Ulrich Kintscher

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. pmc Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice
    Janine Krüger
    Cell Commun Signal 11:49. 2013
  2. doi request reprint Cardiovascular magnetic resonance feature tracking in small animals - a preliminary study on reproducibility and sample size calculation
    Tomas Lapinskas
    Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Street 2, LT 50161, Kaunas, Lithuania
    BMC Med Imaging 17:51. 2017
  3. doi request reprint Benefit of Blood Pressure Control in Diabetic Patients
    Ulrich Kintscher
    Center for Cardiovascular Research, CCR, Institute of Pharmacology, Charite Universitaetsmedizin Berlin, Hessische Str 3 4, 10115, Berlin, Germany
    Curr Hypertens Rep 17:50. 2015
  4. ncbi request reprint Inhibiting angiotensin type 1 receptors as a target for diabetes
    Ulrich Kintscher
    Charite Universitatsmedizin Berlin, Institute of Pharmacology, Center for Cardiovascular Research, Hessische Street, 3 4, 10115 Berlin, Germany
    Expert Opin Ther Targets 12:1257-63. 2008
  5. ncbi request reprint INT-131, a PPARgamma agonist for the treatment of type 2 diabetes
    Ulrich Kintscher
    Center for Cardiovascular Research, Institute of Pharmacology, Charité Universitätsmedizin Berlin Hessische Strasse 3 4, 10115 Berlin, Germany
    Curr Opin Investig Drugs 10:381-7. 2009
  6. doi request reprint ONTARGET, TRANSCEND, and PRoFESS: new-onset diabetes, atrial fibrillation, and left ventricular hypertrophy
    Ulrich Kintscher
    Center for Cardiovascular Research CCR, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens Suppl 27:S36-9. 2009
  7. doi request reprint Effect of high-dose valsartan on inflammatory and lipid parameters in patients with Type 2 diabetes and hypertension
    Ulrich Kintscher
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    Diabetes Res Clin Pract 89:209-15. 2010
  8. ncbi request reprint Does adiponectin resistance exist in chronic heart failure?
    Ulrich Kintscher
    Center for Cardiovascular Research CCR, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, Berlin, Germany
    Eur Heart J 28:1676-7. 2007
  9. pmc Irbesartan for the treatment of hypertension in patients with the metabolic syndrome: a sub analysis of the Treat to Target post authorization survey. Prospective observational, two armed study in 14,200 patients
    Ulrich Kintscher
    Center for Cardiovascular Research, Institute of Pharmacology, Charite, Berlin, Germany
    Cardiovasc Diabetol 6:12. 2007
  10. doi request reprint Reuptake inhibitors of dopamine, noradrenaline, and serotonin
    Ulrich Kintscher
    Charite Universitatsmedizin, Institute of Pharmacology, Berlin, Germany
    Handb Exp Pharmacol . 2012

Collaborators

Detail Information

Publications77

  1. pmc Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice
    Janine Krüger
    Cell Commun Signal 11:49. 2013
    ..Here, we analyzed whether DEP-1 activity is differentially regulated in liver, skeletal muscle and adipose tissue under high-fat diet (HFD), examined the role of DEP-1 in insulin resistance in vivo, and its function in insulin signaling...
  2. doi request reprint Cardiovascular magnetic resonance feature tracking in small animals - a preliminary study on reproducibility and sample size calculation
    Tomas Lapinskas
    Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Street 2, LT 50161, Kaunas, Lithuania
    BMC Med Imaging 17:51. 2017
    ..This preliminary study aimed to evaluate the observer's reproducibility of CMR-FT in a small animal (mouse) model and define sample size calculation for future trials...
  3. doi request reprint Benefit of Blood Pressure Control in Diabetic Patients
    Ulrich Kintscher
    Center for Cardiovascular Research, CCR, Institute of Pharmacology, Charite Universitaetsmedizin Berlin, Hessische Str 3 4, 10115, Berlin, Germany
    Curr Hypertens Rep 17:50. 2015
    ..In summary, the present article will discuss selected new topics in the field of hypertension and diabetes focusing on the benefits achieved by blood pressure lowering in these patients. ..
