V Schirrmacher

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. doi request reprint Recombinant Newcastle disease virus expressing human interleukin-2 serves as a potential candidate for tumor therapy
    Heng Zhao
    Department of Food Science and Nutritional Engineering, China Agricultural University, 100083 Beijing, PR China
    Virus Res 136:75-80. 2008
  2. pmc Superantigen reactive Vbeta6+ T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumour cells
    S Müerköster
    Division of Cellular Immunology, G0100, Tumorimmunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Br J Cancer 86:828-36. 2002
  3. ncbi request reprint Antagonistic effects of systemic interleukin 2 on immune Tcell-mediated graft-versus-leukemia reactivity
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Heidelberg
    Clin Cancer Res 4:2635-45. 1998
  4. ncbi request reprint Tumor-immune memory T cells from the bone marrow exert GvL without GvH reactivity in advanced metastasized cancer
    Volker Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, D 69120 Heidelberg, Germany
    Int J Oncol 27:1141-9. 2005
  5. ncbi request reprint Antitumor effects of Newcastle Disease Virus in vivo: local versus systemic effects
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Tumorimmunology Program, D 69120 Heidelberg, Germany
    Int J Oncol 18:945-52. 2001
  6. ncbi request reprint Breaking tolerance to a tumor-associated viral superantigen as a basis for graft-versus-leukemia reactivity
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Tumor Immunology Program, Heidelberg, Germany
    Int J Cancer 87:695-706. 2000
  7. ncbi request reprint T cell-mediated immunotherapy of metastases: state of the art in 2005
    Volker Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Expert Opin Biol Ther 5:1051-68. 2005
  8. ncbi request reprint Loss of endogenous mouse mammary tumor virus superantigen increases tumor resistance
    V Schirrmacher
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg
    J Immunol 161:563-70. 1998
  9. ncbi request reprint Clinical trials of antitumor vaccination with an autologous tumor cell vaccine modified by virus infection: improvement of patient survival based on improved antitumor immune memory
    Volker Schirrmacher
    Division of Cellular Immunology D010, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Cancer Immunol Immunother 54:587-98. 2005
  10. doi request reprint Second International Conference on Cancer Vaccines/Adjuvants/Delivery for the Next Decade (CVADD): Heidelberg, Germany, 10-12 October 2007
    V Schirrmacher
    Division of Cellular Immunology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Immunol Immunother 57:1421-7. 2008

Collaborators

Detail Information

Publications79

  1. doi request reprint Recombinant Newcastle disease virus expressing human interleukin-2 serves as a potential candidate for tumor therapy
    Heng Zhao
    Department of Food Science and Nutritional Engineering, China Agricultural University, 100083 Beijing, PR China
    Virus Res 136:75-80. 2008
    ..As NDV was proposed as a very promising oncolytic agent in a new age of therapeutic viruses, our data strongly support the application of recombinant NDV/IL-2 virus as an anti-tumor agent...
  2. pmc Superantigen reactive Vbeta6+ T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumour cells
    S Müerköster
    Division of Cellular Immunology, G0100, Tumorimmunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Br J Cancer 86:828-36. 2002
    ....
  3. ncbi request reprint Antagonistic effects of systemic interleukin 2 on immune Tcell-mediated graft-versus-leukemia reactivity
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Heidelberg
    Clin Cancer Res 4:2635-45. 1998
    ..The results emphasize the importance of a better understanding of IL-2 function in vivo and of its interaction with immune cell function to improve protocols for optimal application in the clinic to achieve maximal GvL effects...
  4. ncbi request reprint Tumor-immune memory T cells from the bone marrow exert GvL without GvH reactivity in advanced metastasized cancer
    Volker Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, D 69120 Heidelberg, Germany
    Int J Oncol 27:1141-9. 2005
    ..Bone marrow cells from naive donor mice or T cell depleted iBM cells were completely devoid of GvL reactivity. The low number of tumor-immune memory T cells thus conferred the GvL reactivity of iBM cells...
