Markus Engstler

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint The membrane-bound histidine acid phosphatase TbMBAP1 is essential for endocytosis and membrane recycling in Trypanosoma brucei
    Markus Engstler
    Ludwig Maximilians Universitat, Department Biologie I, Genetik, Maria Ward Strasse 1a, Munchen, 80638, Germany
    J Cell Sci 118:2105-18. 2005
  2. ncbi request reprint Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei
    Markus Engstler
    Ludwigs Maximilians Universität, Department Biologie I, Bereich Genetik, Maria Ward Strasse 1a, D 80638 München, Germany
    J Cell Sci 117:1105-15. 2004
  3. pmc Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei
    Markus Engstler
    Ludwig Maximilians Universitat, Department Biologie I, Genetik, 80638 Munchen, Germany
    Genes Dev 18:2798-811. 2004
  4. ncbi request reprint Accumulation of a GPI-anchored protein at the cell surface requires sorting at multiple intracellular levels
    Christoph G Grünfelder
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, Corrensstrasse 38, D 72076 Tubingen, Germany
    Traffic 3:547-59. 2002
  5. ncbi request reprint Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest
    Anne Laure Chanez
    Department of Biology Cell and Developmental Biology, University of Fribourg, Chemin du Musee 10, CH 1700 Fribourg, Switzerland
    J Cell Sci 119:2968-74. 2006
  6. ncbi request reprint Binding affinity and capacity of putative adaptor-mediated sorting of a Type I membrane protein in Leishmania mexicana
    Frank Weise
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, D 72076 Tubingen, Germany
    Mol Biochem Parasitol 142:203-11. 2005
  7. ncbi request reprint Factors affecting the level and localization of the transferrin receptor in Trypanosoma brucei
    Rainer Mussmann
    The Netherlands Cancer Institute, Division of Molecular Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 279:40690-8. 2004
  8. ncbi request reprint Endocytosis, membrane recycling and sorting of GPI-anchored proteins: Trypanosoma brucei as a model system
    Peter Overath
    Universitat Tubingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Mol Microbiol 53:735-44. 2004
  9. pmc Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers
    Christoph G Grünfelder
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, D 72076 Tubingen, Germany
    Mol Biol Cell 14:2029-40. 2003
  10. pmc Procyclin null mutants of Trypanosoma brucei express free glycosylphosphatidylinositols on their surface
    Erik Vassella
    Institut fur Zellbiologie, Universitat Bern, CH 3012 Bern, Switzerland
    Mol Biol Cell 14:1308-18. 2003

Collaborators

  • Tansy C Hammarton
  • Mark C Field
  • Isabel Roditi
  • Andre Schneider
  • Peter Bütikofer
  • M Wiese
  • Adrian B Hehl
  • Rainer Mussmann
  • Peter Overath
  • Frank Weise
  • Christoph G Grünfelder
  • Matthias Homann
  • Henri G A M van Luenen
  • Piet Borst
  • Mihaela Lorger
  • Anne Laure Chanez
  • H Ulrich Göringer
  • Rudo Kieft
  • Erik Vassella
  • York Dieter Stierhof
  • Heinz Schwarz
  • Martin Zacharias
  • Lutz Thilo
  • Bas ter Riet
  • Christina Kuhn
  • Hans Jorg Buhring
  • Isabel Benzel
  • Herlinde Gerrits
  • Cristiane Bentin Toaldo
  • Jos Onderwater
  • Henk Koerten
  • Gareth W Morgan
  • Iris Ansorge
  • Hans Janssen
  • Christine Clayton
  • Jennifer Jelk
  • Jero Calafat
  • Michael Boshart

