Jürgen Eberle

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Expression and function of bcl-2 proteins in melanoma
    Jürgen Eberle
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergy, Skin Cancer Center Charite, Berlin, Germany
    Curr Genomics 9:409-19. 2008
  2. pmc ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis
    S A Quast
    1 Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany 2 Institute for Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany
    Cell Death Dis 4:e839. 2013
  3. pmc Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax
    A Berger
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    Cell Death Dis 4:e477. 2013
  4. ncbi request reprint Apoptosis pathways as promising targets for skin cancer therapy
    J Eberle
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:18-24. 2007
  5. ncbi request reprint Overcoming apoptosis deficiency of melanoma-hope for new therapeutic approaches
    Jürgen Eberle
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergy, Skin Cancer Center Charite, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Drug Resist Updat 10:218-34. 2007
  6. ncbi request reprint Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanoma
    Jürgen Eberle
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 17:1-11. 2008
  7. ncbi request reprint Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik
    Malte Oppermann
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Oncogene 24:7369-80. 2005
  8. ncbi request reprint Selective induction of apoptosis in melanoma cells by tyrosinase promoter-controlled CD95 ligand overexpression
    Lothar F Fecker
    Department of Dermatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 124:221-8. 2005
  9. doi request reprint Efficient melanoma cell killing and reduced melanoma growth in mice by a selective replicating adenovirus armed with tumor necrosis factor-related apoptosis-inducing ligand
    Lothar F Fecker
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, 10117 Berlin, Germany
    Hum Gene Ther 22:405-17. 2011
  10. ncbi request reprint Conditional expression of exogenous Bcl-X(S) triggers apoptosis in human melanoma cells in vitro and delays growth of melanoma xenografts
    Amir M Hossini
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Dermatology, Fabeckstrasse 60 62, 14195 Berlin, Germany
    FEBS Lett 553:250-6. 2003

Collaborators

Detail Information

Publications54

  1. pmc Expression and function of bcl-2 proteins in melanoma
    Jürgen Eberle
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergy, Skin Cancer Center Charite, Berlin, Germany
    Curr Genomics 9:409-19. 2008
    ..Overexpression or induction of proapoptotic Bcl-2 proteins as well as the use of small molecule mimetics for the proapoptotic BH3 domain are further promising strategies...
  2. pmc ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis
    S A Quast
    1 Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany 2 Institute for Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany
    Cell Death Dis 4:e839. 2013
    ..The data unraveled a mechanism by which NOX4-dependent ROS production controls apoptosis via Bax phosphorylation. The pathway may be considered for proapoptotic, anticancer strategies. ..
  3. pmc Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax
    A Berger
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    Cell Death Dis 4:e477. 2013
    ..Thus, modulation of Bax phosphorylation appeared as tightly related to TRAIL sensitivity/resistance in melanoma cells, and therapeutic strategies may be considered...
  4. ncbi request reprint Apoptosis pathways as promising targets for skin cancer therapy
    J Eberle
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:18-24. 2007
    ..Importantly, the involvement of the different pro-apoptotic pathways in specific tumour types needs to be unravelled and understood in order to evaluate drug effectiveness, as well as to modify and optimise therapeutic approaches...
  5. ncbi request reprint Overcoming apoptosis deficiency of melanoma-hope for new therapeutic approaches
    Jürgen Eberle
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergy, Skin Cancer Center Charite, Charite Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Drug Resist Updat 10:218-34. 2007
    ..This review gives a critical overview of proteins involved in melanoma chemoresistance, which are targets for current drug development leading to the best choice for future trials...
  6. ncbi request reprint Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanoma
    Jürgen Eberle
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 17:1-11. 2008
    ..Proapoptotic genes may be employed in improved gene therapeutic strategies, based on conditional oncolytic adenoviral vectors...
  7. ncbi request reprint Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik
    Malte Oppermann
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Oncogene 24:7369-80. 2005
    ....
  8. ncbi request reprint Selective induction of apoptosis in melanoma cells by tyrosinase promoter-controlled CD95 ligand overexpression
    Lothar F Fecker
    Department of Dermatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    J Invest Dermatol 124:221-8. 2005
    ..Our investigations provide evidence that tyrosinase promoter CD95L constructs may be of value for selective induction of apoptosis in therapeutic strategies for melanoma...
  9. doi request reprint Efficient melanoma cell killing and reduced melanoma growth in mice by a selective replicating adenovirus armed with tumor necrosis factor-related apoptosis-inducing ligand
    Lothar F Fecker
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, 10117 Berlin, Germany
    Hum Gene Ther 22:405-17. 2011
    ..We demonstrate that melanoma cells may be efficiently targeted by TRAIL-based gene therapy, and resistance may be overcome by combined chemotherapy...