  5. ncbi request reprint Antitumor effects of Newcastle Disease Virus in vivo: local versus systemic effects
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Tumorimmunology Program, D 69120 Heidelberg, Germany
    Int J Oncol 18:945-52. 2001
    ..Systemic anti-metastatic effects were never observed with NDV alone in contrast to previous results obtained with NDV modified tumor vaccines...
  6. ncbi request reprint Breaking tolerance to a tumor-associated viral superantigen as a basis for graft-versus-leukemia reactivity
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Tumor Immunology Program, Heidelberg, Germany
    Int J Cancer 87:695-706. 2000
    ..These findings suggest that immune responses to SAg can be exploited to break tolerance and augment immune responses to tumors...
  7. ncbi request reprint T cell-mediated immunotherapy of metastases: state of the art in 2005
    Volker Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Expert Opin Biol Ther 5:1051-68. 2005
    ..Translation of these findings into a standardised immunotherapy is, however, not easy and will require coordination and cooperation among academic, private and federal sectors...
  8. ncbi request reprint Loss of endogenous mouse mammary tumor virus superantigen increases tumor resistance
    V Schirrmacher
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg
    J Immunol 161:563-70. 1998
    ..Mls-1a, the mice became again more tumor susceptible. Finally, we demonstrate the ability to transfer immunoresistance and graft-vs-leukemia reactivity from tumor-resistant to tumor-susceptible mice...
  9. ncbi request reprint Clinical trials of antitumor vaccination with an autologous tumor cell vaccine modified by virus infection: improvement of patient survival based on improved antitumor immune memory
    Volker Schirrmacher
    Division of Cellular Immunology D010, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Cancer Immunol Immunother 54:587-98. 2005
    ..Immunization with a tumor vaccine in which individual TAAs are combined with DS from virus infection appears to have a positive effect on antitumor immune memory and on patient survival...
  10. doi request reprint Second International Conference on Cancer Vaccines/Adjuvants/Delivery for the Next Decade (CVADD): Heidelberg, Germany, 10-12 October 2007
    V Schirrmacher
    Division of Cellular Immunology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Immunol Immunother 57:1421-7. 2008
  11. ncbi request reprint T-cell priming in bone marrow: the potential for long-lasting protective anti-tumor immunity
    Volker Schirrmacher
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Trends Mol Med 9:526-34. 2003
  12. ncbi request reprint Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow
    M Feuerer
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Nat Med 7:452-8. 2001
    ..Our findings reveal an innate, specific recognition of breast cancer antigens and point to a possible novel cancer therapy using patients' bone-marrow-derived memory T cells...
  13. ncbi request reprint Enrichment of memory T cells and other profound immunological changes in the bone marrow from untreated breast cancer patients
    M Feuerer
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 92:96-105. 2001
    ..The overall results reveal that BM is a valuable additional compartment for immune diagnosis in pathological conditions and possibly for follow-up treatment strategies...
  14. ncbi request reprint Functional and in situ evidence for nitric oxide production driven by CD40-CD40L interactions in graft-versus-leukemia reactivity
    S Müerköster
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg
    Clin Cancer Res 6:1988-96. 2000
    ..These data provide functional and in situ evidence that the increased CD40 and iNOS expression observed during ADI contribute to the eradication of liver metastases and to the clearance of donor lymphocytes from the liver...
  15. pmc Dissection of tumour and host cells from target organs of metastasis for testing gene expression directly ex vivo
    M Rocha
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 74:1216-22. 1996
    ..The possibility of direct analysis of tumour and host cell properties also provides a new method for the evaluation of the effects of immunisation with tumour vaccines or of gene therapy...
  16. ncbi request reprint Polarization of human monocyte-derived dendritic cells to DC1 by in vitro stimulation with Newcastle Disease Virus
    P Fournier
    German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, Germany
    J BUON 14:S111-22. 2009
    ..The goal of our study was to evaluate the potential for immune activation of human DCs by incubating them in vitro with the Newcastle Disease Virus (NDV), a paramyxovirus with strong immunostimulatory properties...
