Uwe Pleyer

Summary

Affiliation: Humboldt University
Country: Germany

Publications

  1. ncbi request reprint Corticosteroids in ophthalmology
    U Pleyer
    Department of Ophthalmology, University Hospital Charite, Campus Virchow Klinik, Augustenburger Platz 1, 13353 Berlin, Germany
    Ernst Schering Res Found Workshop . 2002
  2. pmc Intraocular pressure effects of common topical steroids for post-cataract inflammation: are they all the same?
    Uwe Pleyer
    Department of Ophthalmology, University Medicine Charité, Humboldt University, Chariteplatz 1, 10117, Berlin, Germany
    Ophthalmol Ther 2:55-72. 2013
  3. doi request reprint [Treatment of posterior noninfectious uveitis : Current situation and future developments]
    U Pleyer
    Augenklinik, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 113:380-90. 2016
  4. doi request reprint [Adenoviral keratoconjunctivitis]
    U Pleyer
    Charite, Augenklinik, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 112:459-69; quiz 469-71. 2015
  5. ncbi request reprint Controversies in NSAIDs Use in Cataract Surgery
    Mikaella Anthia Tsangaridou
    Department of Ophthalmology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Pharm Des 21:4707-17. 2015
  6. doi request reprint [Tropical ophthalmology : Intraocular inflammation caused by "new" infectious pathogens and travel-related infections]
    U Pleyer
    Augenklinik, Uveitis Zentrum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 113:35-46. 2016
  7. doi request reprint [Vernal keratoconjunctivitis]
    U Pleyer
    Augenklinik, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 112:177-89; quiz 190-1. 2015
  8. doi request reprint [Behcet's disease--ophthalmological and general aspects: Part 2: Therapy]
    U Pleyer
    Universitats Augenklinik, Uveitis Zentrum, Charite, Universitatsmedizin Berlin, Humboldt University, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 110:273-84. 2013
  9. doi request reprint [Behçet's disease - ophthalmological and general aspects part I : etiology, pathogenesis and diagnostics]
    U Pleyer
    Universitats Augenklinik, Uveitis Zentrum, Humboldt University, Universitatsmedizin Berlin, Charite, 13353, Berlin, Deutschland
    Ophthalmologe 109:1129-41; quiz 1142-3. 2012
  10. doi request reprint [Comments on the pathogenesis of Behçet's disease. A key to understanding new therapies?]
    U Pleyer
    Augenklinik, Uveitis Zentrum, Charite Universitatsmedizin Berlin, Humboldt University, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 109:563-7. 2012

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Corticosteroids in ophthalmology
    U Pleyer
    Department of Ophthalmology, University Hospital Charite, Campus Virchow Klinik, Augustenburger Platz 1, 13353 Berlin, Germany
    Ernst Schering Res Found Workshop . 2002
    ..For future developments, several directions may be chosen including development of safer drugs with high therapeutic index and application of long-term drug-release systems...
  2. pmc Intraocular pressure effects of common topical steroids for post-cataract inflammation: are they all the same?
    Uwe Pleyer
    Department of Ophthalmology, University Medicine Charité, Humboldt University, Chariteplatz 1, 10117, Berlin, Germany
    Ophthalmol Ther 2:55-72. 2013
    ..The proportion of patients exhibiting an increase of ≥10 mmHg IOP in clinical studies has emerged as the most clinically relevant parameter for ophthalmologists to consider when deciding on which topical corticosteroid to use. ..
  3. doi request reprint [Treatment of posterior noninfectious uveitis : Current situation and future developments]
    U Pleyer
    Augenklinik, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 113:380-90. 2016
    ..This article outlines recent advances and future therapeutic options for the treatment of posterior segment noninfectious uveitis. ..
  4. doi request reprint [Adenoviral keratoconjunctivitis]
    U Pleyer
    Charite, Augenklinik, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 112:459-69; quiz 469-71. 2015
    ..As nosocomial spread of adenoviruses is relatively common, preventive measures remain a major responsibility for ophthalmologists. ..
  5. ncbi request reprint Controversies in NSAIDs Use in Cataract Surgery
    Mikaella Anthia Tsangaridou
    Department of Ophthalmology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Pharm Des 21:4707-17. 2015
    ..In addition, prevention should be of foremost importance and remains an open issue. Identification of risk factors, application of NSAIDs and consequent follow-up are potential essential steps in the avoidance of this complication. ..
  6. doi request reprint [Tropical ophthalmology : Intraocular inflammation caused by "new" infectious pathogens and travel-related infections]
    U Pleyer
    Augenklinik, Uveitis Zentrum, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 113:35-46. 2016
    ..Here, we focus on Chikungunya, Dengue fever, Ebola fever, the West Nile virus and Rickettsioses, which frequently demonstrate ocular involvement. ..
  7. doi request reprint [Vernal keratoconjunctivitis]
    U Pleyer
    Augenklinik, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 112:177-89; quiz 190-1. 2015
    ....
  8. doi request reprint [Behcet's disease--ophthalmological and general aspects: Part 2: Therapy]
    U Pleyer
    Universitats Augenklinik, Uveitis Zentrum, Charite, Universitatsmedizin Berlin, Humboldt University, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 110:273-84. 2013
    ..This article summarizes the current state of knowledge and emphasizes the important role of the ophthalmologist in the therapy of Behcet's disease...
