Frank Hirche

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. pmc Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation
    Gloria Schlegel
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Giessen, Germany
    BMC Vet Res 8:28. 2012
  2. doi request reprint Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection
    Frank Hirche
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle S, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2158-62. 2009
  3. doi request reprint Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Eur J Pharmacol 583:11-7. 2008
  4. ncbi request reprint Lupin protein influences the expression of hepatic genes involved in fatty acid synthesis and triacylglycerol hydrolysis of adult rats
    Anja Bettzieche
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Br J Nutr 99:952-62. 2008
  5. doi request reprint Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    J Nutr Biochem 20:840-7. 2009
  6. doi request reprint Peroxisome proliferator-activated receptor alpha and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats
    Anke Gutgesell
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, D 06108 Halle, Saale, Germany
    Metabolism 58:226-32. 2009
  7. doi request reprint Activities of gamma-butyrobetaine dioxygenase and concentrations of carnitine in tissues of pigs
    Maren Fischer
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    Comp Biochem Physiol A Mol Integr Physiol 153:324-31. 2009
  8. doi request reprint A moderate excess of dietary lysine lowers plasma and tissue carnitine concentrations in pigs
    Maren Fischer
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Br J Nutr 101:190-6. 2009
  9. ncbi request reprint Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Halle, Saale, Germany
    Eur J Pharmacol 605:23-30. 2009
  10. doi request reprint Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice
    Nadine Schmidt
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Nutr 144:638-46. 2014

Collaborators

  • Gabriele I Stangl
  • Klaus Eder
  • R Ringseis
  • Bettina König
  • Sebastian Luci
  • Matthias Girndt
  • Jutta Dierkes
  • Andreas S Mueller
  • Norbert Mielenz
  • Juliane Varady
  • Corinna Brandsch
  • Alexandra Schutkowski
  • Holger Kluge
  • Julia Kuhn
  • Maren Fischer
  • Juliane Radtke
  • Nadine Schmidt
  • Anja C Baur
  • Ulrike Lehmann
  • Eric Seibert
  • Anja Bettzieche
  • Stefanie Geissler
  • Kristin Weisse
  • Anna G Wessels
  • Annett Riedel
  • Christof Ulrich
  • Daniela Max
  • Hagen Kühne
  • Gloria Schlegel
  • Julika Lietzow
  • Nicole M Blum
  • Erika Most
  • Kristin Mueller
  • Josef Pallauf
  • Janine Keller
  • Nicole M Wolf
  • Anke Gutgesell
  • Jane Doberenz
  • Julia Spielmann
  • Anjali Shukla
  • Christian Henning
  • Andreas Kiowski
  • Jörg Bartelt
  • Etienne Corrent
  • Marcus A Glomb
  • Katrin Hasenkopf
  • Sylvia Keller
  • Marcello M Duranti
  • Gerhard Jahreis
  • Matthias Frommhagen
  • Sarah Schumann
  • Martin S Staege
  • Julia Kramer
  • Torsten Theumer
  • Andreas Krombholz
  • Frieder J Schwarz
  • Markus Glomb
  • Nicole Seeburg
  • Alexandra Thiele
  • Thomas Linn
  • Doris Lippmann
  • Uta Keller

Detail Information

Publications39

  1. pmc Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation
    Gloria Schlegel
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Giessen, Germany
    BMC Vet Res 8:28. 2012
    ..Dairy cows are typically in a negative energy balance during early lactation. We investigated the hypothesis that genes of carnitine synthesis and uptake in dairy cows are enhanced during early lactation...
  2. doi request reprint Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection
    Frank Hirche
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle S, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 877:2158-62. 2009
    ..Quantifying the formation of deuterated carnitine from deuterated gamma-butyrobetaine, this method is also suitable for the determination of the activity of gamma-butyrobetaine dioxygenase in tissues...
  3. doi request reprint Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Eur J Pharmacol 583:11-7. 2008
    ..This in turn increases carnitine concentrations in liver and muscle probably by enhancing carnitine uptake into cells...
  4. ncbi request reprint Lupin protein influences the expression of hepatic genes involved in fatty acid synthesis and triacylglycerol hydrolysis of adult rats
    Anja Bettzieche
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Br J Nutr 99:952-62. 2008
    ..Alterations in cholesterol metabolism could not be explained on the basis of mRNA data...
