Jorg Ahrens

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Pharmacology 87:311-7. 2011
  2. pmc Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography
    Florian Wegner
    Department of Neurology, Hannover Medical School, Carl Neuberg Str, 1, 30625 Hannover, Germany
    BMC Neurol 14:136. 2014
  3. doi request reprint The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover, Germany
    Pharmacology 83:217-22. 2009
  4. doi request reprint The non-anaesthetic propofol analogue 2,6-di-tert-butylphenol fails to modulate GABA(A) receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 83:95-8. 2009
  5. doi request reprint A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor
    Jorg Ahrens
    Department of Anesthesiology, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Anesth Analg 107:1875-83. 2008
  6. doi request reprint Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 379:371-8. 2009
  7. doi request reprint The anaesthetic steroid alphaxalone positively modulates alpha1-glycine receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 82:228-32. 2008
  8. doi request reprint Strychnine-sensitive glycine receptors mediate the analgesic but not the hypnotic effects of emulsified volatile anaesthetics
    Jorg Ahrens
    Department of Anaesthesiology, OE 8050, Hannover Medical School, Hannover, Germany
    Pharmacology 81:195. 2008
  9. doi request reprint Modulation of glycine receptor function by the synthetic cannabinoid HU210
    Reyhan Demir
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Pharmacology 83:270-4. 2009
  10. doi request reprint Lack of positive allosteric modulation of mutated alpha(1)S267I glycine receptors by cannabinoids
    Nilufar Foadi
    Clinic for Anaesthesia and Critical Care Medicine OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:477-82. 2010