  9. doi request reprint [Behçet's disease - ophthalmological and general aspects part I : etiology, pathogenesis and diagnostics]
    U Pleyer
    Universitats Augenklinik, Uveitis Zentrum, Humboldt University, Universitatsmedizin Berlin, Charite, 13353, Berlin, Deutschland
    Ophthalmologe 109:1129-41; quiz 1142-3. 2012
    ..This article summarizes the current state of knowledge and emphasizes the important role of the ophthalmologist in the diagnosis and therapy of Behçet's disease...
  10. doi request reprint [Comments on the pathogenesis of Behçet's disease. A key to understanding new therapies?]
    U Pleyer
    Augenklinik, Uveitis Zentrum, Charite Universitatsmedizin Berlin, Humboldt University, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 109:563-7. 2012
    ..g. directed against heat shock proteins plays an important role in Behçet's syndrome. This article is intended to evaluate the more recent knowledge on this disorder and evaluate new therapeutic options...
  11. ncbi request reprint [Modulation of immune mediated diseases of the eye]
    U Pleyer
    Universitats Augenklinik, Charite Virchow Klinikum, Humboldt Universitat zu Berlin
    Klin Monbl Augenheilkd 214:160-70. 1999
    ..This review attempts to address some topics of the current knowledge of the use of immunomodulating agents in ophthalmology...
  12. ncbi request reprint Delayed mustard gas keratopathy: clinical findings and confocal microscopy
    U Pleyer
    Department of Ophthalmology, Charite, Berlin, Germany
    Am J Ophthalmol 128:506-7. 1999
    ..To describe the clinical manifestations and confocal microscopic findings in a patient with delayed mustard gas keratopathy...
  13. ncbi request reprint Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4
    U Pleyer
    Department of Ophthalmology, Humboldt University, Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 238:531-6. 2000
    ..In this study we investigated the effect of adenovirus-mediated gene transfer of the Th2 cytokine interleukin-4 (IL-4) to rat corneas in an experimental keratoplasty model...
  14. pmc Detection of Borrelia burgdorferi DNA in urine of patients with ocular Lyme borreliosis
    U Pleyer
    Department of Ophthalmology, Charite, Humboldt University, Campus Virchow Hospital, Augustenburger Platz 1, D 13353 Berlin, Germany
    Br J Ophthalmol 85:552-5. 2001
    ..To evaluate the diagnostic value of the polymerase chain reaction (PCR) to detect Borrelia burgdorferi DNA in patients with ocular Lyme borreliosis...
  15. ncbi request reprint Corneal allograft rejection: current understanding. I. Immunobiology and basic mechanisms
    U Pleyer
    Department of Ophthalmology, Charite, Humboldt University, Berlin, Germany
    Ophthalmologica 215:254-62. 2001
    ..As knowledge increases, it is hoped that a better understanding of the immunobiology may result in improved preventive and therapeutic measures...
  16. ncbi request reprint Efficiency and toxicity of liposome-mediated gene transfer to corneal endothelial cells
    U Pleyer
    Department of Ophthalmology, Charite, Campus Virchow, Humboldt University, Augustenburger Platz 1, D 13353 Berlin, Germany
    Exp Eye Res 73:1-7. 2001
    ..The ability to deliver genes to BCEC via liposomes could be valuable, since the use of other vectors for transfection may be limited by undesired effects...
  17. ncbi request reprint Outcome of penetrating keratoplasty in rheumatoid arthritis
    Uwe Pleyer
    Department of Ophthalmology, Charite, Campus Virchow Hospital, Berlin, Germany
    Ophthalmologica 216:249-55. 2002
    ..The purpose of this study was to determine the anatomical and functional results of therapeutic penetrating keratoplasty (PK) in these patients...
  18. ncbi request reprint Therapeutic indications for local anti-infectives. Viral ocular infections: topical treatment and prevention
    U Pleyer
    University Eye Clinic, Charite Humboldt University Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    Dev Ophthalmol 33:281-96. 2002
  19. ncbi request reprint Gene therapy in immune-mediated diseases of the eye
    Uwe Pleyer
    Department of Ophthalmology, Humboldt University, Charite Campus Virchow, Augustenburger Platz 1, D 13353 Berlin, Germany
    Prog Retin Eye Res 22:277-93. 2003
    ..Many of these approaches are still in early phases of study for the treatment of clinical relevant immune-mediated diseases...
  20. ncbi request reprint [Immunomodulation in penetrating keratoplasty. Current status and perspectives]
    U Pleyer
    Augenklinik, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin
    Ophthalmologe 100:1036-44. 2003
    ..In addition, this review attempts to address some new concepts of tolerance induction following penetrating keratoplasty...
