M Cornberg

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. ncbi request reprint Treatment of chronic hepatitis C with PEGylated interferon and ribavirin
    Markus Cornberg
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Carl Neuberg Strasse 1, D 30623 Hannover, Germany
    Curr Gastroenterol Rep 4:23-30. 2002
  2. doi request reprint [Entecavir - options and obstacles of an effective treatment for chronic hepatitis B]
    M Cornberg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule, Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Dtsch Med Wochenschr 135:32-7. 2010
  3. doi request reprint Hepatitis C virus infection from the perspective of heterologous immunity
    Markus Cornberg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany German Center for Infection research DZIF, Partner Site Hannover Braunschweig, Germany Electronic address
    Curr Opin Virol 16:41-8. 2016
  4. doi request reprint [Specific infections in organ transplantation]
    M Cornberg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30623, Hannover, Deutschland
    Internist (Berl) 57:38-48. 2016
  5. pmc Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting
    Benjamin Maasoumy
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e55285. 2013
  6. pmc Hepatitis B surface antigen concentrations in patients with HIV/HBV co-infection
    Jerzy Jaroszewicz
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e43143. 2012
  7. doi request reprint [New direct-acting antiviral agents for the treatment of chronic hepatitis C in 2014]
    M Cornberg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Internist (Berl) 55:390-400. 2014
  8. pmc Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response
    Manuela F Meyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Virol J 4:58. 2007
  9. ncbi request reprint Present and future therapy for hepatitis C virus
    Markus Cornberg
    German Competence Network for Viral Hepatitis Kompetenznetz Hepatitis, Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology, and Endocrinology, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Expert Rev Anti Infect Ther 4:781-93. 2006
  10. ncbi request reprint Treatment of chronic hepatitis B
    M Cornberg
    Department of Gastroenterology, Medizinische Hochschule Hannover, Germany
    Minerva Gastroenterol Dietol 56:451-65. 2010

Detail Information

Publications62

  1. ncbi request reprint Treatment of chronic hepatitis C with PEGylated interferon and ribavirin
    Markus Cornberg
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School Hannover, Carl Neuberg Strasse 1, D 30623 Hannover, Germany
    Curr Gastroenterol Rep 4:23-30. 2002
    ..This review describes recent advances in the treatment of HCV infection with PEGylated interferon (interferon modified with polyethylene glycol [PEG] ) combined with ribavirin...
  2. doi request reprint [Entecavir - options and obstacles of an effective treatment for chronic hepatitis B]
    M Cornberg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule, Hannover, Carl Neuberg Strasse 1, 30625 Hannover
    Dtsch Med Wochenschr 135:32-7. 2010
    ..In summary, Entecavir adds a new milestone in the treatment of chronic hepatitis B...
  3. doi request reprint Hepatitis C virus infection from the perspective of heterologous immunity
    Markus Cornberg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany German Center for Infection research DZIF, Partner Site Hannover Braunschweig, Germany Electronic address
    Curr Opin Virol 16:41-8. 2016
    ..This review discusses how other infections can alter the natural course of hepatitis C and how HCV infection influence unrelated infections. ..
  4. doi request reprint [Specific infections in organ transplantation]
    M Cornberg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30623, Hannover, Deutschland
    Internist (Berl) 57:38-48. 2016
    ..In this context Aspergillus spp. are one of the most commonly occurring fungal diseases. The epidemiology, risk factors, diagnostics, prophylaxis and therapy of invasive aspergillosis are presented...
  5. pmc Eligibility and safety of triple therapy for hepatitis C: lessons learned from the first experience in a real world setting
    Benjamin Maasoumy
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 8:e55285. 2013
    ..The aim of our study was to analyze the eligibility and safety of P/R/PI treatment in a real world setting of a tertiary referral center...
  6. pmc Hepatitis B surface antigen concentrations in patients with HIV/HBV co-infection
    Jerzy Jaroszewicz
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e43143. 2012
    ..In conclusion, HBsAg decline is dependent on an effective immune status. Restoration of CD4 T-cells during treatment with cART including nucleos(t)ide analogues seems to be important for HBsAg decrease and subsequent HBsAg loss...
