James Adjaye

Summary

Affiliation: Max Planck Institute for Molecular Genetics
Country: Germany

Publications

  1. pmc Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells
    Justyna Jozefczuk
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics
    J Vis Exp . 2012
  2. doi request reprint Molecular characterization of cultured adult human liver progenitor cells
    Justyna Jozefczuk
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Tissue Eng Part C Methods 16:821-34. 2010
  3. ncbi request reprint Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression
    James Adjaye
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Physiol Genomics 31:315-27. 2007
  4. ncbi request reprint The origins of human embryonic stem cells: a biological conundrum
    Thore C Brink
    Department of Vertebrate Genomics Molecular Embryology and Aging, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Cells Tissues Organs 188:9-22. 2008
  5. pmc Activation of the immune response is a key feature of aging in mice
    Thore C Brink
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Biogerontology 10:721-34. 2009
  6. pmc FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast
    Smita Sudheer
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells Dev 21:2987-3000. 2012
  7. pmc Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development
    Jonathan Goke
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Comput Biol 7:e1002304. 2011
  8. pmc Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
    Alessandro Prigione
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 6:e27352. 2011
  9. pmc Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network
    Nancy Mah
    Computational Biology and Data Mining Group, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 6:e24351. 2011
  10. doi request reprint Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity
    Boris Greber
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, Germany
    Stem Cells Dev 17:1065-77. 2008

