Carsten Munk

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. doi request reprint Identification of a conserved interface of HIV-1 and FIV Vifs with Cullin 5.
    Qinyong Gu
    J Virol . 2017
  2. pmc A functional conserved intronic G run in HIV-1 intron 3 is critical to counteract APOBEC3G-mediated host restriction
    Marek Widera
    Retrovirology 11:72. 2014
  3. pmc Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction
    Dragana Slavkovic Lukic
    Research Program Infection and Cancer, Department Genome Modifications and Carcinogenesis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Retrovirology 10:76. 2013
  4. pmc Running loose or getting lost: how HIV-1 counters and capitalizes on APOBEC3-induced mutagenesis through its Vif protein
    Carsten Munk
    Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University, 40225 Dusseldorf, Germany
    Viruses 4:3132-61. 2012
  5. pmc High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity
    Eva K Pauli
    Institute of Molecular Virology, Centre of Molecular Biology of Inflammation ZMBE, Westfaelische Wilhelms University Muenster, Munster, Germany
    Retrovirology 6:38. 2009
  6. pmc Systems-biology approaches to discover anti-viral effectors of the human innate immune response
    Carsten Munk
    Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University, Dusseldorf 40225, Germany
    Viruses 3:1112-30. 2011
  7. pmc Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C
    Zeli Zhang
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    J Virol 90:10193-10208. 2016
  8. pmc APOBEC4 Enhances the Replication of HIV-1
    Daniela Marino
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    PLoS ONE 11:e0155422. 2016
  9. pmc Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors
    Zeli Zhang
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Dusseldorf, Building 23 12 U1 82, Moorenstr 5, 40225, Dusseldorf, Germany
    Retrovirology 13:46. 2016
  10. pmc Feline Immunodeficiency Virus Vif N-Terminal Residues Selectively Counteract Feline APOBEC3s
    Qinyong Gu
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    J Virol 90:10545-10557. 2016

Collaborators

  • Jörg Zielonka
  • Ignacio G Bravo
  • Kei Sato
  • Steffen Erkelenz
  • Heiner Schaal
  • Didier Trono
  • Egbert Flory
  • Naoya Yuhki
  • Christel Kamp
  • Qinyong Gu
  • Zeli Zhang
  • Dieter Haussinger
  • Klaus Cichutek
  • Ananda Ayyappan Jaguva Vasudevan
  • Marek Widera
  • Mario Perkovic
  • Henning Hofmann
  • Holger Gohlke
  • Anika Hain
  • Sander H J Smits
  • Daniela Marino
  • Gerald G Schumann
  • Axel V Horn
  • Kay Martin Hanschmann
  • Frank Hillebrand
  • Dragana Slavkovic Lukic
  • Eva Dörrschuck
  • Eva K Pauli
  • Christoph G W Gertzen
  • Carsten M nk
  • Dieter H ussinger
  • Sascha Hasheminasab
  • Renate König
  • Lucía Cano Ortiz
  • Manimehalai Jeyaraj
  • Ananda A Jaguva Vasudevan
  • Stanislaw Schmidt
  • Jens Ove Heckel
  • Björn Philipp Kloke
  • Michael D Mühlebach
  • Ana Cláudia Franco
  • Daniel Mulnaes
  • Jan Hendrik Trösemeier
  • Ananda Vasudevan
  • Sabine Klawitter
  • Ulrike Held
  • Johannes Lower
  • Roswitha Löwer
  • Andre Berger
  • Kay Martin O Hanschmann
  • Jeffrey S Han
  • Anja Bock
  • Robert A Jabulowsky
  • Agnes Hotz-Wagenblatt
  • Darius Widera
  • Rafael Dellen
  • Aikaterini Krikoni
  • Barbara Kaltschmidt
  • Janet Lei
  • Wolfgang Kaisers
  • Michael Mühle
  • Martin Lochelt
  • Joachim Denner
  • Valerie Bosch
  • Karl Köhrer
  • Yannick Bulliard
  • René Deenen
  • Tanya Pfeiffer
  • Michael Gombert
  • Ann Mareen Räthe
  • Nicole Fischer
  • Ralf R Tönjes
  • Andreas Spötter
  • Heidi Kuiper
  • Ronny Möller
  • Christina Ehrhardt
  • Stephan Ludwig
  • Mirco Schmolke