  10. ncbi request reprint Conditional expression of exogenous Bcl-X(S) triggers apoptosis in human melanoma cells in vitro and delays growth of melanoma xenografts
    Amir M Hossini
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Dermatology, Fabeckstrasse 60 62, 14195 Berlin, Germany
    FEBS Lett 553:250-6. 2003
    ..Our results indicate that Bcl-X proteins are of major importance for control of apoptosis in malignant melanoma...
  11. ncbi request reprint Efficient TRAIL-R1/DR4-mediated apoptosis in melanoma cells by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
    Bahtier M Kurbanov
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invest Dermatol 125:1010-9. 2005
    ..Thus, DR4 expression in vivo and the high efficiency of DR4-mediated apoptosis may suggest reassessment of the suitability of TRAIL and especially of DR4-based strategies for melanoma treatment...
  12. doi request reprint The BH3-only protein Bim(L) overrides Bcl-2-mediated apoptosis resistance in melanoma cells
    Michael Plötz
    Department of Dermatology and Allergy, Skin Cancer Center Charite, Chariteplatz 1, 10117 Berlin, Germany
    Cancer Lett 335:100-8. 2013
    ..Thus, BimL reveals an outstanding proapoptotic potential in melanoma cells, and strategies for its re-expression appear of interest. These have been reported for B-Raf inhibitors, and their efficacy may be partly attributed to BimL...
  13. pmc General Sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMAC
    Sandra Annika Quast
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    PLoS ONE 7:e39290. 2012
    ..As both TRAIL and IK1 inhibitors had shown only minor side effects in clinical trials, a clinical application of this combination is conceivable...
  14. doi request reprint RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells
    Anja Berger
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    J Invest Dermatol 134:430-40. 2014
    ..The pro-apoptotic effects of L-779,450 may explain the antitumor effects of RAF inhibition and may be considered when evaluating RAF inhibitors for melanoma therapy. ..
  15. ncbi request reprint Viral and nonviral factors causing nonspecific replication of tumor- and tissue-specific promoter-dependent oncolytic adenoviruses
    Almudena Hurtado Picó
    Department of Cardiology and Pneumonology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Mol Ther 11:563-77. 2005
    ..Consideration of these factors may help optimize ttsP-dependent RRCA vectors and may thereby improve their safety...
  16. ncbi request reprint CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants
    Jürgen Eberle
    Department of Dermatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, 14195 Berlin, Germany
    Oncogene 22:9131-41. 2003
    ..Due to these data, transfection of CD95L proofs as a highly efficient tool against melanoma cells in vitro and in vivo, and targeted expression of CD95L may thus represent a suitable strategy for melanoma therapy...
  17. doi request reprint Resistance of cutaneous anaplastic large-cell lymphoma cells to apoptosis by death ligands is enhanced by CD30-mediated overexpression of c-FLIP
    Frank K Braun
    Department of Dermatology and Allergy, Charite University Medical Center Berlin, HTCC Skin Cancer Center, Berlin, Germany
    J Invest Dermatol 130:826-40. 2010
    ..These in vitro findings may be indicative of the clinical situation of cALCL. Further clarifying the defects in apoptosis pathways in cutaneous lymphomas may lead to improved therapies for these disorders...
  18. doi request reprint Activation of mitochondrial apoptosis pathways in cutaneous squamous cell carcinoma cells by diclofenac/hyaluronic acid is related to upregulation of Bad as well as downregulation of Mcl-1 and Bcl-w
    Paul M Rodust
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    Exp Dermatol 21:520-5. 2012
    ..The findings illuminate the mode of action of diclofenac/HA in SCC cells as well as principles of their resistance, which may allow further adaptation and improvement of the new therapy...
  19. ncbi request reprint Endothelin-1 decreases basic apoptotic rates in human melanoma cell lines
    Jürgen Eberle
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    J Invest Dermatol 119:549-55. 2002
    ..This antiapoptotic activity of endothelin for melanoma cells combined with upregulation of endothelin receptors in the tumor may be a crucial step for melanoma progression...
