R Ringseis

Summary

Affiliation: Martin Luther University
Country: Germany

Publications

  1. ncbi request reprint Oxidized fat induces oxidative stress but has no effect on NF-kappaB-mediated proinflammatory gene transcription in porcine intestinal epithelial cells
    R Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, 06108, Halle Saale, Germany
    Inflamm Res 56:118-25. 2007
  2. ncbi request reprint Formation of conjugated linoleic acid metabolites in human vascular endothelial cells
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhaldenstrasse 26, D 06108 Halle Saale, Germany
    Biochim Biophys Acta 1761:377-83. 2006
  3. ncbi request reprint LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Str 26, D 06108 Halle Saale, Germany
    Biochim Biophys Acta 1761:1235-43. 2006
  4. ncbi request reprint Conjugated linoleic acids exert similar actions on prostanoid release from aortic and coronary artery smooth muscle cells
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    Int J Vitam Nutr Res 76:281-9. 2006
  5. pmc Feeding oxidized fat during pregnancy up-regulates expression of PPARalpha-responsive genes in the liver of rat fetuses
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Lipids Health Dis 6:6. 2007
  6. doi request reprint Conjugated linoleic acid isomers reduce cholesterol accumulation in acetylated LDL-induced mouse RAW264.7 macrophage-derived foam cells
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, 06108, Halle Saale, Germany
    Lipids 43:913-23. 2008
  7. ncbi request reprint Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 56:175-83. 2007
  8. doi request reprint Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate increases intestinal carnitine absorption in rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 58:58-64. 2008
  9. ncbi request reprint Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle, Saale, Germany
    J Nutr Biochem 19:594-603. 2008
  10. doi request reprint Tripeptides from dietary proteins inhibit TNFalpha-induced monocyte adhesion to human aortic endothelial cells
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    Regul Pept 154:91-6. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Oxidized fat induces oxidative stress but has no effect on NF-kappaB-mediated proinflammatory gene transcription in porcine intestinal epithelial cells
    R Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, 06108, Halle Saale, Germany
    Inflamm Res 56:118-25. 2007
    ..Thus, the present study aimed to explore the effect of oxidized frying oil on PPARgamma DNA-binding and proinflammatory responses in intestinal epithelial cells...
  2. ncbi request reprint Formation of conjugated linoleic acid metabolites in human vascular endothelial cells
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhaldenstrasse 26, D 06108 Halle Saale, Germany
    Biochim Biophys Acta 1761:377-83. 2006
    ..In conclusion, regarding the biological activity reported for CD20:2t12c14 and other metabolites of CLA, the present results indicate that metabolites of CLA are possibly also involved in mediating the anti-atherogenic actions of CLA...
  3. ncbi request reprint LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Str 26, D 06108 Halle Saale, Germany
    Biochim Biophys Acta 1761:1235-43. 2006
    ..However, it provides no explanation for the outcome of most human studies reporting unaltered or even increased plasma and LDL cholesterol concentrations in response to supplementation with CLA...
  4. ncbi request reprint Conjugated linoleic acids exert similar actions on prostanoid release from aortic and coronary artery smooth muscle cells
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    Int J Vitam Nutr Res 76:281-9. 2006
    ..g., coronary arteries or systemic vasculature (aorta), but partially depends on the pathophysiological status of SMCs. The observed anti-inflammatory effect of CLAs may contribute to the anti-atherogenic actions of CLA...
  5. pmc Feeding oxidized fat during pregnancy up-regulates expression of PPARalpha-responsive genes in the liver of rat fetuses
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    Lipids Health Dis 6:6. 2007
    ....
  6. doi request reprint Conjugated linoleic acid isomers reduce cholesterol accumulation in acetylated LDL-induced mouse RAW264.7 macrophage-derived foam cells
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, 06108, Halle Saale, Germany
    Lipids 43:913-23. 2008
    ..05). In conclusion, the present study showed that CLA isomers reduce cholesterol accumulation in RAW264.7 macrophage-derived foam cells presumably by enhancing lipid acceptor-dependent cholesterol efflux...
  7. ncbi request reprint Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 56:175-83. 2007
    ..Furthermore, the present results also indicate that an increased carnitine biosynthesis also contributes to the clofibrate-induced increase in hepatic carnitine concentration...
  8. doi request reprint Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate increases intestinal carnitine absorption in rats
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Pharmacol Res 58:58-64. 2008
    ..05). In conclusion, the present study shows that administration of clofibrate to rats increases carnitine absorption in small intestine which is probably due to the observed upregulation of OCTN2 mediated by activation of PPARalpha...
  9. ncbi request reprint Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle, Saale, Germany
    J Nutr Biochem 19:594-603. 2008
    ..This suggests that CLA isomers are ineffective in MMP-associated extracellular matrix degradation which is thought to contribute to the progression and rupture of advanced atherosclerotic plaques...