  4. ncbi request reprint Inhibiting angiotensin type 1 receptors as a target for diabetes
    Ulrich Kintscher
    Charite Universitatsmedizin Berlin, Institute of Pharmacology, Center for Cardiovascular Research, Hessische Street, 3 4, 10115 Berlin, Germany
    Expert Opin Ther Targets 12:1257-63. 2008
    ..The mechanisms of the insulin-sensitizing/anti-diabetic effect are not fully understood, and may involve AT1 receptor-dependent pathways and 'pleiotropic' actions of ARBs including activation of insulin-sensitising PPARgamma...
  5. ncbi request reprint INT-131, a PPARgamma agonist for the treatment of type 2 diabetes
    Ulrich Kintscher
    Center for Cardiovascular Research, Institute of Pharmacology, Charité Universitätsmedizin Berlin Hessische Strasse 3 4, 10115 Berlin, Germany
    Curr Opin Investig Drugs 10:381-7. 2009
    ....
  6. doi request reprint ONTARGET, TRANSCEND, and PRoFESS: new-onset diabetes, atrial fibrillation, and left ventricular hypertrophy
    Ulrich Kintscher
    Center for Cardiovascular Research CCR, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens Suppl 27:S36-9. 2009
    ..Recent results from three large clinical endpoint trials with the angiotensin-II receptor blocker telmisartan regarding new-onset diabetes, atrial fibrillation, and left ventricular hypotrophy will be discussed...
  7. doi request reprint Effect of high-dose valsartan on inflammatory and lipid parameters in patients with Type 2 diabetes and hypertension
    Ulrich Kintscher
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    Diabetes Res Clin Pract 89:209-15. 2010
    ..The present study aimed to explore the impact of the angiotensin type 1 receptor blocker valsartan (VAL) on inflammatory-/lipid-/glucose parameters in hypertensive diabetic patients with and without coronary artery disease (CAD)...
  8. ncbi request reprint Does adiponectin resistance exist in chronic heart failure?
    Ulrich Kintscher
    Center for Cardiovascular Research CCR, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, Berlin, Germany
    Eur Heart J 28:1676-7. 2007
  9. pmc Irbesartan for the treatment of hypertension in patients with the metabolic syndrome: a sub analysis of the Treat to Target post authorization survey. Prospective observational, two armed study in 14,200 patients
    Ulrich Kintscher
    Center for Cardiovascular Research, Institute of Pharmacology, Charite, Berlin, Germany
    Cardiovasc Diabetol 6:12. 2007
    ..Therefore the efficacy, safety and metabolic profile of Irbesartan either as monotherapy or in combination therapy was assessed in patients with the metabolic syndrome in a large observational cohort in primary care...
  10. doi request reprint Reuptake inhibitors of dopamine, noradrenaline, and serotonin
    Ulrich Kintscher
    Charite Universitatsmedizin, Institute of Pharmacology, Berlin, Germany
    Handb Exp Pharmacol . 2012
    ..This chapter will discuss the history of this drug class in appetite control, its mechanism of action, and the clinical effects of selected drugs from this class...
  11. ncbi request reprint PPARgamma-mediated insulin sensitization: the importance of fat versus muscle
    Ulrich Kintscher
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, 10115 Berlin, Germany
    Am J Physiol Endocrinol Metab 288:E287-91. 2005
    ..Finally, these early and elegant studies using tissue-specific PPARgamma knockout mouse models pinpoint adipose tissue as the major target of TZD-mediated improvement of hyperlipidemia and insulin sensitization...
  12. ncbi request reprint p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells
    Ulrich Kintscher
    Institute of Pharmacology and Toxicology, Charite Hospital, Humboldt University Berlin, D 10117 Berlin, Germany
    Biochem Biophys Res Commun 305:552-6. 2003
    ..These findings support an important role for p38 MAPK in modulating AngII-mediated VSMC hyperplasia...
