Stephan Sehmisch

Summary

Country: Germany

Publications

  1. doi request reprint [Stabilization of unstable intertrochanteric fractures with the proximal femoral nail]
    S Sehmisch
    Abteilung Unfallchirurgie, Plastische und Wiederherstellungschirurgie, Universitatsmedizin Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Deutschland
    Oper Orthop Traumatol 25:63-83; quiz 83-4. 2013
  2. pmc Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur
    M Tezval
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Osteoporos Int 21:251-61. 2010
  3. pmc Improvement of femoral bone quality after low-magnitude, high-frequency mechanical stimulation in the ovariectomized rat as an osteopenia model
    M Tezval
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Robert Koch Str No 40, 37075 Goettingen, Germany
    Calcif Tissue Int 88:33-40. 2011
  4. doi request reprint Evaluation of bone quality and quantity in osteoporotic mice--the effects of genistein and equol
    S Sehmisch
    Department of Trauma Surgery, Plastic and Reconstructive Surgery, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Phytomedicine 17:424-30. 2010
  5. doi request reprint Effects of isoflavones equol and genistein on bone quality in a rat osteopenia model
    S Sehmisch
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Goettingen, Germany
    Phytother Res 24:S168-74. 2010
  6. doi request reprint Short-term effects of parathyroid hormone on rat lumbar vertebrae
    Stephan Sehmisch
    Department of Trauma and Reconstructive Surgery, University of Goettingen, Germany
    Spine (Phila Pa 1976) 34:2014-21. 2009
  7. pmc Effects of low-magnitude, high-frequency mechanical stimulation in the rat osteopenia model
    S Sehmisch
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Osteoporos Int 20:1999-2008. 2009
  8. doi request reprint The use of flat panel volumetric computed tomography (fpVCT) in osteoporosis research
    Stephan Sehmisch
    University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    Acad Radiol 16:394-400. 2009
  9. doi request reprint Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation
    S Sehmisch
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Phytother Res 23:851-8. 2009
  10. doi request reprint [Results of a prospective multicenter trial for treatment of acromioclavicular dislocation]
    S Sehmisch
    Klinik für Unfallchirurgie, Plastische und Wiederherstellungschirurgie, Universitat Gottingen
    Sportverletz Sportschaden 22:139-45. 2008