  17. ncbi request reprint Recombinant Newcastle disease virus (NDV) with inserted gene coding for GM-CSF as a new vector for cancer immunogene therapy
    M Janke
    Division of Cellular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Gene Ther 14:1639-49. 2007
    ....
  18. ncbi request reprint Generation of dendritic cells from human bone marrow mononuclear cells: advantages for clinical application in comparison to peripheral blood monocyte derived cells
    L Bai
    German Cancer Research Center, Division of Cellular Immunology, D 69120 Heidelberg, Germany
    Int J Oncol 20:247-53. 2002
    ..These results suggest that BM-DC as produced here may be a very economic and useful source of professional antigen-presenting cells for anti-tumor immunotherapeutic protocols...
  19. ncbi request reprint A novel tumour model system for the study of long-term protective immunity and immune T cell memory
    Yolanda D Mahnke
    Tumour Immunology Program, Division of Cellular Immunology, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Cell Immunol 221:89-99. 2003
    ..Resistance of treated nu/nu mice against tumour rechallenge revealed the existence of long-term protective immune memory...
  20. pmc Maintenance of long-term tumour-specific T-cell memory by residual dormant tumour cells
    Yolanda D Mahnke
    Division of Cellular Immunology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Immunology 115:325-36. 2005
    ....
  21. ncbi request reprint Specific immune recognition of pancreatic carcinoma by patient-derived CD4 and CD8 T cells and its improvement by interferon-gamma
    F H Schmitz-Winnenthal
    Department of Surgery, and German Cancer Centre, University of Heidelberg, D 69120 Heidelberg, Germany
    Int J Oncol 28:1419-28. 2006
    ..Thus, interferon-gamma appears to be a useful adjuvant cytokine to enhance the immunogenicity of a patients' tumor cells and their recognition by tumor reactive immune cells...
  22. ncbi request reprint T-cell immunity in the induction and maintenance of a tumour dormant state
    V Schirrmacher
    German Cancer Research Centre, Division of Cellular Immunology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Semin Cancer Biol 11:285-95. 2001
    ..Upon restimulation with tumour antigen pulsed autologous dendritic cells, bone marrow-derived memory T cells from cancer patients could be shown to exist and to become activated into potent anti-tumour effector cells...
  23. ncbi request reprint Inhibition of nitric-oxide-mediated apoptosis in Jurkat leukemia cells despite cytochrome c release
    V Umansky
    Division of Cellular Immunology, German Cancer Research Center, D 69120, Heidelberg, Germany
    Exp Cell Res 265:274-82. 2001
    ....
  24. ncbi request reprint Characteristics of a potent tumor vaccine-induced secondary anti-tumor T cell response
    Yolanda D Mahnke
    German Cancer Research Center, Division of Cellular Immunology, D 69120 Heidelberg, Germany
    Int J Oncol 24:1427-34. 2004
    ..Interestingly, the secondary CTL response was inhibited by anti-IL-12 but not by anti-TNF-alpha mAb. The results characterize a strong systemic CD8+ memory T cell response to a cell bound antigen without the use of adjuvant...
  25. ncbi request reprint Bone marrow as a priming site for T-cell responses to blood-borne antigen
    Markus Feuerer
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Nat Med 9:1151-7. 2003
    ..These findings highlight the uniqueness of bone marrow as an organ important for hemato- and lymphopoiesis and for systemic T cell-mediated immunity...
  26. ncbi request reprint Heat-stable antigen (CD24) as ligand for mouse P-selectin
    M Sammar
    Tumor Immunology Programme, German Cancer Research Center, Heidelberg
    Int Immunol 6:1027-36. 1994
    ..It is suggested that in its L2/HNK-1 modified form the HSA molecule on leukocytes could represent a ligand for P-selectin on endothelial cells or platelets...
  27. ncbi request reprint Nucleocytoplasmic transport of HTLV-1 RNA is regulated by two independent LTR encoded nuclear retention elements
    J A King
    Department of Cellular Immunology, German Cancer Research Center, Heidelberg
    Oncogene 16:3309-16. 1998
    ....
