Thomas Thum

Summary

Affiliation: Hannover Medical School
Country: Germany

Publications

  1. doi request reprint Long noncoding RNAs and microRNAs in cardiovascular pathophysiology
    Thomas Thum
    From the Institute of Molecular and Translational Therapeutic Strategies IMTTS, Integrated Research and Treatment Center Transplantation, and REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany T T National Heart and Lung Institute, Imperial College London, London, United Kingdom T T Humanitas Clinical and Research Center, Rozzano, Milan, Italy G C Institute of Genetics and Biomedical Research, National Research Country of Italy, Milan, Italy G C University of Milan, Milan, Italy G C and Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom G C
    Circ Res 116:751-62. 2015
  2. doi request reprint Vascular importance of the miR-212/132 cluster
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    Eur Heart J 35:3224-31. 2014
  3. doi request reprint MicroRNAs in platelet physiology and pathology
    S Dangwal
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Hamostaseologie 33:17-20. 2013
  4. doi request reprint MicroRNA-24 regulates vascularity after myocardial infarction
    Jan Fiedler
    Hannover Medical School, Institute for Molecular and Translational Therapeutic Strategies, Hannover, Germany
    Circulation 124:720-30. 2011
  5. pmc MicroRNA therapeutics in cardiovascular medicine
    Thomas Thum
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    EMBO Mol Med 4:3-14. 2012
  6. pmc Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans
    Thomas Thum
    Institut für Molekulare und Translationale Therapiestrategien, Medizinische Hochschule Hannover, Germany
    Eur Heart J 32:1275-86. 2011
  7. doi request reprint Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease
    Thomas Thum
    Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Liver Int 30:1181-8. 2010
  8. pmc MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart
    Virginija Jazbutyte
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, IFB Tx, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Age (Dordr) 35:747-62. 2013
  9. ncbi request reprint GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in
    Kristine Chobanyan
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 858:32-41. 2007
  10. doi request reprint Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism
    Felix Fleissner
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Circ Res 107:138-43. 2010

Detail Information

Publications86

  1. doi request reprint Long noncoding RNAs and microRNAs in cardiovascular pathophysiology
    Thomas Thum
    From the Institute of Molecular and Translational Therapeutic Strategies IMTTS, Integrated Research and Treatment Center Transplantation, and REBIRTH Excellence Cluster, Hannover Medical School, Hannover, Germany T T National Heart and Lung Institute, Imperial College London, London, United Kingdom T T Humanitas Clinical and Research Center, Rozzano, Milan, Italy G C Institute of Genetics and Biomedical Research, National Research Country of Italy, Milan, Italy G C University of Milan, Milan, Italy G C and Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom G C
    Circ Res 116:751-62. 2015
    ....
  2. doi request reprint Vascular importance of the miR-212/132 cluster
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Carl Neuberg Str 1, Hannover 30625, Germany
    Eur Heart J 35:3224-31. 2014
    ..Many processes in endothelial cells including angiogenic responses are regulated by microRNAs. However, there is limited information available about their complex cross-talk in regulating certain endothelial functions...
  3. doi request reprint MicroRNAs in platelet physiology and pathology
    S Dangwal
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Hamostaseologie 33:17-20. 2013
    ..Here, we present a review on recently identified platelet miRNAs and their role in platelet physiology that is essential for maintaining haemostasis...
  4. doi request reprint MicroRNA-24 regulates vascularity after myocardial infarction
    Jan Fiedler
    Hannover Medical School, Institute for Molecular and Translational Therapeutic Strategies, Hannover, Germany
    Circulation 124:720-30. 2011
    ..Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood...
  5. pmc MicroRNA therapeutics in cardiovascular medicine
    Thomas Thum
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    EMBO Mol Med 4:3-14. 2012
    ..Here, the current knowledge about miRNAs therapeutics in cardiovascular diseases on their way to clinical use are reviewed and discussed...
  6. pmc Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans
    Thomas Thum
    Institut für Molekulare und Translationale Therapiestrategien, Medizinische Hochschule Hannover, Germany
    Eur Heart J 32:1275-86. 2011
    ..Bone marrow-derived endothelial progenitor cells (EPCs) play an important role in endothelial repair and vascular homeostasis. We hypothesized that hyperaldosteronism impairs EPC function and vascularization capacity in mice and humans...
