Hannsjörg W Seyberth

Summary

Affiliation: Philipps University
Country: Germany

Publications

  1. doi An improved terminology and classification of Bartter-like syndromes
    Hannsjörg W Seyberth
    Center for Pediatric and Adolescent Medicine, Philipps University, Marburg, Germany
    Nat Clin Pract Nephrol 4:560-7. 2008
  2. doi Pathophysiology and clinical presentations of salt-losing tubulopathies
    Hannsjörg W Seyberth
    Department of Pediatrics and Adolescent Medicine, Philipps University, Marburg, Germany
    Pediatr Nephrol 31:407-18. 2016
  3. pmc Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasia
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Orphanet J Rare Dis 1:24. 2006
  4. doi Basics and dynamics of neonatal and pediatric pharmacology
    Hannsjörg W Seyberth
    Klinik fur Kinder und Jugendmedizin, Philipps Universitat Marburg, Baldingerstraße, 35043 Marburg, Germany
    Handb Exp Pharmacol 205:3-49. 2011
  5. pmc Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects
    Hannsjörg W Seyberth
    Department of Pediatrics and Adolescent Medicine, Philipps University, Marburg, Germany
    Pediatr Nephrol 26:1789-802. 2011
  6. ncbi Salt handling in the distal nephron: lessons learned from inherited human disorders
    Nikola Jeck
    MD, Univ Children s Hospital, Philipps Univ, Deutschhausstrasse 12, D 35037 Marburg, Germany
    Am J Physiol Regul Integr Comp Physiol 288:R782-95. 2005
  7. ncbi Developing a European framework for research on children's medicines: an examination of the proposed EU regulation on medicinal products for paediatric use
    Hannsjörg W Seyberth
    Philipps University, Marburg, Germany
    Pediatr Nephrol 20:1537-40. 2005
  8. ncbi Salt wasting and deafness resulting from mutations in two chloride channels
    Karl P Schlingmann
    Department of Pediatrics, Philipps University of Marburg, Marburg, Germany
    N Engl J Med 350:1314-9. 2004
  9. ncbi Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Stephan C Reinalter
    Department of Pediatrics, Philipps University Marburg, Deutschhausstrasse 12, D 35053 Marburg, Germany
    Kidney Int 62:253-60. 2002
  10. ncbi Induction of microsomal prostaglandin E2 synthase in the macula densa in children with hypokalemic salt-losing tubulopathies
    Martin Kömhoff
    Department of Pediatrics, Philipps University, Deutschhausstrasse 12, D 35033 Marburg, Germany
    Pediatr Res 55:261-6. 2004