  28. ncbi request reprint Activation of human T cells by a tumor vaccine infected with recombinant Newcastle disease virus producing IL-2
    Markus Janke
    Division of Cellular Immunology, German Cancer Research Center, D 69120 Heidelberg, Germany
    Int J Oncol 33:823-32. 2008
    ..Active specific immunization of patients with ATV-rec(IL-2) should provide the microenvironment at the vaccination site with IL-2 and avoid side effects as seen after systemic IL-2 application...
  29. ncbi request reprint Selective gene transfer to tumor cells by recombinant Newcastle Disease Virus via a bispecific fusion protein
    Huijie Bian
    Division of Cellular Immunology, German Cancer Research Center, D 69120 Heidelberg, Germany
    Int J Oncol 26:431-9. 2005
    ..It required in addition membrane fusion via the viral F-protein. By modification of recombinant NDV with a bispecific molecule, our results demonstrate a novel and safe strategy for selective gene transfer to targeted tumor cells...
  30. doi request reprint Targeting anti-tumor DNA vaccines to dendritic cells via a short CD11c promoter sequence
    Jing Ni
    Division of Cellular Immunology, German Cancer Research Center DKFZ, Tumor Immunology Program, D 69120 Heidelberg, Germany
    Vaccine 27:5480-7. 2009
    ..This short CD11c promoter appears to be a safe and a practical tool for DC-specific gene targeting and for vaccination...
  31. ncbi request reprint Importance of serine 200 for functional activities of the hemagglutinin-neuraminidase protein of Newcastle Disease Virus
    Philippe Fournier
    Division of Cellular Immunology, German Cancer Research Center, D 69129 Heidelberg, Germany
    Int J Oncol 24:623-34. 2004
    ..Molecular modeling revealed that proline 200 in HN influences flexibility of a loop near the entrance to the neuraminidase active site, a function that may be crucial for the functions of this viral protein...
  32. doi request reprint Treatment of advanced metastasized breast cancer with bone marrow-derived tumour-reactive memory T cells: a pilot clinical study
    Florian Schuetz
    Department of Gynecology and Obstetrics, the University Hospital of Heidelberg, Heidelberg, Germany
    Cancer Immunol Immunother 58:887-900. 2009
    ....
  33. ncbi request reprint Cross-infection of tumor cells by contact with T lymphocytes loaded with Newcastle disease virus
    Christina Pfirschke
    Division of Cellular Immunology, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Int J Oncol 34:951-62. 2009
    ..Loading of oncolytic NDV onto activated T cells and adoptive transfer into a tumor-bearing host might enhance the efficacy of adoptive T cell therapy of tumors as well as tumor targeting of oncolytic viruses...
  34. doi request reprint Randomized clinical studies of anti-tumor vaccination: state of the art in 2008
    Philippe Fournier
    Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Expert Rev Vaccines 8:51-66. 2009
    ..The superiority of autologous vaccines suggests that unique tumor-associated antigens are particularly important in generating responsive T cells for a therapeutic effect...
  35. doi request reprint The hemagglutinin-neuraminidase gene of Newcastle Disease Virus: a powerful molecular adjuvant for DNA anti-tumor vaccination
    Jing Ni
    Tumorimmunology Program, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Vaccine 28:6891-900. 2010
    ..The results show that co-expression of HN with a tumor target antigen through bicistronic vectors ensures precise temporal and spatial co-delivery to direct anti-tumor immune responses preferentially towards Th1...
  36. ncbi request reprint Cognate interactions between memory T cells and tumor antigen-presenting dendritic cells from bone marrow of breast cancer patients: bidirectional cell stimulation, survival and antitumor activity in vivo
    Lianhua Bai
    German Cancer Research Center, Division of Cellular Immunology, Heidelberg, Germany
    Int J Cancer 103:73-83. 2003
    ..Our findings suggest that cognate interactions between cancer patient-derived memory BM-T cells and tumor antigen-presenting BM-DCs are important for reciprocal cell stimulation, survival and therapeutic activity...
