Alessandro Prigione

Summary

Affiliation: Max Planck Institute for Molecular Genetics
Country: Germany

Publications

  1. pmc Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential
    May Al-Nbaheen
    Stem Cell Unit, Department of Anatomy 28, College of Medicine, King Saud University, P O Box 2925, Riyadh, 11461, Kingdom of Saudi Arabia
    Stem Cell Rev 9:32-43. 2013
  2. pmc Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes
    Giulia Vigone
    Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia e Biotecnologie Lazzaro Spallanzani, Universita degli Studi di Pavia, Pavia, Italy
    BMC Genomics 14:380. 2013
  3. pmc Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells
    Maurizio Zuccotti
    Sezione di Istologia ed Embriologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Parma, Parma, Italy
    BMC Genomics 12:1-13. 2011
  4. doi request reprint Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming
    Alessandro Prigione
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells 29:1338-48. 2011
  5. pmc Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network
    Nancy Mah
    Computational Biology and Data Mining Group, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 6:e24351. 2011
  6. pmc Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
    Alessandro Prigione
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 6:e27352. 2011
  7. doi request reprint Human induced pluripotent stem cells--from mechanisms to clinical applications
    Katharina Drews
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr 63 73 14195, Berlin, Germany
    J Mol Med (Berl) 90:735-45. 2012
  8. doi request reprint Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells
    Alessandro Prigione
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Int J Dev Biol 54:1729-41. 2010
  9. doi request reprint A transcriptional roadmap to the induction of pluripotency in somatic cells
    Ying Wang
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, Berlin, 14195, Germany
    Stem Cell Rev 6:282-96. 2010
  10. doi request reprint Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation
    Justyna Jozefczuk
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells Dev 20:1259-75. 2011

Collaborators

  • James Adjaye
  • Ying Wang
  • Markus Ralser
  • Bernd Schmeck
  • Nils Blüthgen
  • Edda Klipp
  • Christos C Zouboulis
  • Lukas Chavez
  • Justyna Jozefczuk
  • Maurizio Zuccotti
  • Katharina Wolfrum
  • Nadine Rohwer
  • Barbara Mlody
  • Raul Bukowiecki
  • Hans Lehrach
  • Giulia Vigone
  • May Al-Nbaheen
  • Silvia Garagna
  • Katharina Drews
  • Valeria Merico
  • Lucia Sacchi
  • Riccardo Bellazzi
  • Francesca Mulas
  • Nancy Mah
  • Fabian Bindel
  • Suling J Lin
  • Julio Saez-Rodriguez
  • Thorsten Cramer
  • Heike I Grabsch
  • Christina Grimm
  • Jessica Wappler
  • Ilona Du Bois
  • Patrick Tan
  • Gizem Inak
  • Carmen Lorenz
  • Emanuel Gonçalves
  • Bertram Klinger
  • Stefan Kempa
  • Marjo de Graauw
  • Radhakrishnan Vishnubalaji
  • Moustapha Kassem
  • Matthias Megges
  • Giuliano Mazzini
  • Abdullah Aldahmash
  • Fawzi Al-Jassir
  • Dalia Ali
  • Matteo Gabetta
  • Amel Bouslimi
  • Carlo Alberto Redi
  • Mei Chih Liao
  • Max Flöttmann
  • Alexander Hahn
  • Carlo A Redi
  • Ralf Mrowka
  • Manuela Haltmeier
  • Paola Rebuzzini
  • Martin Schaefer
  • Björn Lichtner
  • Michele Bellone
  • Miguel A Andrade-Navarro
  • Karl Sperling

