Bettina König

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi request reprint Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines
    Bettina König
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    J Nutr Biochem 17:410-8. 2006
  2. pmc Fasting Upregulates PPARalpha Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARalpha Dependent Manner
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PPAR Res 2009:801609. 2009
  3. doi request reprint Monocarboxylate transporter 1 and CD147 are up-regulated by natural and synthetic peroxisome proliferator-activated receptor alpha agonists in livers of rodents and pigs
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Mol Nutr Food Res 54:1248-56. 2010
  4. doi request reprint Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle, Germany
    Biochim Biophys Acta 1780:899-904. 2008
  5. ncbi request reprint Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, D 06108 Halle Saale, Germany
    Biochem Pharmacol 73:574-85. 2007
  6. doi request reprint Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells
    Anke Gutgesell
    Institute of Agricultural and Nutritional Sciences, Martin Luther Universitat Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle, Saale, Germany
    Biochim Biophys Acta 1790:1206-16. 2009
  7. doi request reprint Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, Halle Saale D 06108, Germany
    Br J Nutr 100:355-63. 2008
  8. ncbi request reprint Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Halle, Saale, Germany
    Eur J Pharmacol 605:23-30. 2009
  9. doi request reprint PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis
    Alexander Koch
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, D 06108 Halle Saale, Germany
    Exp Biol Med (Maywood) 233:356-65. 2008
  10. ncbi request reprint Dietary oxidised fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats
    Alexander Koch
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Br J Nutr 98:882-9. 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Differential action of 13-HPODE on PPARalpha downstream genes in rat Fao and human HepG2 hepatoma cell lines
    Bettina König
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    J Nutr Biochem 17:410-8. 2006
    ..Consequently, cellular and secreted triglyceride levels were not changed after incubation of HepG2 cells with 13-HPODE. In conclusion, this study shows that 13-HPODE activates PPARalpha in rat Fao but not in human HepG2 hepatoma cells...
  2. pmc Fasting Upregulates PPARalpha Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARalpha Dependent Manner
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PPAR Res 2009:801609. 2009
    ..For proopiomelanocortin and thyrotropin-beta, genotype-specific differences in pituitary mRNA concentrations were observed. Thus, PPARalpha seems to be involved in transcriptional regulation of pituitary hormones...
  3. doi request reprint Monocarboxylate transporter 1 and CD147 are up-regulated by natural and synthetic peroxisome proliferator-activated receptor alpha agonists in livers of rodents and pigs
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Mol Nutr Food Res 54:1248-56. 2010
    ....
  4. doi request reprint Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle, Germany
    Biochim Biophys Acta 1780:899-904. 2008
    ..In wild-type mice, treatment with WY 14,643 increased mRNA concentrations of MCT1 in liver, kidney and small intestine whereas no up-regulation was observed in PPARalpha-null mice...
  5. ncbi request reprint Activation of PPARalpha lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, D 06108 Halle Saale, Germany
    Biochem Pharmacol 73:574-85. 2007
    ..In conclusion, we could show a novel link between PPARalpha and cholesterol metabolism by demonstrating that PPARalpha activation lowers cholesterol concentration by reducing the abundance of nuclear SREBP-2...
  6. doi request reprint Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells
    Anke Gutgesell
    Institute of Agricultural and Nutritional Sciences, Martin Luther Universitat Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle, Saale, Germany
    Biochim Biophys Acta 1790:1206-16. 2009
    ....
  7. doi request reprint Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, Halle Saale D 06108, Germany
    Br J Nutr 100:355-63. 2008
    ..CLA lead to an accumulation of TAG and cholesterol in the liver of hens by mechanisms to be elucidated in further studies...
  8. ncbi request reprint Activation of PPARalpha and PPARgamma reduces triacylglycerol synthesis in rat hepatoma cells by reduction of nuclear SREBP-1
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Halle, Saale, Germany
    Eur J Pharmacol 605:23-30. 2009
    ..Thus, these data suggest that the triacylglycerol reducing effect of fibrates and thiazolidinediones is partially caused by inhibition of SREBP-1 activation via up-regulation of Insig...