Collaborators

Detail Information

Publications34

  1. doi request reprint [Stabilization of unstable intertrochanteric fractures with the proximal femoral nail]
    S Sehmisch
    Abteilung Unfallchirurgie, Plastische und Wiederherstellungschirurgie, Universitatsmedizin Gottingen, Robert Koch Strasse 40, 37075, Gottingen, Deutschland
    Oper Orthop Traumatol 25:63-83; quiz 83-4. 2013
    ..Restoration of function and anatomy of the proximal femur. Possibility of full weightbearing after surgery. Less invasive intramedullary osteosynthesis...
  2. pmc Improvement of trochanteric bone quality in an osteoporosis model after short-term treatment with parathyroid hormone: a new mechanical test for trochanteric region of rat femur
    M Tezval
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Osteoporos Int 21:251-61. 2010
    ..We have developed a reproducible biomechanical test and produced trochanteric fractures to evaluate stiffness and strength of this region in addition to histomorphometry...
  3. pmc Improvement of femoral bone quality after low-magnitude, high-frequency mechanical stimulation in the ovariectomized rat as an osteopenia model
    M Tezval
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Robert Koch Str No 40, 37075 Goettingen, Germany
    Calcif Tissue Int 88:33-40. 2011
    ..Low-magnitude, high-frequency mechanical stimulation improves bone strength in the proximal femur and may be a possible nonpharmacologic treatment option for postmenopausal osteoporosis...
  4. doi request reprint Evaluation of bone quality and quantity in osteoporotic mice--the effects of genistein and equol
    S Sehmisch
    Department of Trauma Surgery, Plastic and Reconstructive Surgery, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Phytomedicine 17:424-30. 2010
    ..Further studies may combine these techniques with gene manipulation technology to better understand osteoporosis. Treatment with GEN resulted in improved biomechanical results and enhancement of morphologic parameters...
  5. doi request reprint Effects of isoflavones equol and genistein on bone quality in a rat osteopenia model
    S Sehmisch
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Goettingen, Germany
    Phytother Res 24:S168-74. 2010
    ..Treatment with phytoestrogens induced improved bone quality. EQO and GEN might be alternatives for hormone replacement therapy, although further studies are needed to elucidate possible side effects...
  6. doi request reprint Short-term effects of parathyroid hormone on rat lumbar vertebrae
    Stephan Sehmisch
    Department of Trauma and Reconstructive Surgery, University of Goettingen, Germany
    Spine (Phila Pa 1976) 34:2014-21. 2009
    ..This study is an experimental study in the rat osteopenia model...
  7. pmc Effects of low-magnitude, high-frequency mechanical stimulation in the rat osteopenia model
    S Sehmisch
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Osteoporos Int 20:1999-2008. 2009
    ..There was an improvement of bone quality and density in both osteoporotic and control rats. This treatment may therefore be an attractive option for the treatment of osteoporosis...
  8. doi request reprint The use of flat panel volumetric computed tomography (fpVCT) in osteoporosis research
    Stephan Sehmisch
    University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    Acad Radiol 16:394-400. 2009
    ..In contrast, QCT is able to investigate large samples with low spatial resolution. The aim of this study was to test the usefulness of flat-panel volumetric CT (fpVCT) in a rat model of osteopenia...
  9. doi request reprint Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation
    S Sehmisch
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Phytother Res 23:851-8. 2009
    ..It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT. Testosterone supplementation has positive effects on trabecular bone, which are concurrently counteracted by the loss of cortical bone...
  10. doi request reprint [Results of a prospective multicenter trial for treatment of acromioclavicular dislocation]
    S Sehmisch
    Klinik für Unfallchirurgie, Plastische und Wiederherstellungschirurgie, Universitat Gottingen
    Sportverletz Sportschaden 22:139-45. 2008
    ..7 +/- 8.6) from 4 different hospitals/departments of trauma surgery were analyzed. Clinicofunctional, radiological, as well as subjective parameters were taken into consideration...
  11. doi request reprint Comparison of the phytohormones genistein, resveratrol and 8-prenylnaringenin as agents for preventing osteoporosis
    Stephan Sehmisch
    Department of Trauma and Reconstructive Surgery, University of Goettingen, Goettingen, Germany
    Planta Med 74:794-801. 2008
    ..GEN had a smaller effect on bone biomechanical strength, while RES did not have an effect on bone biomechanical strength or BMD. Therefore, 8PN might be a safe alternative for HRT, but further studies are needed...
  12. doi request reprint Changes in the histomorphometric and biomechanical properties of the proximal femur of ovariectomized rat after treatment with the phytoestrogens genistein and equol
    Mohammad Tezval
