W A Schulz

Summary

Affiliation: Heinrich Heine University
Country: Germany

Publications

  1. pmc Epigenetics of prostate cancer: beyond DNA methylation
    W A Schulz
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    J Cell Mol Med 10:100-25. 2006
  2. ncbi request reprint DNA methylation alterations in urothelial carcinoma
    Anne Neuhausen
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Cancer Biol Ther 5:993-1001. 2006
  3. doi request reprint Epigenetic mechanisms in the biology of prostate cancer
    Wolfgang A Schulz
    Urologische Klinik, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Semin Cancer Biol 19:172-80. 2009
  4. doi request reprint Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs.
    Nicole N sgen
    Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Clin Epigenetics 7:17. 2015
  5. pmc The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies
    Julie Earl
    Epithelial Carcinogenesis Group, F BBVA Cancer Cell Biology programme, CNIO Spanish National Cancer Research Centre, Madrid, Spain
    BMC Genomics 16:403. 2015
  6. pmc DNA Methylation and the HOXC6 Paradox in Prostate Cancer
    Anna Vinarskaja
    Department of Urology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Cancers (Basel) 3:3714-25. 2011
  7. doi request reprint Epigenetics of urothelial carcinoma
    Wolfgang A Schulz
    Department of Urology, Heinrich Heine University, Universitatsstr 1, 40225, Dusseldorf, Germany
    Methods Mol Biol 1238:183-215. 2015
  8. pmc Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation
    A R Florl
    Department of Urology, Heinrich Heine University Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    Br J Cancer 91:985-94. 2004
  9. pmc E-cadherin involved in inactivation of WNT/beta-catenin signalling in urothelial carcinoma and normal urothelial cells
    I Thievessen
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Br J Cancer 88:1932-8. 2003
  10. pmc Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer
    Qiong Wu
    Dept of Urology, Heinrich Heine University, Dusseldorf, Germany
    Mol Cancer 4:16. 2005

Detail Information

Publications80

  1. pmc Epigenetics of prostate cancer: beyond DNA methylation
    W A Schulz
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    J Cell Mol Med 10:100-25. 2006
    ..The aberrant differentiation state of prostate carcinoma cells also results in distorted mutual interactions between epithelial and stromal cells in the tumor that promote tumor growth, invasion, and metastasis...
  2. ncbi request reprint DNA methylation alterations in urothelial carcinoma
    Anne Neuhausen
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Cancer Biol Ther 5:993-1001. 2006
    ..In conclusion, markers of genome-wide hypomethylation seem optimally suited for urothelial carcinoma detection, whereas combinations of hypermethylation and hypomethylation assays hold promise for classification...
  3. doi request reprint Epigenetic mechanisms in the biology of prostate cancer
    Wolfgang A Schulz
    Urologische Klinik, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Semin Cancer Biol 19:172-80. 2009
    ..Because of their crucial role, epigenetic alterations may become highly useful for diagnostics and therapy of prostate cancer...
  4. doi request reprint Inter-locus as well as intra-locus heterogeneity in LINE-1 promoter methylation in common human cancers suggests selective demethylation pressure at specific CpGs.
    Nicole N sgen
    Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Clin Epigenetics 7:17. 2015
    ..With a broader selection of loci, locus-specific LINE-1 methylation could become a tool for tumor detection...
  5. pmc The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies
    Julie Earl
    Epithelial Carcinogenesis Group, F BBVA Cancer Cell Biology programme, CNIO Spanish National Cancer Research Centre, Madrid, Spain
    BMC Genomics 16:403. 2015
    ....
  6. pmc DNA Methylation and the HOXC6 Paradox in Prostate Cancer
    Anna Vinarskaja
    Department of Urology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    Cancers (Basel) 3:3714-25. 2011
    ....