Detail Information

Publications17

  1. ncbi request reprint The membrane-bound histidine acid phosphatase TbMBAP1 is essential for endocytosis and membrane recycling in Trypanosoma brucei
    Markus Engstler
    Ludwig Maximilians Universitat, Department Biologie I, Genetik, Maria Ward Strasse 1a, Munchen, 80638, Germany
    J Cell Sci 118:2105-18. 2005
    ..During differentiation of the organism from bloodstream to insect stage, TbMBAP1 is down-regulated and differentially modified in parallel with a 10-fold decrease in the rate of endocytosis...
  2. ncbi request reprint Kinetics of endocytosis and recycling of the GPI-anchored variant surface glycoprotein in Trypanosoma brucei
    Markus Engstler
    Ludwigs Maximilians Universität, Department Biologie I, Bereich Genetik, Maria Ward Strasse 1a, D 80638 München, Germany
    J Cell Sci 117:1105-15. 2004
    ..VSG recycling provides an interesting model for studies on the cellular trafficking and sorting of GPI-anchored proteins...
  3. pmc Cold shock and regulation of surface protein trafficking convey sensitization to inducers of stage differentiation in Trypanosoma brucei
    Markus Engstler
    Ludwig Maximilians Universitat, Department Biologie I, Genetik, 80638 Munchen, Germany
    Genes Dev 18:2798-811. 2004
    ..We propose a hierarchical model of three events that regulate differentiation after transmission to the tsetse: sensing the temperature change, surface access of a putative receptor, and sensing of a chemical cue...
  4. ncbi request reprint Accumulation of a GPI-anchored protein at the cell surface requires sorting at multiple intracellular levels
    Christoph G Grünfelder
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, Corrensstrasse 38, D 72076 Tubingen, Germany
    Traffic 3:547-59. 2002
    ....
  5. ncbi request reprint Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest
    Anne Laure Chanez
    Department of Biology Cell and Developmental Biology, University of Fribourg, Chemin du Musee 10, CH 1700 Fribourg, Switzerland
    J Cell Sci 119:2968-74. 2006
    ..Thus, our results support a working model in which mitochondrial fission triggers a checkpoint for cytokinesis...
  6. ncbi request reprint Binding affinity and capacity of putative adaptor-mediated sorting of a Type I membrane protein in Leishmania mexicana
    Frank Weise
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, D 72076 Tubingen, Germany
    Mol Biochem Parasitol 142:203-11. 2005
    ..A quantitative analysis of these in vivo results indicates specific binding to a putative adaptor complex with an affinity of about 10-4M to 50,000 sorting sites on the cell surface...
  7. ncbi request reprint Factors affecting the level and localization of the transferrin receptor in Trypanosoma brucei
    Rainer Mussmann
    The Netherlands Cancer Institute, Division of Molecular Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 279:40690-8. 2004
    ..This flexibility is made possible by the promoter-proximal position of the two genes in the variant surface glycoprotein expression site...
  8. ncbi request reprint Endocytosis, membrane recycling and sorting of GPI-anchored proteins: Trypanosoma brucei as a model system
    Peter Overath
    Universitat Tubingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Mol Microbiol 53:735-44. 2004
    ..Because the endocytic rate varies widely at different stages in the parasite's life cycle, trypanosomes may be used for investigating developmental aspects of their endocytic system...
  9. pmc Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers
    Christoph G Grünfelder
    Max Planck Institut fur Biologie, Abteilung Membranbiochemie, D 72076 Tubingen, Germany
    Mol Biol Cell 14:2029-40. 2003
    ....
  10. pmc Procyclin null mutants of Trypanosoma brucei express free glycosylphosphatidylinositols on their surface
    Erik Vassella
    Institut fur Zellbiologie, Universitat Bern, CH 3012 Bern, Switzerland
    Mol Biol Cell 14:1308-18. 2003
    ..These have been overlooked in the past because they partition in a solvent fraction (chloroform/water/methanol) that is normally discarded when GPI-anchored proteins are purified...
  11. ncbi request reprint The expression level determines the surface distribution of the transferrin receptor in Trypanosoma brucei
    Rainer Mussmann
    Division of Molecular Biology, and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Mol Microbiol 47:23-35. 2003
    ..These results suggest that the TfR flagellar pocket retention mechanism is easily saturated and that control of the expression level is critical to maintain the restricted surface distribution of the receptor...
  12. ncbi request reprint Hydrodynamic flow-mediated protein sorting on the cell surface of trypanosomes
    Markus Engstler
    Institut fur Mikrobiologie und Genetik, Technische Universitat Darmstadt, Schnittspahnstrasse 10, 64287, Darmstadt, Germany
    Cell 131:505-15. 2007
    ....
  13. ncbi request reprint The Trypanosoma brucei cyclin, CYC2, is required for cell cycle progression through G1 phase and for maintenance of procyclic form cell morphology
    Tansy C Hammarton
    Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, Scotland, United Kingdom
    J Biol Chem 279:24757-64. 2004
    ....
  14. ncbi request reprint New approaches to the microscopic imaging of Trypanosoma brucei
    Mark C Field
    Wellcome Trust Laboratories for Molecular Parasitology, Department of Biological Sciences, Imperial College, Exhibition Road, London SW7 2AY, UK
    Microsc Microanal 10:621-36. 2004
    ..brucei at the light and ultrastructural levels, an essential component of analysis of gene function and hence identification of therapeutic targets...
  15. pmc Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers
    Mihaela Lorger
    Department of Microbiology and Genetics, Darmstadt University of Technology, 64287 Darmstadt, Germany
    Eukaryot Cell 2:84-94. 2003
    ..Aptamers tethered to an antigenic side group are capable of directing antibodies to the surface of the parasite in vitro. In this manner, the RNAs might provide a new strategy for a therapeutic intervention to fight sleeping sickness...
  16. ncbi request reprint Trypanosomes change their transferrin receptor expression to allow effective uptake of host transferrin
    Henri G A M van Luenen
    The Netherlands Cancer Institute, Division of Molecular Biology and Centre for Biomedical Genetics, Plesmanlaan 121, 1060 CX Amsterdam, The Netherlands
    Mol Microbiol 58:151-65. 2005
    ..Our results illustrate the striking genetic flexibility of trypanosomes...
  17. ncbi request reprint Serum-stable RNA aptamers to an invariant surface domain of live African trypanosomes
    Matthias Homann
    Institute of Microbiology and Genetics, Darmstadt University of Technology, Schnittspahnstrasse 10, D 64287 Darmstadt, Germany
    Comb Chem High Throughput Screen 9:491-9. 2006
    ..We demonstrate that antigen-tagged preparations of the aptamer can bind to live trypanosomes and that they can be used to re-direct immunoglobulins to the parasite surface...