F Bartel

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi request reprint Germline genetics of the p53 pathway affect longevity in a gender specific manner
    Sebastian Groß
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Magdeburger Str 14, D 06097 Halle Saale, Germany
    Curr Aging Sci 7:91-100. 2014
  2. doi request reprint Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Clin Cancer Res 14:89-96. 2008
  3. ncbi request reprint Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Int J Cancer 117:469-75. 2005
  4. ncbi request reprint Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma
    F Bartel
    University of Halle Wittenberg, Faculty of Medicine, Institute for Pathology, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Int J Cancer 95:168-75. 2001
  5. ncbi request reprint Expression of alternatively and aberrantly spliced transcripts of the MDM2 mRNA is not tumor-specific
    F Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, D 06097 Halle Saale, Germany
    Int J Oncol 24:143-51. 2004
  6. pmc mdm2 mRNA level is a prognostic factor in soft tissue sarcoma
    H Taubert
    Institute of Pathology, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
    Mol Med 6:50-9. 2000
  7. ncbi request reprint Radiosensitization in sarcoma cell lines with a p53 missense mutation correlates with prevention of irradiation G2/M arrest but not with induction of apoptosis
    M Bache
    Department of Radiotherapy and Institute of Pathology, Martin Luther University of Halle Wittenberg, D 06097 Halle Saale, Germany
    Oncol Rep 8:1007-11. 2001
  8. ncbi request reprint A MboII polymorphism in exon 11 of the human MDM2 gene occuring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility?
    H Taubert
    Institute of Pathology, Faculty of Medicine, Martin Luther University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Mutat Res 456:39-44. 2000
  9. ncbi request reprint Gains in chromosomes 7, 8q, 15q and 17q are characteristic changes in malignant but not in benign peripheral nerve sheath tumors from patients with Recklinghausen's disease
    H Schmidt
    Institute of Pathology, Martin Luther University Halle Wittenberg, Magdeburger Strasse 14, D 06097, Halle, Germany
    Cancer Lett 155:181-90. 2000
  10. pmc The p53 status in juvenile chronic arthritis and rheumatoid arthritis
    H Taubert
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Exp Immunol 122:264-9. 2000

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Germline genetics of the p53 pathway affect longevity in a gender specific manner
    Sebastian Groß
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Magdeburger Str 14, D 06097 Halle Saale, Germany
    Curr Aging Sci 7:91-100. 2014
    ..Our data support the hypothesis that genetic variants that are associated with lower activity of p53--and therefore increased tumor risk--are associated with prolonged lifespan in a gender-specific manner...
  2. doi request reprint Both germ line and somatic genetics of the p53 pathway affect ovarian cancer incidence and survival
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Clin Cancer Res 14:89-96. 2008
    ..Although p53 is one of the most studied genes/proteins in ovarian carcinomas, the predictive value of p53 alterations is still ambiguous...
  3. ncbi request reprint Significance of HDMX-S (or MDM4) mRNA splice variant overexpression and HDMX gene amplification on primary soft tissue sarcoma prognosis
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Int J Cancer 117:469-75. 2005
    ..In summary, our data indicate that both the overexpression of the HDMX-S transcript as well as HDMX gene amplification are important prognostic markers for STS...
  4. ncbi request reprint Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma
    F Bartel
    University of Halle Wittenberg, Faculty of Medicine, Institute for Pathology, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Int J Cancer 95:168-75. 2001
    ..01, chi(2) test). Although the presence of spliced forms was associated with late-stage tumor phenotypes (p = 0.05, chi(2) test), we observed no relationship between the presence of splice variants and patient outcome...
  5. ncbi request reprint Expression of alternatively and aberrantly spliced transcripts of the MDM2 mRNA is not tumor-specific
    F Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, D 06097 Halle Saale, Germany
    Int J Oncol 24:143-51. 2004
    ..Although we cannot exclude that alterations in MDM2 preferentially occur during cancer development, our data rather indicate that in this context the commonly observed transcript variants may also possess a normal physiological function...
  6. pmc mdm2 mRNA level is a prognostic factor in soft tissue sarcoma
    H Taubert
    Institute of Pathology, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
    Mol Med 6:50-9. 2000
    ..However, clinical relevance of mdm2 mRNA expression is poorly investigated...