  13. pmc Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma
    Anna Foryst-Ludwig
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS Genet 4:e1000108. 2008
    ....
  14. ncbi request reprint Molecular characterization of new selective peroxisome proliferator-activated receptor gamma modulators with angiotensin receptor blocking activity
    Michael Schupp
    Center for Cardiovascular Research, Institute of Pharmacology and Toxicology, Charité Campus Mitte Charité Universitätsmedizin Berlin, Hessische Str, 3 4 10115 Berlin, Germany
    Diabetes 54:3442-52. 2005
    ..This may provide a new therapeutic option for better cardiovascular risk management in metabolic diseases and may initiate the development of new classes of drugs combining potent antihypertensive and antidiabetic actions...
  15. pmc PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice
    Anna Foryst-Ludwig
    Center for Cardiovascular Research, Institute of Pharmacology Charité Universitätsmedizin Berlin, Germany
    Cardiovasc Diabetol 9:64. 2010
    ....
  16. doi request reprint Estrogen receptor-beta signals left ventricular hypertrophy sex differences in normotensive deoxycorticosterone acetate-salt mice
    Dennis Gürgen
    Department of Nephrology and Intensive Care Medicine Campus Virchow Klinikum, Center forCardiovascular Research Medical Faculty, Charite Berlin, Berlin, Germany
    Hypertension 57:648-54. 2011
    ..Our findings address the possibility of sex-specific cardiovascular therapies...
  17. doi request reprint Sexual dimorphism in obesity-mediated left ventricular hypertrophy
    Christian Böhm
    Center for Cardiovascular Research, Department of Pharmacology and Metabolic Research, Charite Universitatsmedizin Berlin, Germany
    Am J Physiol Heart Circ Physiol 305:H211-8. 2013
    ..9-fold induction by angiotensin II (10 μM). The present study demonstrates a sex-dependent regulation of diet-induced LVH associated with sexual dimorphic expression of adipocytokines in epicardial adipose tissue. ..
  18. ncbi request reprint PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin
    Ronald Clasen
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 46:137-43. 2005
    ..ARB-induced adiponectin stimulation is likely to be mediated via PPARgamma activation involving a post-transcriptional mechanism...
  19. doi request reprint Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan
    Markus Clemenz
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    Diabetes 57:1405-13. 2008
    ..Activation of the PPARalpha ligand binding domain (LBD) was investigated using transactivation assays...
  20. ncbi request reprint Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites
    Michael Schupp
    Center for Cardiovascular Research, Institute of Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 47:586-9. 2006
    ..The present study characterizes the active losartan metabolite EXP3179 as a partial PPAR-gamma agonist. PPAR-gamma activation by EXP3179 may help us to understand the beneficial metabolic effects of losartan observed in clinical trials...
  21. doi request reprint Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation
    Kai Kappert
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, Berlin, Germany
    Hypertension 54:738-43. 2009
    ..Our data show that sufficient serum levels of EXP3179 are present under losartan treatment. PPARgamma activation by AT1R-blockers may translate into synergistic beneficial actions in monocytes...
  22. ncbi request reprint Insulin facilitates monocyte migration: a possible link to tissue inflammation in insulin-resistance
    Kai Kappert
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Hessische Str 3 4, D 10115 Berlin, Germany
    Biochem Biophys Res Commun 365:503-8. 2008
    ....
  23. doi request reprint Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability
    Anna Foryst-Ludwig
    Center for Cardiovascular Research CCR Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    Am J Physiol Heart Circ Physiol 301:H115-22. 2011
    ..Collectively, our data demonstrate that sex differences in exercise-induced cardiac hypertrophy are associated with changes in cardiac substrate availability and utilization...
  24. pmc Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity
    Kai Kappert
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Berlin, Germany
    PLoS ONE 8:e70542. 2013
    ..Here we aimed to determine the role of serpinB8/furin in obesity-associated chronic inflammation...
