Affiliation: Friedrich Schiller University
- Improved glucose metabolism in mice lacking alpha-tocopherol transfer proteinMarc Birringer
Dept of Human Nutrition, Inst of Nutrition, University of Jena, Dornburger Strasse 29, 07743, Jena, Germany
Eur J Nutr 46:397-405. 2007..The alpha-tocopherol transfer protein (alpha-TTP) mediates the transfer of alpha-tocopherol (alpha-TOH) from hepatocytes to very-low-density lipoproteins, thereby controlling plasma levels of alpha-TOH...
- Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stressMarc Birringer
Department of Human Nutrition, Institute of Nutrition, Friedrich Schiller University of Jena, Jena, Germany
Free Radic Biol Med 49:1315-22. 2010..Taken together, these results indicate that long-chain metabolites may be responsible for antiproliferative properties of vitamin E vitamers...
- Analysis of vitamin E metabolites in biological specimenMarc Birringer
Department of Human Nutrition, Institute of Nutrition, Friedrich Schiller University, Jena, Germany
Mol Nutr Food Res 54:588-98. 2010..Special emphasis is laid on analytical applications for the identification and quantification of metabolites with a modified hydroxychromanol ring or a truncated side chain...
- Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stressTim J Schulz
Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
Cell Metab 6:280-93. 2007....
- Antioxidants prevent health-promoting effects of physical exercise in humansMichael Ristow
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
Proc Natl Acad Sci U S A 106:8665-70. 2009..Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans...
- α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophagesMaria Wallert
Department of Nutritional Biochemistry and Physiology, Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany
Mol Nutr Food Res 59:1524-34. 2015..The long-chain metabolite α-13'-carboxychromanol (α-13'-COOH) is formed by hepatic α-tocopherol (α-TOH) catabolism and acts as a regulatory metabolite via pathways that are different from its metabolic precursor...
- Role of sirtuins in lifespan regulation is linked to methylation of nicotinamideKathrin Schmeisser
1 Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany 2
Nat Chem Biol 9:693-700. 2013..elegans longevity. Taken together, sirtuin-mediated lifespan extension depends on methylation of NAM, providing an unexpected mechanistic role for sirtuins beyond histone deacetylation. ..
- In vitro fermented nuts exhibit chemopreventive effects in HT29 colon cancer cellsStefanie Lux
Department of Nutritional Toxicology, Institute of Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 24, Jena, Germany
Br J Nutr 108:1177-86. 2012....
- Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotypingTim J Schulz
University of Jena, Institute of Nutrition, Jena, Germany
PLoS ONE 2:e1013. 2007..This indicates that sustained post hoc analyses in regards to efficacy of disruption for every single study group member may be required...
- Small-molecule targeting of the mitochondrial compartment with an endogenously cleaved reversible tagJens Ripcke
Department of Human Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 29, Jena, Germany
Chembiochem 10:1689-96. 2009..Overall, reversible tagging combines decreased tag-related cytotoxicity with increased bioactivity, and this potentially provides a novel concept in mitochondrial pharmacology...
- Complexity of vitamin E metabolismLisa Schmölz
Lisa Schmölz, Stefan Lorkowski, Maria Wallert, Department of Nutritional Biochemistry and Physiology, Institute of Nutrition, Friedrich Schiller University Jena, Germany and Competence Center for Nutrition and Cardiovascular Health, Halle Jena Leipzig, 07743 Jena, Germany
World J Biol Chem 7:14-43. 2016..To evaluate individual vitamin E status, the analytical procedures used for detecting and quantifying vitamin E and its metabolites are crucial. The latest methods in analytics are presented. ..
- Regulatory metabolites of vitamin E and their putative relevance for atherogenesisMaria Wallert
Department of Nutritional Biochemistry, Institute of Nutrition, Friedrich Schiller University Jena, Germany
Redox Biol 2:495-503. 2014..We speculate that the metabolites contribute to physiological as well as pathophysiological processes. ..
- Long-chain metabolites of α-tocopherol occur in human serum and inhibit macrophage foam cell formation in vitroMaria Wallert
Department of Nutritional Biochemistry, Institute of Nutrition, Friedrich Schiller University Jena, 07743 Jena, Germany
Free Radic Biol Med 68:43-51. 2014..We speculate that α-LCMs represent a new class of regulatory metabolites. Further studies are required to elucidate their physiological role and contribution to cardiovascular disease. ..
- Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich AtaxiaKim Zarse
Department of Human Nutrition, Inst of Nutrition, University of Jena, 29 Dornburger St, Jena D 07743, Germany
FASEB J 21:1271-5. 2007..Taken together, impaired mitochondrial metabolism due to RNAi-mediated inhibition of the frataxin homologue frh-1 causes both impaired respiration as well as decreased life span in the multicellular eukaryote C. elegans...