  7. doi request reprint Epigenetics of urothelial carcinoma
    Wolfgang A Schulz
    Department of Urology, Heinrich Heine University, Universitatsstr 1, 40225, Dusseldorf, Germany
    Methods Mol Biol 1238:183-215. 2015
    ..There are indeed excellent biomarker candidates for DNA-methylation-based diagnostics of urothelial carcinoma, whereas miRNAs are well investigated, but there are still many discrepancies between studies published to date. ..
  8. pmc Coordinate hypermethylation at specific genes in prostate carcinoma precedes LINE-1 hypomethylation
    A R Florl
    Department of Urology, Heinrich Heine University Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    Br J Cancer 91:985-94. 2004
    ..Hypermethylation allows detection of >82% of PCas. PCa may fall into three classes, that is, with few DNA methylation changes, with frequent hypermethylation, or with additional LINE-1 hypomethylation...
  9. pmc E-cadherin involved in inactivation of WNT/beta-catenin signalling in urothelial carcinoma and normal urothelial cells
    I Thievessen
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Br J Cancer 88:1932-8. 2003
    ..However, decreased E-cadherin expression occurring in many TCC, often as a consequence of promoter hypermethylation, may confer inappropriate responsiveness to WNT factors...
  10. pmc Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer
    Qiong Wu
    Dept of Urology, Heinrich Heine University, Dusseldorf, Germany
    Mol Cancer 4:16. 2005
    ..We have therefore investigated whether the intermediate region harboring the oncogene candidate ID4 is also part of the amplicon...
  11. ncbi request reprint Understanding urothelial carcinoma through cancer pathways
    Wolfgang A Schulz
    Department of Urology, Heinrich Heine University Dusseldorf, Germany
    Int J Cancer 119:1513-8. 2006
    ..This may reflect its origin from more differentiated urothelial cells possessing a high regenerative potential rather than a stem cell population...
  12. ncbi request reprint Methylation of endogenous human retroelements in health and disease
    W A Schulz
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Curr Top Microbiol Immunol 310:211-50. 2006
    ..The emerging insights into the pathophysiological importance of endogenous retroelements accentuate the gaps in our knowledge of how these elements are controlled in normal developing and mature cells...
  13. ncbi request reprint Genomewide DNA hypomethylation is associated with alterations on chromosome 8 in prostate carcinoma
    Wolfgang A Schulz
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Genes Chromosomes Cancer 35:58-65. 2002
    ..This association suggests that DNA hypomethylation and alterations in chromosome 8 may be mechanistically linked to each other in prostate carcinoma...
  14. pmc Factor interaction analysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer
    Wolfgang A Schulz
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Mol Cancer 6:14. 2007
    ..In a former study including many metastatic cases, they strongly correlated with each other. To elucidate a possible interaction between the two alterations, we investigated their relationship in less advanced prostate cancers...
  15. pmc Insights into cancer mechanisms from genomic research on urological cancers
    Wolfgang A Schulz
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Genome Med 3:20. 2011
    ..Consideration of these variations alongside the common basic cancer mechanisms might be important for the successful development of targeted therapies...
  16. ncbi request reprint Transcription factor networks in embryonic stem cells and testicular cancer and the definition of epigenetics
    Wolfgang A Schulz
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Epigenetics 2:37-42. 2007
    ..Intriguingly, the ES cell transcription factor network fits current as well as past definitions of 'epigenetic'...
  17. pmc Changes in cortical cytoskeletal and extracellular matrix gene expression in prostate cancer are related to oncogenic ERG deregulation
    Wolfgang A Schulz
    Department of Urology, Heinrich Heine University, Moorenstr 5, 40225 Dusseldorf, Germany
    BMC Cancer 10:505. 2010
    ..Previous studies have suggested changes in the expression of specific components in prostate cancer, especially of 4.1 proteins (encoded by EPB41 genes) which form nodes in this network...
