Reinhard Dammann

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi request reprint Frequent promoter methylation of tumor-related genes in sporadic and men2-associated pheochromocytomas
    R Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Exp Clin Endocrinol Diabetes 113:1-7. 2005
  2. ncbi request reprint Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis
    R Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Histol Histopathol 18:665-77. 2003
  3. ncbi request reprint CpG island methylation and expression of tumour-associated genes in lung carcinoma
    Reinhard Dammann
    AWG Tumour Genetics of the Medical Faculty, Martin Luther University, Halle Wittenberg, 06097 Halle Saale, Germany
    Eur J Cancer 41:1223-36. 2005
  4. ncbi request reprint The tumor suppressor RASSF1A in human carcinogenesis: an update
    R Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Germany
    Histol Histopathol 20:645-63. 2005
  5. ncbi request reprint Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma
    Reinhard Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, 06097 Halle Saale, Germany
    Oncogene 22:3806-12. 2003
  6. ncbi request reprint CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Thyroid 16:633-42. 2006
  7. ncbi request reprint Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Cancer Res 62:3698-701. 2002
  8. ncbi request reprint Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
    Claudia Seidel
    AWG Tumor Genetics of the Medical Faculty, Martin Luther University Halle Wittenberg, Magdeburger Strasse 2, Halle Saale, Germany
    Mol Carcinog 46:865-71. 2007
  9. pmc Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter
    Maria Strunnikova
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, 06097 Halle, Germany
    Mol Cell Biol 25:3923-33. 2005
  10. ncbi request reprint Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system
    Antonia Laerm
    Universitätsklinik und Poliklinik für Innere Medizin I, Sektion Molek GI Onkologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Hepatol 46:89-97. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Frequent promoter methylation of tumor-related genes in sporadic and men2-associated pheochromocytomas
    R Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Exp Clin Endocrinol Diabetes 113:1-7. 2005
    ..Combined methylation of RASSF1 A and p16 was found only in MEN2-related pheochromocytomas. Thus, a subset of hereditary pheochromocytomas displays preferential methylation of p16 and RASSF1 A...
  2. ncbi request reprint Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis
    R Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Histol Histopathol 18:665-77. 2003
    ..g. poor differentiation, aggressiveness, and invasion). Thus, RASSF1A methylation could serve as a useful marker for the prognosis of cancer patients and could become important in early detection of cancer...
  3. ncbi request reprint CpG island methylation and expression of tumour-associated genes in lung carcinoma
    Reinhard Dammann
    AWG Tumour Genetics of the Medical Faculty, Martin Luther University, Halle Wittenberg, 06097 Halle Saale, Germany
    Eur J Cancer 41:1223-36. 2005
    ..02), and exposure to asbestos (P=0.017) or squamous cell carcinoma (P=0.011), respectively. These results have identified genes whose aberrant promoter methylation could play a crucial role in the malignancy of lung carcinoma...
  4. ncbi request reprint The tumor suppressor RASSF1A in human carcinogenesis: an update
    R Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Germany
    Histol Histopathol 20:645-63. 2005
    ..The tumor suppressor RASSF1A may act as a negative Ras effector inhibiting cell growth and inducing cell death. Thus, RASSF1A may represent an epigenetically inactivated bona fide tumor suppressor in human carcinogenesis...
  5. ncbi request reprint Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma
    Reinhard Dammann
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, 06097 Halle Saale, Germany
    Oncogene 22:3806-12. 2003
    ..001, chi(2) test). In conclusion, our data indicate that inactivation of the RASSF1A gene is a frequent event in pancreatic cancer and suggest an inverse correlation between RASSF1A silencing and K-ras activation...
  6. ncbi request reprint CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Thyroid 16:633-42. 2006
    ..To understand the role of epigenetic inactivation of tumor-related genes in the pathogenesis of thyroid cancer, we investigated the methylation profile of distinct thyroid neoplasms...
  7. ncbi request reprint Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Cancer Res 62:3698-701. 2002
    ..However, RASSF1A hypermethylation was detected three times more frequently in thyroid cancers. Thus, RASSF1A inactivation may play a crucial role in the malignancy of thyroid carcinoma...
  8. ncbi request reprint Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
    Claudia Seidel
    AWG Tumor Genetics of the Medical Faculty, Martin Luther University Halle Wittenberg, Magdeburger Strasse 2, Halle Saale, Germany
    Mol Carcinog 46:865-71. 2007
    ..036). In summary, our results suggest that alteration of the Sav-RASSF1-Hpo tumor suppressor pathway may occur through hypermethylation of the CpG island promoter of MST1, MST2 and/or RASSF1A in human sarcomas...