Collaborators

Detail Information

Publications51

  1. pmc Preparation of mouse embryonic fibroblast cells suitable for culturing human embryonic and induced pluripotent stem cells
    Justyna Jozefczuk
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics
    J Vis Exp . 2012
    ....
  2. doi request reprint Molecular characterization of cultured adult human liver progenitor cells
    Justyna Jozefczuk
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Tissue Eng Part C Methods 16:821-34. 2010
    ..Our study confirms the progenitor identity of type 1 cells and identifies novel markers that could be used for further studies on their characteristics and isolation using marker-based cell sorting strategies...
  3. ncbi request reprint Conserved molecular portraits of bovine and human blastocysts as a consequence of the transition from maternal to embryonic control of gene expression
    James Adjaye
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Physiol Genomics 31:315-27. 2007
    ....
  4. ncbi request reprint The origins of human embryonic stem cells: a biological conundrum
    Thore C Brink
    Department of Vertebrate Genomics Molecular Embryology and Aging, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Cells Tissues Organs 188:9-22. 2008
    ..hESCs are a distinct cell type lacking in the human embryo but, nonetheless, resemble the ICM in their ability to differentiate into cells representative of the endodermal, ectodermal and mesodermal cell lineages...
  5. pmc Activation of the immune response is a key feature of aging in mice
    Thore C Brink
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Biogerontology 10:721-34. 2009
    ..In addition, we propose LPO as a potential biomarker of aging...
  6. pmc FGF inhibition directs BMP4-mediated differentiation of human embryonic stem cells to syncytiotrophoblast
    Smita Sudheer
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells Dev 21:2987-3000. 2012
    ..We show that the inhibition of the FGF pathway acts as a key in directing BMP4-mediated hESC differentiation to syncytiotrophoblast...
  7. pmc Combinatorial binding in human and mouse embryonic stem cells identifies conserved enhancers active in early embryonic development
    Jonathan Goke
    Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Comput Biol 7:e1002304. 2011
    ....
  8. pmc Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
    Alessandro Prigione
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 6:e27352. 2011
    ..Nevertheless, we believe it will be essential to develop reprogramming protocols capable of safeguarding the integrity of the genome of aged somatic cells, before employing iPSC-based therapy for age-associated disorders...
  9. pmc Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network
    Nancy Mah
    Computational Biology and Data Mining Group, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 6:e24351. 2011
    ....
  10. doi request reprint Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity
    Boris Greber
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, Germany
    Stem Cells Dev 17:1065-77. 2008
    ..Our results therefore help to better understand how pluripotency is mediated at the transcriptional level...
  11. pmc In silico identification of a core regulatory network of OCT4 in human embryonic stem cells using an integrated approach
    Lukas Chavez
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    BMC Genomics 10:314. 2009
    ..Recent studies on reprogramming somatic cells to induced pluripotent stem cells highlight OCT4 as a key regulator of pluripotency...
  12. doi request reprint Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation
    Justyna Jozefczuk
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells Dev 20:1259-75. 2011
    ..The findings may be vital to the refinement of protocols for the efficient derivation of functional patient-specific HLCs for regenerative and toxicology studies...
  13. doi request reprint Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells
    Alessandro Prigione
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Int J Dev Biol 54:1729-41. 2010
    ....
  14. pmc Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage
    Lukas Chavez
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, D 14195 Berlin, Germany
    Genome Res 20:1441-50. 2010
    ....
  15. ncbi request reprint Functional genomics of human pre-implantation development
    Smita Sudheer
    Max Planck Institute for Molecular Genetics, Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Ihnestrasse 73, D 14195 Berlin, Germany
    Brief Funct Genomic Proteomic 6:120-32. 2007
    ..g. MAPK, PI3K, WNT, TGF-beta) involved in the switch from maternal to embryonic control of gene transcription during human pre-implantation development...
  16. ncbi request reprint Aging of human sebocytes in vitro induced by exposure to a defined hormone environment
    Evgenia Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute of Clinical Pharmacology and Toxicology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
    Dermatology 213:262-3. 2006
  17. doi request reprint Comparative molecular portraits of human unfertilized oocytes and primordial germ cells at 10 weeks of gestation
    Ferdinand Diedrichs
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, Berlin, Germany
    Int J Dev Biol 56:789-97. 2012
    ..Ultimately, this would have a profound relevance for reproductive as well as regenerative medicine...
  18. doi request reprint The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts
    Katharina Drews
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr 63 73, 14195 Berlin, Germany
    Biomaterials 33:4059-68. 2012
    ..The data presented here should provide the basis for further investigations into other immunosuppressing strategies that might facilitate efficient mRNA-mediated cellular reprogramming in human cells...
  19. doi request reprint Human induced pluripotent stem cells--from mechanisms to clinical applications
    Katharina Drews
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr 63 73 14195, Berlin, Germany