  25. doi request reprint Sex-specific mTOR signaling determines sexual dimorphism in myocardial adaptation in normotensive DOCA-salt model
    Dennis Gürgen
    Department of Nephrology and Intensive Care Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 61:730-6. 2013
    ..Maintenance of both mTORC1 and mTORC2 signaling seems to be essential for adaptive cardiac remodeling in females and supports a rationale for sex-specific therapeutic strategies in left ventricular hypertrophy...
  26. doi request reprint Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode
    Matthias Goebel
    Institute of Pharmacy, Freie Universitat Berlin, Berlin, Germany
    Bioorg Med Chem 18:5885-95. 2010
    ....
  27. doi request reprint High-dose treatment with telmisartan induces monocytic peroxisome proliferator-activated receptor-γ target genes in patients with the metabolic syndrome
    Ilse Nirmala Bähr
    Center for Cardiovascular Research, Institute of Pharmacology, Outpatient Clinic, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Hypertension 58:725-32. 2011
    ..These data implicate that the angiotensin type 1 receptor blocker telmisartan activates PPARγ in circulating monocytes of patients with the metabolic syndrome...
  28. pmc Sexual dimorphic regulation of body weight dynamics and adipose tissue lipolysis
    Verena Benz
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e37794. 2012
    ..Since these processes are sex-specifically controlled, we investigated sexual dimorphisms in metabolic processes during BW-dynamics (gain-loss-regain)...
  29. ncbi request reprint The endothelium and vascular inflammation in diabetes
    Martin M Hartge
    Center for Cardiovascular Research, Charite Universitaetsmedizin Berlin, Hessische Strasse 3 4, 10115 Berlin, Germany
    Diab Vasc Dis Res 4:84-8. 2007
    ..In the presence of insulin resistance, these processes are potentiated and they provide a basis for the macrovascular disease seen in diabetes...
  30. doi request reprint Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain
    Kristin Schmerbach
    Center for Cardiovascular Research Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Brain Res 1208:225-33. 2008
    ..Therefore, we conclude that a direct synergistic neuroprotective action of parallel ARB and TZD treatment is unlikely...
  31. pmc Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoid-induced hepatic gluconeogenesis
    Robin Winkler
    Institute of Pharmacology, Department of Endocrinology, Diabetes and Nutrition, Charité Medical University, The Center for Cardiovascular Research, Berlin, Germany
    Diabetes 61:513-23. 2012
    ..Selective pharmacological inhibition of HDAC6 may provide a future therapeutic option against the prodiabetogenic actions of glucocorticoids...
  32. doi request reprint Characterization of telmisartan-derived PPARγ agonists: importance of moiety shift from position 6 to 5 on potency, efficacy and cofactor recruitment
    Lena Herbst
    Institute of Pharmacology, Center for Cardiovascular Research, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin Germany
    ChemMedChem 7:1935-42. 2012
    ....
  33. doi request reprint Sex- and age-dependent effects of Gpr30 genetic deletion on the metabolic and cardiovascular profiles of diet-induced obese mice
    Luca Meoli
    Center for Cardiovascular Research Charité, Hessische Str 3 4, 10115 Berlin, Germany Electronic address
    Gene 540:210-6. 2014
    ..Collectively our results point to a potential role of Gpr30 in preserving lipid metabolism and cardiac function in a sex- and age-dependent fashion. ..
  34. doi request reprint Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome
    Svetlana Slavic
    Center for Cardiovascular Research CCR and Institute of Pharmacology, Charite Universitatsmedizin, Hessische Strasse 3 4, 10115 Berlin, Germany
    J Mol Med (Berl) 91:811-23. 2013
    ..Inhibition of proteolysis and TGF-β1 expression and reduced collagen content by rimonabant may attenuate destruction of the extracellular matrix and decrease fibrosis after MI...