  18. ncbi request reprint Molecular biology of prostate cancer
    W A Schulz
    Department of Urology, Heinrich Heine University Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Mol Hum Reprod 9:437-48. 2003
    ..Further successful transfer of results from molecular biology to the clinic will, however, require integration of the amassed molecular data into a biological framework model of prostate carcinoma...
  19. ncbi request reprint Effects of WNT/beta-catenin pathway activation on signaling through T-cell factor and androgen receptor in prostate cancer cell lines
    M V Cronauer
    Department of Urology, Heinrich Heine Universitat, D 40225 Dusseldorf, Germany
    Int J Oncol 26:1033-40. 2005
    ..In summary, the data from our study support the idea that activation of WNT/beta-catenin signaling in AR-positive prostate cancer cells may predominantly act through AR-dependent mechanisms rather than classical TCF-dependent mechanisms...
  20. ncbi request reprint Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder
    F Kimura
    Urologische Klinik, , , Germany
    Mutat Res 458:49-54. 2001
    ..Thus, on their own, the MTHFR, MS and CBS genotypes do not appear to act upon susceptibility to TCC or influence the extent of DNA hypomethylation in this cancer...
  21. ncbi request reprint Novel mutations of the von hippel-lindau tumor-suppressor gene and rare DNA hypermethylation in renal-cell carcinoma cell lines of the clear-cell type
    A J Meyer
    Department of Urology, University of Dusseldorf, Germany
    Int J Cancer 87:650-3. 2000
    ..In contrast, hypermethylation of the gene is probably a rare event. The high frequency of transversion mutations suggests a role for exogenous carcinogens in the etiology of clear-cell RCCs...
  22. ncbi request reprint Hypermethylation of the tumor necrosis factor receptor superfamily 6 (APT1, Fas, CD95/Apo-1) gene promoter at rel/nuclear factor kappaB sites in prostatic carcinoma
    S Santourlidis
    Urologische Klinik, , , Germany
    Mol Carcinog 32:36-43. 2001
    ..Thus, although the TNFRSF6 gene can be inactivated efficiently by DNA methylation, hypermethylation occurs neither frequently nor extensively in human carcinomas and appears to play a limited role in downregulation of Fas expression...
  23. pmc Destabilization of chromosome 9 in transitional cell carcinoma of the urinary bladder
    F Kimura
    Urologische Klinik, , Moorenstrasse 5, , Germany
    Br J Cancer 85:1887-93. 2001
    ....
  24. ncbi request reprint Loss of function of the tissue specific transcription factor HNF1 alpha in renal cell carcinoma and clinical prognosis
    A G Anastasiadis
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Anticancer Res 19:2105-10. 1999
    ..Human renal cell carcinogenesis is associated with loss of expression of tissue-specific genes and loss of function of tissue-specific transcription factors such as HNF(hepatic nuclear factor)1 alpha...
  25. ncbi request reprint Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma
    C Steinhoff
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Arch Toxicol 74:521-6. 2000
    ....
  26. ncbi request reprint Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma
    S Fritzsche
    Department of Urology, Heinrich Heine University, Dusseldorf, Moorenstr 5, 40225 Dusseldorf, Germany
    Endocr Relat Cancer 13:839-49. 2006
    ..The present study confirms and extends previous reports by demonstrating concomitant down-regulation and a significant association with recurrence of SPRY genes...
  27. pmc DKC1 overexpression associated with prostate cancer progression
    P Sieron
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Br J Cancer 101:1410-6. 2009
    ..In this study, we report DKC1 overexpression in prostate cancers...
  28. pmc DNA methylation and expression of LINE-1 and HERV-K provirus sequences in urothelial and renal cell carcinomas
    A R Florl
    Urologische Klinik, , , Germany
    Br J Cancer 80:1312-21. 1999
    ....