  7. doi request reprint [New direct-acting antiviral agents for the treatment of chronic hepatitis C in 2014]
    M Cornberg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Internist (Berl) 55:390-400. 2014
    ..With sofosbuvir (SOF) and simeprevir (SMV), two new DAA are available. More DAA are in clinical development...
  8. pmc Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response
    Manuela F Meyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Virol J 4:58. 2007
    ..Thus, these cases highlight that clearance of low levels of HCV viremia is possible in the absence of a strong adaptive immune response which might explain the low seroconversion rate after occupational exposure to HCV...
  9. ncbi request reprint Present and future therapy for hepatitis C virus
    Markus Cornberg
    German Competence Network for Viral Hepatitis Kompetenznetz Hepatitis, Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology, and Endocrinology, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Expert Rev Anti Infect Ther 4:781-93. 2006
    ..This review focuses on the present and future concepts for treating HCV infection, including prevention of infection, antiviral therapy of acute and chronic HCV and the management of patients after liver transplantation...
  10. ncbi request reprint Treatment of chronic hepatitis B
    M Cornberg
    Department of Gastroenterology, Medizinische Hochschule Hannover, Germany
    Minerva Gastroenterol Dietol 56:451-65. 2010
    ..Still, whom to treat, which therapy regimen to use, and when to begin treatment remain the challenges in the management HBV-infected patients. This review focuses on the current treatment concepts for chronic hepatitis B...
  11. doi request reprint [Prevention of virus hepatitis A to E]
    M Cornberg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Internist (Berl) 52:250-64. 2011
    ..Hepatitis E vaccines have been evaluated in phase III studies. The development of HEV vaccines becomes more relevant since chronic HEV infections have been reported in immunosuppressed individuals...
  12. ncbi request reprint Prophylaxis, diagnosis and therapy of hepatitis B virus (HBV) infection: the German guidelines for the management of HBV infection
    M Cornberg
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Z Gastroenterol 45:1281-328. 2007
  13. doi request reprint The German guideline for the management of hepatitis B virus infection: short version
    M Cornberg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Viral Hepat 15:1-21. 2008
  14. ncbi request reprint Clearance of chronic HCV infection during acute delta hepatitis
    K Deterding
    Dept of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Infection 37:159-62. 2009
    ..These data suggest that HCV can be cleared by bystander mechanisms during acute infections with other pathogens which may be considered in the development of immunotherapies for hepatitis C...
  15. ncbi request reprint Current and future treatment of hepatitis C
    M P Manns
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Hannover, Germany
    Indian J Gastroenterol 20:C47-51. 2001
    ..Hopefully, new treatment modalities will be available in the near future. Helicase, protease and the RNA polymerase are potential targets to suppress HCV replication and several immunotherapeutic approaches are explored...
  16. doi request reprint Cross-genotype-specific T-cell responses in acute hepatitis E virus (HEV) infection
    A Gisa
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Viral Hepat 23:305-15. 2016
    ..Our data of cross-genotype HEV-specific T-cell responses might suggest a potential role in cross-genotype-specific protection between HEV genotypes 1 and 3. ..
  17. ncbi request reprint Treatment of acute hepatitis C with interferon alfa-2b
    E Jaeckel
    Medizinische Hochschule Hannover, Germany
    N Engl J Med 345:1452-7. 2001
    ..2 weeks of treatment. Therapy was well tolerated in all but one patient, who stopped therapy after 12 weeks because of side effects. CONCLUSIONS: Treatment of acute hepatitis C with interferon alfa-2b prevents chronic infection...
  18. doi request reprint Pneumococcal meningitis during antiviral treatment with interferon and ribavirin in a splenectomized patient with chronic hepatitis C - do not miss vaccination before starting therapy
    J Hadem
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Z Gastroenterol 46:880-2. 2008
    ..He had not received vaccination against Streptococcus pneumoniae. This case report reminds us that splenectomized patients without previous pneumococcal vaccination should receive such vaccination before immunomodulatory treatment...