  9. pmc Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter
    Maria Strunnikova
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, 06097 Halle, Germany
    Mol Cell Biol 25:3923-33. 2005
    ..Our data suggest that in epithelial cells, histone inactivation may trigger de novo DNA methylation of the RASSF1A promoter and this system may serve as a model for CpG island inactivation of tumor suppressor genes...
  10. ncbi request reprint Prospero-related homeobox 1 (PROX1) is frequently inactivated by genomic deletions and epigenetic silencing in carcinomas of the bilary system
    Antonia Laerm
    Universitätsklinik und Poliklinik für Innere Medizin I, Sektion Molek GI Onkologie, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    J Hepatol 46:89-97. 2007
    ..Hence, we examined whether inactivation of the PROX1 gene can be demonstrated in malignant tumors of the bilary system...
  11. ncbi request reprint Frequent epigenetic inactivation of the RASSF1A gene in hepatocellular carcinoma
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Oncogene 22:1866-71. 2003
    ..Thus, RASSF1A hypermethylation could be useful as a marker of malignancy and to distinguish between the distinct forms of highly differentiated liver neoplasm...
  12. ncbi request reprint Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma
    Mia Spugnardi
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, California 90404, USA
    Cancer Res 63:1639-43. 2003
    ..Our findings indicate that the RASSF1A gene is turned off in a significant number of melanomas and that CpG promoter region hypermethylation may play a role in the transcriptional inactivation of the RASSF1A gene in malignant melanoma...
  13. ncbi request reprint A polymorphism at codon 133 of the tumor suppressor RASSF1A is associated with tumorous alteration of the breast
    Undraga Schagdarsurengin
    AG Tumorgenetik der Medizinischen Fakultät, Halle Saale, Germany
    Int J Oncol 27:185-91. 2005
    ..Our data indicate that the mutant T-allele of RASSF1A at codon 133 is correlated with an increased number of breast tumors...
  14. pmc Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma
    Angelo Agathanggelou
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Cancer Res 63:5344-51. 2003
    ..The identified targets are involved in diverse cellular processes; this should help toward understanding mechanisms that contribute to RASSF1A biological activity...
  15. ncbi request reprint Inactivation of RAS association domain family 1A gene in cervical carcinomas and the role of human papillomavirus infection
    Igor Kuzmin
    Basic Research Program, Science Applications International Corporation Frederick, Inc, NCI Frederick, Frederick, Maryland, 21702, USA
    Cancer Res 63:1888-93. 2003
    ..Our data imply that the presence of HPVs in cervical carcinomas alleviates the requirement for RASSF1A inactivation and suggests that these two events may engage the same tumorigenic pathway...
  16. ncbi request reprint RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1
    Stella Tommasi
    Biology Department, Beckman Research Institute of the City of Hope, Duarte, California, CA 91010, USA
    Oncogene 21:2713-20. 2002
    ..However, aberrations in tumors have so far not been found. The presence of a Ras association domain common to NORE1, RASSF1, and RASSF3 suggests their possible involvement in Ras-like signaling pathways...
  17. pmc Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma
    Barbara Seliger
    Martin Luther University Halle Wittenberg, Institute of Medical Immunology, Halle, Germany
    J Transl Med 7:90. 2009
    ..Aberrant expression of UCHL1 has been found in a number of human solid tumors including renal cell carcinoma (RCC). In RCC, UCHL1 overexpression is associated with tumor progression and an altered von Hippel Lindau gene expression...
  18. ncbi request reprint RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma
    Lillian Shuk Nga Chow
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China
    Int J Cancer 109:839-47. 2004
    ..In vivo nude mice assay demonstrated the dramatic reduction of tumorigenic potential in the RASSF1A-transfected clones. Our results provide strong evidence to support RASSF1A as a target tumor suppressor gene on 3p21.3 in NPC...
  19. ncbi request reprint Methylation of the RASSF1A gene in human cancers
    Gerd P Pfeifer
    Department of Biology, City of Hope Medical Center, Duarte, CA 91010, USA
    Biol Chem 383:907-14. 2002
    ..A high frequency of methylation of RASSF1A is found also in breast cancers, renal cell carcinomas, ovarian, gastric and bladder cancers, and in neuroblastomas. The RASSF1A gene is a candidate for a tumor suppressor gene in 3p21.3...