  29. ncbi request reprint The androgen receptor in hormone-refractory prostate cancer: relevance of different mechanisms of androgen receptor signaling (Review)
    M V Cronauer
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Int J Oncol 23:1095-102. 2003
    ..The following review will discuss the elements involved in androgen receptor signaling and summarize the present knowledge of their biological and clinical relevance in advanced prostate cancer...
  30. pmc Decreased expression of p57(KIP2)mRNA in human bladder cancer
    M Oya
    Urologische Klinik, , Moorenstrasse 5, , D 40225, Germany
    Br J Cancer 83:626-31. 2000
    ..5. However, reminiscent of the situation in Wilms' tumours, expression of the IGF2 gene on the paternal chromosome can also be disturbed in bladder cancers...
  31. ncbi request reprint Downregulation of several fibulin genes in prostate cancer
    Agnes Wlazlinski
    Department of Urology, Heinrich Heine University, Duesseldorf, Germany
    Prostate 67:1770-80. 2007
    ..Fibulins, encoded by FBLN genes, are extracellular matrix proteins influencing cell adhesion and migration. Altered expression of fibulins is associated with progression of several cancer types, but has not been studied in prostate cancer...
  32. ncbi request reprint Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implications
    M V Cronauer
    Department of Urology, Heinrich Heine University, Moorenstrasse 5, Dusseldorf D 40225, Germany
    Eur Urol 43:309-19. 2003
    ..This review will discuss the different elements involved in FGF signaling and summarize the present knowledge of their biological and clinical relevance in urological cancers...
  33. ncbi request reprint [Perspectives for molecular diagnostics exemplified by urothelial bladder carcinoma]
    M O Grimm
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf
    Urologe A 42:650-9. 2003
    ..In conclusion, evaluation of gene profiles of tumors and patients will gain importance for clinicians...
  34. ncbi request reprint [Tumour stem cells--a new concept in tumour biology]
    J Hatina
    Urologische Klinik, Heinrich Heine Universitat Dusseldorf, Germany
    Dtsch Med Wochenschr 132:1629-32. 2007
    ..Detailed characterization of tumour stem cells may contribute to a better understanding of the underlying biology of the respective tumours and lead to novel curative therapies...
  35. pmc Frequent and heterogeneous expression of cyclin-dependent kinase inhibitor WAF1/p21 protein and mRNA in urothelial carcinoma
    S Clasen
    Urologische Klinik, , , Germany
    Br J Cancer 77:515-21. 1998
    ..The expression of p21 and its prevalence in low-stage tumours may reflect residual growth-regulatory influences potentially impeding but not necessarily inhibiting tumour development...
  36. ncbi request reprint Transcriptional regulation of the human LINE-1 retrotransposon L1.2B
    C Steinhoff
    Urologische Klinik und Biologisch Medizinisches Forschungszentrum, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Genet Genomics 270:394-402. 2003
    ..Since neither promoter activity nor the efficiency of repression by methylation differed between normal and tumor cells, the re-activation of LINE-1 sequences observed in tumor cells is probably caused by hypomethylation of the promoter...
  37. ncbi request reprint [Microarrays]
    M O Grimm
    Urologische Klinik der Heinrich Heine Universität Düsseldorf
    Urologe A 43:653-8. 2004
    ..Increased expression of enzymes of steroid biosynthesis and the androgen receptor appears to be part of the molecular signature of hormone refractory prostate cancer...
  38. ncbi request reprint Suppression of clonogenicity by mammalian Dnmt1 mediated by the PCNA-binding domain
    Simeon Santourlidis
    Urologische Klinik Heinrich Heine Universität, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Biochem Cell Biol 82:589-96. 2004
    ..Suppression of clonogenicity by Dnmt1 overexpression may act as a fail-safe mechanism against carcinogenicity of sustained Dnmt1 overexpression...
  39. doi request reprint Chromosomal instability in bladder cancer
    Andrea R Florl
    Department of Urology, Heinrich Heine University Duesseldorf, Urologische Klinik, Heinrich Heine Universitat, Moorenstr 5, 40225 Dusseldorf, Germany
    Arch Toxicol 82:173-82. 2008
    ....