Detail Information

Publications17

  1. doi request reprint Identification of a conserved interface of HIV-1 and FIV Vifs with Cullin 5.
    Qinyong Gu
    J Virol . 2017
    ..While our structural model suggests that the diverse FIV and HIV-1 Vifs use conserved residues for Cullin 5 binding, FIV Vif binds Cullin 5 independently of zinc in contrast to HIV-1 Vif...
  2. pmc A functional conserved intronic G run in HIV-1 intron 3 is critical to counteract APOBEC3G-mediated host restriction
    Marek Widera
    Retrovirology 11:72. 2014
    ..The competition between these exons determines the ability to evade APOBEC3G-mediated antiviral effects due to optimal vif expression...
  3. pmc Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction
    Dragana Slavkovic Lukic
    Research Program Infection and Cancer, Department Genome Modifications and Carcinogenesis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Retrovirology 10:76. 2013
    ..Due to a long-lasting FV-host coevolution, Bet proteins mainly counteract restriction by A3s from their cognate or highly related host species...
  4. pmc Running loose or getting lost: how HIV-1 counters and capitalizes on APOBEC3-induced mutagenesis through its Vif protein
    Carsten Munk
    Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University, 40225 Dusseldorf, Germany
    Viruses 4:3132-61. 2012
    ..Both experimental evidence and the substantiation of the underlying dynamics through coevolutionary models are presented as complementary views of a coevolutionary arms race...
  5. pmc High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity
    Eva K Pauli
    Institute of Molecular Virology, Centre of Molecular Biology of Inflammation ZMBE, Westfaelische Wilhelms University Muenster, Munster, Germany
    Retrovirology 6:38. 2009
    ..It further turned out that APOBEC expression is part of a general IFNbeta response to infection. However, although strongly induced, APOBEC3G does not negatively affect influenza A virus propagation...
  6. pmc Systems-biology approaches to discover anti-viral effectors of the human innate immune response
    Carsten Munk
    Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University, Dusseldorf 40225, Germany
    Viruses 3:1112-30. 2011
    ....
  7. pmc Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C
    Zeli Zhang
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    J Virol 90:10193-10208. 2016
    ..This finding indicates that internal interactions outside the A3 binding region in HIV-1 Vif influence the capacity to induce degradation of A3C/A3F...
  8. pmc APOBEC4 Enhances the Replication of HIV-1
    Daniela Marino
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    PLoS ONE 11:e0155422. 2016
    ..We hypothesize that A4 may have a natural role in modulating host promoters or endogenous LTR promoters. ..
  9. pmc Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors
    Zeli Zhang
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University Dusseldorf, Building 23 12 U1 82, Moorenstr 5, 40225, Dusseldorf, Germany
    Retrovirology 13:46. 2016
    ..Only A3Z3 and A3Z2Z3 inhibit Vif-deficient FIV. Feline A3s also are restriction factors for HIV and Simian immunodeficiency viruses (SIV). Surprisingly, HIV-2/SIV Vifs can counteract feline A3Z2Z3...
  10. pmc Feline Immunodeficiency Virus Vif N-Terminal Residues Selectively Counteract Feline APOBEC3s
    Qinyong Gu
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    J Virol 90:10545-10557. 2016
    ..Our data support a complex model of multiple Vif-A3 interactions in which the specific region for selective A3 counteraction is discrete from a general A3 binding domain...
  11. pmc Prototype foamy virus Bet impairs the dimerization and cytosolic solubility of human APOBEC3G
    Ananda Ayyappan Jaguva Vasudevan
    Clinic for Gastroenterology, Hepatology, and Infectiology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    J Virol 87:9030-40. 2013
    ....
  12. pmc An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA
    Marek Widera
    Institute for Virology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    J Virol 87:2707-20. 2013
    ..These observations suggest that an appropriate ratio of Vif-to-A3G protein levels is required for optimal virus replication and that part of Vif level regulation is effected by the novel G run identified here...
  13. pmc Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity
    Axel V Horn
    Section PR2 Retroelements, Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, 63225 Langen, Germany, Department of Embryology, Carnegie Institution of Washington, 3520 San Martin Drive, Baltimore, MD 21218, USA, Division of Medical Biotechnology, Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, 63225 Langen, Germany, Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University, 40225 Dusseldorf, Germany and Biostatistics Section, Paul Ehrlich Institut, Paul Ehrlich Strasse 51 59, 63225 Langen, Germany
    Nucleic Acids Res 42:396-416. 2014
    ..Furthermore, we demonstrate that the amount of L1 complementary DNA synthesized by L1 reverse transcriptase is reduced by ≈ 50% if overexpressed A3C is present...
  14. pmc Cellular restriction factors of feline immunodeficiency virus
    Jörg Zielonka
    Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University, Dusseldorf 40225, Germany
    Viruses 3:1986-2005. 2011
    ..We describe here the molecular mechanisms that explain how FIV maintains its replication in feline cells, but is largely prevented from cross-species infections by cellular restriction factors...
  15. pmc An ancient history of gene duplications, fusions and losses in the evolution of APOBEC3 mutators in mammals
    Carsten Munk
    Clinic for Gastroenterology, Hepatology and Infectiology, Medical Faculty, Heinrich Heine University, Dusseldorf, Germany
    BMC Evol Biol 12:71. 2012
    ..Further, the expression of A3 activity/ies shapes the way both viral and host genomes evolve...
  16. pmc Vif of feline immunodeficiency virus from domestic cats protects against APOBEC3 restriction factors from many felids
    Jörg Zielonka
    Clinic for Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Building 23 12 U1 87, Moorenstr 5, 40225 Dusseldorf, Germany
    J Virol 84:7312-24. 2010
    ..We conclude that the replication of HIV-1 in some feline cells is inhibited only by feline A3 restriction factors and the absence of the appropriate receptor or coreceptor...
  17. pmc Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases
    Eva Dörrschuck
    Division of Medical Biotechnology, Paul Ehrlich Institut, Langen, Germany
    J Virol 85:3842-57. 2011
    ..These results strongly imply that human and porcine A3s could inhibit PERV replication in vivo, thereby reducing the risk of infection of human cells by PERV in the context of pig-to-human xenotransplantation...