  19. doi request reprint Dominance of hepatitis C virus (HCV) is associated with lower quantitative hepatitis B surface antigen and higher serum interferon-γ-induced protein 10 levels in HBV/HCV-coinfected patients
    S B Wiegand
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany German Centre for Infectious Disease Research DZIF, Partner Site Hannover Braunschweig, Germany
    Clin Microbiol Infect 21:710.e1-9. 2015
    ..Lower HBsAg and higher IP-10 levels in HCV-dominant HBV/HCV-coinfected patients suggest that HCV suppresses HBV DNA replication and also HBsAg production by immune mechanisms...
  20. doi request reprint [Knowledge and management of hepatitis B virus infected patients in Germany]
    K Deterding
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 137:774-80. 2012
    ....
  21. pmc Development and evaluation of a baseline-event-anticipation score for hepatitis delta
    B Calle Serrano
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany German Center for Infection research DZIF, Partner Side HepNet Study House, Hannover, Germany
    J Viral Hepat 21:e154-63. 2014
    ..Delta hepatitis is associated with a very severe long-term outcome. The BEA score is easy to apply and predicts with a very high accuracy the development of liver-related complications in patients with hepatitis delta...
  22. pmc Expression of leptin and leptin receptor isoforms in the human stomach
    H Mix
    Department of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, Germany
    Gut 47:481-6. 2000
    ..Recently, leptin expression was also noted in other tissues, including rat gastric mucosa. Information on leptin and leptin receptor expression in the human stomach is lacking...
  23. ncbi request reprint [German guidelines on diagnosis and therapy of hepatitis B]
    H Wedemeyer
    Medizinische Hochschule Hannover, Germany
    Dtsch Med Wochenschr 132:1775-82. 2007
    ..Finally, the importance of HBV in the context of organ and bone marrow transplantation, treatment of coinfections and children and prophylaxis of HBV is covered...
  24. doi request reprint Fulminant hepatic failure due to chemotherapy-induced hepatitis B reactivation: role of rituximab
    M A Stange
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
    Z Gastroenterol 48:258-63. 2010
    ..Pre-emptive antiviral treatments should be administered since delayed antiviral treatment is frequently unable to prevent liver failure...
  25. ncbi request reprint Isolated anti-HBV core phenotype in anti-HCV-positive patients is associated with hepatitis C virus replication
    H Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30623 Hannover, Germany
    Clin Microbiol Infect 10:70-2. 2004
    ..This finding represents new information regarding the immunopathogenesis of chronic HCV infection and supports previous data indicating impaired humoral immune responses in HCV infection...
  26. doi request reprint Cross-genotype-reactivity of the immunodominant HCV CD8 T-cell epitope NS3-1073
    P Fytili
    Medizinische Hochschule Hannover, Abt Gastroenterologie, Hepatologie und Endokrinologie, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Vaccine 26:3818-26. 2008
    ..Thus, partial cross-genotype recognition of HCV NS3(1073)-specific CD8 T cells is possible; however, even single aa exchanges can significantly limit the potential efficacy of vaccines containing the NS3(1073)-wild-type peptide...
  27. doi request reprint Hepatitis B core-related antigen (HBcrAg) levels in the natural history of hepatitis B virus infection in a large European cohort predominantly infected with genotypes A and D
    B Maasoumy
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hanover, Germany German Center for Infection research DZIF, Partner Site Hannover Braunschweig, Bialystok, Poland
    Clin Microbiol Infect 21:606.e1-10. 2015
    ..In HBeAg-negative patients, HBcrAg may help to distinguish between inactive carriers (ENQ) and those with active disease (ENH)...
  28. doi request reprint Peginterferon plus adefovir versus either drug alone for hepatitis delta
    Heiner Wedemeyer
    Hannover Medical School, Hannover, Germany
    N Engl J Med 364:322-31. 2011
    ..There is no currently approved treatment. We investigated the safety and efficacy of 48 weeks of treatment with peginterferon alfa-2a plus adefovir dipivoxil, peginterferon alfa-2a alone, and adefovir dipivoxil alone...