  20. doi request reprint Efficient and selective tumor cell lysis and induction of apoptosis in melanoma cells by a conditional replication-competent CD95L adenovirus
    Lothar F Fecker
    Department of Dermatology and Allergy, HTCC Skin Cancer Center Charité, Charite Universitatsmedizin Berlin
    Exp Dermatol 19:e56-66. 2010
    ..Finally, the combination of adenoviral replication and CD95L-mediated apoptosis resulted in an enhanced repression of melanoma cell growth. This new adenoviral vector may provide a basis for an efficient targeting of melanoma...
  21. doi request reprint Sensitization of melanoma cells for death ligand-induced apoptosis by an indirubin derivative--Enhancement of both extrinsic and intrinsic apoptosis pathways
    Anja Berger
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    Biochem Pharmacol 81:71-81. 2011
    ..Furthermore, combinations with kinase inhibitors, such as indirubin 8-Rha-β may help for a breakthrough of TRAIL-mediated strategies in melanoma...
  22. doi request reprint Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP
    Lothar F Fecker
    Department of Dermatology and Allergy, HTCC Skin Cancer Center Charité, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invest Dermatol 130:2098-109. 2010
    ..Thus, induction of apoptosis appears to be highly characteristic of the mode of action of diclofenac/HA, and the therapeutic effect may be related to sensitization of neoplastic keratinocytes for death ligand-induced apoptosis...
  23. ncbi request reprint The role of nuclear factor-kappa B and melanogenesis in tumor necrosis factor-alpha-induced apoptosis of normal human melanocytes
    Jing Shang
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Skin Pharmacol Appl Skin Physiol 15:321-9. 2002
    ..NF-kappaB mediates the transcription of antiapoptotic factors which may block TNF-alpha-induced apoptosis at early steps of the signal cascade...
  24. ncbi request reprint Loss of proapoptotic Bcl-2-related multidomain proteins in primary melanomas is associated with poor prognosis
    Lothar F Fecker
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invest Dermatol 126:1366-71. 2006
    ..The study underlines the particular role of the mitochondrial apoptosis pathway and of proapoptotic Bcl-2-related proteins for melanoma progression...
  25. doi request reprint Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling
    Nadya Al-Yacoub
    Department of Dermatology and Allergy, Skin Cancer Center Charité HTCC, Charite University Medical Center Berlin, Berlin, Germany
    J Invest Dermatol 132:2263-74. 2012
    ..An improved understanding of the pathways may facilitate its targeted use and the selection of suitable combinations...
  26. doi request reprint Nonsteroidal anti-inflammatory drugs induce apoptosis in cutaneous T-cell lymphoma cells and enhance their sensitivity for TNF-related apoptosis-inducing ligand
    Frank K Braun
    Department of Dermatology and Allergy, Skin Cancer Center Charité HTCC, Charite University Medical Center Berlin, Berlin, Germany
    J Invest Dermatol 132:429-39. 2012
    ..The study provides a rationale for the use of NSAIDs as a new therapeutic option for CTCL patients. Supporting this concept, ex vivo lymphoma cells of CTCL patients also revealed significant sensitivity for NSAID treatment...
  27. ncbi request reprint Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression
    Meryem Bektas
    Department of Dermatology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Fabeckstr 60 62, Berlin 14195, Germany
    Oncogene 24:178-87. 2005
    ..This link between Bcl-2 and SphK1 might be an additional clue to chemotherapy resistance of malignant melanoma...
  28. ncbi request reprint Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide
    Lothar F Fecker
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    J Invest Dermatol 118:1019-25. 2002
    ....
  29. pmc Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK)
    Michael Plötz
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    PLoS ONE 7:e34549. 2012
    ..This pathway appears to play a supplementary role also for other proapoptotic family members, and its unraveling may help to overcome therapy resistance in cancer...
  30. ncbi request reprint Dimethyl sulfoxide enhances doxycycline-dependent protein expression in Tet-On cells
    Malte Oppermann
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Biotechniques 42:304, 306, 308 passim. 2007
  31. ncbi request reprint Proliferation of human melanoma cells is under tight control of protein kinase C alpha
    Konstantin Krasagakis
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Berlin, Germany
    J Cell Physiol 199:381-7. 2004
    ..The presented data demonstrate a cause-effect relationship between PKC-alpha and melanoma cell growth, whereby PKC-alpha reversely influences the rate of cell proliferation...
  32. doi request reprint New caspase-independent but ROS-dependent apoptosis pathways are targeted in melanoma cells by an iron-containing cytosine analogue
    Jeannine C Franke
    Department of Dermatology and Allergy, Skin Cancer Center Charite, Chariteplatz 1, 10117 Berlin, Germany
    Biochem Pharmacol 79:575-86. 2010
    ..New proapoptotic pathways are of particular interest for melanoma as they may open new options for targeting this highly therapy-refractory tumor...