  20. ncbi request reprint Frequent epigenetic inactivation of cystatin M in breast carcinoma
    U Schagdarsurengin
    AWG Tumour Genetics of the Medical Faculty, Institute for Human Genetics, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Oncogene 26:3089-94. 2007
    ..These data suggest that cystatin M may encode a novel epigenetically inactivated candidate tumour suppressor gene...
  21. ncbi request reprint Frequent intra-tumoural heterogeneity of promoter hypermethylation in malignant melanoma
    M Rastetter
    AWG Tumour Genetics of the Medical Faculty, Martin Luther University Halle Wittenberg, Germany
    Histol Histopathol 22:1005-15. 2007
    ..In prognosis studies, missing the intra-tumoural sample representativeness may result in a reduction of the sensitivities or specificities...
  22. ncbi request reprint Frequent hypermethylation of the RASSF1A gene in prostate cancer
    Limin Liu
    Department of Biology, Beckman Research Institute, City of Hope Cancer Center, Duarte, California, CA 91010, USA
    Oncogene 21:6835-40. 2002
    ..Testing for RASSF1A methylation should become useful in prostate cancer early detection and diagnosis and might aid prognosis by gauging the potential status of progression...
  23. ncbi request reprint Alterations of cancer-related genes in soft tissue sarcomas: hypermethylation of RASSF1A is frequently detected in leiomyosarcoma and associated with poor prognosis in sarcoma
    Claudia Seidel
    Autonomous Work Group Tumor Genetics of the Medical Faculty, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Int J Cancer 114:442-7. 2005
    ..Thus, the methylation status of cancer-related genes was distinct in different STS and methylation of RASSF1A promoter can serve as prognostic marker in STSs...
  24. ncbi request reprint Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene
    Sarah L Fenton
    Section of Medical and Molecular Genetics, Department of Reproductive and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham, United Kingdom
    Cancer Res 64:102-7. 2004
    ..As p120(E4F) has been reported previously to interact with p14ARF, retinoblastoma, and p53, these findings provide an important link between the function of RASSF1A and other major human tumor suppressor genes...
  25. ncbi request reprint Control of microtubule stability by the RASSF1A tumor suppressor
    Limin Liu
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Oncogene 22:8125-36. 2003
    ..In addition, knowledge of the microtubule-targeting function of RASSF1 may aid in the development of new anticancer drugs...
  26. ncbi request reprint The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1
    Sara Ortiz-Vega
    Diabetes Unit and Medical Services, Massachusetts General Hospital, Boston, Massachusetts, MA 02114, USA
    Oncogene 21:1381-90. 2002
    ..The preferential ability of RASSF1A to heterodimerize with Nore and thereby associate with Ras-like GTPases may be relevant to its putative tumor suppressor function...
  27. ncbi request reprint Cultivated keratinocytes express N-methyl-D-aspartate receptors of the NMDAR2D type
    Matthias Fischer
    Department of Dermatology and Venereology, Martin Luther University Halle Wittenberg, Ernst Kromayer Str 5, 06097 Halle Saale, Germany
    Arch Dermatol Res 297:316-8. 2006
    ..This characteristic is consistent with previously published functional investigations in KC. The identification of the NMDAR2D subtype in KC may be of value for the development of new therapeutic approaches...
  28. ncbi request reprint Tumor susceptibility of Rassf1a knockout mice
    Stella Tommasi
    Division of Biology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Res 65:92-8. 2005
    ..The data are consistent with the tumor-suppressive role of Rassf1a, which may explain its frequent epigenetic inactivation in human tumors...
  29. ncbi request reprint RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network
    Cai Guo
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Curr Biol 17:700-5. 2007
    ..RASSF1A, MST2, or WW45 can rescue this defect. The complex of RASSF1A, MST2, WW45, and LATS1 consists of several tumor suppressors, is conserved in mammalian cells, and appears to be involved in controlling mitotic exit...
  30. ncbi request reprint The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex
    Limin Liu
    Cell Cycle 6:1663-5. 2007
    ..Here, we have used different methods to investigate the association of RASSF1A and Cdc20. We show that there is no interaction between RASSF1A and Cdc20 and conclude that further investigation of the mitotic role of RASSF1A is required...
  31. ncbi request reprint Reduced expression and increased CpG dinucleotide methylation of the rat APOBEC-1 promoter in transgenic rabbits
    Frank Apostel
    Klinik und Poliklinik für Innere Medizin, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, Germany
    Biochim Biophys Acta 1577:384-94. 2002
    ..Thus, the weak proximal rat APOBEC-1 promoter appears to be down-regulated in the rabbit and may be species-specific...