  29. doi request reprint Improvement of liver function parameters in advanced HCV-associated liver cirrhosis by IFN-free antiviral therapies
    K Deterding
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Aliment Pharmacol Ther 42:889-901. 2015
    ..To what extent liver function also improves in cirrhotic patients with chronic hepatitis C receiving novel interferon-free (IFN-free) therapies is unknown...
  30. ncbi request reprint [Treatment of chronic hepatitis C with PEG-interferon alpha-2b and ribavirin: 24 weeks of therapy are sufficient for HCV genotype 2 and 3]
    M Cornberg
    Abteilung für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover
    Z Gastroenterol 41:517-22. 2003
    ..Thus, we suggest treating all patients with HCV-genotype 2 and 3 for only 24 weeks when PEG-IFN alpha-2b is used in combination with ribavirin...
  31. doi request reprint Impaired TRAIL-dependent cytotoxicity of CD1c-positive dendritic cells in chronic hepatitis C virus infection
    S Ciesek
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Viral Hepat 15:200-11. 2008
    ..The impaired DC cytotoxicity could represent a novel mechanism for the increased prevalence of autoimmunity in HCV infection...
  32. pmc Treating viral hepatitis C: efficacy, side effects, and complications
    M P Manns
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Gut 55:1350-9. 2006
    ..This review describes the efficacy and optimisation of the current standard therapy of hepatitis C and its problems in special patient populations. New treatment directions beyond interferon alpha based therapies are on the horizon...
  33. doi request reprint [Hepatitis E virus infection: a paradigm shift?]
    S Pischke
    Gastroenterologie, Medizinische Hochschule Hannover
    Dtsch Med Wochenschr 135:1129-33. 2010
    ..In this review we summarize the current state-of-the-art on the knowledge of HEV-infections in industrialised countries...
  34. doi request reprint Correlation between the Elecsys HBsAg II assay and the Architect assay for the quantification of hepatitis B surface antigen (HBsAg) in the serum
    Karsten Wursthorn
    Dept of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Clin Virol 50:292-6. 2011
    ..Studies have shown that serum HBsAg quantification during, and at end of, treatment may predict long-term HBsAg loss...
  35. doi request reprint The German Hep-Net acute hepatitis C cohort: impact of viral and host factors on the initial presentation of acute hepatitis C virus infection
    K Deterding
    Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1 30625 Hannover
    Z Gastroenterol 47:531-40. 2009
    ..Antiviral treatment with interferon alpha was initiated in 171 patients (66 %) within 4 months after the diagnosis of acute hepatitis C...
  36. doi request reprint The clinical significance of drug-drug interactions in the era of direct-acting anti-viral agents against chronic hepatitis C
    B Maasoumy
    Department for Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Aliment Pharmacol Ther 38:1365-72. 2013
    ..Both currently approved DAAs, the protease inhibitors (PIs) telaprevir (TVR) and boceprevir (BOC), are substrates and inhibitors of P-glycoprotein and the cytochrome P450 3A4, which are regularly involved in DDIs...
  37. doi request reprint Detection of low HCV viraemia by repeated HCV RNA testing predicts treatment failure to triple therapy with telaprevir
    B Maasoumy
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Aliment Pharmacol Ther 39:85-92. 2014
    ..Treatment duration (24 vs. 48 weeks) is based on HCV RNA results at weeks 4 and 12 of PI therapy when HCV RNA must be 'undetectable' to allow shorter therapy...
  38. doi request reprint [Hepatitis associated cryoglobulinemia]
    S Pischke
    Abteilung Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, 30625, Hannover
    Internist (Berl) 49:297-304. 2008
    ..Cases of rapid worsening under therapy with interferon alpha have also been reported. A promising new option is the use of rituximab...