  10. doi request reprint Tripeptides from dietary proteins inhibit TNFalpha-induced monocyte adhesion to human aortic endothelial cells
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    Regul Pept 154:91-6. 2009
    ....
  11. ncbi request reprint CLA isomers inhibit TNFalpha-induced eicosanoid release from human vascular smooth muscle cells via a PPARgamma ligand-like action
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhaldenstrasse 26, D 06108 Halle Saale, Germany
    Biochim Biophys Acta 1760:290-300. 2006
    ..With respect to the effects of CLA on experimental atherosclerosis, our findings suggest that the anti-inflammatory effect of CLA is at least partially responsible for the anti-atherogenic effects of CLA observed in vivo...
  12. doi request reprint Influence of pharmacological PPARalpha activators on carnitine homeostasis in proliferating and non-proliferating species
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle Saale, Germany
    Pharmacol Res 60:179-84. 2009
    ....
  13. doi request reprint Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells
    Robert Ringseis
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat, Halle Wittenberg, Emil Abderhalden Strasse 26, 06108, Halle Saale, Germany
    Eur J Nutr 47:59-67. 2008
    ..Polyunsaturated fatty acids stimulate collagen formation through NF-kappaB activation...
  14. doi request reprint Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    Eur J Pharmacol 583:11-7. 2008
    ..This in turn increases carnitine concentrations in liver and muscle probably by enhancing carnitine uptake into cells...
  15. ncbi request reprint Conjugated linoleic acids have no effect on TNF alpha-induced adhesion molecule expression, U937 monocyte adhesion, and chemokine release in human aortic endothelial cells
    Sabine Schleser
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhaldenstrasse 26, D 06108 Halle Saale, Germany
    Atherosclerosis 186:337-44. 2006
    ..This study suggests that anti-atherogenic effects of CLA observed in vivo are probably not mediated by reduced monocyte-endothelial cell interactions...
  16. doi request reprint Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Emil Abderhalden Strasse 26, D 06108 Halle Saale, Germany
    J Nutr Biochem 20:840-7. 2009
    ..It is concluded that nonproliferating species are also able to cover their increased demand for carnitine during fasting by an increased carnitine synthesis and uptake into cells...
  17. doi request reprint Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells
    Anke Gutgesell
    Institute of Agricultural and Nutritional Sciences, Martin Luther Universitat Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle, Saale, Germany
    Biochim Biophys Acta 1790:1206-16. 2009
    ....
  18. doi request reprint Peroxisome proliferator-activated receptor alpha and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats
    Anke Gutgesell
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, D 06108 Halle, Saale, Germany
    Metabolism 58:226-32. 2009
    ..It is moreover suggested that down-regulation of PPARalpha in the liver may be a means to conserve energy and metabolic substrates for milk production in the mammary gland...
  19. ncbi request reprint Dietary oxidized cholesterol decreases expression of hepatic microsomal triglyceride transfer protein in rats
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Halle Saale, Germany
    J Nutr Biochem 15:103-11. 2004
    ..In conclusion, the data of this study suggest, that dietary oxidized cholesterol affects VLDL assembly and/or secretion by reducing the synthesis of MTP but not by impairing hepatic lipogenesis or synthesis of apolipoprotein B...
  20. doi request reprint Activities of gamma-butyrobetaine dioxygenase and concentrations of carnitine in tissues of pigs
    Maren Fischer
    Institute of Agricultural and Nutritional Sciences, Martin Luther University of Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    Comp Biochem Physiol A Mol Integr Physiol 153:324-31. 2009
    ..In conclusion, this study shows that liver and kidney are the major sites of carnitine synthesis and that neonatal pigs do not have an insufficient carnitine status...
  21. ncbi request reprint Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    J Nutr 137:77-83. 2007
    ..This study shows that OF prevents an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes involved in oxidation of fatty acids, whereas CLA does not exert such an effect...
  22. doi request reprint Downregulation of peroxisome proliferator-activated receptor alpha and its coactivators in liver and skeletal muscle mediates the metabolic adaptations during lactation in mice
    Anke Gutgesell
    Institute of Agricultural and Nutritional Sciences, Martin Luther Universitat Halle Wittenberg, Von Danckelmann Platz 2, D 06120 Halle Saale, Germany
    J Mol Endocrinol 43:241-50. 2009
    ....
  23. ncbi request reprint Peptides and hydrolysates from casein and soy protein modulate the release of vasoactive substances from human aortic endothelial cells
    R Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Str 26, D 06108 Halle Saale, Germany
    Biochim Biophys Acta 1721:89-97. 2005
    ....