  7. doi request reprint Measurement and diagnostic use of hepatic cytochrome P450 metabolism of oleic acid in liver disease
    Thomas Thum
    Institute for Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Liver Int 30:1181-8. 2010
    ..Furthermore, the extent of the oleic acid oxidation product cis-9,10-epoxyoctadecanoic acid (cis-EODA) in humans and its plasma levels in patients with impaired liver function are not known...
  8. pmc MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart
    Virginija Jazbutyte
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, IFB Tx, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    Age (Dordr) 35:747-62. 2013
    ..Our results suggest an involvement of miR-22 in age-associated cardiac changes, such as cardiac fibrosis...
  9. ncbi request reprint GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in
    Kristine Chobanyan
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 858:32-41. 2007
    ..The GC-MS assay reported here should be suitable to probe for DDAH activity in various disease models...
  10. doi request reprint Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism
    Felix Fleissner
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Circ Res 107:138-43. 2010
    ..The endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) is increased in patients with coronary artery disease and may regulate function of circulating angiogenic progenitor cells (APCs) by small regulatory RNAs...
  11. doi request reprint Long noncoding RNA Chast promotes cardiac remodeling
    Janika Viereck
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Integriertes Forschungs und Behandlungszentrum Transplantation IFB Tx, Hannover Medical School, D 30625 Hannover, Germany Excellence Cluster REBIRTH, Hannover Medical School, D 30625 Hannover, Germany
    Sci Transl Med 8:326ra22. 2016
    ..These results indicate that Chast can be a potential target to prevent cardiac remodeling and highlight a general role of lncRNAs in heart diseases...
  12. doi request reprint MicroRNAs in myocardial infarction
    Jan Fiedler
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    Arterioscler Thromb Vasc Biol 33:201-5. 2013
    ....
  13. ncbi request reprint MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease
    Dorothee Hartmann
    From Institute of Molecular and Translational Therapeutic Strategies IMTTS, IFB Tx, Hannover Medical School, Germany D H, J F, K S, A J, A P, K Z, J R, A F, K S, S B, T T Department of Cardiology and Angiology, Hannover Medical School, Germany K S, D H K, N F, J H, J B Cellular Neurophysiology, Center of Physiology, Hannover Medical School, Germany M B Department of Vascular and Endovascular Surgery, Technical University Munich, Germany L M Cluster of Excellence REBIRTH, Hannover Medical School, Germany D H K, N F, J H, J B, T T JRG Translational Hematology of Congenital Disease, Cluster of Excellence REBIRTH, Institute of Experimental Hematology, Hannover Medical School
    Circulation 134:1973-1990. 2016
    ..The capacity of this transcription factor in orchestrating endothelial-important microRNAs (miRNAs/miR) is unknown...
  14. doi request reprint Circulating miR-210 predicts survival in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Clin J Am Soc Nephrol 6:1540-6. 2011
    ..We tested whether circulating miRNAs in the plasma of critically ill patients with acute kidney injury (AKI) at the inception of renal replacement therapy are deregulated and may predict survival...
  15. doi request reprint Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome
    Christian Widera
    Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany
    J Mol Cell Cardiol 51:872-5. 2011
    ..The present study tempers speculations about the potential usefulness of cardiomyocyte-enriched microRNAs as diagnostic or prognostic markers in ACS...
  16. doi request reprint miR-21 promotes fibrosis in an acute cardiac allograft transplantation model
    Shashi Kumar Gupta
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, OE 8886, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Cardiovasc Res 110:215-26. 2016
    ..MicroRNAs, a class of small non-coding RNAs, play a critical role in the development of cardiovascular disease, but the role of microRNAs in cardiac allograft failure is not well understood...
  17. doi request reprint Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injury
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS and Department of Medicine Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Clin Chem 61:191-201. 2015
    ..We tested whether circulating lncRNAs in plasma of critically ill patients with acute kidney injury (AKI) at inception of renal replacement therapy were deregulated and might predict survival...