  35. ncbi request reprint Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity
    Michael Schupp
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Campus Charite Mitte, Charite Universitatsmedizin Berlin, Berlin, Germany
    Circulation 109:2054-7. 2004
    ..The peroxisome proliferator-activated receptor-gamma (PPARgamma) is the central regulator of insulin and glucose metabolism improving insulin sensitivity. We investigated the regulation of PPARgamma function by ARBs...
  36. pmc Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21
    Knut Mai
    Department of Endocrinology, Diabetes and Nutrition, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Diabetes 58:1532-8. 2009
    ....
  37. doi request reprint Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
    Elena Kaschina
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Circulation 118:2523-32. 2008
    ..This study is the first to examine the effect of direct angiotensin II type 2 (AT(2)) receptor stimulation on postinfarct cardiac function with the use of the novel nonpeptide AT(2) receptor agonist compound 21 (C21)...
  38. ncbi request reprint Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study
    Jurgen Scholze
    Department of Medicine, Outpatient Clinic, CCM, Charite Universitatsmedizin Berlin, Luisenstrasse 11 13, 10117 Berlin, Germany
    Circulation 115:1991-8. 2007
    ..To identify an optimal treatment regimen for obese hypertensive patients, we studied the interactions between a drug-based weight loss approach by sibutramine and different antihypertensive drug regimens...
  39. doi request reprint Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
    Jan H Schefe
    Center for Cardiovascular Research CCR Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Strasse 3 4, Berlin, Germany
    J Hypertens 26:1787-94. 2008
    ..The effects of prorenin and of renin inhibitors on the signal transduction cascade of the (pro)renin receptor are currently unknown...
  40. doi request reprint High-mobility group A1 protein: a new coregulator of peroxisome proliferator-activated receptor-γ-mediated transrepression in the vasculature
    Mandy Bloch
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Germany
    Circ Res 110:394-405. 2012
    ..The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) is an important regulator of gene transcription in vascular cells and mediates the vascular protection observed with antidiabetic glitazones...
  41. doi request reprint Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart
    Dilyara Lauer
    Center for Cardiovascular Research and Institute of Pharmacology, Charite Universitatsmedizin, Berlin, Hessische Strasse 3 4, D 10115 Berlin, Germany
    Hypertension 63:e60-7. 2014
    ....
  42. ncbi request reprint Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection
    Duska Dragun
    Department of Nephrology, Charite University Hospital, Berlin, Germany
    N Engl J Med 352:558-69. 2005
    ..Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients...
  43. doi request reprint Metabolic impact of estrogen signalling through ERalpha and ERbeta
    Anna Foryst-Ludwig
    Center for Cardiovascular Research CCR, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    J Steroid Biochem Mol Biol 122:74-81. 2010
    ..In contrast, ERbeta activation seems to be detrimental for the maintenance of regular glucose and lipid homeostasis. Metabolic actions of both receptors in relevant tissues will be discussed...
  44. doi request reprint Steroidal and Nonsteroidal Mineralocorticoid Receptor Antagonists Cause Differential Cardiac Gene Expression in Pressure Overload-induced Cardiac Hypertrophy
    Jana Grune
    Institute of Pharmacology, Center for Cardiovascular Research, Charite Universitaetsmedizin Berlin, Berlin, Germany Department of Veterinary Pathology, College of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany DZHK German Center for Cardiovascular Research, partner site Berlin, Berlin, Germany and Department of Cardiology Research, Bayer Health Care, Wuppertal, Germany
    J Cardiovasc Pharmacol 67:402-11. 2016
    ..4 ± 4.3 mg; VEH: 39.3 ± 3.1 mg; P < 0.05). These data show beneficial effects of nonsteroidal MR antagonism by FIN on left ventricular mass development in pressure overload associated with a distinct cardiac gene expression profile. ..
  45. pmc Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice
    Janine Krüger
    Center for Cardiovascular Research CCR, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Hessische Str 3 4, 10115 Berlin, Charite Universitatsmedizin Berlin, Germany
    Mol Metab 4:325-36. 2015
    ..Downregulating density-enhanced phosphatase-1 (DEP-1) resulted in an improved metabolic status in previous analyses. This phenotype was primarily caused by hepatic DEP-1 reduction...
