G Haeseler

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint Topical antiseptics for the treatment of sore throat block voltage-gated neuronal sodium channels in a local anaesthetic-like manner
    Vanessa Buchholz
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 380:161-8. 2009
  2. ncbi request reprint Succinylcholine metabolite succinic acid alters steady state activation in muscle sodium channels
    G Haeseler
    Department of Anesthesiology, Hannover Medical School, Hannover, Germany
    Anesthesiology 92:1385-91. 2000
  3. ncbi request reprint High-affinity blockade of voltage-operated skeletal muscle sodium channels by 2,6-dimethyl-4-chlorophenol
    G Haeseler
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Eur J Anaesthesiol 23:190-6. 2006
  4. ncbi request reprint Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels
    Gertrud Haeseler
    Department of Anesthesiology, Hannover Medical School, Germany
    Pain 126:234-44. 2006
  5. doi request reprint Endotoxin reduces availability of voltage-gated human skeletal muscle sodium channels at depolarized membrane potentials
    Gertrud Haeseler
    Department of Anesthesiology, Hannover Medical School, Germany
    Crit Care Med 36:1239-47. 2008
  6. ncbi request reprint Blockade of voltage-operated neuronal and skeletal muscle sodium channels by S(+)- and R(-)-ketamine
    Gertrud Haeseler
    Department of Anesthesiology, OE 8050 Hannover Medical School, D 30623 Hannover, Germany
    Anesth Analg 96:1019-26, table of contents. 2003
  7. ncbi request reprint High-affinity block of voltage-operated rat IIA neuronal sodium channels by 2,6 di-tert-butylphenol, a propofol analogue
    G Haeseler
    Hannover Medical School, Department of Anesthesiology, Hannover, Germany
    Eur J Anaesthesiol 20:220-4. 2003
  8. pmc Block of voltage-operated sodium channels by 2,6-dimethylphenol, a structural analogue of lidocaine's aromatic tail
    Gertrud Haeseler
    Department of Anaesthesiology, Hannover Medical School, Germany
    Br J Pharmacol 137:285-93. 2002
  9. ncbi request reprint Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol
    G Haeseler
    Hannover Medical School, Department of Anaesthesiology, D 30623 Hannover, Germany
    Eur J Anaesthesiol 19:571-9. 2002
  10. pmc Structural requirements for voltage-dependent block of muscle sodium channels by phenol derivatives
    G Haeseler
    Department of Anaesthesiology, Hannover Medical School, D 30623 Hannover, Germany
    Br J Pharmacol 132:1916-24. 2001

Detail Information

Publications29

  1. doi request reprint Topical antiseptics for the treatment of sore throat block voltage-gated neuronal sodium channels in a local anaesthetic-like manner
    Vanessa Buchholz
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 380:161-8. 2009
    ..Both drugs show an increased effect at depolarised membrane potentials or in conditions of high-frequency discharges...
  2. ncbi request reprint Succinylcholine metabolite succinic acid alters steady state activation in muscle sodium channels
    G Haeseler
    Department of Anesthesiology, Hannover Medical School, Hannover, Germany
    Anesthesiology 92:1385-91. 2000
    ..The aim of this study was to examine effects of one product of succinylcholine hydrolysis, succinic acid, on voltage-gated muscle sodium (Na+) channels...
  3. ncbi request reprint High-affinity blockade of voltage-operated skeletal muscle sodium channels by 2,6-dimethyl-4-chlorophenol
    G Haeseler
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Eur J Anaesthesiol 23:190-6. 2006
    ..The aim of this study was to show the effect of halogenation in the para-position on the potency of this compound to block voltage-operated sodium channels...
  4. ncbi request reprint Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels
    Gertrud Haeseler
    Department of Anesthesiology, Hannover Medical School, Germany
    Pain 126:234-44. 2006
    ..2) Slow inactivation--a physiological mechanism to suppress ectopic activity in response to slow shifts in membrane potential--increases binding affinity for sufentanil, fentanyl and tramadol. (3) Morphine has no such effects...
  5. doi request reprint Endotoxin reduces availability of voltage-gated human skeletal muscle sodium channels at depolarized membrane potentials
    Gertrud Haeseler
    Department of Anesthesiology, Hannover Medical School, Germany
    Crit Care Med 36:1239-47. 2008
    ..This study was designed to investigate a potential direct interaction of lipopolysaccharides from Escherichia coli with voltage-gated human skeletal muscle sodium channels (NaV1.4) in vitro...