  24. doi request reprint Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron
    Gaiping Wen
    Institute of Agricultural and Nutritional Sciences, Martin Luther Universitat Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle Saale, Germany
    Biochem Pharmacol 79:768-76. 2010
    ..In conclusion, the present study shows that mouse OCTN2 is a direct target gene of PPARalpha and that transcriptional upregulation of OCTN2 by PPARalpha is likely mediated via PPRE1 in its first intron...
  25. ncbi request reprint Effects of dietary fat and oxidized cholesterol on gene expression in rat liver as assessed by cDNA expression array analysis
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhalden Strasse 26, 06108, Halle Saale, Germany
    Eur J Nutr 44:231-41. 2005
    ..However, the various biological effects of oxysterols such as cytotoxicity, atherogenicity or mutagenicity suggest that other genes may be also affected by oxysterols than lipid metabolism...
  26. doi request reprint Short communication: Dietary conjugated linoleic acid down-regulates fatty acid transporters in the mammary glands of lactating rats
    A Gutgesell
    Institut fur Agrar und Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Von Danckelmann Platz 2, Halle Saale, Germany
    J Dairy Sci 92:1169-73. 2009
    ..The mechanism through which CLA inhibits expression of fatty acid transporters deserves further study...
  27. ncbi request reprint Dietary conjugated linoleic acids lower the triacylglycerol concentration in the milk of lactating rats and impair the growth and increase the mortality of their suckling pups
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhaldenstrasse 26, D 06108 Halle Saale, Germany
    J Nutr 134:3327-34. 2004
    ..This might be the reason for reduced growth rates and an increased mortality of suckling pups...
  28. ncbi request reprint Oxidized fat reduces milk triacylglycerol concentrations by inhibiting gene expression of lipoprotein lipase and fatty acid transporters in the mammary gland of rats
    Robert Ringseis
    Institute of Agricultural and Nutritional Sciences, Martin Luther University, D 06108 Halle Saale, Germany
    J Nutr 137:2056-61. 2007
    ..The study, moreover, indicates that an oxidized fat impairs normal metabolic adaptations during lactation, which promote the utilization of metabolic substrates by the mammary gland for the synthesis of milk...
  29. ncbi request reprint Insufficient dietary vitamin e increases the concentration of 7beta-hydroxycholesterol in tissues of rats fed salmon oil
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhaldenstraszligbeta e 26, D 06108 Halle Saale, Germany
    J Nutr 132:3732-5. 2002
    ....
  30. ncbi request reprint Dietary oxidized cholesterol increases expression and activity of antioxidative enzymes and reduces the concentration of glutathione in the liver of rats
    Robert Ringseis
    Institute of Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Int J Vitam Nutr Res 74:86-92. 2004
    ..These effects were independent of the dietary fat. In conclusion, the study suggests that dietary oxidized cholesterol stresses the antioxidant defense system in rats...
  31. ncbi request reprint High dietary iron concentrations enhance the formation of cholesterol oxidation products in the liver of adult rats fed salmon oil with minimal effects on antioxidant status
    Corinna Brandsch
    Institute of Nutritional Sciences, Martin Luther University of Halle Wittenberg, Germany
    J Nutr 132:2263-9. 2002
    ..These results suggest that feeding a high iron diet does not generally affect the antioxidant status of rats but enhances the formation of COP, particularly if the diet is rich in polyunsaturated fatty acids...
  32. ncbi request reprint Detection of conjugated dienoic fatty acids in human vascular smooth muscle cells treated with conjugated linoleic acid
    Andre Muller
    Institut fur Biochemie und Lebensmittelchemie, Universitat Hamburg, Grindelallee 117, D 20146 Hamburg, Germany
    Biochim Biophys Acta 1737:145-51. 2005
    ..Future studies using highly purified conjugated metabolites of CLA are necessary to study their role in mediating biological effects of CLA in cell culture systems...
  33. ncbi request reprint Development of an alternative eluent system for Ag+-HPLC analysis of conjugated linoleic acid isomers
    Andre Muller
    Department of Food Chemistry, Institute of Biochemistry and Food Chemistry, University of Hamburg, Germany
    J Sep Sci 29:358-65. 2006
    ..Therefore, results should be confirmed by GC-FID and GC-MS...
  34. ncbi request reprint Identification of conjugated linoleic acid elongation and beta-oxidation products by coupled silver-ion HPLC APPI-MS
    Andre Muller
    Institute of Biochemistry and Food Chemistry, Department of Food Chemistry, University of Hamburg, Grindelallee 117, 20146 Hamburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 837:147-52. 2006
    ..The developed LC-MS method is useful for the analysis of CLA elongation and beta-oxidation products, especially with trans,trans-configuration, which are difficult to analyze by conventional GC-MS techniques...