Collaborators

Detail Information

Publications24

  1. doi request reprint Defective polysialylation and sialylation induce opposite effects on gating of the skeletal Na+ channel NaV1.4 in Chinese hamster ovary cells
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Pharmacology 87:311-7. 2011
    ..Furthermore, only the loss of Sia had a significant effect on recovery from fast inactivation. Our data demonstrate for the first time that gating of voltage-gated sodium channels seems to be differentially regulated by polySia and Sia...
  2. pmc Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography
    Florian Wegner
    Department of Neurology, Hannover Medical School, Carl Neuberg Str, 1, 30625 Hannover, Germany
    BMC Neurol 14:136. 2014
    ....
  3. doi request reprint The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover, Germany
    Pharmacology 83:217-22. 2009
    ..3 micromol/l and alpha(1)beta = 144.3 +/- 22.7 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for cannabidiol mediating some of its anti-inflammatory and neuroprotective properties...
  4. doi request reprint The non-anaesthetic propofol analogue 2,6-di-tert-butylphenol fails to modulate GABA(A) receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 83:95-8. 2009
    ..Our results support the assumption that modulation of inhibitory GABA(A) receptor function is responsible for the anaesthetic effects of propofol in vivo...
  5. doi request reprint A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor
    Jorg Ahrens
    Department of Anesthesiology, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Anesth Analg 107:1875-83. 2008
    ..In the present study we investigated the role of this residue on the interaction of propofol with the glycine alpha(1) and alpha(1)beta receptor...
  6. doi request reprint Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 379:371-8. 2009
    ..9 +/- 21.5 microM and alpha(1)beta = 154.3 +/- 32.1 microM). These in vitro results demonstrate that ajulemic acid modulates strychnine-sensitive glycine receptors in clinically relevant concentrations...
  7. doi request reprint The anaesthetic steroid alphaxalone positively modulates alpha1-glycine receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 82:228-32. 2008
    ..9 +/- 21.5 micromol/l. Taking into account the results of other groups, our study suggests that neuroactive steroids might be an interesting class of compounds to probe subunit-specific effects of glycine receptors...
  8. doi request reprint Strychnine-sensitive glycine receptors mediate the analgesic but not the hypnotic effects of emulsified volatile anaesthetics
    Jorg Ahrens
    Department of Anaesthesiology, OE 8050, Hannover Medical School, Hannover, Germany
    Pharmacology 81:195. 2008
  9. doi request reprint Modulation of glycine receptor function by the synthetic cannabinoid HU210
    Reyhan Demir
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Pharmacology 83:270-4. 2009
    ..7 +/- 46.2 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for HU210 mediating some of its anti-inflammatory and anti-nociceptive properties...
  10. doi request reprint Lack of positive allosteric modulation of mutated alpha(1)S267I glycine receptors by cannabinoids
    Nilufar Foadi
    Clinic for Anaesthesia and Critical Care Medicine OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:477-82. 2010
    ..An investigation of the impact of such mutations on the in vivo interaction of cannabinoids with glycine receptors should permit a better understanding of the molecular determinants of action of cannabinoids...
  11. ncbi request reprint 2,6 di-tert-butylphenol, a nonanesthetic propofol analog, modulates alpha1beta glycine receptor function in a manner distinct from propofol
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Anesth Analg 99:91-6. 2004
    ..Propofol and its nonanesthetic structural analog do not differ in their ability to coactivate the glycine receptor but differ in their ability to directly activate the receptor in the absence of the natural agonist...
  12. doi request reprint Interaction of alfaxalone with the neuronal and the skeletal muscle sodium channel
    Nilufar Foadi
    Clinic for Anaesthesia and Critical Care Medicine, Veterinary School of Medicine, Hannover, Germany
    Pharmacology 89:295-302. 2012
    ..Alfaxalone preferentially blocked slow inactivated channels and therefore could provide membrane-stabilizing effects in ischemic/hypoxic tissues where slow inactivation is regarded to play a crucial role...
  13. pmc Structural features of phenol derivatives determining potency for activation of chloride currents via alpha(1) homomeric and alpha(1)beta heteromeric glycine receptors
    Gertrud Haeseler
    Department of Anaesthesiology, OE 8050, Hannover Medical School, D 30623 Hannover, Germany
    Br J Pharmacol 145:916-25. 2005
    ..The presence of the beta subunit is not required for both effects...
  14. doi request reprint Endotoxin reduces availability of voltage-gated human skeletal muscle sodium channels at depolarized membrane potentials
    Gertrud Haeseler
    Department of Anesthesiology, Hannover Medical School, Germany
    Crit Care Med 36:1239-47. 2008
    ..This study was designed to investigate a potential direct interaction of lipopolysaccharides from Escherichia coli with voltage-gated human skeletal muscle sodium channels (NaV1.4) in vitro...
  15. doi request reprint Inhibition of voltage-gated Na⁺ channels by the synthetic cannabinoid ajulemic acid
    Nilufar Foadi
    From the Department of Anesthesia and Critical Care Medicine, and Department of Neurology and Clinical Neurophysiology, Medizinische Hochschule Hannover, Hannover, Germany
    Anesth Analg 118:1238-45. 2014
    ..Cannabinoids interact with several molecules within the pain circuit, including a potent inhibition of voltage-gated sodium channels. In this study, we closely characterized this property on neuronal and nonneuronal sodium channels...
  16. pmc 4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors
    Jeanne de la Roche
    Clinic for Anesthesia and Critical Care Medicine, OE 8050, Hannover Medical School, Carl Neuberg Str, 1, 30625, Hannover, Germany
    BMC Neurol 12:104. 2012
    ..The aim of this in vitro study was to characterize the effects of 4-chloropropofol (4-chloro-2,6-dimethylphenol) at four glycine receptor mutations...
  17. doi request reprint Topical antiseptics for the treatment of sore throat block voltage-gated neuronal sodium channels in a local anaesthetic-like manner
    Vanessa Buchholz
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 380:161-8. 2009
    ..Both drugs show an increased effect at depolarised membrane potentials or in conditions of high-frequency discharges...
  18. doi request reprint A combination of topical antiseptics for the treatment of sore throat blocks voltage-gated neuronal sodium channels
    Nilufar Foadi
    Clinic for Anaesthesia and Critical Care Medicine OE8050, Hannover Medical School, Carl Neuberg Str 1, 30623, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 387:991-1000. 2014
    ..In the presence of amylmetacresol, dichloro-benzylalcohol and lidocaine, a prominent block of inward sodium currents is apparent. ..
  19. ncbi request reprint Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels
    Gertrud Haeseler
    Department of Anesthesiology, Hannover Medical School, Germany
    Pain 126:234-44. 2006
    ..2) Slow inactivation--a physiological mechanism to suppress ectopic activity in response to slow shifts in membrane potential--increases binding affinity for sufentanil, fentanyl and tramadol. (3) Morphine has no such effects...
  20. doi request reprint The distinct effects of lipid emulsions used for "lipid resuscitation" on gating and bupivacaine-induced inhibition of the cardiac sodium channel Nav1.5
    Felix Nadrowitz
    From the Departments of Anesthesiology and Intensive Care Medicine and Neurology, Hannover Medical School, Hannover, Germany and Institute for Physiology and Pathophysiology, Friedrich Alexander Universitat Erlangen Nurnberg, Germany
    Anesth Analg 117:1101-8. 2013
    ..5. In this study, we sought to determine whether lipid emulsions functionally interact with Nav1.5 or counteract inhibition by bupivacaine...
  21. doi request reprint Paracetamol fails to positively modulate and directly activate chloride currents in human α1-glycine receptors
    Jeanne de la Roche
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover, Germany
    Pharmacology 87:115-20. 2011
    ..Consequently, the analgesic actions of paracetamol leading to pain relief appear to be mediated via other mechanisms, but not via activation of spinal glycinergic pathways...
  22. pmc Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits
    Florian Wegner
    Department of Neurology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e36946. 2012
    ....
  23. doi request reprint Reduced post-operative neutrophil activation in liver transplant recipients suffering from post-hepatitic cirrhosis
    Björn Jüttner
    Departments of Anesthesiology, Hannover Medical School, Hannover, Germany
    Clin Transplant 23:921-9. 2009
    ..This study was designed to investigate whether neutrophil function is immediately affected by liver transplantation...
  24. doi request reprint Role of cannabinoids in the treatment of pain and (painful) spasticity
    Matthias Karst
    Department of Anaesthesiology, Pain Clinic, Hannover Medical School, Hannover, Germany
    Drugs 70:2409-38. 2010
    ..Therefore, different methods of administration and other types of cannabinoids, such as endocannabinoid modulators, should be tested in future trials...