  21. ncbi request reprint [Intraocular inflammations. A diagnostic and therapeutic challenge]
    U Pleyer
    Augenklinik des Campus Virchow Klinikum, Charite Universitatsmedizin, Berlin
    Ophthalmologe 102:325-8. 2005
  22. ncbi request reprint [Uveitis in childhood. Small patients--big problems]
    U Pleyer
    Augenklinik, Universitatsmedizin Berlin Charite, Campus Virchow Klinikum, 13353 Berlin
    Ophthalmologe 102:461-2. 2005
  23. ncbi request reprint Effects of a selective glucocorticoid receptor agonist on experimental keratoplasty
    Uwe Pleyer
    Department of Ophthalmology, Institute of Pharmacy, Charite, Humboldt University, Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 243:450-5. 2005
    ..We set out to evaluate the effect of a SEGRA compound following topical application on the course of experimental orthotopic corneal grafts...
  24. ncbi request reprint [Differential diagnosis and therapy of graft rejection after keratoplasty]
    U Pleyer
    Campus Virchow Klinikum, Charite, Universitatsmedizin Berlin
    Klin Monbl Augenheilkd 222:863-9. 2005
    ..This article is intended to provide a review on differential diagnoses and current therapeutic measures...
  25. ncbi request reprint [Combination of epilenticular IOL-implantation and pars plana lentectomy in traumatic cataract patients]
    U Pleyer
    Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin
    Klin Monbl Augenheilkd 223:68-9. 2006
  26. ncbi request reprint [Introduction to the topic: bacterial keratitis. From the proven to the new]
    U Pleyer
    Charite, Universitats Augenklinik, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Ophthalmologe 104:7-8. 2007
  27. ncbi request reprint [Bacterial keratitis. Current diagnostic aspects]
    U Pleyer
    Charite, Universitatsaugenklinik, Campus Virchow Klinikum, 13353, Augustenburger Platz 1, Berlin, Germany
    Ophthalmologe 104:9-14. 2007
    ..This article reviews the current data and procedures available for the diagnosis of bacterial keratitis...
  28. ncbi request reprint [Ocular toxoplasmosis]
    U Pleyer
    Augenklinik, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Deutschland
    Ophthalmologe 104:603-15, quiz 616. 2007
    ..The present article reviews the epidemiology, pathogenesis, clinical presentation and management of toxoplasmic retinochoroiditis...
  29. doi request reprint [Mycophenol acid in ocular automimmune disorders--can we optimise this therapy?]
    U Pleyer
    Universitats Augenklinik, Charité Campus Virchow Klinik, Berlin
    Klin Monbl Augenheilkd 225:66-9. 2008
    ..This prospective study was undertaken to evaluate the effect of conversion from mycophenolate mofetil (MMF) to an enteric-coated mycophenolate sodium (EC-MPS)...
  30. doi request reprint [Intraocular pressure related to uveitis]
    U Pleyer
    Universitats Augenklinik, Charite, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin
    Ophthalmologe 105:431-7. 2008
    ..Despite the availability of many new medical treatments for both conditions, control of IOP in these patients remains challenging...
  31. doi request reprint [Will intracameral cefuroxime become the new standard in endophthalmitis prevention?]
    U Pleyer
    Universitats Augenklinik, Charité Campus Virchow Klinik, Berlin
    Klin Monbl Augenheilkd 225:934-40. 2008
    ....
  32. doi request reprint [Sympathetic ophthalmia]
    U Pleyer
    Charite, Universitats Augenklinik, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Deutschland
    Ophthalmologe 106:167-75; quiz 176. 2009
    ..As the occurrence of sympathetic ophthalmia is probably more frequent following vitreoretinal surgery, more attention has to be paid to this potentially bilateral blinding disorder...
  33. doi request reprint The taming of the shrew? The immunology of corneal transplantation
    Uwe Pleyer
    Department of Ophthalmology, Charite University Berlin, Germany
    Acta Ophthalmol 87:488-97. 2009
    ..This review gives an update on corneal immunobiology and the mechanisms of corneal graft rejection, focusing on antigen presentation, as well as on the molecular and cellular mediators of this particular immune response...
  34. doi request reprint [Diagnostics and differential diagnosis of acute retinal necrosis]
    U Pleyer
    Universitats Augenklinik, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 106:1074-82. 2009
    ..This review is intended to provide an overview of the diagnostics and differential diagnosis of this rare but important disorder...
  35. doi request reprint [Diagnostic and therapeutic aspects of herpes virus associated uveitis]
    U Pleyer
    Universitats Augenklinik, Charité Campus Virchow Klinik, Berlin, Germany
    Klin Monbl Augenheilkd 227:407-12. 2010
    ..This review is intended to provide an overview on the diagnosis and differential diagnosis of this important disorder...
  36. doi request reprint [Aqueous humor analysis: a diagnostic tool in intraocular inflammation]
    U Pleyer
    Universitats Augenklinik, Charité Campus Virchow Klinik, Berlin
    Klin Monbl Augenheilkd 227:953-60. 2010
    ..This article describes the different considerations and processes that are important to ensure optimal results for these different diagnostic laboratory procedures...
  37. doi request reprint [Anti-TNF-α treatment for uveitis. Analysis of the current situation]
    U Pleyer
    Universitats Augenklinik, Charite, Campus Virchow Klinikum, Humboldt Universitat zu Berlin, Augustenburger Platz 1, 13353 Berlin
    Ophthalmologe 108:13-20. 2011
    ..Neutralization of TNF-α might therefore be a promising strategy for prevention and treatment of uveitis. Here we review the principle effects, therapeutic value, and potential side effects of anti-TNF agents in uveitis...