    Department of Trauma Surgery, Plastic and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Planta Med 76:235-40. 2010
    ..Thus, of the studied substances, EQ seems to be a possible alternative to hormone replacement therapy, but further studies are needed...
  13. doi request reprint Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Germany
    J Endocrinol 211:157-68. 2011
    ..In conclusion, it is conceivable that 4-MBC may improve bone tissue in osteoporotic organisms; osteoporotic patients with fractures could benefit from daidzein treatment...
  14. doi request reprint Effects of black cohosh (Cimicifuga racemosa) and estrogen on metaphyseal fracture healing in the early stage of osteoporosis in ovariectomized rats
    Leila Kolios
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Planta Med 76:850-7. 2010
    ..Already-initiated Cimicifuga racemosa therapy for menopausal symptoms could be continued during fracture healing without hesitation...
  15. pmc Musculoskeletal response to whole-body vibration during fracture healing in intact and ovariectomized rats
    Ewa K Stuermer
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch St 40, 37075 Goettingen, Germany
    Calcif Tissue Int 87:168-80. 2010
    ..The chosen vibration regimen (90 Hz, 0.5 mm, 4 x g acceleration, 15 min twice a day) was effective in improving musculoskeletal tissues in ovariectomized rats but was not optimal for fracture healing...
  16. doi request reprint Equol but not genistein improves early metaphyseal fracture healing in osteoporotic rats
    Leila Kolios
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    Planta Med 75:459-65. 2009
    ..Genistein rather negatively influenced fracture healing. The metaphyseal osteotomy model in ovariectomized rats allows an accurate study of the therapeutic effects of antiosteoporotic substances on the fracture healing process...
  17. doi request reprint Influence of intermittent administration of parathyroid hormone on muscle tissue and bone healing in orchiectomized rats or controls
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch 40, 37075 Goettingen, Germany
    J Endocrinol 209:9-19. 2011
    ..The effect was less if PTH was applied every other day. The findings may show up trends for therapeutic treatment of male patients...
  18. doi request reprint Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch 40, 37075 Goettingen, Germany
    Bone 47:480-92. 2010
    ..In perspective, PTH may represent a treatment for enhancement of fracture healing. The findings need to be confirmed by follow-up studies on other animals...
  19. pmc Do estrogen and alendronate improve metaphyseal fracture healing when applied as osteoporosis prophylaxis?
    Leila Kolios
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Calcif Tissue Int 86:23-32. 2010
    ..The process of fracture healing occurred nearly physiologically (shamlike). Notably, ALN hardly improved metaphyseal callus properties when assessed as osteoporosis prophylaxis, but to a lesser extent than E...
  20. doi request reprint Absence of positive effect of black cohosh (Cimicifuga racemosa) on fracture healing in osteopenic rodent model
    Leila Kolios
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Germany
    Phytother Res 24:1796-806. 2010
    ..Callus formation was slightly improved under CR. Estrogen improved fracture healing in severe osteopenic bone, while the extent of callus formation played a minor role...
  21. pmc Identification of a vibration regime favorable for bone healing and muscle in estrogen-deficient rats
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University Medical Center Goettingen, Robert Koch 40, 37075, Goettingen, Germany
    Calcif Tissue Int 92:509-20. 2013
    ..Horizontal WBV showed no positive or negative effects. Further studies are needed to elucidate the effects of WBV on different physiological systems, and precautions must be taken when implementing WBV in the treatment of patients...
  22. ncbi request reprint Standardized bending and breaking test for the normal and osteoporotic metaphyseal tibias of the rat: effect of estradiol, testosterone, and raloxifene
    Ewa K Stürmer
    Department of Trauma and Reconstructive Surgery, Georg August University of Gottingen, Gottingen, Germany
    J Bone Miner Res 21:89-96. 2006
    ..This was validated in a right-left comparison and a bioassay with soy-free food, estradiol, raloxifene, and testosterone in orchidectomized rats...
  23. doi request reprint Effect of daidzein, 4-methylbenzylidene camphor or estrogen on gastrocnemius muscle of osteoporotic rats undergoing tibia healing period
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    J Endocrinol 201:253-62. 2009
    ..D and 4-MBC react similar to estrogen thereby improving oxidative cell metabolism in severe osteoporotic rats. The level of mitochondrial activity was higher, though no significant morphological differences could be shown...
  24. doi request reprint The Elastic Bridge Plating of the Forearm Fracture: A Prospective Study
    Ewa K Stuermer
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Robert Koch Straße 40, 37099, Gottingen, Germany
    Eur J Trauma Emerg Surg 35:147-52. 2009