  39. doi request reprint Hepatitis C virus core antigen testing in liver and kidney transplant recipients
    B Heidrich
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany Integrated Research and Treatment Center Transplantation IFB Tx, Hannover Medical School, Hannover, Germany
    J Viral Hepat 21:769-79. 2014
    ..HCVcoreAg testing can be used to monitor HCV viral loads in patients after organ transplantation. However, the assay is not recommended to monitor antiviral therapies...
  40. doi request reprint Real-world use, effectiveness and safety of anti-viral treatment in chronic hepatitis C genotype 3 infection
    M Cornberg
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany and German Center for Infection Research DZIF, Partner Site Hannover Braunschweig, Germany
    Aliment Pharmacol Ther . 2017
    ..Treatment of chronic hepatitis C genotype 3 (GT3) is more challenging compared with other genotypes. Since 2014, several new treatment regimens have been approved but sometimes based on limited data...
  41. doi request reprint [Which treatment options are validated for chronic viral hepatitis?]
    C Höner zu Siederdissen
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Zentrum Innere Medizin, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625, Hannover, Deutschland
    Internist (Berl) 54:1427-8, 1430-3. 2013
    ..In the last 10 years, a dramatic change has occurred in the treatment of chronic viral hepatitis, particularly in the area of hepatitis B and hepatitis C...
  42. ncbi request reprint Morphological and molecular characterization of human gastric mucous cells in long-term primary culture
    S Wagner
    Dept of Gastroenterology and Hepatology, Medizinische Hochschule Hannover, D 30623, Hannover, Germany
    Pflugers Arch 436:871-81. 1998
    ..This primary cell culture model enables the regulation of mucin secretion and mucin gene expression in man to be investigated...
  43. doi request reprint [Diagnostics and therapy of hepatitis]
    C P Strassburg
    Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625, Hannover, Deutschland
    Internist (Berl) 50:1358-68. 2009
    ..Hepatitis A does not lead to chronic infection. This was also assumed for hepatitis E. However, reports indicate chronic courses in selected patient groups. A vaccine for hepatitis E is currently not yet available...
  44. doi request reprint Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection
    Kerstin A Stegmann
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Gastroenterology 138:1885-97. 2010
    ..Natural killer (NK) cells might be associated with control of HCV infection. We examined the effects of IFNalpha on human NK cells and its relevance to HCV infection...
  45. ncbi request reprint Treatment with daily consensus interferon (CIFN) plus ribavirin in non-responder patients with chronic hepatitis C: a randomized open-label pilot study
    Markus Cornberg
    Abt Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover, Germany
    J Hepatol 44:291-301. 2006
    ..Therapeutic options for hepatitis C non-responder patients are limited...
  46. ncbi request reprint Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+ T cells in healthy individuals and chronic hepatitis C patients
    Verena Schlaphoff
    Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Carl Neuberg Str 1, 30625 Hannover, Germany
    Vaccine 25:6793-806. 2007
    ..Thus, this study suggests that HCV-specific memory cells can be induced by peptide vaccination and that a reversion of functional impaired phenotypes by therapeutic vaccination is possible in chronic HCV infection...
  47. ncbi request reprint Mycophenolate mofetil in combination with recombinant interferon alfa-2a in interferon-nonresponder patients with chronic hepatitis C
    Markus Cornberg
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Hepatol 37:843-7. 2002
    ..The present study is a pilot study evaluating the efficacy and safety of combination therapy with interferon alfa-2a and MMF in interferon alfa nonresponder patients...
  48. doi request reprint [Laboratory requirements to diagnose viral hepatitis under the development of guidelines]
    Hans Becker
    Medizinische Hochschule Hannover, Klinik fur Gastroenterologie, Hepatologie und Endokrinologie, Germany
    Z Gastroenterol 55:32-38. 2017
    ..The results and the new treatment options against hepatitis C should motivate to continue the education in the field of viral hepatitis in an intensified manor...
  49. ncbi request reprint Making sense of muscle fatigue and liver lesions
    J Hadem
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Hannover, Germany
    Z Gastroenterol 45:609-11. 2007
    ..The woman deteriorated rapidly and finally died from intracranial tumor spread and septic complications. This case stresses the diagnostic and therapeutic difficulties of acute ectopic ACTH syndrome in the setting of SCLC...