    J Mol Med (Berl) 90:735-45. 2012
    ..Furthermore, we will give an overview of particular envisaged human iPSC applications and point out which improvements are yet to come and what has been achieved so far...
  20. doi request reprint A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells
    Ying Wang
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, 14195, Berlin, Germany
    Stem Cell Rev 7:331-41. 2011
    ..In addition, 8-Br-cAMP and VPA have a synergistic effect on cellular reprogramming, which may be in part due to the transient down-regulation of the p53 signaling pathway during the early stages of reprogramming...
  21. pmc A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells
    Marc Jung
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e10709. 2010
    ..In the current era of systems biology driven research, we envisage that our integrated embryonic stem cell database will prove beneficial to the booming field of ES, iPS and cancer research...
  22. pmc Combined ultra-low input mRNA and whole-genome sequencing of human embryonic stem cells
    Florian Mertes
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr 63 73, 14195, Berlin, Germany
    BMC Genomics 16:925. 2015
    ..Nevertheless, investigating such sample material often limits the analysis to either the genome or transcriptome. We describe here a combined analysis of both types of nucleic acids from the same sample material...
  23. doi request reprint BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells
    Björn Lichtner
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr 63 73, 14195 Berlin, Germany Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Thielallee 63, 14195 Berlin, Germany
    Biomaterials 34:9789-802. 2013
    ..Our study has identified BMP10, a cardiac-specific protein, as a superior alternative to BMP4 for inducing trophoblast differentiation in human pluripotent stem cells...
  24. pmc Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells
    Sven Geissler
    Julius Wolff Institute, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e52700. 2012
    ..Based on specific differences observed between the impact of chronological and in vitro MSC aging we conclude that both are distinct processes...
  25. doi request reprint Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming
    Alessandro Prigione
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells 29:1338-48. 2011
    ..Finally, we speculate that this random rearrangement of mtDNA molecules might prove beneficial for the derivation of mutation-free iPSCs from patients with mtDNA disorders...
  26. ncbi request reprint Whole-genome approaches for large-scale gene identification and expression analysis in mammalian preimplantation embryos
    James Adjaye
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Ihnestrasse 73, D 14195 Berlin, Germany
    Reprod Fertil Dev 17:37-45. 2005
    ..The present review describes the various approaches whereby classical embryology fuses with molecular biology, high-throughput genomics and systems biology to address and solve questions related to early development in mammals...
  27. pmc The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells
    Katharina Wolfrum
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e13703. 2010
    ..Implications of this, with respect to the stability of the undifferentiated state and long-term differentiation potential of iPSCs, warrant further studies...
  28. doi request reprint A transcriptional roadmap to the induction of pluripotency in somatic cells
    Ying Wang
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, Berlin, 14195, Germany
    Stem Cell Rev 6:282-96. 2010
    ..We anticipate that these findings might aid in the establishment of more efficient protocols for inducing pluripotency in somatic cells...
  29. pmc Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal
    Boris Greber
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Berlin, Germany
    BMC Dev Biol 7:46. 2007
    ..To obtain further insights into the regulation of self-renewal, we have silenced hES/hEC cell-specific genes in NCCIT hEC cells and analysed the downstream effects by means of microarrays...
  30. ncbi request reprint Generation of amplified RNAs and cDNA libraries from single mammalian cells
    James Adjaye
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Methods Mol Med 132:117-24. 2007
    ..The cDNA pools can be used directly for gene-specific reverse transcriptase polymerase chain reaction or processed for ligation into vectors of choice whereas the amplified RNA can be used for microarray-based expression profiling...
  31. pmc Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging
    Thore C Brink
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Biogerontology 10:549-64. 2009
    ..This study, in addition, rejects the free radical hypothesis which postulates that the production rate of ROS, and not its stability, determines life span...
  32. pmc Cancer stem cells in solid tumors: elusive or illusive?
    Yvonne Welte
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, 14195 Berlin, Germany
    Cell Commun Signal 8:6. 2010
    ....
  33. ncbi request reprint Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells
    James Adjaye
    Max Planck Institute for Molecular Genetics Department of Vertebrate Genomics, Ihnestrasse 73, D 14195 Berlin, Germany
    Stem Cells 23:1514-25. 2005
    ..These data enhance our understanding of the first step in human cellular differentiation and, hence, the derivation of both embryonic stem cells and trophoblastic stem cells from these lineages...
  34. pmc HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2
    Alessandro Prigione
    Molecular Embryology and Ageing Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Neuroproteomics, Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
    Stem Cells 32:364-76. 2014
    ..These findings implicate the HIF1α pathway as an enabling regulator of cellular reprogramming...
  35. pmc Human embryonic stem cells and embryonal carcinoma cells have overlapping and distinct metabolic signatures
    Raed Abu Dawud