  7. ncbi request reprint Radiosensitization in sarcoma cell lines with a p53 missense mutation correlates with prevention of irradiation G2/M arrest but not with induction of apoptosis
    M Bache
    Department of Radiotherapy and Institute of Pathology, Martin Luther University of Halle Wittenberg, D 06097 Halle Saale, Germany
    Oncol Rep 8:1007-11. 2001
    ..The results support the hypothesis that the prevention of irradiation induced G2/M arrest but not the induction of apoptosis plays a critical role in determining radiosensitivity in sarcoma cell lines with p53 mutations...
  8. ncbi request reprint A MboII polymorphism in exon 11 of the human MDM2 gene occuring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility?
    H Taubert
    Institute of Pathology, Faculty of Medicine, Martin Luther University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Mutat Res 456:39-44. 2000
    ..We suggest that this polymorphism might be associated with an increased cancer susceptibility...
  9. ncbi request reprint Gains in chromosomes 7, 8q, 15q and 17q are characteristic changes in malignant but not in benign peripheral nerve sheath tumors from patients with Recklinghausen's disease
    H Schmidt
    Institute of Pathology, Martin Luther University Halle Wittenberg, Magdeburger Strasse 14, D 06097, Halle, Germany
    Cancer Lett 155:181-90. 2000
    ..On the other hand in the MPNSTs from NF1-patients the most frequent gains were found in #7, and statistically significant in 15q, and 17q...
  10. pmc The p53 status in juvenile chronic arthritis and rheumatoid arthritis
    H Taubert
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Clin Exp Immunol 122:264-9. 2000
    ..Expression of P53 protein was comparable for JCA and RA synovectomy samples. For all RA samples P53 protein was detectable, whereas one sample of a JCA patient failed to express P53 protein...
  11. ncbi request reprint Transfection with mdm2-antisense or wtp53 results in radiosensitization and an increased apoptosis of a soft tissue sarcoma cell line
    U Grünbaum
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Anticancer Res 21:2065-71. 2001
    ..We can therefore conclude that the sensitivity of radiation therapy is enhanced by DNA transfection with wtp53 or mdm-2 AS ODNs for the correction of the p53-mdm2 balance in STS in vitro...
  12. ncbi request reprint Gains of 12q are the most frequent genomic imbalances in adult fibrosarcoma and are correlated with a poor outcome
    H Schmidt
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Genes Chromosomes Cancer 34:69-77. 2002
    ..In adult fibrosarcomas, a gain of 12q22 correlated significantly (P = 0.028) with a poor overall survival rate...
  13. ncbi request reprint Stem cell-associated genes are extremely poor prognostic factors for soft-tissue sarcoma patients
    H Taubert
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Oncogene 26:7170-4. 2007
    ..Importantly, tumors of patients with the poorest prognosis were of all four tumor stages, suggesting that their risk is based upon coexpression of stem cell-associated genes rather than on tumor stage...
  14. ncbi request reprint Increased survivin transcript levels: an independent negative predictor of survival in soft tissue sarcoma patients
    M Kappler
    Institute of Pathology, University of Halle-Wittenberg, Halle, Germany
    Int J Cancer 95:360-3. 2001
    ..Only survivin DeltaEx3 and/or full-length survivin variants but not survivin 2B were identified. Our results suggest that a higher level of survivin mRNA is an independent predictor of survival for STS patients...
  15. ncbi request reprint The effects of knockdown of wild-type survivin, survivin-2B or survivin-delta3 on the radiosensitization in a soft tissue sarcoma cells in vitro under different oxygen conditions
    M Kappler
    Department of Radiotherapy, Faculty of Medicine, University of Halle Wittenberg, Halle Saale, Germany
    Cancer Gene Ther 14:994-1001. 2007
    ..However, knockdown of wild-type survivin caused radiosensitization in the megacolony assay...
  16. ncbi request reprint Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma
    H Taubert
    Faculty of Medicine, Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Oncogene 26:1098-100. 2007
    ..This is the first report showing a correlation between expression of a gene involved in stem cell self-renewal and prognosis of cancer patients...
  17. ncbi request reprint Expression of cathepsin B, D and L protein in juvenile idiopathic arthritis
    H Taubert
    Institute of Pathology, Faculty of Medicine, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Autoimmunity 35:221-4. 2002
    ..In summary, the comparable expression of cathepsins B, D and L in RA and JIA synovectomy tissue suggests that they may play a similarly important role in destroying synovial tissue and cartilage matrix in the course of HA and RA...