  38. ncbi request reprint Local overexpression of nerve growth factor in rat corneal transplants improves allograft survival
    Nianqiao Gong
    Department of Ophthalmology, Charite University Medicine, Berlin, Germany
    Invest Ophthalmol Vis Sci 48:1043-52. 2007
    ..To investigate the effect and mechanisms of nerve growth factor (NGF) gene therapy to promote allograft survival in experimental rat corneal transplantation...
  39. ncbi request reprint The influence of inducible costimulator fusion protein (ICOSIg) gene transfer on corneal allograft survival
    Daniel Fabian
    Institute of Medical Immunology, Charite University Medicine Berlin, Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1515-21. 2007
    ..The purpose of this paper is to analyse the effects of local or systemic administration of adenovirus type 5 encoding the inducible costimulator fusion protein (AdICOSIg) on its influence on prolonging corneal allograft survival...
  40. doi request reprint Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival
    Svetlana Stanojlovic
    Department of Ophthalmology, Charite University Medicine, 10117, Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 248:1447-56. 2010
    ..To analyze the immune modulatory effect of low-dose systemic treatment with rapamycin (Rapa) alone or in combination with cyclosporin A (CsA) in a high-responder corneal allograft model...
  41. doi request reprint Survival of corneal allografts following topical treatment with the immunomodulator mycophenolate mofetil
    Eckart Bertelmann
    Clinic of Ophthalmology, Campus Virchow Klinikum, Charité University School of Medicine Berlin, Berlin, Germany
    Ophthalmologica 224:38-41. 2010
    ..To evaluate the efficacy and safety of topically applied mycophenolate mofetil (MMF) for the prophylaxis of corneal graft rejection in an experimental keratoplasty model...
  42. ncbi request reprint Efficiency of cytokine gene transfer in corneal endothelial cells and organ-cultured corneas mediated by liposomal vehicles and recombinant adenovirus
    Eckart Bertelmann
    Department of Ophthalmology, Charite, Humboldt University, Berlin, Germany
    Ophthalmic Res 35:117-24. 2003
    ....
  43. ncbi request reprint Effects of spironolactone on corneal allograft survival in the rat
    Ljiljana Otasevic
    Department of Ophthalmology, Charite University Medicine Berlin, Berlin, Germany
    Ophthalmic Res 39:325-9. 2007
    ..In this study, we investigated the effects of spironolactone on the prevention of corneal allograft rejection in a MHC class I/II mismatch rat corneal transplant model...
  44. doi request reprint Control of TNF-induced dendritic cell maturation by hybrid-type N-glycans
    Stephan Schlickeiser
    Institute of Medical Immunology, Charite University Medicine Berlin, D 13353 Berlin, Germany
    J Immunol 186:5201-11. 2011
    ....
  45. ncbi request reprint Lipid-mediated gene transfer of acidic fibroblast growth factor into human corneal endothelial cells
    Haike Dannowski
    Department of Ophthalmology, Charite Universitatsmedizin Berlin, Campus Virchowklinikum, Augustenburger Platz 1, Berlin D 13353, Germany
    Exp Eye Res 80:93-101. 2005
    ..This may indicate that even a low transfection rate is sufficient to produce a concentration of FGF-1 that will have a stimulatory effect on HCECs...
  46. ncbi request reprint Gene transfer of cyto-protective molecules in corneal endothelial cells and cultured corneas: analysis of protective effects in vitro and in vivo
    Nianqiao Gong
    Department of Ophthalmology, Charite University Medicine Berlin, Germany
    Biochem Biophys Res Commun 357:302-7. 2007
    ..However, gene transfer of a single cyto-protective molecule does not prevent its rejection upon transplantation in a MHC class I/II disparate rat model...
  47. doi request reprint Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells
    Stefan Mergler
    Department of Ophthalmology, Campus Virchow Clinic, Charite, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Histochem Cell Biol 137:743-61. 2012
    ..In conclusion, conjunctiva express TRPV1, TRPV2, and TRPV4 channels which may provide novel drug targets for dry eye therapeutics. Their usage may have fewer side effects than those currently encountered with less selective drugs...
  48. ncbi request reprint Immunomodulatory therapy in ophthalmology - is there a place for topical application?
    Eckart Bertelmann
    Augenklinik Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin, Deutschland
    Ophthalmologica 218:359-67. 2004
    ..Taken together, topical immunomodulatory therapy will not replace systemic therapy but further treatment options can be expected...
  49. ncbi request reprint Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival
    Nianqiao Gong
    Department of Ophthalmology, Charite University Medicine Berlin, Germany
    J Gene Med 8:459-67. 2006
    ..To analyse the effects of local (ex vivo) or systemic (in vivo) administration of adenovirus type 5 encoding CTLA4Ig (AdCTLA4Ig) on its influence to prolong corneal allograft survival and to study the underlying mechanisms...
  50. ncbi request reprint Risk factors for endothelial cell loss post-keratoplasty
    Eckart Bertelmann
    Clinic of Ophthalmology, Charité University School of Medicine Berlin, Berlin, Germany
    Acta Ophthalmol Scand 84:766-70. 2006
    ..The aim of this study was to determine the rate of endothelial cell loss in our patients and to detect dependencies on donor-and recipient-related factors...