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 7:e39896. 2012
    ..These results shed light on the metabolite layer of pluripotent stem cells and could potentially establish novel metabolic markers of self renewal and pluripotency...
  36. ncbi request reprint Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal
    Boris Greber
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, Berlin D 14195, Germany
    Stem Cells 25:455-64. 2007
    ....
  37. pmc Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays
    James Adjaye
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Ihnestrasse 73, D 14195, Berlin, Germany
    BMC Genomics 5:83. 2004
    ..The objective of this study was to investigate the feasibility and reproducibility of cross-species analysis employing a human cDNA microarray as probe...
  38. doi request reprint Analysis of the methylome of human embryonic stem cells employing methylated DNA immunoprecipitation coupled to next-generation sequencing
    Christina Grimm
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Methods Mol Biol 873:281-95. 2012
    ..Here, we describe a protocol for the preparation of MeDIP samples suitable for next-generation sequencing on a Genome Analyser (Illumina)...
  39. doi request reprint Chromatin immunoprecipitation-based analysis of gene regulatory networks operative in human embryonic stem cells
    Marc Jung
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Methods Mol Biol 873:269-80. 2012
    ....
  40. doi request reprint The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells
    Alessandro Prigione
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Stem Cells 28:721-33. 2010
    ....
  41. doi request reprint Generation of iPSC lines from primary human chorionic villi cells
    Björn Lichtner
    Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany
    Stem Cell Res 15:697-9. 2015
    ..Pluripotency was confirmed both in vivo and in vitro. The transcriptomes of the CV-derived iPSC lines and the human embryonic stem cell lines-H1 and H9 have a Pearson correlation of 0.929 and 0.943 respectively. ..
  42. doi request reprint Generation of iPSC lines from primary human amniotic fluid cells
    Katharina Drews
    Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany
    Stem Cell Res 15:712-4. 2015
    ..A comparative transcriptome analysis of the AF-derived iPSC line 41 and the human embryonic stem cell lines (H1 and H9) revealed a Pearson correlation of 0.953 and 0.941 respectively. ..
  43. doi request reprint Metabolic restructuring and cell fate conversion
    Alessandro Prigione
    Max Delbrueck Center for Molecular Medicine MDC, Robert Roessle Str 10, 13125, Berlin, Germany
    Cell Mol Life Sci 72:1759-77. 2015
    ....
  44. doi request reprint Mitochondrial function in pluripotent stem cells and cellular reprogramming
    Raul Bukowiecki
    Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
    Gerontology 60:174-82. 2014
    ..Here, we review these recent findings and discuss their implications in the context of stem cell biology, aging research, and regenerative medicine...
  45. pmc Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing?
    Evgenia Makrantonaki
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
    PLoS ONE 7:e50393. 2012
    ..Furthermore, our data give evidence that skin could be used as a good alternative to understand ageing of different tissues such as CNS...
  46. pmc The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines
    Christian Ra Regenbrecht
    Max Planck Institute for Molecular Genetics, Department for Vertebrate Genomics, Ihnestr, 73, D 14195 Berlin, Germany
    BMC Med Genomics 1:49. 2008
    ..We compared the expression profiles of NCCIT cells with that of the cancer cell lines in order to identify common genistein-dependent transcriptional changes and accompanying signaling cascades...
  47. pmc A Systems Biology Approach to Deciphering the Etiology of Steatosis Employing Patient-Derived Dermal Fibroblasts and iPS Cells
    Justyna Jozefczuk
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics Berlin, Germany
    Front Physiol 3:339. 2012
    ..We anticipate that a larger cohort of patients and matched controls will confirm our preliminary findings presented here...
  48. doi request reprint A strand-specific library preparation protocol for RNA sequencing
    Tatiana Borodina
    Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, Ihnestrasse 63 73, Berlin, Germany
    Methods Enzymol 500:79-98. 2011
    ..Prior to final amplification, the dUTP-marked strand is selectively degraded by Uracil-DNA-Glycosylase (UDG). The remaining strand is amplified to generate a cDNA library suitable for sequencing...
  49. doi request reprint Quantitative real-time PCR-based analysis of gene expression
    J Jozefczuk
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics Molecular Embryology and Aging group, Ihnestrasse 63 73, Berlin, Germany
    Methods Enzymol 500:99-109. 2011
    ..An inherent advantage of QRT-PCR is the large dynamic range, remarkable sensitivity, and sequence-specificity. We provide a detailed step by step guide to the principles underlying a successful QRT-PCR experiment...
  50. doi request reprint Episomal plasmid-based generation of induced pluripotent stem cells from fetal femur-derived human mesenchymal stromal cells
    Matthias Megges
    Institute for Stem Cell Research and Regenerative Medicine, Heinrich Heine University Duesseldorf, Moorenstr 5, 40225 Duesseldorf, Germany Max Planck Institute for Molecular Genetics, Ihnestraße 63 73, 14195 Berlin, Germany Department of Biology, Chemistry and Pharmacy, Institute of Chemistry and Biochemistry, Freie Universitat Berlin, Thielallee 63, 14195, Berlin, Germany
    Stem Cell Res 16:128-32. 2016
    ..Successful induction of pluripotency in two iPS-cell lines was demonstrated in vitro and by the Pluritest...
  51. doi request reprint Generation of iPSC lines from a Nijmegen Breakage Syndrome patient
    Barbara Mlody
    Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany
    Stem Cell Res 15:629-32. 2015
    ..Pluripotency was confirmed both in vivo and in vitro. ..