Affiliation: Klinikum rechts der Isar
- A new approach towards ikimine A analoguesJürgen Krauss
Department Pharmazie Zentrum für Pharmaforschung, Ludwig Maximilians Universitat Munchen, Butenandtstr 5 13, 81377 Munich, Germany
Nat Prod Res 18:397-401. 2004..This aldehyde was converted to the ikimine A analogon with O-methyl hydroxylamine hydrochloride. This product and the intermediate alkylpyridines were tested in the agar diffusion assay for antibacterial and antifungal activities...
- A convenient cellular assay for the identification of the molecular target of ergosterol biosynthesis inhibitors and quantification of their effects on total ergosterol biosynthesisChristoph Müller
Department für Pharmazie, Zentrum für Pharmaforschung, Ludwig Maximilians Universitat, Munchen, Butenandtstr 5 13, 81377 Munich, Germany
Steroids 78:483-93. 2013..The described cellular assay was analytically and biologically validated and used to characterize the novel ergosterol biosynthesis inhibitor JK-250...
- Synthesis and biological evaluation of new niphathesine analoguesJürgen Krauss
Department Pharmazie, Zentrum für Pharmaforschung, Ludwig Maximilians Universitat Munchen, Munchen, Germany
Arch Pharm (Weinheim) 340:154-8. 2007..Key steps of the syntheses are a Sonogashira reaction of appropriate aryl iodides with undec-10-ynol or undec-10-ynoic acid derivatives. The resulting compounds were tested in an agar diffusion assay against several bacteria and fungi...
- Synthesis by ring-closing metathesis and cytotoxic evaluation of novel thienylmacrolactonesJürgen Krauss
Department of Pharmacy Center for Drug Research, Ludwig Maximilians University, Butenandtstr 5 13, 81377 Munich, Germany
Sci Pharm 80:29-36. 2012..The target lactones showed only insignificant cytotoxicity, while an intermediate simple thienyl carbinol showed very promising cytotoxicity...