  18. ncbi request reprint Cytogenetic characterization of six malignant peripheral nerve sheath tumors: comparison of karyotyping and comparative genomic hybridization
    H Schmidt
    Institute of Pathology, Martin Luther University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle, Germany
    Cancer Genet Cytogenet 128:14-23. 2001
    ..When comparing the CGH results with those of karyotyping an overlap in the most frequent gains in 7q, 8q, 15q, and 17q was observed. However, we found more frequent losses in 19q in the metaphase investigations...
  19. ncbi request reprint Knockdown of survivin expression by small interfering RNA reduces the clonogenic survival of human sarcoma cell lines independently of p53
    Matthias Kappler
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle S, Germany
    Cancer Gene Ther 11:186-93. 2004
    ..Our findings suggest that survivin-specific siRNA could be a selective treatment to kill sarcoma cells regardless of the presence or absence of wild-type p53 alleles...
  20. ncbi request reprint Elevated expression level of survivin protein in soft-tissue sarcomas is a strong independent predictor of survival
    Matthias Kappler
    Institute of Pathology, University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Clin Cancer Res 9:1098-104. 2003
    ..The aim of this study was to evaluate the prognostic value of survivin protein expression in tumor tissue extracts in a group of well-characterized soft-tissue sarcoma (STS) patients...
  21. ncbi request reprint MDM2 and its splice variant messenger RNAs: expression in tumors and down-regulation using antisense oligonucleotides
    Frank Bartel
    Institute of Pathology, Faculty of Medicine, University of Halle Wittenberg, D 06097 Halle Saale, Germany
    Mol Cancer Res 2:29-35. 2004
    ..We also discuss the progress that has been made in the development of antisense oligonucleotides targeted to MDM2 for use as a potential cancer therapy...
  22. ncbi request reprint Loss of heterozygosity at 12q14-15 often occurs in stage I soft tissue sarcomas and is associated with MDM2 amplification in tumors at various stages
    Helge Taubert
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Mod Pathol 16:1109-16. 2003
    ..A concomitant occurrence of deletions and amplifications resulting from deficiencies in the nonhomologous end-joining pathway could in part explain this finding...
  23. ncbi request reprint Small polydispersed circular DNA contains strains of mobile genetic elements and occurs more frequently in permanent cell lines of malignant tumors than in normal lymphocytes
    Hannelore Schmidt
    Institute of Pathology, University of Halle Wittenberg, D 06097 Halle Saale, Germany
    Oncol Rep 22:393-400. 2009
    ..We suggest that the whole spcDNA including retrotranspositional elements and telomeric sequences may play a role for chromosomal rearrangements and genomic instability...
  24. doi request reprint Association of HDM2 transcript levels with age of onset and prognosis in soft tissue sarcomas
    Helge Taubert
    Institute of Pathology, Faculty of Medicine, University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Mol Cancer Res 6:1575-81. 2008
    ....
  25. ncbi request reprint Elevated expression of survivin-splice variants predicts a poor outcome for soft-tissue sarcomas patients
    Helge Taubert
    Institute of Pathology, Faculty of Medicine, University Halle Wittenberg, Magdeburger Strasse 14, D 06097 Halle Saale, Germany
    Oncogene 24:5258-61. 2005
    ....
  26. ncbi request reprint Radiosensitization, after a combined treatment of survivin siRNA and irradiation, is correlated with the activation of caspases 3 and 7 in a wt-p53 sarcoma cell line, but not in a mt-p53 sarcoma cell line
    Matthias Kappler
    Institute of Radiotherapy, University of Halle Wittenberg, D 06097 Halle Saale, Germany
    Oncol Rep 13:167-72. 2005
    ..Our findings suggest that the wt-p53-caspase pathway is of importance for the radiosensitization induced by targeting survivin, which may have an impact on future gene therapeutical treatments...
  27. ncbi request reprint Radiosensitization of a human soft tissue sarcoma cell line US8-93 (mt-p53) with the oxidizer sodium peroxodisulfate
    Matthias Bache
    Department of Radiotherapy, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
    Oncol Rep 12:889-93. 2004
    ..Our results implicate sodium peroxodisulfate to be a potentially useful agent to improve the radiobiological efficacy in radioresistant soft tissue sarcomas as exemplified for the cell line US8-93...