  37. ncbi request reprint Human tumor cell infection by Newcastle Disease Virus leads to upregulation of HLA and cell adhesion molecules and to induction of interferons, chemokines and finally apoptosis
    B Washburn
    German Cancer Research Center, Division of Cellular Immunology, D 69120 Heidelberg, Germany
    Int J Oncol 21:85-93. 2002
    ..These results provide explanations for the function of the virus-modified autologous tumor vaccine ATV-NDV with which promising clinical results have already been obtained...
  38. ncbi request reprint Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma
    Carmen Choi
    Tumor Immunology Program, The German Cancer Research Center, INF 280, 69 120 Heidelberg, Germany
    Blood 105:2132-4. 2005
    ..BM-residing T cells possessed a higher functional capacity upon specific reactivation than PB-derived T cells with regard to interferon gamma (IFN-gamma) secretion, perforin production, and cytotoxicity...
  39. ncbi request reprint Antitumor vaccination in patients with head and neck squamous cell carcinomas with autologous virus-modified tumor cells
    Jochen Karcher
    Department of Head and Neck Surgery, University of Heidelberg, Heidelberg, Germany
    Cancer Res 64:8057-61. 2004
    ..This could be supported by antitumor immune responses that we observed especially in long-term surviving patients...
  40. ncbi request reprint An effective tumor vaccine optimized for costimulation via bispecific and trispecific fusion proteins
    Maximilian Aigner
    German Cancer Research Center, Division of Cellular Immunology, Heidelberg, Germany
    Int J Oncol 32:777-89. 2008
    ..Our data describe new bioactive molecules which in combination with an established virus-modified tumor vaccine greatly augments the antitumor activity of T cells from healthy donors and cancer patients...
  41. ncbi request reprint T-cell triggering by CD3- and CD28-binding molecules linked to a human virus-modified tumor cell vaccine
    Claudia Haas
    German Cancer Research Center DKFZ, Division of Cellular Immunology, D010, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Vaccine 23:2439-53. 2005
    ..This was revealed by T cell proliferation, upregulation of CD69 and CD25 and by release of cytokines, interferons and chemokines. The new molecules combine high-effectivity with specificity and safety...
  42. pmc Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors
    Philipp Beckhove
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    J Clin Invest 114:67-76. 2004
    ....
  43. ncbi request reprint Expression of RIG-I, IRF3, IFN-beta and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus
    Holger Wilden
    Division of Cellular Immunology, German Cancer Research Center, D 69120 Heidelberg, Germany
    Int J Oncol 34:971-82. 2009
    ..A strong expression of these genes can explain the resistance of normal cells to NDV infection and a weak antiviral gene expression the broad susceptibility of tumor cells...
  44. doi request reprint Newcastle disease virus: a promising vector for viral therapy, immune therapy, and gene therapy of cancer
    Volker Schirrmacher
    Division of Cellular Immunology D010, German Cancer Research Center DKFZ, Heidelberg, Germany
    Methods Mol Biol 542:565-605. 2009
    ....
  45. ncbi request reprint Selective gene transfer in vitro to tumor cells via recombinant Newcastle disease virus
    Huijie Bian
    Division of Cellular Immunology, German Cancer Research Center, D010, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Gene Ther 12:295-303. 2005
    ..These results demonstrate that a recombinant NDV carrying a foreign gene can be successfully targeted to a specific tumor through a bispecific protein, which thereby increases the selectivity of gene transfer...
  46. ncbi request reprint Sulfated glycosaminoglycans enhance tumor cell invasion in vitro by stimulating plasminogen activation
    G Brunner
    Division of Cellular Immunology, German Cancer Research Centre, Heidelberg, Germany
    Exp Cell Res 239:301-10. 1998
    ....
  47. pmc Three types of human lung tumour cell lines can be distinguished according to surface expression of endogenous urokinase and their capacity to bind exogenous urokinase
    R Schwartz Albiez
    Institute of Immunology and Genetics, German Cancer Research Center, Heidelberg
    Br J Cancer 65:51-7. 1992
    ..This may reflect the different in vivo growth behaviour and origin of the respective tumour groups...