  40. ncbi request reprint Multiple mechanisms downregulate CDKN1C in human bladder cancer
    Michele J Hoffmann
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Int J Cancer 114:406-13. 2005
    ..Thus, CDKN1C downregulation in TCC seems to occur by several different mechanisms. This finding and the ability of p57(KIP2) to induce senescence in urothelial cells make CDKN1C a good candidate for a tumor suppressor at 11p in TCC...
  41. ncbi request reprint Hypomethylation of the XIST gene promoter in prostate cancer
    Thilo Laner
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Oncol Res 15:257-64. 2005
    ..Detection of partially hypomethylated XIST alleles in prostate cancer tissues might be useful for the identification of cases with pronounced hypomethylation, which tend to be more aggressive...
  42. ncbi request reprint In situ detection of global DNA hypomethylation in exfoliative urine cytology of patients with suspected bladder cancer
    Hans Helge Seifert
    Department of Urology, University Hospital Dusseldorf, Heinrich Heine University Dusseldorf, Moorenstr 5, D 40225 Dusseldorf, Germany
    Exp Mol Pathol 82:292-7. 2007
    ..Immunocytochemical staining with the 5-methylcytosine antibody allows simultaneous individual assessment of nuclear morphology and methylation status of a given sample...
  43. doi request reprint [Bladder carcinoma cell lines as models of the pathobiology of bladder cancer. Review of the literature and establishment of a new progression series]
    J Hatina
    Forschungslabor der Urologischen Klinik, Universitatsklinikum, Dusseldorf, Germany
    Urologe A 47:724-34. 2008
    ..Only a few cell lines are available as models of non-invasive papillary bladder cancer and no progression series have yet been established...
  44. doi request reprint [Signal transduction in urothelial cancer: how exactly do we know the targets for targeted therapy?]
    G Niegisch
    Urologische Klinik, Medizinische Fakultat, Heinrich Heine Universitat, Moorenstraße 5, 40625 Düsseldorf, Deutschland
    Urologe A 49:1401-5. 2010
    ..Target genes of cancer pathways are regulated by epigenetic mechanisms, which determine their inducibility. Elucidating these control mechanisms could therefore prove important for developing targeted therapies for urothelial carcinoma...
  45. ncbi request reprint Refined mapping of allele loss at chromosome 10q23-26 in prostate cancer
    Barbara Leube
    Institute of Human Genetics, University of Dusseldorf, Dusseldorf, Germany
    Prostate 50:135-44. 2002
    ..Allele loss of at least two segments in 10q, one mapping to the PTEN gene and one more distal were described in prostate cancer, with loss more frequent in advanced prostate cancer...
  46. ncbi request reprint Imbalances of chromosome arm 1p in pediatric and adult germ cell tumors are caused by true allelic loss: a combined comparative genomic hybridization and microsatellite analysis
    Susanne Zahn
    Clinic of Pediatric Oncology, Haematology and Immunology, Heinrich Heine University, Dusseldorf, Germany
    Genes Chromosomes Cancer 45:995-1006. 2006
    ..However, since two postpubertal tumors with LOH at 1p progressed, a prognostic relevance in this age group seems possible, warranting a prospective evaluation...
  47. ncbi request reprint Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer
    Max Hornstein
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Cancer Genomics Proteomics 5:123-36. 2008
    ..Allelic losses on chromosome 8p are common in prostate carcinoma, but it is not known exactly how they contribute to cancer development and progression...
  48. doi request reprint Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer
    Olusola Y Dokun
    Department of Urology, Heinrich Heine University, Duesseldorf, Germany
    Int J Cancer 123:2798-807. 2008
    ..S100A4, S100A9 and LCN2 are genes with moderate CpG-density that show a less stringent relationship between DNA methylation and gene expression. Therefore, changes in methylation of these genes in cancer should be interpreted cautiously...