  46. doi request reprint Estrogen receptor alpha supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells
    Marie Brinckmann
    Center for Cardiovascular Research CCR and Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    J Mol Cell Cardiol 47:66-75. 2009
    ..These findings suggest that cardiac ERalpha supports survival of cardiomyocytes through post-infarct cardiac c-kit+ cells, which may contribute to cardioprotection against cardiac injury...
  47. doi request reprint Impact of HDL on adipose tissue metabolism and adiponectin expression
    Sophie Van Linthout
    Charite, University Medicine Berlin, Campus Benjamin Franklin, Department of Cardiology, Berlin, Germany
    Atherosclerosis 210:438-44. 2010
    ....
  48. ncbi request reprint Endothelial dysfunction and its role in diabetic vascular disease
    Martin M Hartge
    Center for Cardiovascular Research, Institute for Pharmacology, Charite Berlin, Hessische Strasse 3 4, 10115 Berlin, Germany
    Endocrinol Metab Clin North Am 35:551-60, viii-ix. 2006
    ..Subsequently future therapeutic approaches for the treatment of diabetic cardiovascular disease should target the dysfunctional endothelium first...
  49. doi request reprint Deoxycorticosterone acetate-salt mice exhibit blood pressure-independent sexual dimorphism
    Aysun Karatas
    Department of Nephrology and Intensive Care, Medicine Campus, Virchow Klinikum, Berlin, Germany
    Hypertension 51:1177-83. 2008
    ..We suggest that sex-specific calcineurin activation determines the maladaptive cardiac and renal hypertrophic responses and accompanying organ injury in male mice...
  50. ncbi request reprint Angiotensin II induces peroxisome proliferator-activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation
    Yi Zhao
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Christian Albrechts University of Kiel, Kiel, Germany
    J Neurochem 94:1395-401. 2005
    ..AT2 receptor/PPARgamma-dependent neurite outgrowth may play an important role during neuroprotective processes...
  51. doi request reprint Proprotein convertase furin enhances survival and migration of vascular smooth muscle cells via processing of pro-nerve growth factor
    Daniel Urban
    Department of Medicine Cardiology, Deutsches Herzzentrum Berlin, Germany
    J Biochem 153:197-207. 2013
    ..These results indicate that furin determines the balance between proNGF and β-NGF in proliferating VSMCs, thus impacting on VSMC survival and migration and is also important in neointima formation...
  52. doi request reprint Bezafibrate maintenance therapy in patients with advanced chronic hepatitis C
    Viola Knop
    University Hospital Charite, Campus Virchow Klinikum, Department of Gastroenterology and Hepatology, Berlin, Germany
    Eur J Gastroenterol Hepatol 25:594-600. 2013
    ..The aim of the present study was to assess the efficacy and safety of bezafibrate in patients with advanced chronic hepatitis C...
  53. pmc Glucose-dependent insulinotropic polypeptide reduces fat-specific expression and activity of 11β-hydroxysteroid dehydrogenase type 1 and inhibits release of free fatty acids
    Ozlem Gögebakan
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Department of Endocrinology, Diabetes and Nutrition, Berlin, Germany
    Diabetes 61:292-300. 2012
    ..This process appears to depend on a modification of 11β-HSD1 activity. In general, the presented data support that GIP has direct and insulin-independent effects on adipose tissue...
  54. ncbi request reprint The metabolic syndrome: cluster with a self-fulfilling loop?
    Markus Clemenz
    Center for Cardiovascular Research, Institute of Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 24:257-8. 2006
  55. doi request reprint Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload
    Daniela Fliegner
    Institute of Gender in Medicine, Charité Medical University Berlin, Germany
    Am J Physiol Regul Integr Comp Physiol 298:R1597-606. 2010
    ..Female sex offers protection against ventricular chamber dilation in the TAC model. Both female sex and ERbeta attenuate the development of fibrosis and apoptosis, thus slowing the progression to heart failure...