  51. ncbi request reprint Longterm visual prognosis of patients with ocular Adamantiades-Behçet's disease treated with interferon-alpha-2a
    Lothar Krause
    Department of Ophthalmology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Rheumatol 35:896-903. 2008
    ..Interferon-alpha (IFN-alpha) has proven to be effective in mucocutaneous ABD and has been reported to improve ocular lesions. We examined the longterm effects of IFN-alpha-2a in a case series of 45 patients with ocular involvement...
  52. doi request reprint Corneal permeation studies of everolimus microemulsion
    Yuecel Baspinar
    Institute of Pharmacy, Free University of Berlin, Berlin, Germany
    J Ocul Pharmacol Ther 24:399-402. 2008
    ..The aim of this study was to determine the permeation rate of everolimus through freshly isolated pig cornea (ex vivo)...
  53. doi request reprint Intraocular antibody synthesis against rubella virus and other microorganisms in Fuchs' heterochromic cyclitis
    Peter C Ruokonen
    Augenklinik Charité Universitätsmedizin Berlin CVK Germany, Augustenburger Platz 1, 13353 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 248:565-71. 2010
    ..Fuchs' heterochromic cyclitis (FHC) is a common intraocular disease of uncertain etiology that has recently been related to rubella virus (RV) infection...
  54. doi request reprint Characterization of transient receptor potential vanilloid channel 4 (TRPV4) in human corneal endothelial cells
    Stefan Mergler
    Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Department of Ophthalmology, Augustenburger Platz 1, 13353 Berlin, Germany
    Exp Eye Res 93:710-9. 2011
    ..There is functional TRPV4 expression in HCEC-12 and in its clonal daughter cell lines based on Ca(2+) transients and underlying currents induced by known activators of this channel...
  55. ncbi request reprint Intraocular availability of topically applied mycophenolate mofetil in rabbits
    Sigrid Knapp
    Institut fur Pharmazie, Humboldt Universitat zu Berlin, Goethestr 54, 13086 Berlin, Germany
    J Ocul Pharmacol Ther 19:181-92. 2003
    ..g. following corneal transplantation, the MMF/HP-beta-CD formulation could be an useful topical treatment. Furthermore, the present study shows that MMF-CD is superior to MMF-SP by increasing intraocular availability...
  56. ncbi request reprint Increased endothelial survival of organ-cultured corneas stored in FGF-2-supplemented serum-free medium
    Peter W Rieck
    Department of Ophthalmology, Charité Medical Faculty, Humboldt University Berlin, Germany
    Invest Ophthalmol Vis Sci 44:3826-32. 2003
    ..To investigate the effect of FGF-2 on corneal endothelial cell survival in porcine and human corneas during corneal storage in a serum-free medium...
  57. ncbi request reprint EGF suppresses hydrogen peroxide induced Ca2+ influx by inhibiting L-type channel activity in cultured human corneal endothelial cells
    Stefan Mergler
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    Exp Eye Res 80:285-93. 2005
    ..As EGF overcomes H2O2-induced rises in [Ca2+]i, its presence during eye bank storage could improve the outcome of corneal transplant surgery...
  58. ncbi request reprint Formulation of sirolimus eye drops and corneal permeation studies
    Guido Buech
    Institute of Pharmacy, Free University of Berlin, Berlin, Germany
    J Ocul Pharmacol Ther 23:292-303. 2007
    ..They are not suitable to achieve therapeutic concentrations in the aqueous humour of patients with intact cornea...
  59. ncbi request reprint [Corneal wound healing. II. Treatment of disorders of wound healing]
    P W Rieck
    Augenklinik Charité, Universitatsmedizin Berlin, Campus Wirchow Klinikum, Berlin
    Ophthalmologe 100:1109-30. 2003
  60. doi request reprint Ocular surface temperature gradient is increased in eyes with bacterial corneal ulcers
    Matthias K J Klamann
    Department of Ophthalmology, Charite University Medicine Berlin, Berlin, Germany
    Ophthalmic Res 49:52-6. 2013
    ..To investigate the ocular surface temperature gradient in eyes with bacterial corneal ulcers...
  61. doi request reprint Ocular involvement in Adamantiades-Behçet's disease in Berlin, Germany
    Lothar Krause
    Department of Ophthalmology, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 247:661-6. 2009
    ..Berlin is the city with the highest number of non-native German inhabitants, and its multi-ethnic character renders it uniquely appropriate for epidemiological studies on ABD...
  62. ncbi request reprint Effects of local and systemic viral interleukin-10 gene transfer on corneal allograft survival
    N Gong
    Department of Ophthalmology, Charite University Medicine Berlin, Germany
    Gene Ther 14:484-90. 2007
    ..Our data indicate systemic expression of the vIL-10 gene is required to modulate the cytokine expression profile in the draining lymph nodes, which might be a pre-requisite for the success of cytokine gene therapy...
  63. doi request reprint Prolongation of corneal allograft survival by topical application of everolimus in experimental keratoplasty
    X Q Li
    Department of Ophthalmology Charité Universitatsmedizin Berlin, Berlin, Germany
    Ophthalmic Res 40:309-14. 2008
    ..Commonly, the topical application of immunomodulatory agents is preferred over systemic use, in order to reduce the side effects...