  18. doi request reprint Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure
    Regalla Kumarswamy
    From the Institute of Molecular and Translational Therapeutic Strategies IMTTS, IFB Tx R K, I V, J F, A H, T T and REBIRTH Excellence Cluster T T, Hannover Medical School, Hannover, Germany INSERM, U744, University Lille Nord de France, Lille, France C B, F M, G L, P D G, F P Institut Pasteur de Lille, Lille, France C B, F M, G L, P D G, F P Centre Hospitalier Régional et Universitaire de Lille, Lille, France C B, G L, P D G, F P Faculté de Médecine de Lille, Lille, France C B, G L and National Heart and Lung Institute, Imperial College London, London, United Kingdom T T
    Circ Res 114:1569-75. 2014
    ..Long noncoding RNAs represent a novel class of molecules regulating gene expression. Long noncoding RNAs are present in body fluids, but their potential as biomarkers was never investigated in cardiovascular disease...
  19. ncbi request reprint Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line
    Thomas Thum
    Fraunhofer Institute of Toxicology and Experimental Medicine ITEM, Drug Research and Medical Biotechnology, 30625, Hannover, Germany
    FEBS Lett 555:567-71. 2003
    ..The enhanced eNOS gene/protein expression and enzyme activity correlate well. Our findings are suggestive for a novel role of growth hormone in endothelial biology, and particularly NO production...
  20. pmc Regulation and function of miRNA-21 in health and disease
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    RNA Biol 8:706-13. 2011
    ..Due to the critical functions of its target proteins in various signaling pathways, miR-21 has become an attractive target for genetic and pharmacological modulation in various disease conditions...
  21. doi request reprint Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease
    Christian Wolf
    Institut für Molekulare und Translationale Therapiestrategien IMTTS, Medizinische Hochschule, Hannover, Germany
    Int J Cardiol 156:289-94. 2012
    ..Unlike circulating ADMA, very little is known about urinary ADMA and DMA concentrations and a predictive value in CAD patients...
  22. doi request reprint Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction
    Shashi Kumar Gupta
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 68:1557-71. 2016
    ..Microribonucleic acids (miRNAs) are known to be key players in cardiovascular disease but their involvement in cardiac autophagy and aging is not well understood...
  23. doi request reprint MicroRNA target sites as genetic tools to enhance promoter-reporter specificity for the purification of pancreatic progenitor cells from differentiated embryonic stem cells
    Ulf Diekmann
    Institute of Clinical Biochemistry, Hannover Medical School, 30625, Hannover, Germany
    Stem Cell Rev 9:555-68. 2013
    ....
  24. doi request reprint Regulation of cardiac and renal ischemia-reperfusion injury by microRNAs
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies, Germany
    Free Radic Biol Med 64:78-84. 2013
    ..This review highlights the latest developments regarding the role of microRNAs in cardiac and renal I/R injury. ..
  25. doi request reprint Circulating miR-423_5p fails as a biomarker for systemic ventricular function in adults after atrial repair for transposition of the great arteries
    Oktay Tutarel
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Int J Cardiol 167:63-6. 2013
    ..Its role in patients with a systemic right ventricle and reduced ejection fraction after atrial repair for transposition of the great arteries has not been evaluated...
  26. doi request reprint MicroRNAs in diabetes and diabetes-associated complications
    Johan Lorenzen
    Hannover Medical School, Institute of Molecular and Translational Therapeutic Strategies, Carl Neuberg Str 1, Hannover 30625, Germany
    RNA Biol 9:820-7. 2012
    ....
  27. pmc Critical role of the nitric oxide/reactive oxygen species balance in endothelial progenitor dysfunction
    Felix Fleissner
    Institute of Molecular and Translational Therapeutic Strategies, IFB Tx, Hannover Medical School, Hannover, Germany
    Antioxid Redox Signal 15:933-48. 2011
    ..We also focus on the underlying molecular mechanisms and potential emerging drug- and gene-based therapeutic strategies to improve EPC function in cardiovascular diseased patients...
  28. ncbi request reprint Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes
    Thomas Thum
    Fraunhofer Institute of Toxicology and Experimental Medicine, Centre for Drug Research and Medical Biotechnology, Nikolai Fuchs Str 1, 30625, Hannover, Germany
    Arch Toxicol 82:89-101. 2008
    ..In conclusion, xenobiotic induced hepatotoxicity may arise via several mechanisms and gene expression profiling helps to pinpoint location and pathways perturbed by drugs and chemicals...