  56. doi request reprint Sex differences in exercise-induced cardiac hypertrophy
    Anna Foryst-Ludwig
    Department of Translational Pharmacology, Center for Cardiovascular Research, Charite Universitaetsmedizin Berlin, Hessische Str 3 4, 10115, Berlin, Germany
    Pflugers Arch 465:731-7. 2013
    ....
  57. doi request reprint A polymorphic microsatellite repeat within the ECE-1c promoter is involved in transcriptional start site determination, human evolution, and Alzheimer's disease
    Yaosi Li
    Center for Cardiovascular Research Institute of Pharmacology, Charite Universitatsmedizin Berlin, 10115 Berlin, Germany
    J Neurosci 32:16807-20. 2012
    ..Our data indicate that a short genomic repeat structure constitutes a novel core promoter element, coincides with human evolution, and contributes to the pathogenesis of AD...
  58. ncbi request reprint Cardiac PPARalpha expression in patients with dilated cardiomyopathy
    Michael Schupp
    Center for Cardiovascular Research, CCR, Institute of Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, CCM, Hessischestr 3 4, 10115 Berlin, Germany
    Eur J Heart Fail 8:290-4. 2006
    ..The peroxisome proliferator-activated receptor alpha (PPARalpha) is a central regulator of myocardial fatty acid (FA) metabolism implicated in the pathogenesis of heart failure...
  59. doi request reprint Sex-specific differences in Type 2 Diabetes Mellitus and dyslipidemia therapy: PPAR agonists
    Verena Benz
    Charite Universitatsmedizin Berlin, Berlin, Germany
    Handb Exp Pharmacol . 2012
    ..Given a high prevalence of those metabolic disorders, and thus a broad use of PPAR agonists, the present review will discuss distinct aspects of sex-specific differences in antiobesity treatment using those groups of PPAR ligands...
  60. pmc Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate
    Anna Foryst-Ludwig
    From the Institute of Pharmacology, Center for Cardiovascular Research, Charite Universitaetsmedizin Berlin, 10115 Berlin, Germany, the DZHK German Center for Cardiovascular Research, 10115 Berlin, Germany
    J Biol Chem 290:23603-15. 2015
    ..The identification of a lipokine involved in physiological cardiac growth may help to develop future lipid-based therapies for pathological LVH or heart failure. ..
  61. ncbi request reprint Angiotensin II, PPAR-gamma and atherosclerosis
    Ulrich Kintscher
    Institute of Pharmacology and Toxicology, Charite Hospital, Humboldt University Berlin, D 10117 Berlin, Germany
    Front Biosci 9:359-69. 2004
    ....
  62. ncbi request reprint [Olmesartan after experimental myocardial infarct compared with ramipril: organ protective effect]
    Ulrich Kintscher
    Center for Cardiovascular Research, Institut fur Pharmakologie und Toxikologie, Campus Charite Mitte, HessischeStrasse 3 4, 10115 Berlin
    Krankenpfl J 43:112. 2005
  63. doi request reprint ANP system activity predicts variability of fat mass reduction and insulin sensitivity during weight loss
    Maria Brachs
    Department of Endocrinology and Metabolism, Charite Universitatsmedizin, Berlin, Germany Charité Center for Cardiovascular Research CCR, Berlin, Germany Experimental and Clinical Research Center ECRC, Berlin, Germany
    Metabolism 65:935-43. 2016
    ..Therefore, we investigated the impact of systemic, adipose and myocellular ANP system on metabolic and anthropometric improvements during weight loss...