  6. ncbi request reprint Blockade of voltage-operated neuronal and skeletal muscle sodium channels by S(+)- and R(-)-ketamine
    Gertrud Haeseler
    Department of Anesthesiology, OE 8050 Hannover Medical School, D 30623 Hannover, Germany
    Anesth Analg 96:1019-26, table of contents. 2003
    ..These results suggest that ketamine is less effective than lidocaine-like local anesthetics in stabilizing the inactivated channel state...
  7. ncbi request reprint High-affinity block of voltage-operated rat IIA neuronal sodium channels by 2,6 di-tert-butylphenol, a propofol analogue
    G Haeseler
    Hannover Medical School, Department of Anesthesiology, Hannover, Germany
    Eur J Anaesthesiol 20:220-4. 2003
    ....
  8. pmc Block of voltage-operated sodium channels by 2,6-dimethylphenol, a structural analogue of lidocaine's aromatic tail
    Gertrud Haeseler
    Department of Anaesthesiology, Hannover Medical School, Germany
    Br J Pharmacol 137:285-93. 2002
    ..This is consistent with the hypothesis that the 'aromatic tail' determines the state-dependent interaction of local anaesthetics with the sodium channel...
  9. ncbi request reprint Voltage-dependent block of neuronal and skeletal muscle sodium channels by thymol and menthol
    G Haeseler
    Hannover Medical School, Department of Anaesthesiology, D 30623 Hannover, Germany
    Eur J Anaesthesiol 19:571-9. 2002
    ..We studied the blocking effects of thymol and menthol on voltage-activated sodium currents in vitro as possible molecular target sites...
  10. pmc Structural requirements for voltage-dependent block of muscle sodium channels by phenol derivatives
    G Haeseler
    Department of Anaesthesiology, Hannover Medical School, D 30623 Hannover, Germany
    Br J Pharmacol 132:1916-24. 2001
    ..Blocking potency is increased by halogenation and by methylation with increasing numbers of methyl groups...
  11. pmc Structural features of phenol derivatives determining potency for activation of chloride currents via alpha(1) homomeric and alpha(1)beta heteromeric glycine receptors
    Gertrud Haeseler
    Department of Anaesthesiology, OE 8050, Hannover Medical School, D 30623 Hannover, Germany
    Br J Pharmacol 145:916-25. 2005
    ..The presence of the beta subunit is not required for both effects...
  12. ncbi request reprint The anesthetic propofol modulates gating in paramyotonia congenita mutant muscle sodium channels
    G Haeseler
    Department of Anesthesiology, OE8050, Hannover Medical School, D 30623 Hannover, Germany
    Muscle Nerve 24:736-43. 2001
    ..Our in vitro results show that inactivation-deficient sodium channels are specifically targeted and blocked by propofol. This might reduce enhanced muscle excitability experienced by affected patients in vivo...
  13. ncbi request reprint Propofol blocks human skeletal muscle sodium channels in a voltage-dependent manner
    G Haeseler
    Department of Anesthesiology, OE8050, Hannover Medical School, D 30623 Hannover, Germany
    Anesth Analg 92:1192-8. 2001
    ..6 microM. These results suggest that propofol significantly blocks sarcolemmal sodium channels at clinically relevant concentrations while maintaining potentials close to the physiological resting potential...
  14. ncbi request reprint Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na(+) channel
    G Haeseler
    Department of Anaesthesia, OE 8050 Hannover Medical School, D 30623, Hannover, Germany
    Eur J Pharmacol 416:11-8. 2001
    ..However, for all compounds, the effect on inactivation was accompanied by a substantial block of the peak current amplitude...
  15. ncbi request reprint Structural requirements of phenol derivatives for direct activation of chloride currents via GABA(A) receptors
    B Mohammadi
    Department of Neurology and Neurophysiology, Hannover Medical School, D-30623, Hannover, Germany
    Eur J Pharmacol 421:85-91. 2001
    ..These results show that the position of the aliphatic substituents with respect to the phenolic hydroxyl group is the crucial structural feature for direct GABA(A) activation by phenol derivatives...
  16. pmc High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues
    G Haeseler
    Department of Anesthesiology, Hannover Medical School, Hannover, Germany
    Br J Pharmacol 155:265-75. 2008
    ..The clinical use of local anaesthetics is still limited by severe side effects, in particular, arrhythmias and convulsions. These side effects render the search for new local anaesthetics a matter of high interest...
  17. ncbi request reprint 2,6 di-tert-butylphenol, a nonanesthetic propofol analog, modulates alpha1beta glycine receptor function in a manner distinct from propofol
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Anesth Analg 99:91-6. 2004
    ..Propofol and its nonanesthetic structural analog do not differ in their ability to coactivate the glycine receptor but differ in their ability to directly activate the receptor in the absence of the natural agonist...