  29. doi request reprint Mitochondrial long noncoding RNAs as blood based biomarkers for cardiac remodeling in patients with hypertrophic cardiomyopathy
    Janina Kitow
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, IFB Tx, Hannover Medical School, Hannover, Germany
    Am J Physiol Heart Circ Physiol 311:H707-12. 2016
    ..4 and uc022bqu.1 were upregulated in patients with HOCM and they were also able to identify HOCM and could be developed as useful clinical biomarkers in the future. ..
  30. doi request reprint Non-coding RNAs as modulators of the cardiac fibroblast phenotype
    Maria Teresa Piccoli
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    J Mol Cell Cardiol 92:75-81. 2016
    ....
  31. doi request reprint Long Noncoding RNAs in Urine Are Detectable and May Enable Early Detection of Acute T Cell-Mediated Rejection of Renal Allografts
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies and Department of Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Clin Chem 61:1505-14. 2015
    ..They are detectable in the blood of patients with acute kidney injury. We tested whether lncRNAs are present in urine and may serve as new predictors of outcome in renal transplant patients with acute rejection...
  32. pmc Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany Department of Internal Medicine, Division of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany
    Eur Heart J 36:2184-96. 2015
    ..Osteopontin (OPN) is a multifunctional cytokine critically involved in cardiac fibrosis. However, the underlying mechanisms are unresolved. Non-coding RNAs are powerful regulators of gene expression and thus might mediate this process...
  33. doi request reprint Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines
    Seema Dangwal
    From the Institute of Molecular and Translational Therapeutic Strategies IMTTS S D, C B, J M L, R K, J F, T T, Integrated Research and Treatment Center Transplantation, IFB Tx J M L, C S F, T T, and Institute of Transplant Immunology C S F, Hannover Medical School, Hannover, Germany Heart and Diabetes Center NRW, Ruhr University Bochum, Bad Oeynhausen, Germany B S, D T IZKF Laboratory for Microarray Applications, University Hospital of Wuerzburg, Wuerzburg, Germany C J S and National Heart and Lung Institute, Imperial College London, London, United Kingdom T T
    Arterioscler Thromb Vasc Biol 35:1480-8. 2015
    ..Here, we investigated influence of impaired wound healing on the plasma miRNA signature and their functional importance in patients with type 2 diabetes mellitus...
  34. doi request reprint Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study
    Julia Osipova
    Institute of Molecular and Translational Therapeutic Strategies J O, S D, I V, K S, J M L, T T, IFB Tx, Department of Cardiology C W, Department of Paediatric Kidney, Liver, and Metabolic Diseases D H, Hannover Medical School, 30625 Hannover, Germany Department of Paediatrics D C F, C S, U J, M H, University Hospital Rostock, 18051 Rostock, Germany and National Heart and Lung Institute T T, Imperial College London, London W12 ONN, United Kingdom
    J Clin Endocrinol Metab 99:E1661-5. 2014
    ..Circulating microRNAs (miRNAs/miRs) are used as novel biomarkers for diseases. miR-21, miR-126, and miR-210 are known to be deregulated in vivo or in vitro under diabetic conditions...
  35. pmc Circulating microRNAs are not eliminated by hemodialysis
    Filippo Martino
    Institute for Molecular and Translational Treatment Strategies IMTTS, Hannover Medical School, Hannover, Germany
    PLoS ONE 7:e38269. 2012
    ..In patients with acute kidney injury on dialysis therapy changes of miRNA patterns had been detected. It remains unclear if and how the dialysis procedure itself affects circulating microRNA level...
  36. doi request reprint Circulating and urinary microRNAs in kidney disease
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS and Department of Medicine, Division of Nephrology and Hypertension, Hanover Medical School, Hannover, Germany
    Clin J Am Soc Nephrol 7:1528-33. 2012
    ..The aim of the present article is to give an outline of recent work on circulating and urinary microRNAs as well as their potential paracrine activity in kidney disease...
  37. doi request reprint Pathologic endothelial response and impaired function of circulating angiogenic cells in patients with Fabry disease
    Johan M Lorenzen
    Hannover Medical School, Institute of Molecular and Translational Therapeutic Strategies, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Basic Res Cardiol 108:311. 2013
    ..Fabry patients show a dysfunction of CAC and a pathologic endothelial response. ERT improves CAC and endothelial function and thus may attenuate development of cardiovascular disease in the long term in this patient population...