  48. pmc Expression and enhanced secretion of proteochondroitin sulphate in a metastatic variant of a mouse lymphoma cell line
    R Schwartz Albiez
    German Cancer Research Center, Institute of Immunology and Genetics, Heidelberg, Federal Republic of Germany
    Br J Cancer 57:569-75. 1988
    ..The possible consequences of the enhanced secretion of CS/DS by ESb-cells are discussed in terms of the postulated role of CS/DS in cellular adhesion, growth regulation and interactions with the immune system...
  49. ncbi request reprint Nitric oxide-induced apoptosis in tumor cells
    V Umansky
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, D 69120 Heidelberg, Germany
    Adv Cancer Res 82:107-31. 2001
    ..In this review, we will concentrate on the current knowledge about the role of NO as an effector of apoptosis in tumor cells and discuss the mechanisms of NO-mediated apoptosis...
  50. ncbi request reprint Bone marrow microenvironment facilitating dendritic cell: CD4 T cell interactions and maintenance of CD4 memory
    Markus Feuerer
    Tumor Immunology Program, German Cancer Research Center, DKFZ, D 69120 Heidelberg, Germany
    Int J Oncol 25:867-76. 2004
    ..Together these findings suggest that DC-T cell interactions in BM play an important role in immune responses to blood-borne antigen and in the establishment of systemic immunity and long-term memory...
  51. ncbi request reprint The shaping of a polyvalent and highly individual T-cell repertoire in the bone marrow of breast cancer patients
    Nora Sommerfeldt
    Department of Cellular Immunology, The German Cancer Research Center, Heidelberg, Germany
    Cancer Res 66:8258-65. 2006
    ..Our data show a highly individual T-cell repertoire for recognition of TAAs in breast cancer patients. This has potential relevance for T-cell immune diagnostics, for tumor vaccine design, and for predicting immune responsiveness...
  52. ncbi request reprint Melanoma-reactive T cells in the bone marrow of melanoma patients: association with disease stage and disease duration
    Jan Muller-Berghaus
    Skin Cancer Unit, German Cancer Research Center Heidelberg and University Hospital Mannheim, Mannheim, Germany and Division of Cellular Immunology, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Cancer Res 66:5997-6001. 2006
    ..These findings provide new insights into the generation of T-cell responses in melanoma patients...
  53. ncbi request reprint Stimulation of human natural interferon-alpha response via paramyxovirus hemagglutinin lectin-cell interaction
    Jinyang Zeng
    Division of Cellular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Mol Med (Berl) 80:443-51. 2002
    ..The results clarify molecular mechanisms involved in pattern recognition during innate immune responses...
  54. ncbi request reprint A tumor vaccine containing anti-CD3 and anti-CD28 bispecific antibodies triggers strong and durable antitumor activity in human lymphocytes
    Claudia Haas
    German Cancer Research Center, Division of Cellular Immunology, Heidelberg, Germany
    Int J Cancer 118:658-67. 2006
    ..The reagents can also be combined with Newcastle Disease Virus (NDV)-based oncolytic virotherapy...
  55. ncbi request reprint Tumor-targeted gene transfer in vivo via recombinant Newcastle disease virus modified by a bispecific fusion protein
    Huijie Bian
    Division of Cellular Immunology, German Cancer Research Center, D010, 69120 Heidelberg, Germany
    Int J Oncol 27:377-84. 2005
    ....
  56. doi request reprint Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis
    Christoph Domschke
    Department of Obstetrics and Gynecology, University Hospital of Heidelberg, Heidelberg, Germany
    Cancer Res 69:8420-8. 2009
    ..These findings shed light on the relation between immune response and cancer prognosis...
  57. pmc Anti-CD2 antibodies induce T cell unresponsiveness in vivo
    B Guckel
    Institute for Immunology and Genetics, German Cancer Research Center, Heidelberg
    J Exp Med 174:957-67. 1991
    ..These results document that CD2-mediated signals induce a state of T cell unresponsiveness in vivo...