  49. ncbi request reprint Epigenetic inactivation of the placentally imprinted tumor suppressor gene TFPI2 in prostate carcinoma
    Teodora Ribarska
    Department of Urology, Heinrich Heine University, 40225 Dusseldorf, Germany
    Cancer Genomics Proteomics 7:51-60. 2010
    ..We have studied expression, DNA methylation and histone modifications of TFPI2, a presumed tumor suppressor, and that of other genes in the 7q21 imprinted gene cluster in prostate cancer...
  50. ncbi request reprint Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies
    Michele J Hoffmann
    Department of Urology, Heinrich Heine University, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Biochem Pharmacol 72:1577-88. 2006
    ..These different localizations might indicate additional control of CTCFL function via intracellular compartmentation...
  51. ncbi request reprint Activity of E2F-dependent promoters in bladder carcinoma cells and their use for tumour-specific targeting of p53-induced apoptosis
    Christine Steinhoff
    Urologische Klinik, Heinrich Heine Universitat, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Int J Oncol 21:1033-40. 2002
    ..normal uroepithelial cells. This approach could be useful in targeting apoptosis to TCC and other carcinomas lacking p53 and RB function...
  52. ncbi request reprint Decreased Fas expression in advanced-stage bladder cancer is not related to p53 status
    Simone Maas
    Department of Urology, Heinrich Heine University, Duesseldorf, Germany
    Urology 63:392-7. 2004
    ..Fas is a transcriptional target of p53, which is often mutated in bladder cancers. Therefore, Fas expression and its relation to p53 mutation was investigated...
  53. ncbi request reprint Causes and consequences of DNA hypomethylation in human cancer
    Michele J Hoffmann
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Biochem Cell Biol 83:296-321. 2005
    ..Finally, because of their relation to tumor progression and metastasis, DNA hypomethylation markers may be particularly useful to classify cancer and predict their clinical course...
  54. ncbi request reprint Hedgehog signaling in normal urothelial cells and in urothelial carcinoma cell lines
    Ingo Thievessen
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    J Cell Physiol 203:372-7. 2005
    ..However, SHH induced GLI-dependent promoter activity in normal urothelial cells. Taken together, our data suggest that the hedgehog pathway is weakly active in normal adult urothelial cells and of limited importance in TCC...
  55. ncbi request reprint Peculiar structure and location of 9p21 homozygous deletion breakpoints in human cancer cells
    Andrea R Florl
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Genes Chromosomes Cancer 37:141-8. 2003
    ..Therefore, an unknown mechanism appears to be involved in the generation of CDKN2A deletions during carcinogenesis...
  56. ncbi request reprint Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma
    Fumihiro Kimura
    Urologische Klinik, Heinrich Heine Universitat Dusseldorf, Germany
    Int J Cancer 104:568-78. 2003
    ..This relative downregulation probably contributes to hypomethylation of repetitive DNA but does not determine its extent alone...
  57. doi request reprint [Epigenetics in urothelial cancer: Pathogenesis, improving diagnostics and developing novel treatment options]
    G Niegisch
    Medizinische Fakultat, Urologische Klinik, Heinrich Heine Universitat Dusseldorf, Moorenstraße 5, 40225, Dusseldorf, Deutschland
    Urologe A 54:526-32. 2015
    ..DNA methylation changes and altered miRNA expression provide promising biomarkers for diagnosis and prognosis that need further validation in comprehensive and well-standardized studies. ..
  58. ncbi request reprint Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma
    F Kimura
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Prostate 45:225-31. 2000
    ..Therefore, homozygosity or heterozygosity for such weaker alleles may underlie susceptibility to prostatic carcinoma...
