Karl Heinz Klempnauer

Summary

Country: Germany

Publications

  1. Jakobs A, Steinmann S, Henrich S, Schmidt T, Klempnauer K. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300. J Biol Chem. 2016;291:26098-26108 pubmed
    ..Its selectivity for the LAP* isoform also makes helenalin acetate an interesting tool to dissect the functions of the LAP* and LAP isoforms. ..
  2. Uttarkar S, Frampton J, Klempnauer K. Targeting the transcription factor Myb by small-molecule inhibitors. Exp Hematol. 2017;47:31-35 pubmed publisher
    ..Characterization of these compounds suggests disruption of the protein-protein-interaction of Myb and the coactivator p300 as a suitable strategy to inhibit Myb. ..
  3. Falkenberg K, Jakobs A, Matern J, Dörner W, Uttarkar S, Trentmann A, et al. Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ. Biochim Biophys Acta. 2017;1864:1349-1358 pubmed publisher
    ..The finding that WFA is a potent inhibitor of C/EBPβ suggests that inhibition of C/EBPβ might contribute to the biological activities of WFA. ..
  4. Fehler O, Singh P, Haas A, Ulrich D, Müller J, Ohnheiser J, et al. An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4. Nucleic Acids Res. 2014;42:11107-18 pubmed publisher
    ..Overall, our work identifies PABP as a novel functionally relevant Pdcd4 interaction partner that contributes to the regulation of translation by Pdcd4. ..

Detail Information

Publications4

  1. Jakobs A, Steinmann S, Henrich S, Schmidt T, Klempnauer K. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300. J Biol Chem. 2016;291:26098-26108 pubmed
    ..Its selectivity for the LAP* isoform also makes helenalin acetate an interesting tool to dissect the functions of the LAP* and LAP isoforms. ..
  2. Uttarkar S, Frampton J, Klempnauer K. Targeting the transcription factor Myb by small-molecule inhibitors. Exp Hematol. 2017;47:31-35 pubmed publisher
    ..Characterization of these compounds suggests disruption of the protein-protein-interaction of Myb and the coactivator p300 as a suitable strategy to inhibit Myb. ..
  3. Falkenberg K, Jakobs A, Matern J, Dörner W, Uttarkar S, Trentmann A, et al. Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ. Biochim Biophys Acta. 2017;1864:1349-1358 pubmed publisher
    ..The finding that WFA is a potent inhibitor of C/EBPβ suggests that inhibition of C/EBPβ might contribute to the biological activities of WFA. ..
  4. Fehler O, Singh P, Haas A, Ulrich D, Müller J, Ohnheiser J, et al. An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4. Nucleic Acids Res. 2014;42:11107-18 pubmed publisher
    ..Overall, our work identifies PABP as a novel functionally relevant Pdcd4 interaction partner that contributes to the regulation of translation by Pdcd4. ..