Detail Information

Publications17

  1. pmc Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential
    May Al-Nbaheen
    Stem Cell Unit, Department of Anatomy 28, College of Medicine, King Saud University, P O Box 2925, Riyadh, 11461, Kingdom of Saudi Arabia
    Stem Cell Rev 9:32-43. 2013
    ....
  2. pmc Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes
    Giulia Vigone
    Laboratorio di Biologia dello Sviluppo, Dipartimento di Biologia e Biotecnologie Lazzaro Spallanzani, Universita degli Studi di Pavia, Pavia, Italy
    BMC Genomics 14:380. 2013
    ..Here, we isolated CCs from antral mouse oocytes of known developmental incompetence (NSN-CCs) or competence (SN-CCs) and compared their transcriptomes with the aim of identifying distinct marker transcripts...
  3. pmc Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells
    Maurizio Zuccotti
    Sezione di Istologia ed Embriologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Parma, Parma, Italy
    BMC Genomics 12:1-13. 2011
    ..The aim of this study was to investigate the identity and extension of this maternal Oct4-TN, as much as whether its presence is circumscribed to the egg or maintained beyond fertilisation...
  4. doi request reprint Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming
    Alessandro Prigione
    Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells 29:1338-48. 2011
    ..Finally, we speculate that this random rearrangement of mtDNA molecules might prove beneficial for the derivation of mutation-free iPSCs from patients with mtDNA disorders...
  5. pmc Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network
    Nancy Mah
    Computational Biology and Data Mining Group, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 6:e24351. 2011
    ....
  6. pmc Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
    Alessandro Prigione
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 6:e27352. 2011
    ..Nevertheless, we believe it will be essential to develop reprogramming protocols capable of safeguarding the integrity of the genome of aged somatic cells, before employing iPSC-based therapy for age-associated disorders...
  7. doi request reprint Human induced pluripotent stem cells--from mechanisms to clinical applications
    Katharina Drews
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr 63 73 14195, Berlin, Germany
    J Mol Med (Berl) 90:735-45. 2012
    ..Furthermore, we will give an overview of particular envisaged human iPSC applications and point out which improvements are yet to come and what has been achieved so far...
  8. doi request reprint Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells
    Alessandro Prigione
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Int J Dev Biol 54:1729-41. 2010
    ....
  9. doi request reprint A transcriptional roadmap to the induction of pluripotency in somatic cells
    Ying Wang
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestrasse 63 73, Berlin, 14195, Germany
    Stem Cell Rev 6:282-96. 2010
    ..We anticipate that these findings might aid in the establishment of more efficient protocols for inducing pluripotency in somatic cells...
  10. doi request reprint Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation
    Justyna Jozefczuk
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    Stem Cells Dev 20:1259-75. 2011
    ..The findings may be vital to the refinement of protocols for the efficient derivation of functional patient-specific HLCs for regenerative and toxicology studies...
  11. doi request reprint Metabolic restructuring and cell fate conversion
    Alessandro Prigione
    Max Delbrueck Center for Molecular Medicine MDC, Robert Roessle Str 10, 13125, Berlin, Germany
    Cell Mol Life Sci 72:1759-77. 2015
    ....
  12. doi request reprint Mitochondrial function in pluripotent stem cells and cellular reprogramming
    Raul Bukowiecki
    Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
    Gerontology 60:174-82. 2014
    ..Here, we review these recent findings and discuss their implications in the context of stem cell biology, aging research, and regenerative medicine...
  13. pmc HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2
    Alessandro Prigione
    Molecular Embryology and Ageing Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Neuroproteomics, Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
    Stem Cells 32:364-76. 2014
    ..These findings implicate the HIF1α pathway as an enabling regulator of cellular reprogramming...
  14. doi request reprint The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells
    Alessandro Prigione
    Department of Vertebrate Genomics, Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D 14195 Berlin, Germany
    Stem Cells 28:721-33. 2010
    ....
  15. pmc The LARGE principle of cellular reprogramming: lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells
    Katharina Wolfrum
    Molecular Embryology and Aging Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS ONE 5:e13703. 2010
    ..Implications of this, with respect to the stability of the undifferentiated state and long-term differentiation potential of iPSCs, warrant further studies...
  16. pmc Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A
    Nadine Rohwer
    Hepatologie und Gastroenterologie, Campus Virchow Klinikum, Charite, Berlin, Germany
    Oncotarget 7:6693-710. 2016
    ..In theory, this experimental approach is applicable to any cancer-driving gene or pathway and promises to identify various new targets for combination therapies...
  17. doi request reprint Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders
    Barbara Mlody
    Max Delbrueck Center for Molecular Medicine MDC, Berlin, Germany
    Semin Cell Dev Biol 52:102-9. 2016
    ..Finally, we provide an update of the PSC-based models of mitochondria-related brain disorders and discuss the challenges and opportunities that may exist on the road to develop a new era of brain disease modeling and therapy. ..