  9. doi request reprint PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis
    Alexander Koch
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, D 06108 Halle Saale, Germany
    Exp Biol Med (Maywood) 233:356-65. 2008
    ..It also shows that PPAR alpha mediates changes of whole-body carnitine homeostasis in mice by upregulation of carnitine transporters and enzymes involved in carnitine synthesis...
  10. ncbi request reprint Dietary oxidised fat up regulates the expression of organic cation transporters in liver and small intestine and alters carnitine concentrations in liver, muscle and plasma of rats
    Alexander Koch
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Br J Nutr 98:882-9. 2007
    ..The present study supports the hypothesis that nutrients acting as PPARalpha agonists influence whole-body carnitine homeostasis...
  11. ncbi request reprint Thermally oxidized oil increases the expression of insulin-induced genes and inhibits activation of sterol regulatory element-binding protein-2 in rat liver
    Alexander Koch
    Institute of Agricultural and Nutritional Sciences, Martin Luther University, D 06108 Halle Saale, Germany
    J Nutr 137:2018-23. 2007
    ....
  12. ncbi request reprint Feeding of a deep-fried fat causes PPARalpha activation in the liver of pigs as a non-proliferating species
    Sebastian Luci
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Br J Nutr 97:872-82. 2007
    ..Up-regulation of SREBP and its target genes in liver and small intestine suggests that the oxidised fat could stimulate synthesis of cholesterol and TAG in these tissues...
  13. ncbi request reprint PPARalpha agonists up-regulate organic cation transporters in rat liver cells
    Sebastian Luci
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Biochem Biophys Res Commun 350:704-8. 2006
    ..We conclude that PPARalpha agonists increase carnitine concentrations in livers of rats and cells by an increased uptake of carnitine into the cell but not by an increased carnitine biosynthesis...
  14. doi request reprint PPARα modulates the TSH β-subunit mRNA expression in thyrotrope TαT1 cells and in a mouse model
    Nicole Wege
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Mol Nutr Food Res 57:376-89. 2013
    ..In this study, we examined the role of PPARα in regulation of the hypothalamus-pituitary-thyroid axis...
  15. ncbi request reprint LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Str 26, D 06108 Halle Saale, Germany
    Biochim Biophys Acta 1761:1235-43. 2006
    ..However, it provides no explanation for the outcome of most human studies reporting unaltered or even increased plasma and LDL cholesterol concentrations in response to supplementation with CLA...
  16. pmc High Leucine Diets Stimulate Cerebral Branched-Chain Amino Acid Degradation and Modify Serotonin and Ketone Body Concentrations in a Pig Model
    Anna G Wessels
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, 06120, Halle Saale, Germany
    PLoS ONE 11:e0150376. 2016
    ..Changes in cerebral tryptophan, along with the changes in amino acid-derived metabolites in the plasma may limit the use of high Leu diets to treat muscle atrophy or to increase muscle growth. ..
  17. pmc Plant Oils as Potential Sources of Vitamin D
    Anja C Baur
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Front Nutr 3:29. 2016
    ..However, the UVB-exposed WGO was less effective to improve the 25(OH)D plasma concentration than a supplementation with vitamin D3. ..
  18. pmc Tissue-specific expression of monocarboxylate transporters during fasting in mice
    Alexandra Schutkowski
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    PLoS ONE 9:e112118. 2014
    ..Since, MCT isoforms 1-4 are also necessary for the cellular uptake of drugs, the fasting-induced modifications of MCT expression have to be considered in future clinical care algorithms. ..
  19. pmc Vitamin D receptor regulates intestinal proteins involved in cell proliferation, migration and stress response
    Hagen Kühne
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    Lipids Health Dis 13:51. 2014
    ....