Collaborators

Detail Information

Publications20

  1. doi An improved terminology and classification of Bartter-like syndromes
    Hannsjörg W Seyberth
    Center for Pediatric and Adolescent Medicine, Philipps University, Marburg, Germany
    Nat Clin Pract Nephrol 4:560-7. 2008
    ....
  2. doi Pathophysiology and clinical presentations of salt-losing tubulopathies
    Hannsjörg W Seyberth
    Department of Pediatrics and Adolescent Medicine, Philipps University, Marburg, Germany
    Pediatr Nephrol 31:407-18. 2016
    ..Of note, the combination of a salt- and potassium-rich diet together with an adequate fluid intake is always the basis of long-term treatment in all SLTs. ..
  3. pmc Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasia
    H J Girschick
    Children s Hospital, University of Wurzburg, Germany
    Orphanet J Rare Dis 1:24. 2006
    ..There is a lack of knowledge as to how the variability and clinical severity of the HP phenotype (especially pain and walking impairment) are related to metabolic disturbances or impairments, subsequent to the molecular defect...
  4. doi Basics and dynamics of neonatal and pediatric pharmacology
    Hannsjörg W Seyberth
    Klinik fur Kinder und Jugendmedizin, Philipps Universitat Marburg, Baldingerstraße, 35043 Marburg, Germany
    Handb Exp Pharmacol 205:3-49. 2011
    ..A basic understanding of the developmental dynamics in pediatric pharmacology is also essential to delineating the future directions and priority areas of pediatric drug research and development...
  5. pmc Bartter- and Gitelman-like syndromes: salt-losing tubulopathies with loop or DCT defects
    Hannsjörg W Seyberth
    Department of Pediatrics and Adolescent Medicine, Philipps University, Marburg, Germany
    Pediatr Nephrol 26:1789-802. 2011
    ..It appears that in most patients with SLT, a combination of solute supplementation with some drug treatment (e.g., indomethacin) is needed for a lifetime...
  6. ncbi Salt handling in the distal nephron: lessons learned from inherited human disorders
    Nikola Jeck
    MD, Univ Children s Hospital, Philipps Univ, Deutschhausstrasse 12, D 35037 Marburg, Germany
    Am J Physiol Regul Integr Comp Physiol 288:R782-95. 2005
    ..As the first line treatment in hyperprostaglandin E syndrome includes cyclooxygenase inhibitors, we propose some hypotheses about the mysterious role of PGE(2) in the etiology of renal salt-losing disorders...
  7. ncbi Developing a European framework for research on children's medicines: an examination of the proposed EU regulation on medicinal products for paediatric use
    Hannsjörg W Seyberth
    Philipps University, Marburg, Germany
    Pediatr Nephrol 20:1537-40. 2005
  8. ncbi Salt wasting and deafness resulting from mutations in two chloride channels
    Karl P Schlingmann
    Department of Pediatrics, Philipps University of Marburg, Marburg, Germany
    N Engl J Med 350:1314-9. 2004
  9. ncbi Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Stephan C Reinalter
    Department of Pediatrics, Philipps University Marburg, Deutschhausstrasse 12, D 35053 Marburg, Germany
    Kidney Int 62:253-60. 2002
    ..Using the COX-2 selective inhibitor rofecoxib, we investigated the role of COX-2 in the pathophysiology of HPS/aBS...
  10. ncbi Induction of microsomal prostaglandin E2 synthase in the macula densa in children with hypokalemic salt-losing tubulopathies
    Martin Kömhoff
    Department of Pediatrics, Philipps University, Deutschhausstrasse 12, D 35033 Marburg, Germany
    Pediatr Res 55:261-6. 2004
    ..Co-induction of COX-2 and mPGES in cells of the macula densa suggests that PGE(2) activates renin secretion in humans...
  11. ncbi Late-onset manifestation of antenatal Bartter syndrome as a result of residual function of the mutated renal Na+-K+-2Cl- co-transporter
    Carsten A Pressler
    Department of Pediatrics, Philipps University of Marburg, Marburg, Germany
    J Am Soc Nephrol 17:2136-42. 2006
    ..The partial function of NKCC2-F177Y, which is not negatively affected by NKCC2-D918fs, therefore explains a mild and late-onset phenotype and for the first time establishes a mild phenotype-associated SLC12A1 gene mutation...
  12. ncbi Genetics of hereditary disorders of magnesium homeostasis
    Karl P Schlingmann
    Department of Pediatrics, Philipps University, Deutschhausstrasse 12, 35037 Marburg, Germany
    Pediatr Nephrol 19:13-25. 2004
    ....
  13. ncbi Barttin increases surface expression and changes current properties of ClC-K channels
    Siegfried Waldegger
    Department of Pediatrics, Philipps University of Marburg, Deutschhausstr 12, 35033 Marburg, Germany
    Pflugers Arch 444:411-8. 2002
    ..The results demonstrate regulation of a CLC chloride channel by an accessory protein and indicate that ClC-K activation by barttin is required for adequate tubular salt reabsorption...
  14. ncbi Increased systolic blood pressure with rofecoxib in congenital furosemide-like salt loss
    Martin Kömhoff
    Department of Pediatrics, Philipps University Marburg, D 35033 Marburg, Germany
    Nephrol Dial Transplant 21:1833-7. 2006
    ....
  15. ncbi Perinatal management of a preterm neonate affected by hyperprostaglandin E2 syndrome (HPS)
    Martin Kömhoff
    Department of Paediatrics, Philipps University Marburg, Marburg, Germany
    Acta Paediatr 94:1690-3. 2005
    ..Neonates affected by hyperprostaglandin E(2) syndrome (HPS) present with severe polyuria. Both urinary losses as well as prostaglandin synthesis inhibitors may precipitate acute renal failure (ARF)...
  16. ncbi Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family
    Karl P Schlingmann
    Department of Pediatrics, Philipps University of Marburg, Deutschhausstrasse 12, D 35037 Marburg, Germany
    Nat Genet 31:166-70. 2002
    ..TRPM6 is expressed in intestinal epithelia and kidney tubules. These findings indicate that TRPM6 is crucial for magnesium homeostasis and implicate a TRPM family member in human disease...
  17. ncbi Bartter's and Gitelman's syndrome
    Hannsjörg W Seyberth
    Center of Pediatrics and Adolescent Medicine at Philipps University Marburg, Marburg, Germany
    Curr Opin Pediatr . 2016
    ..By taking the quite heterogeneous presentations and the apparently different pathophysiologies as the basis, the applicability of the physiologic classification has been tested...
  18. ncbi Determination of misoprostol free acid in human breast milk and serum by gas chromatography/negative ion chemical ionization tandem mass spectrometry
    Bernhard Watzer
    Department of Pediatrics, Philipps University Marburg, Deutschhausstrasse 12, D 35033 Marburg, Germany
    J Mass Spectrom 37:927-33. 2002
    ..The limit of quantification for MPA was approximately 1 pg ml(-1) in breast milk and serum samples. The correlation coefficients of the calibration curves for MPA were r > 0.997 in the 0.5-2000 pg ml(-1) range for both tested matrices...
  19. ncbi Low-dose aspirin in pregnancy: maternal and neonatal aspirin concentrations and neonatal prostanoid formation
    Andreas Leonhardt
    Department of Pediatrics, Philipp s University, Marburg, Germany
    Pediatrics 111:e77-81. 2003
    ..To evaluate maternal and neonatal plasma concentrations of acetylsalicylic acid and salicylic acid and the neonatal endogenous prostanoid formation during low-dose aspirin prophylaxis (LDA; 100 mg daily) in pregnant women...
  20. ncbi Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies
    Melanie Peters
    Department of Pediatrics, Philipps University Marburg, Marburg, Germany
    Am J Med 112:183-90. 2002
    ..The aim of this study was to characterize the clinical features associated with each mutation in a large cohort of genetically defined patients...