  64. pmc Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography
    Yanling Ouyang
    Charite, University Medicine Berlin, Department of Ophthalmology, Berlin, Germany
    PLoS ONE 10:e0127683. 2015
    ..To describe the clinical finding of subretinal fluid (SRF) in the posterior pole by spectral domain optical coherence tomography (SD-OCT) in eyes with active ocular toxoplasmosis (OT)...
  65. doi request reprint Functional significance of thermosensitive transient receptor potential melastatin channel 8 (TRPM8) expression in immortalized human corneal endothelial cells
    Stefan Mergler
    Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Department of Ophthalmology, Augustenburger Platz 1, 13353 Berlin, Germany Electronic address
    Exp Eye Res 116:337-49. 2013
    ..Taken together, functional TRPM8 expression in HCEC-12 and freshly dissociated HCEC suggests that HCE function can adapt to thermal variations through activation of this channel subtype. ..
  66. ncbi request reprint Interferon alfa-2a in the treatment of ocular Adamantiades-Behçet's disease
    Lothar Krause
    Department of Ophthalmology, University Medical Center Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    Adv Exp Med Biol 528:511-9. 2003
  67. doi request reprint Dry eye symptoms in patients after eyelid reconstruction with full-thickness eyelid defects: using the Tomey TG-1000 thermographer
    Johannes Gonnermann
    Department of Ophthalmology, Charite, University Medicine Berlin, Berlin, Germany
    Ophthalmic Res 48:192-8. 2012
    ....
  68. ncbi request reprint Cytomegalovirus retinitis in Wegener's granulomatosis: case report and review of the literature
    Eckart Bertelmann
    Clinic of Ophthalmology, Charité University School of Medicine Berlin, Berlin, Germany
    Acta Ophthalmol Scand 83:258-61. 2005
    ..To present the first case of cytomegalovirus (CMV) retinitis in a Wegener's granulomatosis patient on systemic cyclosporine A (CsA) therapy...
  69. doi request reprint TRPV channels mediate temperature-sensing in human corneal endothelial cells
    Stefan Mergler
    Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Department of Ophthalmology, Augustenburger Platz 1, 13353 Berlin, Germany
    Exp Eye Res 90:758-70. 2010
    ..Taken together, TRPV activity modulation by temperature underlies essential homeostatic mechanisms contributing to the support of corneal endothelial function under different ambient conditions...
  70. doi request reprint Anti-TNF-alpha treatment: a possible promoter in endogenous uveitis? observational report on six patients: occurrence of uveitis following etanercept treatment
    Vinodh Kakkassery
    Charite, University School of Medicine Berlin, Department of Ophthalmology, Berlin, Germany
    Curr Eye Res 35:751-6. 2010
    ..This report describes the occurrence of intraocular inflammation after treatment with the TNF-alpha antagonist etanercept...
  71. ncbi request reprint Ocular drug permeation following experimental excimer laser treatment on the isolated pig eye
    Martina Scholz
    Humboldt University, Institute of Pharmacy, Department of Pharmaceutical Technology, Berlin, German
    J Ocul Pharmacol Ther 18:177-83. 2002
    ..These results suggest that PRK may significantly reduce the corneal barrier function and alter pharmacokinetics of topical medication...
  72. ncbi request reprint Corneal allograft rejection: current understanding. 2. Clinical implications
    Eckart Bertelmann
    Department of Ophthalmology, Charite, Humboldt University, Berlin, Germany
    Ophthalmologica 216:2-12. 2002
  73. ncbi request reprint Serum cytokine receptor levels in noninfectious uveitis
    Necip Torun
    Charite, University School of Medicine Berlin, Clinic of Ophthalmology, Campus Virchow Klinikum, Augustenburger Platz 1, DE 13353 Berlin, Germany
    Ophthalmic Res 37:112-6. 2005
    ..Understanding of the role of cytokines in uveitis may provide new clues to its treatment. Therefore, the purpose of our study was to evaluate systemic cytokine receptor expression in patients with noninfectious uveitis...
  74. pmc Thermosensitive transient receptor potential channels in human corneal epithelial cells
    Stefan Mergler
    Department of Ophthalmology, Campus Virchow Clinic, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Cell Physiol 226:1828-42. 2011
    ..We conclude that HCEC possess in addition to thermosensitive TRPV3 activity TRPV1, TRPV2, and TRPV4 activity. Their activation confers temperature sensitivity at the ocular surface, which may protect the cornea against such stress...
  75. doi request reprint [Diseases of the outer eye in rheumatoid arthritis]
    E Feist
    Augenklinik, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Berlin, Germany
    Z Rheumatol 69:403-10. 2010
    ..This article gives an overview of clinical aspects, pathogenetic background as well as therapeutic options for ocular involvement in rheumatoid arthritis...
  76. doi request reprint Ocular syphilis--indicator of previously unknown HIV-infection
    Jan Kunkel
    Department of Medicine I, Gastroenterology, Infectious Diseases and Rheumatology, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Infect 58:32-6. 2009
    ..To detect the prevalence of HIV-co-infection in patients with ocular syphilis and to compare ocular syphilis in HIV-positive and -negative patients...