  58. ncbi request reprint The mouse filensin gene: structure and evolutionary relation to other intermediate filament genes
    F Gounari
    Abteilung 710, Schwerpunkt Tumorimmunologie, Deutsches Krebsforschungzentrum, Heidelberg, Germany
    FEBS Lett 413:371-8. 1997
    ..Altogether, these observations indicate that the lens beaded filaments form an independent class of IF...
  59. ncbi request reprint DNA vaccination with asparaginyl endopeptidase (Sm32) from the parasite Schistosoma mansoni: anti-fecundity effect induced in mice
    K Chlichlia
    Department of Tropical Hygiene, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Vaccine 20:439-47. 2001
    ..The results suggest that Sm32 may be a candidate antigen for the generation of an anti-pathology vaccine against schistosomes...
  60. ncbi request reprint Host mediated anti-tumor effect of oncolytic Newcastle disease virus after locoregional application
    Leonidas Apostolidis
    Division of Cellular Immunology, German Cancer Research Center, Im Neuenheimer Feld 18 20, D 69120 Heidelberg, Germany
    Int J Oncol 31:1009-19. 2007
    ..v. application; and ii) that oncolytic NDV can mediate effects even against a virus-resistant tumor line. The involvement of host anti-tumor immune responses as an important mechanism in therapies based on oncolytic NDV will be discussed...
  61. ncbi request reprint Induction of interferon-alpha and tumor necrosis factor-related apoptosis-inducing ligand in human blood mononuclear cells by hemagglutinin-neuraminidase but not F protein of Newcastle disease virus
    Jinyang Zeng
    German Cancer Research Center, Division of Cellular Immunology, 69120 Heidelberg, Germany
    Virology 297:19-30. 2002
    ..Upon contact with BHK cells expressing HN but not F at their cell surface, human PBMC produced IFN-alpha and some cells, including monocytes and T lymphocytes, upregulated cell surface TRAIL expression...
  62. pmc Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase
    Mostafa Jarahian
    German Cancer Research Center, Heidelberg, Germany
    J Virol 83:8108-21. 2009
    ..These results suggest that direct activation of NK cells contributes to the antitumor effects of NDV...
  63. ncbi request reprint Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes
    Nora Sommerfeldt
    Department of Cellular Immunology, The German Cancer Research Center, D010 Im Neuenheimer Feld, 69120 Heidelberg, Germany
    Cancer Res 66:7716-23. 2006
    ....
  64. ncbi request reprint Tumor selective replication of Newcastle disease virus: association with defects of tumor cells in antiviral defence
    Christoph Fiola
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 119:328-38. 2006
    ..These results can explain the tumor selective replication behavior of this interesting antineoplastic virus...
  65. ncbi request reprint Two ways to induce innate immune responses in human PBMCs: paracrine stimulation of IFN-alpha responses by viral protein or dsRNA
    Philippe Fournier
    German Cancer Research Center, Division of Cellular Immunology D010, Im Neuenheimer Feld 280, D 69121 Heidelberg, Germany
    Int J Oncol 23:673-80. 2003
    ....
  66. ncbi request reprint In vivo efficacy of systemic tumor targeting of a viral RNA vector with oncolytic properties using a bispecific adapter protein
    Huijie Bian
    Division of Cellular Immunology, German Cancer Research Center, D 69120 Heidelberg, Germany
    Int J Oncol 29:1359-69. 2006
    ..The demonstration of significant systemic anti-tumor activity of this viral vector suggests potential for augmentation by inclusion of one or more therapeutic genes...
  67. ncbi request reprint Redox events in HTLV-1 Tax-induced apoptotic T-cell death
    Katerina Chlichlia
    Division of Cellular Immunology G0100, Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, Germany
    Antioxid Redox Signal 4:471-7. 2002
    ..The relevance of these observations to HTLV-1 virus-mediated T-cell transformation and leukemogenesis are discussed...
  68. ncbi request reprint Antitumor vaccination of patients with glioblastoma multiforme: a pilot study to assess feasibility, safety, and clinical benefit
    Hans Herbert Steiner
    Department of Neurosurgery, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Clin Oncol 22:4272-81. 2004
    ..Also, we determined the influence on progression-free survival and overall survival and on vaccination-induced antitumor reactivity...