  64. ncbi request reprint Statins regulate alpha2beta1-integrin expression and collagen I-dependent functions in human vascular smooth muscle cells
    Kristof Graf
    Deutsches Herzzentrum Berlin, Department of Medicine Cardiology, Berlin, Germany
    J Cardiovasc Pharmacol 41:89-96. 2003
    ..The current study indicates that HMG-CoA reductase inhibitors increase cell-matrix interaction with collagen I via induction of alpha2beta1-integrins and increased adhesion to collagen I...
  65. ncbi request reprint Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 296:890-6. 2002
    ..These results demonstrate that hypoxia enhances adhesion of VSMC on extracellular matrix proteins by activating beta(1)-integrin...
  66. ncbi request reprint Angiotensin II-augmented migration of VSMCs towards PDGF-BB involves Pyk2 and ERK 1/2 activation
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Medicine Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Basic Res Cardiol 97:334-42. 2002
    ....
  67. ncbi request reprint Leptin induces endothelial cell migration through Akt, which is inhibited by PPARgamma-ligands
    Stephan Goetze
    Department of Medicine Cardiology, German Heart Institute Berlin, Germany
    Hypertension 40:748-54. 2002
    ..Moreover, inhibition of leptin-directed migration by the PPARgamma-ligands TRO and CIG through inhibition of Akt underscores their potential in the prevention of diabetes-associated complications...
  68. ncbi request reprint A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth
    Dennis Bruemmer
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California Los Angeles, Warren Hall, Suite 24 130, 900 Veteran Avenue, Los Angeles, CA 90095 7073, USA
    Eur J Pharmacol 466:225-34. 2003
    ....
  69. ncbi request reprint Does the AT2-receptor mediate anti-atherosclerotic actions?
    Ulrich Kintscher
    J Hypertens 23:1469-70. 2005
  70. doi request reprint T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
    Ulrich Kintscher
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 28:1304-10. 2008
    ..Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue inflammation and IR...
  71. ncbi request reprint PPAR activators inhibit endothelial cell migration by targeting Akt
    Stephan Goetze
    Department of Medicine Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 293:1431-7. 2002
    ..These results provide first evidence for the antimigratory effects of PPAR-activators in EC. By inhibiting EC migration PPAR-activators may protect the vasculature from pathological alterations associated with metabolic disorders...
  72. ncbi request reprint PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4
    Ulrich Kintscher
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, School of Medicine, Los Angeles, Calif 90095, USA
    Circ Res 91:e35-44. 2002
    ..The full text of this article is available at http://www.circresaha.org...
  73. pmc Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
    Dennis Bruemmer
    Division of Endocrinology, Diabetes and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, Warren Hall, Suite 24 130, 900 Veteran Avenue, Los Angeles, California 90095, USA
    J Clin Invest 112:1318-31. 2003
    ..These data suggest an important role for leukocyte-derived OPN in mediating Ang II-accelerated atherosclerosis and aneurysm formation...
  74. ncbi request reprint TGF-beta(1) induces peroxisome proliferator-activated receptor gamma1 and gamma2 expression in human THP-1 monocytes
    Ulrich Kintscher
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 297:794-9. 2002
    ..TGF-beta(1) also induced the expression of three C/EBPisoforms (alpha, beta, and delta). Induction of PPARgamma1 and gamma2 in monocytes by TGF-beta(1) may contribute to the anti-inflammatory effects of this growth factor...
  75. ncbi request reprint Telmisartan inhibits CD4-positive lymphocyte migration independent of the angiotensin type 1 receptor via peroxisome proliferator-activated receptor-gamma
    Daniel Walcher
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Hypertension 51:259-66. 2008
    ..These data provide a novel mechanism to explain how telmisartan modulates lymphocyte activation by its PPARgamma-activating properties...
  76. doi request reprint The cardiometabolic drug rimonabant: after 2 years of RIO-Europe and STRADIVARIUS
    Ulrich Kintscher
    Eur Heart J 29:1709-10. 2008
  77. ncbi request reprint Pharmacological differences of glitazones: does peroxisome proliferator-activated receptor-alpha activation make the difference?
    Ulrich Kintscher
    J Am Coll Cardiol 52:882-4. 2008