  33. ncbi request reprint Blockade of death receptor-mediated pathways early in the signaling cascade coincides with distinct apoptosis resistance in cutaneous T-cell lymphoma cells
    Frank K Braun
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invest Dermatol 127:2425-37. 2007
    ..Parallels with regard to expression of apoptosis regulators were seen in peripheral blood mononuclear cells and biopsies of CTCL patients. This study may indicate defects in apoptosis in CTCL and may help to guide CTCL therapy...
  34. pmc Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells
    Daniela Beck
    Division of Dermatologic Oncology, Department of Dermatology, University of Tubingen, 72076 Tubingen, Germany
    Sci Signal 6:ra7. 2013
    ..Thus, thapsigargin or other inducers of ER stress may be useful in combination therapies to overcome vemurafenib resistance...
  35. ncbi request reprint Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis
    I Nindl
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:34-9. 2007
    ..Different mutation rates of p53, p16(INK4a) and Ha-ras in cutaneous squamous cell carcinoma (SCC) and the earlier stage actinic keratosis (AK) have been reported...
  36. doi request reprint Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study
    C Ulrich
    Department of Dermatology, Skin Cancer Center, Charite University Hospital, 10117 Berlin, Germany
    Br J Dermatol 161:78-84. 2009
    ..Despite encouraging reports of protective effects of broad-spectrum sunscreens in immunocompetent patients, evidence for the prevention of NMSC in immunocompromised patients is still missing...
  37. doi request reprint [cFLIP diminishes CD95-induced apoptosis of CD30-stimulated cutaneous anaplastic large T cell lymphoma (cALCL) cells]
    B Hirsch
    Institut fur Pathologie, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12203 Berlin
    Pathologe 31:193-8. 2010
    ..Knockdown of cFLIP restores sensitivity to CD95-mediated apoptosis. We conclude that the anti-apoptotic function of CD30 antibodies should be kept in mind if CD30 antibody-based therapeutic concepts for ALCL lymphoma are considered...
  38. doi request reprint Sensitization of Melanoma Cells for Death Ligand TRAIL Is Based on Cell Cycle Arrest, ROS Production, and Activation of Proapoptotic Bcl-2 Proteins
    Sandra Annika Quast
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    J Invest Dermatol 135:2794-804. 2015
    ..These data provide a general understanding on TRAIL sensitization as well as an alternative view on CDK inhibitors and may suggest selective targeting of melanoma cells by cell cycle inhibition and TRAIL. ..
  39. doi request reprint Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D
    Anja Heinemann
    Department of Dermatology, University Hospital Essen, Essen, Germany
    Cancer Res 72:460-71. 2012
    ..Taken together, our study shows that tumor-suppressive miR-34a and miR-34c act as ULBP2 repressors. These findings also implicate p53 in ULBP2 regulation, emphasizing the role of the specific NKG2DL in tumor immune surveillance...
  40. doi request reprint Sensitization of melanoma cells for TRAIL-induced apoptosis by activation of mitochondrial pathways via Bax
    Sandra Annika Quast
    Department of Dermatology and Allergy, Skin Cancer Center, University Medical Center Charite, Berlin, Germany
    Eur J Cell Biol 93:42-8. 2014
    ..Thus, direct or indirect targeting of Bax represents a suitable strategy to overcome TRAIL resistance in melanoma and may allow the establishment of TRAIL-based therapeutic approaches. ..
  41. doi request reprint UV-induced squamous cell carcinoma--a role for antiapoptotic signalling pathways
    P M Rodust
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergy, HTCC Skin Cancer Center Charité, 10117 Berlin, Germany
    Br J Dermatol 161:107-15. 2009
    ..The final unravelling of apoptosis regulation in epithelial skin cancer may allow the development of new targeted therapeutic strategies...
  42. doi request reprint Apoptosis-inducing activity of Helleborus niger in ALL and AML
    Patrick Jesse
    Department of Pediatric Oncology Hematology, Charite, Universitatsmedizin Berlin, Berlin, Germany
    Pediatr Blood Cancer 52:464-9. 2009
    ..Indications include various types of brain tumors in children, as well as prostate cancer, leukemia and lymphoma. Our aim was to investigate the therapeutic effects of these extracts apart from the traditional use...
  43. ncbi request reprint Direct effects on proliferation, antigen expression and melanin synthesis of cultured normal human melanocytes in response to UVB and UVA light
    M Badawy Abdel-Naser
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Photodermatol Photoimmunol Photomed 19:122-7. 2003
    ..As epidermal melanocytes are seen as the major targets of UV light, the present study was conducted to evaluate the direct effects of UVA and UVB irradiation on melanocytes in vitro...