  77. ncbi request reprint [Gene therapy in ophthalmology. Review of options and trends in corneal diseases]
    U Pleyer
    , , Augustenburger Platz 1, 13353 Berlin
    Klin Monatsbl Augenheilkd 218:140-7. 2001
    ..Currently, insufficient gene transfer technologies and safety concerns prevent the broad application in humans. However, a broad spectrum of applications can be supposed...
  78. ncbi request reprint [Analysis of the aqueous humor in keratoplasty patients with keratitis. Initial results]
    A Liekfeld
    Augenklinik, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Augustenburger Platz 1, 13353 Berlin
    Ophthalmologe 98:456-9. 2001
    ..For these reasons we use aqueous humor analysis in certain corneal transplant patients to determine intraocular antibody production. The aim of this study was to evaluate the diagnostic value of such an analysis of aqueous humor...
  79. ncbi request reprint [Transcorneal-paracorneal penetration route for topical application of drugs to the eyt. Mycophenolate mofetil as a model substance]
    E Bertelmann
    Augenklinik Charité, Campus Virchow Klinikum, Medizinische Fakultat der Humboldt Universitat Berlin, Berlin, Germany
    Ophthalmologe 100:696-701. 2003
    ..There are only few studies to demonstrate the relationship of both penetration routes. The immuno-modulator mycophenolate mofetil (MMF), ester and pro-drug of mycophenolic acid (MPA), is a promising substance for such studies...
  80. ncbi request reprint [Current practice of immune prophylaxis and therapy in perforating keratoplasty. A survey of members of the Cornea Section of the German Ophthalmological Society]
    E Bertelmann
    Augenklinik Charité Universitätsmedizin Berlin, Campus Virchow Klinikum, Berlin
    Ophthalmologe 100:1031-5. 2003
    ..The aim of the present study was to evaluate clinical practice in planning and treatment of perforating keratoplasty (KPL) in Germany...
  81. ncbi request reprint [Confocal microscopy in corneal dystrophies: a comparison between confocal slit scanning (ConfoScan P2) and laser scanning microscopy (Rostock Cornea Modul-HRT II)]
    N Bailly
    Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augenklinik, 13353 Berlin
    Klin Monbl Augenheilkd 223:735-42. 2006
    ..The object of this work was a comparison of confocal images of corneal dystrophies made by a slit scanning microscope versus a laser scanning microscope...
  82. ncbi request reprint [Ocular toxocariasis. From biology to therapy]
    E Bertelmann
    Charite, Universitatsaugenklinik, Campus Virchow Klinikum, 13353, Augustenburger Platz 1, Berlin, Germany
    Ophthalmologe 104:35-9. 2007
    ..A well timed adequate therapy can stabilize the visual acuity in many cases...
  83. ncbi request reprint [The role of uveitis in demyelinating diseases of the central nervous system]
    A M Beyer
    Neurologische Klinik und Poliklinik, Charite Universitatsmedizin Berlin, Campus Charite Mitte, Chariteplatz 1, Berlin, Germany
    Nervenarzt 78:1389-98. 2007
    ..Therefore, further studies are warranted in order to reveal whether administration of early immunomodulatory therapy can delay or even prevent the clinical manifestation of MS in a distinct subgroup of patients presenting with uveitis...
  84. doi request reprint Ocular involvement is associated with HLA-B51 in Adamantiades-Behçet's disease
    L Krause
    Department of Ophthalmology, Campus Benjamin Franklin, Charite Universitaetsmedizin Berlin, Berlin, Germany
    Eye (Lond) 23:1182-6. 2009
    ..To evaluate the association of HLA-B51 and ocular involvement in Adamantiades-Behçet's disease...
  85. doi request reprint [Meibomian glands : part III. Dysfunction - argument for a discrete disease entity and as an important cause of dry eye]
    E Knop
    Forschungslabor der Augenklinik, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum CVK, Ziegelstrasse 5 9, 10117, Berlin, Deutschland
    Ophthalmologe 106:966-79. 2009
    ..Particularly important is the inspection of the meibomian orifices and diagnostic expression by mild mechanical compression of the lid...
  86. doi request reprint [Janus-faced?: Effects and side-effects of interferon therapy in ophthalmology]
    N Stubiger
    Augenklinik, Charite Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Deutschland
    Ophthalmologe 108:204-12. 2011
    ....
  87. doi request reprint [Intravitreal implants: drug carriers and carriers of hope?]
    S Winterhalter
    Universitätsaugenklinik Charité, Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 108:222-9. 2011
    ..Dexamethasone implants were already approved for the therapy of retinal vein occlusions and are used successfully. Diabetic macular edema would be another possible indication for dexamethasone implants...
  88. ncbi request reprint Corticosteroids in ophthalmology: past-present-future
    Zacharias Sherif
    Department of Ophthalmology, Charite Virchow Klinikum, Humboldt University, D 13353 Berlin, Germany
    Ophthalmologica 216:305-15. 2002
  89. ncbi request reprint Calcium influx induced by activation of receptor tyrosine kinases in SV40-transfected human corneal endothelial cells
    Stefan Mergler
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Universitätsklinikum Charité der Humboldt Universität zu Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D 13353 Berlin, Germany
    Exp Eye Res 77:485-95. 2003
    ..These data regarding Ca(2+) inflow through Ca(2+) channels could be useful for investigation of culture and vitality conditions of HCEC...