    ..4% had additional severe injuries of the same arm. Bridge plating without interfragmentary compression is a reliable surgical procedure even for forearm fractures with low risk of infection and nonunion. ..
  25. doi request reprint Whole body vibration during fracture healing intensifies the effects of estradiol and raloxifene in estrogen-deficient rats
    Ewa K Stuermer
    Institute for Research in Operative Medicine, Faculty of Health, School of Medicine, Witten Herdecke University, Cologne, Germany Department of Trauma Surgery and Reconstructive Surgery, University of Goettingen, Robert Koch 40, 37075 Goettingen, Germany Electronic address
    Bone 64:187-94. 2014
    ..The therapies studied are all currently approved for human use, suggesting ready applicability to clinical practice. To better understand the effects of WBV on osteopenic bones, the ideal vibration regime will require further study...
  26. pmc Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia
    Daniel B Hoffmann
    Department of Trauma and Reconstructive Surgery, University of Goettingen, 37075 Goettingen, Germany
    J Nutr Metab 2016:6893137. 2016
    ..Higher concentrations of 8-PN are not advisable for safety reasons. Adjunctive therapy with WBVV demonstrates no convincing effects on bones. ..
  27. doi request reprint The Impact of Strontium Ranelate on Metaphyseal Bone Healing in Ovariectomized Rats
    Marina Komrakova
    Department of Trauma Surgery and Reconstructive Surgery, University Medical Center Gottingen, Robert Koch St 40, 37075, Gottingen, Germany
    Calcif Tissue Int 97:391-401. 2015
    ..SR has a positive effect on osteoporotic bone healing in rat and SR treatment can be continued after the fracture occurs or applied directly after the fracture...
  28. doi request reprint Effect of Urocortin on strength and microarchitecture of osteopenic rat femur
    Mohammad Tezval
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Goettingen, Germany
    J Bone Miner Metab 33:154-60. 2015
    ..Nd/mm(2) = 11.7, proximal femur Tb.Ar = 60.2% and N.Nd/mm(2) = 25.2). Our results show that short-term treatment with UCN seems to have a positive effect on the metaphyseal bone structure and strength of the femur in ovariectomized rats...
  29. ncbi request reprint [Feasibility of flat-panel volumetric computed tomography (fpVCT) in experimental small animal imaging of osteoporosis - initial experience]
    R Valencia
    Abteilung Diagnostische Radiologie, Universitätsklinikum Göttingen
    Radiologe 46:893-9. 2006
    ..Technical details, potential applications, and our initial experience with a fpVCT prototype scanner in the imaging of osteoporosis in a rat model are presented...
  30. pmc Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat
    E K Stuermer
    Department of Trauma Surgery, Plastic and Reconstructive Surgery, Georg August University of Goettingen, Robert Koch Str 40, 37099, Gottingen, Germany
    Langenbecks Arch Surg 395:163-72. 2010
    ..Quality and speed of fracture healing in osteoporotic fractures are crucial with regard to the outcome of patients. The question arises whether established antiosteoporotic drugs can further improve fracture healing...
  31. pmc Effect of testosterone, raloxifene and estrogen replacement on the microstructure and biomechanics of metaphyseal osteoporotic bones in orchiectomized male rats
    E K Stuermer
    Department of Trauma and Reconstructive Surgery, Georg August University of Goettingen, Robert Koch Str 40, 37099 Goettingen, Germany
    World J Urol 27:547-55. 2009
    ..Currently, osteoporosis research is rarely undertaken in males but an increase in male life expectancy in the company of hypogonadism suggests the necessity for potential therapeutic options...
  32. doi request reprint [Acute colonic pseudo-obstruction (Ogilvie's syndrome), a life-threatening complication after total hip replacement]
    M Tezval
    Klinik für Unfallchirurgie, Plastische und Wiederherstellungschirurgie der Universitätsklinik Göttingen, Gottingen
    Zentralbl Chir 134:263-6. 2009
    ..It results in a massive colon dilatation without mechanical obstructions and can lead to a life-threatening colon perforation with a high mortality...
  33. pmc In Vivo siRNA Delivery Using JC Virus-like Particles Decreases the Expression of RANKL in Rats
    Daniel B Hoffmann
    Department of Trauma Surgery and Reconstructive Surgery, University Medical Center Gottingen, Gottingen, Germany
    Mol Ther Nucleic Acids 5:e298. 2016
    ..Our data indicate that this is an efficient and safe route for in vivo delivery of gene modulatory tools to study important molecular factors in a rat osteoporosis model. ..
  34. pmc Navigated cementless total knee arthroplasty - medium-term clinical and radiological results
    Jan P Schüttrumpf
    Department of Trauma Surgery, Plastic and Reconstructive Surgery, University Medicine Gottingen, D 37099 Göttingen, Germany
    Open Orthop J 6:160-3. 2012
    ..The excellent radiological osteointegration of the prosthetic components, coated with a microporous pure titanium layer and implanted with a press-fit technique, should be emphasized...