  38. doi request reprint Cardiovascular importance of the microRNA-23/27/24 family
    Claudia Bang
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    Microcirculation 19:208-14. 2012
    ..Moreover, we illustrate a novel therapeutic application of the miRNA-23/27/24 cluster in vascular disorders and ischemic heart disease...
  39. doi request reprint MicroRNAs and vascular (dys)function
    Dorothee Hartmann
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Vascul Pharmacol 55:92-105. 2011
    ..Furthermore, we discuss how manipulation of these miRNAs could represent a novel therapeutic approach in the treatment of vascular dysfunction...
  40. ncbi request reprint Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease
    Dimitrios Tsikas
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:229-39. 2007
    ..17+/-4.2) being insignificantly lower (P=0.46). Between urinary DMA and ADMA there was a positive correlation (R=0.6655, P<0.0001) in coronary artery disease, but no correlation (R=0.27339) was found in end-stage liver disease...
  41. pmc Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice
    Malte Kölling
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hanover Medical School, 30625 Hannover, Germany
    Mol Ther 25:165-180. 2017
    ..In conclusion, miR-21 antagonism rescued various functional and structural parameters in mice with diabetic nephropathy and, thus, might be a viable option in the treatment of patients with diabetic kidney disease...
  42. pmc MicroRNAs in Serum and Bile of Patients with Primary Sclerosing Cholangitis and/or Cholangiocarcinoma
    Torsten Voigtländer
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany Integrated Research and Treatment Center Transplantation IFB Tx, Hannover Medical School, Hannover, Germany
    PLoS ONE 10:e0139305. 2015
    ..Our aim was to evaluate miRNA patterns in serum and bile of patients with PSC and/or CC...
  43. pmc SERCA2a gene therapy restores microRNA-1 expression in heart failure via an Akt/FoxO3A-dependent pathway
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Eur Heart J 33:1067-75. 2012
    ..We studied the effects of therapeutic AAV9.SERCA2a gene therapy on cardiac miRNome expression and focused on regulation, expression, and function of miR-1 in reverse remodelled failing hearts...
  44. doi request reprint MicroRNAs as mediators and therapeutic targets in chronic kidney disease
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Nat Rev Nephrol 7:286-94. 2011
    ..The therapeutic potential of miRNA-based treatment strategies in CKD are discussed...
  45. doi request reprint Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Arterioscler Thromb Vasc Biol 32:361-9. 2012
    ..Here, we investigated whether microRNA (miR)-21, a microRNA enriched in fibroblasts and involved in general fibrosis, has a role in cardiac EndMT...
  46. doi request reprint Trapping of NAPQI, the intermediate toxic paracetamol metabolite, by aqueous sulfide (S²⁻) and analysis by GC-MS/MS
    Arne Trettin
    Institute of Clinical Pharmacology, Hannover Medical School, 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 963:99-105. 2014
    ..We showed NAPQI in vitro formation from APAP by recombinant cyclooxygenase-1 as well as by dog liver homogenate. In vivo formation of NAPQI was demonstrated in mice given paracetamol intraperitoneally (about 150 mg/kg)...
  47. pmc Functional microRNA library screening identifies the hypoxamir miR-24 as a potent regulator of smooth muscle cell proliferation and vascularization
    Jan Fiedler
    1 Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    Antioxid Redox Signal 21:1167-76. 2014
    ..Dependent on the stimulus, SMC can either be in a proliferative (synthetic) or differentiated state. Alterations of SMC phenotype also appear in several disease settings, further contributing to disease progression...
  48. ncbi request reprint MicroRNAs in platelet biogenesis and function
    Seema Dangwal
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Thromb Haemost 108:599-604. 2012
    ..In the present review we highlight recently identified megakaryocytic/platelet miRNAs and discuss their role in platelet biogenesis and functions essential to maintain haemostasis in the body...
  49. doi request reprint Non-coding RNAs in cardiac remodeling and heart failure
    Regalla Kumarswamy
    Institute of Molecular and Translational Therapeutic Strategies, Hannover, Germany
    Circ Res 113:676-89. 2013
    ....
  50. pmc Circulating microRNAs in patients with Shiga-Toxin-producing E. coli O104:H4 induced hemolytic uremic syndrome
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover, Germany
    PLoS ONE 7:e47215. 2012
    ..MicroRNAs are small ribonucleotides orchestrating gene expression. We tested whether circulating microRNAs in serum of HUS patients during the 2011 epidemics are altered in this patient cohort and related to clinical manifestations...