  5. doi request reprint Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    J Nutr Biochem 20:840-7. 2009
    ..It is concluded that nonproliferating species are also able to cover their increased demand for carnitine during fasting by an increased carnitine synthesis and uptake into cells...
  6. doi request reprint Peroxisome proliferator-activated receptor alpha and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats
    Anke Gutgesell
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, D 06108 Halle, Saale, Germany
    Metabolism 58:226-32. 2009
    ..It is moreover suggested that down-regulation of PPARalpha in the liver may be a means to conserve energy and metabolic substrates for milk production in the mammary gland...
  7. doi request reprint Activities of gamma-butyrobetaine dioxygenase and concentrations of carnitine in tissues of pigs
    Maren Fischer
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    Comp Biochem Physiol A Mol Integr Physiol 153:324-31. 2009
    ..In conclusion, this study shows that liver and kidney are the major sites of carnitine synthesis and that neonatal pigs do not have an insufficient carnitine status...
  8. doi request reprint A moderate excess of dietary lysine lowers plasma and tissue carnitine concentrations in pigs
    Maren Fischer
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Br J Nutr 101:190-6. 2009
    ....
  9. ncbi request reprint Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Halle, Saale, Germany
    Eur J Pharmacol 605:23-30. 2009
    ..Thus, these data suggest that the triacylglycerol reducing effect of fibrates and thiazolidinediones is partially caused by inhibition of SREBP-1 activation via up-regulation of Insig...
  10. doi request reprint Dietary vitamin D inadequacy accelerates calcification and osteoblast-like cell formation in the vascular system of LDL receptor knockout and wild-type mice
    Nadine Schmidt
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Nutr 144:638-46. 2014
    ..05) and tumor necrosis factor α (+134%, P < 0.001) than the +D group. Collectively, the findings imply low vitamin D status as a causal factor for vascular calcification and atherosclerosis. ..
  11. doi request reprint Lupin protein isolate and cysteine-supplemented casein reduce calcification of atherosclerotic lesions in apoE-deficient mice
    Kristin Weisse
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    Br J Nutr 103:180-8. 2010
    ..This effect seems not to be mediated by effects on plasma lipoproteins, homocysteine and circulating minerals...
  12. ncbi request reprint Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c
    Julia Spielmann
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Ann Nutr Metab 51:387-92. 2007
    ....
  13. doi request reprint Glucoraphanin does not reduce plasma homocysteine in rats with sufficient Se supply via the induction of liver ARE-regulated glutathione biosynthesis enzymes
    Nicole M Blum
    Institute of Agricultural and Nutritional Sciences, Preventive Nutrition Group, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, D 06120, Halle Saale, Germany
    Food Funct 2:654-64. 2011
    ..As a consequence, higher dietary GRA concentrations should be used in future experiments to test if GRA or sulforaphane can be established as HCys lowering compounds...
  14. doi request reprint Fasting and caloric restriction increases mRNA concentrations of novel organic cation transporter-2 and carnitine concentrations in rat tissues
    Sebastian Luci
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Ann Nutr Metab 52:58-67. 2008
    ..In this study, we tested the hypothesis that fasting and caloric restriction, conditions under which PPARalpha activation also occurs, cause similar effects...
  15. ncbi request reprint Vitamin D3 supplementation does not modify cardiovascular risk profile of adults with inadequate vitamin D status
    Eric Seibert
    Department of Internal Medicine II, Martin Luther University Halle Wittenberg, Ernst Grube Strasse 40, 06120, Halle Saale, Germany
    Eur J Nutr . 2015
    ..The current study aimed to elucidate whether this vitamin D3 dose impacts cardiovascular risk markers of adults during the winter months...
  16. doi request reprint Supplementation of L-carnitine in pigs: absorption of carnitine and effect on plasma and tissue carnitine concentrations
    Maren Fischer
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Germany
    Arch Anim Nutr 63:1-15. 2009
    ..It is also shown that plasma and tissue carnitine concentrations in young pigs can be markedly increased by supplementation of carnitine...