  69. ncbi request reprint High cell surface expression of Newcastle disease virus proteins via replicon vectors demonstrates syncytia forming activity of F and fusion promotion activity of HN molecules
    Jinyang Zeng
    Division of Cellular Immunology, German Cancer Research Center, D010, D 69129 Heidelberg, Germany
    Int J Oncol 25:293-302. 2004
    ..F alone, expressed via this vector, displayed residual fusion activity suggesting its proteolytic cleavage and its functional independence from HN...
  70. ncbi request reprint Efficient engraftment of human primary breast cancer transplants in nonconditioned NOD/Scid mice
    Philipp Beckhove
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany P Beckhove2dkfz heidelberg de
    Int J Cancer 105:444-53. 2003
    ..The reproducible growth behavior and preservation of characteristic features suggest that this new xenotransplant model is relevant and can be recommended for testing new anticancer therapies...
  71. ncbi request reprint Antitumor activity of Titanocene Y against freshly explanted human breast tumor cells and in xenografted MCF-7 tumors in mice
    Philipp Beckhove
    Deutsches Krebsforschungszentrum, Abteilung Zellulare Immunologie, Heidelberg, Germany
    Anticancer Drugs 18:311-5. 2007
    ....
  72. ncbi request reprint Dynamic differentiation of activated human peripheral blood CD8+ and CD4+ effector memory T cells
    Jochen Schwendemann
    Department of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    J Immunol 175:1433-9. 2005
    ....
  73. ncbi request reprint TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus
    Birgit Washburn
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Immunol 170:1814-21. 2003
    ..These results show that TRAIL induction on human Mphi after NDV stimulation is independent from viral replication and that TRAIL mediates the tumoricidal activity of NDV-stimulated human Mphi...
  74. ncbi request reprint High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients
    Friedrich H Schmitz-Winnenthal
    Department of General Surgery, the University Hospital of Heidelberg, Germany
    Cancer Res 65:10079-87. 2005
    ..The bone marrow can therefore be considered an important organ for antitumor immune responses in pancreatic cancer...
  75. ncbi request reprint Influence of adjuvant hormone therapy and chemotherapy on the immune system analysed in the bone marrow of patients with breast cancer
    Erich Franz Solomayer
    Departments of Obstetrics and Gynecology, University of Tuebingen, 72076 Tuebingen, Germany
    Clin Cancer Res 9:174-80. 2003
    ..In this study, we analyzed the effect of hormone therapy and chemotherapy on the immune activation status in bone marrow...
  76. ncbi request reprint T cell memory, anergy and immunotherapy in breast cancer
    Volker Schirrmacher
    J Mammary Gland Biol Neoplasia 7:201-8. 2002
    ..The findings should encourage further studies in breast cancer on active specific immunotherapy with tumor vaccines or adoptive immunotherapy with activated memory T cells...
  77. ncbi request reprint Antitumor immunization of head and neck squamous cell carcinoma patients with a virus-modified autologous tumor cell vaccine
    Christel Herold-Mende
    Molecular Cell Biology Group, Department of Head and Neck Surgery, University of Heidelberg, Saarbrucken, Germany
    Adv Otorhinolaryngol 62:173-83. 2005
    ..Head and neck squamous cell carcinomas (HNSCCs) are aggressive tumors with poor 5-year survival rates, thus demanding new treatment concepts...
  78. ncbi request reprint Combination of thalidomide and cisplatin in an head and neck squamous cell carcinomas model results in an enhanced antiangiogenic activity in vitro and in vivo
    Gergely P Vasvari
    Molecular Cell Biology Group, Department of Otorhinolaryngology, Head and Neck Surgery, University of Heidelberg, INF 400, Germany
    Int J Cancer 121:1697-704. 2007
    ..Altogether, our findings reveal new insights into thalidomide-mediated antitumor and antiangiogenic effects and its interaction with cytostatic drugs...
  79. pmc Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis
    Orit Goldshmidt
    Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 99:10031-6. 2002
    ..The increased potency of the secreted enzyme makes it a promising target for anticancer drug development...