  59. ncbi request reprint Inhibition of p53 function diminishes androgen receptor-mediated signaling in prostate cancer cell lines
    Marcus V Cronauer
    Department of Urology, Heinrich Heine University, Dusseldorf D 40225, Germany
    Oncogene 23:3541-9. 2004
    ..Thus, our findings suggest that there is a balance of AR and p53 expression during the androgen-dependent growth of prostate cancer, which is obliterated during further progression of the disease...
  60. ncbi request reprint Activities of MAP-kinase pathways in normal uroepithelial cells and urothelial carcinoma cell lines
    Sandra Swiatkowski
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Exp Cell Res 282:48-57. 2003
    ..However, autonomous proliferation of TCC lines--unexpectedly--appears much less dependent on MAPK activation and may rather be promoted by defects in cell cycle regulation...
  61. ncbi request reprint p21 and p53 Immunostaining and survival following systemic chemotherapy for urothelial cancer
    Feliksas Jankevicius
    Department of Urology, Düsseldorf University School of Medicine, Germany
    Urol Int 69:174-80. 2002
    ..The WAF1/p21 gene is transcriptionally activated by p53 and mediates p53-dependent G1 arrest following DNA damage. Therefore, p53 and p21 expression might be related to urothelial tumor response to cytotoxic therapy...
  62. ncbi request reprint p27KIP1-expression in human renal cell cancers: implications for clinical outcome
    Aristotelis G Anastasiadis
    Department of Urology, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Anticancer Res 23:217-21. 2003
    ..The aim of this study was to evaluate p27 expression in renal cell cancer and to assess its association with stage and grade as well as its relationship to patient outcome...
  63. ncbi request reprint A new and reliable culture system for superficial low-grade urothelial carcinoma of the bladder
    Hans Helge Seifert
    Department of Urology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    World J Urol 25:297-302. 2007
    ..Therefore, this culture system can widely be used for functional experiments on early stage bladder cancer...
  64. ncbi request reprint Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population
    Jianhui Zhang
    Institute of Pathology, University of Duesseldorf, Moorenstr 5, Germany
    Carcinogenesis 24:905-9. 2003
    ..In summary, the association of the NQO1 C609T polymorphism with ESCC in genetically distinct populations makes a strong argument for its importance in carcinogenesis of ESCC in the German Caucasian and the northern Chinese population...
  65. ncbi request reprint Heparin-binding epidermal growth factor-like growth factor isoforms and epidermal growth factor receptor/ErbB1 expression in bladder cancer and their relation to clinical outcome
    Christopher Kramer
    Department of Urology, Heinrich Heine University, Dusseldorf, Germany
    Cancer 109:2016-24. 2007
    ..In bladder cancer, overexpression of both HB-EGF and EGFR have been observed, but to the authors' knowledge the prognostic significance of different modes of HB-EGF signaling have remained unclear...
  66. ncbi request reprint Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines
    Sascha Raschke
    Urologische Klinik, Heinrich Heine Universitat, Dusseldorf, Germany
    Genes Chromosomes Cancer 42:58-67. 2005
    ..Aberrant RAG-mediated recombination may be responsible in T-ALL, and exuberant DNA repair by nonhomologous end-joining is the likely prevailing mechanism in SCCHN, but a distinct mechanism in TCC and glioma remains to be elucidated...
  67. ncbi request reprint Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells
    Frank Windhofer
    Department of Urology, Heinrich Heine University Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany
    Mutat Res 638:56-65. 2008
    ..Moreover, in contrast to prevailing interpretations, our observations suggest that MMEJ, despite its error-proneness, in some instances may act as a failsafe mechanism against overprocessing during NHEJ...
  68. ncbi request reprint Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
    Michele J Hoffmann
    1Department of Urology Heinrich Heine University Düsseldorf, Germany
    Cancer Biol Ther 6:1403-12. 2007
    ..SIRT1 appears to be generally increased in prostate cancers. Intriguingly, our data suggest a direct influence of increased EZH2 on altered DNA methylation patterns in prostate cancer...