  50. ncbi request reprint [Differential mucin expression in the gastrointestinal tract]
    M Cornberg
    Abteilung Gastroenterologie und Hepatologie, Institut für Versuchstierkunde, Medizinische Hochschule Hannover, Hannover, Deutschland
    Z Gastroenterol 39:369-76, 378. 2001
    ..A modified mucin expression reflects pathophysiological conditions and may support the pathohistological diagnosis...
  51. ncbi request reprint Fate and function of hepatitis-C-virus-specific T-cells during peginterferon-alpha2b therapy for acute hepatitis C
    Johannes Wiegand
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Antivir Ther 12:303-16. 2007
    ..However, recent studies described a decline in HCV-specific CD8+ T-cells during interferon treatment, suggesting that the success of acute HCV therapy might be independent of adaptive immunity...
  52. ncbi request reprint Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection
    Xandra Volkmann
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 43:1311-6. 2006
    ..845; 95% CI). In conclusion, hepatic caspase activity might play a role in HCV clearance and could also predict the efficacy of antiviral therapy...
  53. ncbi request reprint Long-term follow-up after successful interferon therapy of acute hepatitis C
    Johannes Wiegand
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
    Hepatology 40:98-107. 2004
    ..Waning of anti-HCV humoral immunity and presence of HCV-specific CD8(+) (but not CD4(+)) T cells highlights the complexity of T-cell and B-cell memory to HCV, which might be significantly altered by IFN treatment...
  54. ncbi request reprint New approaches and therapeutic modalities for the treatment of patients with chronic hepatitis C
    Markus Cornberg
    Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology, and Endocrinology Carl Neuberg Str, 1, D 3065 Hannover, Germany
    Ann Hepatol 4:144-50. 2005
    ..This review focuses on the optimization of the current standard therapy of hepatitis C and future treatment directions beyond pegylated interferon alpha and ribavirin...
  55. ncbi request reprint Significance of the caspase family in Helicobacter pylori induced gastric epithelial apoptosis
    A Potthoff
    Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Germany
    Helicobacter 7:367-77. 2002
    ..H. pylori infection results in an increased epithelial apoptosis in gastritis and duodenal ulcer patients. We investigated the role and type of activation of caspases in H. pylori-induced apoptosis in gastric epithelial cells...
  56. ncbi request reprint Hepatitis A virus infection suppresses hepatitis C virus replication and may lead to clearance of HCV
    Katja Deterding
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Hepatol 45:770-8. 2006
    ..While some studies suggested an incidence of fulminant hepatitis A of up to 35%, this could not be confirmed by others...
  57. ncbi request reprint Polyethylene glycol-interferon: current status in hepatitis C virus therapy
    Heiner Wedemeyer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Gastroenterol Hepatol 17:S344-50. 2002
    ..The combination of PEG-interferon and ribavirin improves the overall sustained response rates to 54-56% and represents the new standard therapy for patients with chronic hepatitis C infection in most patients...
  58. doi request reprint Intrahepatic long-term persistence of parvovirus B19 and its role in chronic viral hepatitis
    Chun Wang
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Med Virol 81:2079-88. 2009
    ..These results indicate that B19V can persist in the liver. However, there is no evidence that B19V is a "hepatitis virus" worsening liver disease in European patients with chronic hepatitis C...
  59. doi request reprint Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: a European perspective
    Jerzy Jaroszewicz
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl Neuberg Str 1, Hannover, Germany
    J Hepatol 52:514-22. 2010
    ..However, there is limited information on HBsAg levels considering the dynamic natural course of HBV-infection. This study aimed to determine HBsAg levels in the different phases of HBV-infection in European HBsAg-positive patients...
  60. ncbi request reprint Treatment of acute hepatitis C-how to explain the differences?
    Heiner Wedemeyer
    Gastroenterology 131:682-3; author reply 683-4. 2006
  61. ncbi request reprint Whom? When? How? Another piece of evidence for early treatment of acute hepatitis C
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