  18. doi request reprint Modulation of glycine receptor function by the synthetic cannabinoid HU210
    Reyhan Demir
    Clinic for Anaesthesia and Critical Care Medicine, Hannover Medical School, Hannover, Germany
    Pharmacology 83:270-4. 2009
    ..7 +/- 46.2 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for HU210 mediating some of its anti-inflammatory and anti-nociceptive properties...
  19. ncbi request reprint [Cricothyroidotomy training on cadavers - experiences in the education of medical students, anaesthetists, and emergency physicians]
    D Breitmeier
    Institut fur Rechtsmedizin, Medizinische Hochschule Hannover
    Anasthesiol Intensivmed Notfallmed Schmerzther 39:94-100. 2004
    ..technique of surgical cricothyroidotomy be practiced on cadavers and should it be a compulsory part of the teaching curriculum? Is it wise to use a speculum for the insertion of the endotracheal tube? What is the optimum size of the tube?..
  20. ncbi request reprint Implicit memory varies as a function of hypnotic electroencephalogram stage in surgical patients
    Sinikka Münte
    Department of Anaesthesiology, Medical School of Hannover, Germany
    Anesth Analg 97:132-8, table of contents. 2003
    ..Increased reading speed for semantically rich content words indicates that anesthetized patients are able to process acoustic information during light and moderate, but not deep, hypnosis...
  21. doi request reprint The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover, Germany
    Pharmacology 83:217-22. 2009
    ..3 micromol/l and alpha(1)beta = 144.3 +/- 22.7 micromol/l). These in vitro results suggest that strychnine-sensitive glycine receptors may be a target for cannabidiol mediating some of its anti-inflammatory and neuroprotective properties...
  22. doi request reprint The non-anaesthetic propofol analogue 2,6-di-tert-butylphenol fails to modulate GABA(A) receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 83:95-8. 2009
    ..Our results support the assumption that modulation of inhibitory GABA(A) receptor function is responsible for the anaesthetic effects of propofol in vivo...
  23. doi request reprint A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor
    Jorg Ahrens
    Department of Anesthesiology, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Anesth Analg 107:1875-83. 2008
    ..In the present study we investigated the role of this residue on the interaction of propofol with the glycine alpha(1) and alpha(1)beta receptor...
  24. doi request reprint Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors
    Jorg Ahrens
    Clinic for Anaesthesia and Critical Care Medicine, OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623, Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 379:371-8. 2009
    ..9 +/- 21.5 microM and alpha(1)beta = 154.3 +/- 32.1 microM). These in vitro results demonstrate that ajulemic acid modulates strychnine-sensitive glycine receptors in clinically relevant concentrations...
  25. doi request reprint The anaesthetic steroid alphaxalone positively modulates alpha1-glycine receptor function
    Jorg Ahrens
    Department of Anaesthesiology, Hannover Medical School, Hannover, Germany
    Pharmacology 82:228-32. 2008
    ..9 +/- 21.5 micromol/l. Taking into account the results of other groups, our study suggests that neuroactive steroids might be an interesting class of compounds to probe subunit-specific effects of glycine receptors...
  26. doi request reprint Strychnine-sensitive glycine receptors mediate the analgesic but not the hypnotic effects of emulsified volatile anaesthetics
    Jorg Ahrens
    Department of Anaesthesiology, OE 8050, Hannover Medical School, Hannover, Germany
    Pharmacology 81:195. 2008
  27. ncbi request reprint Competitive and open channel block of recombinant nAChR channels by different antibiotics
    Friedrich Schlesinger
    Department of Neurology of the Medizinische Hochschule Hannover, 30623 Hannover, Germany
    Neuromuscul Disord 14:307-12. 2004
    ..From our in-vitro results we conclude that competitive inhibition of nAChR channels by antibiotics is an important mechanism underlying the impairment of neuromuscular transmission under clinical conditions...
  28. doi request reprint Lack of positive allosteric modulation of mutated alpha(1)S267I glycine receptors by cannabinoids
    Nilufar Foadi
    Clinic for Anaesthesia and Critical Care Medicine OE 8050, Hannover Medical School, Carl Neuberg Str 1, 30623 Hannover, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:477-82. 2010
    ..An investigation of the impact of such mutations on the in vivo interaction of cannabinoids with glycine receptors should permit a better understanding of the molecular determinants of action of cannabinoids...
  29. pmc An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity
    Martin Leuwer
    University Department of Anaesthesia, The University of Liverpool, UK
    Br J Pharmacol 141:47-54. 2004
    ..Alternatively, they could be interpreted by postulating additional binding sites for lidocaine on fast-inactivated sodium channels...