  51. pmc Aromatase inhibition attenuates desflurane-induced preconditioning against acute myocardial infarction in male mouse heart in vivo
    Virginija Jazbutyte
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, MHH, Hannover, Germany
    PLoS ONE 7:e42032. 2012
    ....
  52. doi request reprint miRNAs involved in the generation, maintenance, and differentiation of pluripotent cells
    Nils Pfaff
    REBIRTH Research Group Reprogramming, Hannover Medical School 30625, Hannover, Germany
    J Mol Med (Berl) 90:747-52. 2012
    ..In this review, we will discuss the role of microRNAs in pluripotent stem cells and their impact on the induction of pluripotency during reprogramming of somatic cells...
  53. doi request reprint Role of microRNAs in immunity and organ transplantation
    Janine C Spiegel
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    Expert Rev Mol Med 13:e37. 2011
    ..We also focus on the molecular mechanisms and therapeutic implications of the use of miRNA-based therapeutic strategies to improve long-term allograft survival...
  54. ncbi request reprint MicroRNA-21: from cancer to cardiovascular disease
    Virginija Jazbutyte
    Institute for Molecular and Translational Therapeutic Strategies, Medical School Hannover, Carl Neuberg Strasse 1, Hannover, Germany
    Curr Drug Targets 11:926-35. 2010
    ..Further, miR-21 regulatory mechanisms and miR-21 downstream targets are discussed. Finally, we highlight the particular role of miR-21 as a therapeutic target in various diseases...
  55. doi request reprint Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes
    Arash Haghikia
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Eur Heart J 32:1287-97. 2011
    ..We investigated the impact of STAT3-mediated regulation of microRNAs for pathophysiological alterations in the heart...
  56. doi request reprint Organic nitrates differentially modulate circulating endothelial progenitor cells and endothelial function in patients with symptomatic coronary artery disease
    Thomas Thum
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany
    Antioxid Redox Signal 15:925-31. 2011
    ..Treatment of symptomatic CAD patients with PETN for 14 days significantly increased levels of circulating EPC and improved markers for EPC function, whereas ISDN was without effects on EPCs and worsened endothelial function...
  57. ncbi request reprint Noncoding RNAs in Heart Failure
    Seema Dangwal
    Institute of Molecular and Translational Therapeutic Strategies, IFBTx, Hannover Medical School, Hannover, Germany
    Handb Exp Pharmacol . 2016
    ..In-depth study of their interaction with gene networks will refine our current view of heart failure and revolutionize the drug development in coming years...
  58. doi request reprint Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches
    Julia Beermann
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany and National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Physiol Rev 96:1297-325. 2016
    ..We specifically focus on non-coding RNAs as potential therapeutic targets and diagnostic biomarkers. ..
  59. doi request reprint Bioinformatics of cardiovascular miRNA biology
    Meik Kunz
    Functional Genomics and Systems Biology Group, Department of Bioinformatics, Biocenter, Wurzburg, Germany Institute for Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    J Mol Cell Cardiol 89:3-10. 2015
    ..In addition, we discuss drawbacks and limitations of bioinformatics algorithms and the necessity of experimental approaches for miRNA target identification. This article is part of a Special Issue entitled 'Non-coding RNAs'. ..
  60. doi request reprint MicroRNAs play a role in spontaneous recovery from acute liver failure
    Katharina John
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    Hepatology 60:1346-55. 2014
    ....
  61. ncbi request reprint Testosterone, cytochrome P450, and cardiac hypertrophy
    Thomas Thum
    Center of Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany
    FASEB J 16:1537-49. 2002
    ..We show alpha-MHC to be significantly repressed in cardiac hypertrophy and restored to normal on testosterone supplementation. We conclude that heart-specific steroid metabolism is of critical importance in cardiac hypertrophy..
  62. ncbi request reprint Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?
    Thomas Thum
    Center of Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Circ Res 94:e1-13. 2004
    ..Therapy of endothelial dysfunction through LOX-1 receptor antagonism will be an interesting avenue to explore. The full text of this article is available online at http://www.circresaha.org...