  69. ncbi request reprint Denaturing high-performance liquid chromatography (DHPLC) as a reliable high-throughput prescreening method for aberrant promoter methylation in cancer
    Beate Betz
    Department of Obstetrics and Gynecology, Heinrich Heine University, Duesseldorf, Germany
    Hum Mutat 23:612-20. 2004
    ..In conclusion, DHPLC is a highly sensitive and convenient method for methylation screening...
  70. ncbi request reprint Do DNA-methylation changes also occur in blood?
    Wolfgang A Schulz
    Lancet Oncol 9:312-3. 2008
  71. ncbi request reprint Estimating cancer survival and clinical outcome based on genetic tumor progression scores
    Jörg Rahnenführer
    Max Planck Institute for Informatics, Stuhlsatzenhausweg 85, D 66123 Saarbrucken, Germany
    Bioinformatics 21:2438-46. 2005
    ..The accumulation of genetic alterations during tumor progression can be used for the assessment of the genetic status of the tumor. For modeling dependences between the genetic events, evolutionary tree models have been applied...
  72. ncbi request reprint Application of a modified real-time PCR technique for relative gene copy number quantification to the determination of the relationship between NKX3.1 loss and MYC gain in prostate cancer
    Roland Kindich
    Clinic of Urology and Pediatric Urology, University of the Saarland, Homburg Saar, Germany
    Clin Chem 51:649-52. 2005
  73. ncbi request reprint Relationship of NKX3.1 and MYC gene copy number ratio and DNA hypomethylation to prostate carcinoma stage
    Roland Kindich
    Clinic of Urology and Pediatric Urology, University of the Saarland, Homburg, Germany
    Eur Urol 49:169-75; discussion 175. 2006
    ..High stage prostate cancers have been reported to frequently harbor chromosome 8 alterations and hypomethylation of LINE-1 retrotransposons. The potential of these parameters for molecular staging of prostate carcinoma was investigated...
  74. ncbi request reprint Expression of death-associated protein kinase during tumour progression of human renal cell carcinomas: hypermethylation-independent mechanisms of inactivation
    Nils Wethkamp
    Institute of Pathology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Eur J Cancer 42:264-74. 2006
    ..Despite persistent DAPK transcription and translation, however, the markedly reduced DAPK enzyme activity in our RCC cell lines suggested a post-translational inactivation of DAPK in RCCs...
  75. ncbi request reprint Genomic and expression analysis of the 3q25-q26 amplification unit reveals TLOC1/SEC62 as a probable target gene in prostate cancer
    Volker Jung
    Clinic of Urology and Pediatric Urology, University of the Saarland, 66421 Homburg Saar, Germany
    Mol Cancer Res 4:169-76. 2006
    ..TLOC1/Sec62 protein is a component of the endoplasmic reticulum protein translocation machinery, whose function during prostate carcinogenesis remains to be determined...
  76. pmc Tumour class prediction and discovery by microarray-based DNA methylation analysis
    Peter Adorjan
    Information Sciences, Biomedical Research and Development, Epigenomics AG, Berlin, Germany
    Nucleic Acids Res 30:e21. 2002
    ..Our results demonstrate that genome-wide analysis of methylation patterns combined with supervised and unsupervised machine learning techniques constitute a powerful novel tool to classify human cancers...
  77. pmc DNA methylation in placentas of interspecies mouse hybrids
    Sabine Schütt
    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Genetics 165:223-8. 2003
    ..Thus, our results strongly suggest that generalized changes in methylation patterns do not occur in trophoblast cells of such hybrids...
  78. ncbi request reprint Methylenetetrahydrofolate reductase C677T polymorphism and risk of adenocarcinoma of the upper gastrointestinal tract
    Mario Sarbia
    Institute of Pathology, Technical University, Munich, Germany
    Scand J Gastroenterol 40:109-11. 2005