  44. doi request reprint Apoptosis induction by Bcl-2 proteins independent of the BH3 domain
    Amir M Hossini
    Charite Universitatsmedizin Berlin, Department of Dermatology and Allergy, Skin Cancer Center Charite, Charite Campus Mitte, Chariteplatz 1, Berlin, Germany
    Biochem Pharmacol 76:1612-9. 2008
    ..These proteins are indicators for new mechanisms in apoptosis control by Bcl-2 proteins, which may supply additional targets for novel therapeutic approaches...
  45. ncbi request reprint Actinic keratosis is an early in situ squamous cell carcinoma: a proposal for reclassification
    J Röwert-Huber
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:8-12. 2007
    ....
  46. ncbi request reprint The role of apoptosis in therapy and prophylaxis of epithelial tumours by nonsteroidal anti-inflammatory drugs (NSAIDs)
    L F Fecker
    Department of Dermatology, Charite, Skin Cancer Center Charite, University Hospital of Berlin, Berlin, Germany
    Br J Dermatol 156:25-33. 2007
    ..Detailed analysis of apoptosis pathways employed by diclofenac in these cells may help to improve therapeutic strategies and to overcome possible mechanisms that are involved in nonresponsiveness...
  47. doi request reprint Aurora Kinase A Is Upregulated in Cutaneous T-Cell Lymphoma and Represents a Potential Therapeutic Target
    Daniel Humme
    Department of Dermatology and Allergy, Skin Cancer Center Charite, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Invest Dermatol 135:2292-300. 2015
    ..These data provide a promising rationale for using Aurora kinase A inhibition as a therapeutic modality of CTCL. ..
  48. ncbi request reprint Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes
    Monika Raisova
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, 14195, Berlin, Germany
    FEBS Lett 516:47-52. 2002
    ..These findings suggest ceramidase inhibitors as a potential new therapeutical class of antiproliferative and cytostatic drugs...
  49. doi request reprint BH3-only proteins: possible proapoptotic triggers for melanoma therapy
    Michael Plötz
    Department of Dermatology, Venerology and Allergology, HTCC Skin Cancer Center, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 23:375-8. 2014
    ..Thus, melanoma therapy might be critically improved by the combination of survival pathway antagonists as BRAF inhibitors with BH3 mimetics...
  50. ncbi request reprint A novel Bcl-x splice product, Bcl-xAK, triggers apoptosis in human melanoma cells without BH3 domain
    A M Hossini
    Department of Dermatology and Allergy, Skin Cancer Center, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin 12203, Germany
    Oncogene 25:2160-9. 2006
    ..By these findings, a completely new class of Bcl-2-related proteins is introduced, which promotes apoptosis independently from the BH3 domain and implies additional, new mechanisms for apoptosis regulation in melanoma cells...
  51. ncbi request reprint Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro
    J Eberle
    Department of Dermatology, Benjamin Franklin University Medical Center, The Free University of Berlin, Germany
    Int J Cancer 71:396-401. 1997
    ..Cultures of congenital melanocytic nevi exhibited intermediate expression of eIF-4A1. Thus, eIF-4A1 overexpression seems to be an important feature of melanoma cells and might contribute to their malignant transformation...
  52. ncbi request reprint The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis
    M Raisova
    Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    J Invest Dermatol 117:333-40. 2001
    ..In fact, betulinic acid induced mitochondrial cytochrome c release and DNA fragmentation in both CD95-resistant and CD95-sensitive melanoma cell populations, independent of the Bax/Bcl-2 ratio...
  53. pmc Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1
    J Eberle
    Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Fabeckstrasse 60 62, 14195 Berlin, Germany
    Br J Cancer 86:1957-62. 2002
    ..Translation initiation factor eIF-4A1 contributes to the control of melanoma cell proliferation and may be taken into consideration when scheduling new therapeutic approaches targeting the translational control...
  54. ncbi request reprint P53 mutation and c-fos overexpression are associated with detection of the antigen VLA-2 in human melanoma cell lines
    G Kroumpouzos
    Department of Dermatology, University Medical Center Steglitz, Free University of Berlin, Germany
    Pigment Cell Res 7:348-53. 1994
    ..The present findings revealed a coexpression of mutant p53 and c-fos proteins being associated with a highly malignant phenotype in melanoma cell lines. Further studies are necessary to clarify the significance of the above findings...