  63. pmc miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2
    Nils Pfaff
    REBIRTH Group Reprogramming, Hannover Medical School, 30625 Hannover, Germany
    EMBO Rep 12:1153-9. 2011
    ..Mechanistically, miRNA-resistant Meox2 overexpression abrogated effects of miR-130/301/721 on reprogramming. In conclusion, the miRNA family miR-130/301/721 enhances iPSC generation via repression of Meox2...
  64. ncbi request reprint Hallmarks of ion channel gene expression in end-stage heart failure
    Jurgen Borlak
    Fraunhofer Institute of Toxicology and Experimental Medicine, Center for Drug Research and Medical Biotechnology, 30625 Hannover, Germany
    FASEB J 17:1592-608. 2003
    ..Overall, the reversal of repressed ion channel gene expression in patients with implanted assist devices exemplifies the complex interactions between pressure load/stretch force and heart-specific gene expression...
  65. doi request reprint MicroRNAs in hypertension: mechanisms and therapeutic targets
    Sandor Batkai
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Carl Neuberg Str 1, 0625 Hannover, Germany
    Curr Hypertens Rep 14:79-87. 2012
    ..This article reviews the potential role of microRNAs in the mechanisms associated with the development and consequences of hypertension and discusses advances in microRNA-based approaches that may be important in treating hypertension...
  66. pmc Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers
    Thomas Thum
    Drug Research and Medical Biotechnology, Fraunhofer Instituteof technology and Experimental Medicien, Hannover, Germany
    Environ Health Perspect 114:1655-61. 2006
    ..Cytochrome P450 monooxygenases (CYP) play an important role in the defense against inhaled toxicants, and expression of CYP enzymes may differ among various lung cells and tissue compartments...
  67. ncbi request reprint Verapamil: new insight into the molecular mechanism of drug oxidation in the human heart
    Markus Walles
    Fraunhofer Institute of Toxicology and Aerosol Research, Center of Drug Research and Medical Biotechnology, Hannover, Germany
    J Chromatogr A 970:117-30. 2002
    ..A fine example of the considerable metabolic competence of human heart is the formation of M1-M4, e.g. dealkylverapamil, norverapamil and isomers of O-demethylverapamil, which were believed to be exclusively produced by the liver...
  68. doi request reprint Biogenesis and regulation of cardiovascular microRNAs
    Johann Bauersachs
    Hannover Medical School, Institute of Molecular and Translational Therapeutic Strategies, Carl Neuberg Strasse 1, Hannover, Germany
    Circ Res 109:334-47. 2011
    ..Better knowledge about regulatory mechanisms of miRNAs in cardiovascular disease will probably lead to improved and novel miRNA-based therapeutic therapies...
  69. doi request reprint Noncoding RNAs as regulators of cardiomyocyte proliferation and death
    Maria Teresa Piccoli
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, IFB Tx, Hannover Medical School, Hannover, Germany Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany
    J Mol Cell Cardiol 89:59-67. 2015
    ..This article is part of a Special Issue entitled SI: Non-coding RNAs. ..
  70. pmc Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization
    Jan Fiedler
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany Integrated Research and Treatment Center Transplantation, Hannover Medical School, Hannover, Germany
    J Am Coll Cardiol 66:2005-15. 2015
    ..Long noncoding ribonucleic acids (lncRNAs) are a subclass of regulatory noncoding ribonucleic acids for which expression and function in human endothelial cells and angiogenic processes is not well studied...
  71. pmc Epigenetic modifications in cardiovascular disease
    Johan M Lorenzen
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover, Germany
    Basic Res Cardiol 107:245. 2012
    ..In addition, RNA-based mechanisms (e.g., microRNAs and long non-coding RNAs) influence the development of disease. We here outline the recent work pertaining to epigenetic changes in a cardiovascular disease setting...
  72. doi request reprint TLR-4+ peripheral blood monocytes and cardiovascular events in patients with chronic kidney disease--a prospective follow-up study
    Johan M Lorenzen
    Division of Nephrology, Department of Internal Medicine, Hannover Medical School, Hannover, Germany
    Nephrol Dial Transplant 26:1421-4. 2011
    ..Atherosclerosis is an inflammatory process mediated by circulating immune cells, including monocytes. There is accumulating evidence for the involvement of Toll-like receptor 4 (TLR-4) as a mediator of atherogenesis...