  28. ncbi request reprint Reduced expression of hMSH2 protein is correlated to poor survival for soft tissue sarcoma patients
    Helge W Taubert
    Institute of Pathology, Faculty of Medicine, Martin Luther University Halle Wittenberg, Halle, Germany
    Cancer 97:2273-8. 2003
    ..Although the protein expression of the two main components of DNA mismatch repair, hMSH2 and hMLH1, has been described in soft tissue sarcoma (STS) patients, its prognostic impact is yet to be determined...
  29. ncbi request reprint Detection of disseminated tumor cells in peripheral blood of patients with breast cancer: correlation to nodal status and occurrence of metastases
    Helge Taubert
    Institute of Pathology, Martin Luther University of Halle Wittenberg, Halle, Germany
    Gynecol Oncol 92:256-61. 2004
    ....
  30. ncbi request reprint Gains of 13q are correlated with a poor prognosis in liposarcoma
    Hannelore Schmidt
    Institute of Pathology, Martin Luther University Halle Wittenberg, Halle, Germany
    Mod Pathol 18:638-44. 2005
    ..Summarizing, all subtypes but well-differentiated liposarcomas showed gains of 13q, which were associated with a poor prognosis...
  31. ncbi request reprint Isolation and enrichment of urologic tumor cells in blood samples by a semi-automated CD45 depletion autoMACS protocol
    Axel Meye
    Department of Urology, Faculty of Medicine, Technical University Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Int J Oncol 21:521-30. 2002
    ..The improved sensitivity and specificity might be of importance when applying the protocol to BS in future clinical studies...
  32. ncbi request reprint Detection of circulating tumor cells from renal carcinoma patients: experiences of a two-center study
    Karen Blümke
    Clinic of Urology, University Halle Wittenberg, Ernst Grube Str 4, D 06120 Halle Saale, Germany
    Oncol Rep 14:895-9. 2005
    ..The occurrence and the quantity of CTC in RCC patients is an early disease event. Furthermore, the occurrence of CTC is correlated with an advanced tumor stage and seems to be associated with a more aggressive tumor phenotype...
  33. ncbi request reprint MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner
    Gareth L Bond
    The Institute for Advanced Study, Princeton, New Jersey 08540, USA
    Cancer Res 66:5104-10. 2006
    ....
  34. ncbi request reprint High bad and bcl-xL gene expression and combined bad, bcl-xL, bax and bcl-2 mRNA levels: molecular predictors for survival of stage 2 soft tissue sarcoma patients
    Thomas Kohler
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany
    Anticancer Res 22:1553-9. 2002
    ..In the combinations of mRNA levels there was more than an additive effect pointing to different pathways of prognostic relevance...
  35. ncbi request reprint Alternative and aberrant splicing of MDM2 mRNA in human cancer
    Frank Bartel
    Department of Molecular Pharmacology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Cell 2:9-15. 2002
    ..In addition, we discuss the potential functions of these variants and how they interact with full-length MDM2 protein...
  36. ncbi request reprint Growth reduction of a xenotransplanted human soft tissue sarcoma by MDM2 antisense therapy via implanted osmotic minipumps
    Peter Wurl
    Clinic of Surgery 1, University of Leipzig, Germany
    Int J Oncol 20:1087-93. 2002
    ..Our findings support the hypothesis that MDM2-AS ODN treatment may exert a tumor inhibiting effect on all MDM2 expressing tumors regardless of the P53-status, this in turn may be of general importance in gene therapy of cancer...
  37. ncbi request reprint Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma
    Peter Wurl
    Lancet 359:943-5. 2002
    ..Co-expression of survivin and TERT transcripts identifies patients at high risk of tumour-related death...
  38. ncbi request reprint Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide
    Thilo Schlott
    Department of Pathology, Center for Pathology, Georg August University, D 37075 Goettingen, Germany
    Anticancer Res 24:3819-29. 2004
    ..Further experiments are necessary to test whether the novel candidate genes favor development of chemoresistance and whether MDM2 mRNA splicing variants contribute to this process in vivo...
  39. ncbi request reprint A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
    Gareth L Bond
    Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    Cell 119:591-602. 2004
    ..In humans, SNP309 is shown to associate with accelerated tumor formation in both hereditary and sporadic cancers. A model is proposed whereby SNP309 serves as a rate-limiting event in carcinogenesis...
  40. ncbi request reprint Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma
    Claudia Seidel
    Autonomous Work Group Tumor Genetics of the Medical Faculty, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Int J Cancer 114:442-7. 2005
    ..Thus, the methylation status of cancer-related genes was distinct in different STS and methylation of RASSF1A promoter can serve as prognostic marker in STSs...