  17. pmc UVB exposure of farm animals: study on a food-based strategy to bridge the gap between current vitamin D intakes and dietary targets
    Alexandra Schutkowski
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PLoS ONE 8:e69418. 2013
    ..001). In conclusion, exposure of hens to UVB is an efficient approach to provide consumers with vitamin D3-enriched foods from animal sources. ..
  18. doi request reprint Study of molecular targets influencing homocysteine and cholesterol metabolism in growing rats by manipulation of dietary selenium and methionine concentrations
    Nicole M Wolf
    Institute of Agricultural and Nutritional Sciences, Preventive Nutrition Group, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    Br J Nutr 104:520-32. 2010
    ....
  19. pmc Vitamin D receptor deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in mice
    Nadine Schmidt
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PLoS ONE 7:e35316. 2012
    ..001). Taken together, these findings indicate vitamin D deficiency as a risk factor for aortic valve and aortic vessel calcification and a stimulator of osteogenic key factor expression in these vascular areas...
  20. pmc Lupin protein isolate versus casein modifies cholesterol excretion and mRNA expression of intestinal sterol transporters in a pig model
    Juliane Radtke
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle Saale, Germany
    Nutr Metab (Lond) 11:9. 2014
    ....
  21. ncbi request reprint Homocysteine thiolactone-induced hyperhomocysteinemia does not alter concentrations of cholesterol and SREBP-2 target gene mRNAS in rats
    Gabriele I Stangl
    Institute of Nutritional Sciences, Martin Luther University Halle Wittenberg, D 06108 Halle Saale, Germany
    Exp Biol Med (Maywood) 232:81-7. 2007
    ..In conclusion, in view of the experimental conditions used here, increased plasma and tissue concentrations of Hcy do not alter cholesterol metabolism of liver and intestine...
  22. doi request reprint L-cysteine down-regulates SREBP-1c-regulated lipogenic enzymes expression via glutathione in HepG2 cells
    Anja Bettzieche
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Ann Nutr Metab 52:196-203. 2008
    ..This study investigates the effects of cysteine on expression of SREBP-regulated hepatic genes...
  23. pmc Plant Oils as Potential Sources of Vitamin D
    Anja C Baur
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Front Nutr 3:29. 2016
    ..However, the UVB-exposed WGO was less effective to improve the 25(OH)D plasma concentration than a supplementation with vitamin D3. ..
  24. pmc High Leucine Diets Stimulate Cerebral Branched-Chain Amino Acid Degradation and Modify Serotonin and Ketone Body Concentrations in a Pig Model
    Anna G Wessels
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, 06120, Halle Saale, Germany
    PLoS ONE 11:e0150376. 2016
    ..Changes in cerebral tryptophan, along with the changes in amino acid-derived metabolites in the plasma may limit the use of high Leu diets to treat muscle atrophy or to increase muscle growth. ..
  25. doi request reprint Maternal vitamin D deficiency causes smaller muscle fibers and altered transcript levels of genes involved in protein degradation, myogenesis, and cytoskeleton organization in the newborn rat
    Daniela Max
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Mol Nutr Food Res 58:343-52. 2014
    ..Fetal stage is critical for the development of skeletal muscle, but little information is available on the impact of maternal vitamin D deficiency on muscles of offspring...
  26. doi request reprint Effect of short-term UVB exposure on vitamin D concentration of eggs and vitamin D status of laying hens
    Julika Lietzow
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, D 06108 Halle, Germany
    J Agric Food Chem 60:799-804. 2012
    ..The present study shows that a short-term exposure of laying hens to UVB light is not an appropriate way to improve the vitamin D content of egg yolk...
  27. ncbi request reprint Effects of dietary thermoxidized fats on expression and activities of hepatic lipogenic enzymes in rats
    Klaus Eder
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    Lipids 38:31-8. 2003
    ..The study suggests that oxidized fats contain substances that suppress gene expression of lipogenic enzymes in the liver...
  28. ncbi request reprint Concentrations of cholesterol oxidation products in raw, heat-processed and frozen-stored meat of broiler chickens fed diets differing in the type of fat and vitamin E concentrations
    Klaus Eder
    Institute of Nutritional Sciences Martin Luther University Halle Wittenberg, Germany
    Br J Nutr 93:633-43. 2005
    ..However, the effects of these factors were not only influenced by interactions between each other, but also depended on the treatment of the muscle and the type of muscle...