  73. doi request reprint LC-MS/MS and GC-MS/MS measurement of plasma and urine di-paracetamol and 3-nitro-paracetamol: proof-of-concept studies on a novel human model of oxidative stress based on oral paracetamol administration
    Arne Trettin
    Institute of Clinical Pharmacology, Hannover Medical School, 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 959:71-81. 2014
    ....
  74. doi request reprint MicroRNAs in the bile of patients with biliary strictures after liver transplantation
    Tim O Lankisch
    Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany Integrated Research and Treatment Center Transplantation, Hannover Medical School, Hannover, Germany
    Liver Transpl 20:673-8. 2014
    ..An analysis of miRNA profiles may be useful in the diagnosis and management of patients with ITBLs. Future studies are needed to prove the potential prognostic value of these miRNAs...
  75. doi request reprint Regulatory RNAs and paracrine networks in the heart
    Janika Viereck
    Institute of Molecular and Translational Therapeutic Strategies, IFB Tx, Hannover Medical School, Carl Neuberg Str 1, Hannover D 30625, Germany
    Cardiovasc Res 102:290-301. 2014
    ..It also highlights therapeutic strategies targeting factors of pathological communication for the treatment of HF. ..
  76. ncbi request reprint Identification of major CYP2C9 and CYP2C19 polymorphisms by fluorescence resonance energy transfer analysis
    Jurgen Borlak
    Fraunhofer Institute of Toxicology and Aerosol Research, Center of Drug Research and Medical Biotechnology, 30625 Hannover, Germany
    Clin Chem 48:1592-4. 2002
  77. doi request reprint Increase of pro-inflammatory cytokine expression in non-demyelinating early cerebral lesions in nervous canine distemper
    Andreas Beineke
    Institut fur Pathologie, Stiftung Tierarztliche Hochschule Hannover, Hannover, Germany
    Viral Immunol 21:401-10. 2008
    ..Furthermore, the lack of light microscopic changes indicates that additional factors besides cytokines are necessary for the development of a distemper-characteristic neuropathology...
  78. ncbi request reprint Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB
    Ralf Gerhard
    Institute of Toxicology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 280:1499-505. 2005
    ....
  79. ncbi request reprint A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol
    Jurgen Borlak
    Fraunhofer Institute of Toxicology and Experimental Mecicine, Center of Drug Research and Medical Biotechnology, Hannover, Germany
    Metabolism 52:1439-43. 2003
    ..Our assay can be used reliably in clinical pharmacology studies and may be used for dose adjustment...
  80. pmc Circulating microRNAs for predicting and monitoring response to mechanical circulatory support from a left ventricular assist device
    Andrew C Morley-Smith
    National Institute for Health Research Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK National Heart and Lung Institute, Imperial College London, London, UK Institute of Molecular and Translational Therapeutic Strategies, Integrated Research and Treatment Center Transplantation, Hannover Medical School, Hannover, Germany
    Eur J Heart Fail 16:871-9. 2014
    ..They are stable in the circulation, readily quantified, and may be useful as new biomarkers. This study sought to identify candidate miR biomarkers for further investigation...
  81. doi request reprint Analytical approaches in microRNA therapeutics
    Sandor Batkai
    Institute of Molecular and Translational Therapeutic Strategies IMTTS, Hannover Medical School, Hannover Germany Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 964:146-52. 2014
    ..This brief review highlights current developments in the field of microRNA analytics, detection techniques for extracellular microRNAs, their synthetic inhibitors, and the dynamics of their interactions. ..
  82. doi request reprint Impact of a Met(11)Thr single nucleotide polymorphism of surfactant protein D on allergic airway inflammation in a murine asthma model
    Carla Winkler
    1Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    Exp Lung Res 40:154-63. 2014
    ..MiR-21 and 155 are differentially regulated in transgenic mice in response to allergic inflammation. Further studies are required to elucidate the impact of this SNP on inflammatory conditions of the lung...
  83. doi request reprint Exosomes: new players in cell-cell communication
    Claudia Bang
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Int J Biochem Cell Biol 44:2060-4. 2012
    ..Moreover, the potential clinical application of exosomes as biomarkers and therapeutic tools will be discussed...
  84. pmc Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
    Philip Wenzel
    Second Medical Clinic, Department of Cardiology and Angiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Atherosclerosis 198:65-76. 2008
    ....