  90. ncbi request reprint Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis
    H Baatz
    Department of Ophthalmology, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Exp Eye Res 73:101-9. 2001
    ..CL(2)MDP-lip prevented the inflammatory reaction of EMIU and inhibited the increase of leukocyte-endothelium interaction in iris vessels. Our findings emphasize the pivotal role macrophages play in the initiation of autoimmune disease...
  91. ncbi request reprint [Ocular toxocariasis. Diagnostic and therapeutic options]
    E Bertelmann
    Augenklinik, Charite Campus Virchow Klinikum, Berlin
    Ophthalmologe 100:950-4. 2003
    ..The diagnosis of ocular toxocariasis can be difficult and the aim of this study was to evaluate the benefit of ELISA testing of vitreous body fluid...
  92. ncbi request reprint [Non-contact donor cornea trephination with a flying spot excimer laser system]
    M Muller
    Klinik und Poliklinik für Augenheilkunde, Charite Universitatsmedizin, Berlin
    Ophthalmologe 102:163-9. 2005
    ..We developed a method to prepare donor grafts for transplantation applying excimer laser techniques. The quality of the cut edges and exposure time were evaluated...
  93. ncbi request reprint [Primary diagnosis of syphilis by the ophthalmologist]
    Agnes Ute Porstmann
    Universitätsaugenklinik Charité, Fakultät der Humboldt Universität Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin
    Klin Monbl Augenheilkd 219:349-52. 2002
    ..According to German sources, recent epidemiological data show a considerable increase of syphilis especially among homosexual men in larger cities...
  94. ncbi request reprint The human corneal endothelium: new insights into electrophysiology and ion channels
    Stefan Mergler
    Department of Ophthalmology, Charite University Medicine Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Prog Retin Eye Res 26:359-78. 2007
    ..A better understanding of the (electro)physiological function of the cornea may lead to the development of clinical relevant new therapeutic and preventive measures...
  95. ncbi request reprint [In vitro bovine and human lens epithelial cell culture studies on inhibition of posterior capsule opacification using a cyclic RGD peptide]
    C Kojetinsky
    Klinik und Poliklinik für Augenheilkunde, Charite Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin
    Ophthalmologe 98:731-5. 2001
    ..The purpose of our study was to investigate whether this peptide is capable of detaching adherent cells and preventing posterior capsule opacification (PCO)...
  96. ncbi request reprint Thalidomide inhibits leukocyte-endothelium interaction in endotoxin-induced uveitis
    H Baatz
    Department of Ophthalmology, Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Ophthalmic Res 33:256-63. 2001
    ..Compared with prednisolone, thalidomide shows earlier inhibition of leukocyte rolling, indicating modulation of adhesion molecule expression and/or function...
  97. pmc Tumour necrosis factor alpha and interleukin 6 gene expression in keratocytes from patients with rheumatoid corneal ulcerations
    J Prada
    Department of Ophthalmology, Charite Campus Virchow, Humboldt University of Berlin, Berlin, Germany
    Br J Ophthalmol 87:548-50. 2003
    ....
  98. ncbi request reprint Successful infliximab treatment of posterior scleritis in a 13-year-old child refractory to other immunosuppressive therapy
    K Weiss
    Universitätsmedizin Charité, Campus Virchow Klinikum, Augenklinik, Augustenburger Platz 1, 13353 Berlin, Germany
    Graefes Arch Clin Exp Ophthalmol 245:1735-7. 2007
    ..We describe the case of a young girl suffering from therapy refractory posterior scleritis successfully treated with the tumor necrosis factor (TNF) inhibitor infliximab...
  99. doi request reprint [Diagnosis and treatment of ocular toxoplasmosis : a survey of German-speaking ophthalmologists]
    N Torun
    Augenklinik, Charite, Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Deutschland
    Ophthalmologe 105:1023-8. 2008
    ..Ocular toxoplasmosis is the most frequent cause of posterior uveitis in Germany. The purpose of this survey was to evaluate current strategies in the management of ocular toxoplasmosis by uveitis specialists in Germany...
  100. ncbi request reprint Retinal toxicity of liposome-incorporated and free ofloxacin after intravitreal injection in rabbit eyes
    B Wiechens
    Department of Ophthalmology, Christian Albrechts University, Kiel, Germany
    Int Ophthalmol 22:133-43. 1998
    ..To prolong the intravitreal antibacterial level OFLX was incorporated into liposomes. This study was performed to investigate the retinal toxicity of liposome-incorporated and free OFLX...
  101. ncbi request reprint Modulation of leukocyte-endothelium interaction by nitric oxide synthase inhibitors: effects on leukocyte adhesion in endotoxin-induced uveitis
    H Baatz
    Department of Ophthalmology, Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Inflamm Res 50:534-43. 2001
    ..To examine the effects of the nitric oxide synthase (NOS) inhibitors aminoguanidine (AG) and L-NAME on leukocyte adhesion in endotoxin-induced uveitis (EIU)...