006
    ..We conclude that PGJ(2) and Delta(12)PGJ(2) formation within the serum represents a mechanism to amplify PGD(2)-induced PCD in trypanosomes via ROS production...
  11. ncbi request reprint Cloning, heterologous expression, and characterization of three aquaglyceroporins from Trypanosoma brucei
    Nestor L Uzcategui
    Biochemical Institute, Department of Pharmaceutical Biochemistry, and Institute of Physiology, University of Tubingen, 72076 Tübingen Germany
    J Biol Chem 279:42669-76. 2004
    ..brucei. This function and especially the so far not investigated transport of dihydroxyacetone may be pivotal for the survival of the parasite survival under non-aerobic or osmotic stress conditions...
  12. ncbi request reprint GPI anchor transamidase of Trypanosoma brucei: in vitro assay of the recombinant protein and VSG anchor exchange
    Xuedong Kang
    Physiologisch Chemisches Institut, University of Tubingen, Germany
    J Cell Sci 115:2529-39. 2002
    ..VSG-hydrazine-biotin was detected by streptavidin in western blots and intracellularly in Golgi-like compartments...
  13. ncbi request reprint A metacaspase of Trypanosoma brucei causes loss of respiration competence and clonal death in the yeast Saccharomyces cerevisiae
    Alexander Szallies
    Verfügungsgebäude der Universität Tübingen, Auf der Morgenstelle 15, Tubingen, Germany
    FEBS Lett 517:144-50. 2002
    ..GFP-fusion reporters of WWM1, ScMCA1 and TbMCA4 localized to the nucleus. Taken together, we suggest that metacaspases may play a role in nuclear function controlling cellular proliferation coupled to mitochondrial biogenesis...
  14. pmc A key role for old yellow enzyme in the metabolism of drugs by Trypanosoma cruzi
    Bruno Kilunga Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Exp Med 196:1241-51. 2002
    ....
  15. ncbi request reprint Prostaglandin production from arachidonic acid and evidence for a 9,11-endoperoxide prostaglandin H2 reductase in Leishmania
    Zakayi Kabututu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Int J Parasitol 32:1693-700. 2002
    ....
  16. ncbi request reprint Spermine isolated and identified as the major trypanocidal compound from the snake venom of Eristocophis macmahoni causes autophagy in Trypanosoma brucei
    Patrick Merkel
    Interfaculty Institute for Biochemistry, University of Tubingen, Hoppe Seyler Strasse 4, D 72076 Tubingen, Germany
    Toxicon 50:457-69. 2007
    ..Using fetal calf serum, spermine was shown to induce autophagy in the parasites using transmission electron microscopy (TEM)...
  17. ncbi request reprint Prostaglandin production from arachidonic acid and evidence for a 9,11-endoperoxide prostaglandin H2 reductase in Leishmania
    Zakayi Kabututu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    Int J Parasitol 33:221-8. 2003
    ....
  18. ncbi request reprint Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypansoma brucei
    Thomas Zeuthen
    Nordic Centre for Water Imbalance Related Disorders, Department of Medical Physiology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Mol Microbiol 61:1598-608. 2006
    ..Ammonia permeability was similarly established for the aquaglyceroporins from Toxoplasma gondii and Trypanosoma brucei. Apparently, these aquaglyceroporins are important for the release of ammonia derived from amino acid breakdown...
  19. ncbi request reprint Stereospecific synthesis of chiral 2,3-dihydro-1,4-benzodithiine and methyl-2,3-dihydro-1,4-benzodithiine derivatives and their toxic effects on Trypanosoma brucei
    Syed Tasadaque Ali Shah
    Physiologisch chemisches Institut der Universität Tübingen, Hoppe Seyler Strasse 4, 72076 Tubingen, Germany
    Chembiochem 6:1438-41. 2005
    ..These compounds showed significant in vitro toxicity of the bloodstream form of Trypanosoma brucei with an IC50 of 11 microM. The parasites' energy metabolism and consumption of oxygen were found to be affected during incubation...
  20. ncbi request reprint Structural and mutational analysis of Trypanosoma brucei prostaglandin H2 reductase provides insight into the catalytic mechanism of aldo-ketoreductases
    Kubata Bruno Kilunga
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    J Biol Chem 280:26371-82. 2005
    ..We also show Tyr52 acts as the general acid catalyst for 9,10-PQ reduction, and thus we not only elucidate the catalytic mechanism of a PGH2 reductase but also provide an insight into the catalytic specificity of AKRs...
  21. ncbi request reprint Kola acuminata proanthocyanidins: a class of anti-trypanosomal compounds effective against Trypanosoma brucei
    B K Kubata
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Int J Parasitol 35:91-103. 2005
    ..This new anti-trypanosomal compound should be further studied to determine its efficacy and suitability as an anti-trypanosomal drug and may be used as a tool to define novel specific drug targets in BF trypanosomes...