  29. ncbi request reprint Excess dietary vitamin E lowers the activities of antioxidative enzymes in erythrocytes of rats fed salmon oil
    Klaus Eder
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    J Nutr 132:3400-4. 2002
    ..The results of the study suggest that an excessive vitamin E intake, when combined with salmon oil in the diet, lowers the activities of antioxidant enzymes in erythrocytes without affecting in vivo hemolysis...
  30. doi request reprint Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate increases intestinal carnitine absorption in rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 58:58-64. 2008
    ..05). In conclusion, the present study shows that administration of clofibrate to rats increases carnitine absorption in small intestine which is probably due to the observed upregulation of OCTN2 mediated by activation of PPARalpha...
  31. ncbi request reprint Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 56:175-83. 2007
    ..Furthermore, the present results also indicate that an increased carnitine biosynthesis also contributes to the clofibrate-induced increase in hepatic carnitine concentration...
  32. doi request reprint Oral intake of 7-dehydrocholesterol increases vitamin D3 concentrations in the liver and kidney
    Julia Kuhn
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle Saale, Germany Electronic address
    J Steroid Biochem Mol Biol . 2015
    ..7-dehydrocholesterol (7-DHC) occurs naturally in food, but its impact on vitamin D metabolism has not yet been examined...
  33. doi request reprint Non-linear increase of vitamin D content in eggs from chicks treated with increasing exposure times of ultraviolet light
    Julia Kuhn
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, Halle Saale 06120, Germany Electronic address
    J Steroid Biochem Mol Biol 148:7-13. 2015
    ..In conclusion, the data show a distinct non-linear dose-response relationship of UVB exposure times on the total vitamin D content in eggs. This article is part of a special issue entitled '17th Vitamin D Workshop'. ..
  34. doi request reprint Isolated Conglutin γ from Lupin, but not Phytate, Lowers Serum Cholesterol Without Influencing Vascular Lesion Development in the ApoE-deficient Mouse Model
    Juliane Radtke
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, 06120, Halle Saale, Germany
    Plant Foods Hum Nutr 70:113-8. 2015
    ..Conclusively, conglutin γ exerts cholesterol-lowering effects but appears to have no anti-atherosclerotic properties in the apoE-deficient mice. Phytate neither affected plasma cholesterol nor aortic lesion development...
  35. doi request reprint Free-range farming: a natural alternative to produce vitamin D-enriched eggs
    Julia Kuhn
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Nutrition 30:481-4. 2014
    ..The aim of this study was to determine whether free-range farming of hens could provide a valuable method to produce vitamin D-enriched eggs...
  36. ncbi request reprint PPARalpha agonists up-regulate organic cation transporters in rat liver cells
    Sebastian Luci
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Biochem Biophys Res Commun 350:704-8. 2006
    ..We conclude that PPARalpha agonists increase carnitine concentrations in livers of rats and cells by an increased uptake of carnitine into the cell but not by an increased carnitine biosynthesis...
  37. ncbi request reprint Pivalate lowers litter sizes and weights in female rats independent of its effect on carnitine status
    Jane Doberenz
    Institute of Agricultural and Nutritional Sciences, Martin Luther Universiy Halle Wittenberg, Emil Abderhaldenstrasse 26, D 06108 Halle Saale, Germany
    Reprod Toxicol 24:83-8. 2007
    ..This study shows for the first time that pivalate affects the reproductive function in female rats independent of its effect on the carnitine status...
  38. doi request reprint Vitamin D3 supplementation: Response and predictors of vitamin D3 metabolites - A randomized controlled trial
    Ulrike Lehmann
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Germany
    Clin Nutr 35:351-8. 2016
    ..The current study aimed to investigate the efficacy of an once-daily oral dose of 20 μg vitamin D3 to improve the vitamin D status and to evaluate predictors of response...
  39. ncbi request reprint Effect of proteins from beef, pork, and turkey meat on plasma and liver lipids of rats compared with casein and soy protein
    Corinna Brandsch
    Institute of Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Nutrition 22:1162-70. 2006
    ....