Patrick Friederich

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A
    P Friederich
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20251 Hamburg, Germany
    Br J Anaesth 92:93-101. 2004
  2. ncbi request reprint Interaction of ropivacaine with cloned cardiac Kv4.3/KChIP2.2 complexes
    Patrick Friederich
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Germany
    Anesthesiology 101:1347-56. 2004
  3. ncbi request reprint Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations
    P Friederich
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
    Anesthesiology 95:954-8. 2001
  4. ncbi request reprint Retigabine stimulates human KCNQ2/Q3 channels in the presence of bupivacaine
    Mark A Punke
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, 52, 20246 Hamburg, Germany
    Anesthesiology 101:430-8. 2004
  5. ncbi request reprint Basic concepts of ion channel physiology and anaesthetic drug effects
    P Friederich
    University of Hamburg, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:343-53. 2003
  6. ncbi request reprint Lidocaine-induced cell death in a human model of neuronal apoptosis
    P Friederich
    Universitätsklinik Eppendorf, Department of Anaesthesiology, Centre for Molecular Neurobiology, Hamburg, Germany
    Eur J Anaesthesiol 19:564-70. 2002
  7. ncbi request reprint Inhibition of human TREK-1 channels by bupivacaine
    Mark A Punke
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Germany
    Anesth Analg 96:1665-73, table of contents. 2003
  8. doi request reprint The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome
    Alexander P Schwoerer
    Department of Vegetative Physiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anesth Analg 111:638-46. 2010
  9. ncbi request reprint Bupivacaine inhibits human neuronal Kv3 channels in SH-SY5Y human neuroblastoma cells
    P Friederich
    Clinic of Anaesthesiology, University Hospital Eppendorf, Institute of Neural Signal Transduction, Centre for Molecular Neurobiology, University of Hamburg, Germany
    Br J Anaesth 88:864-6. 2002
  10. doi request reprint Brief report: identification of the great auricular nerve by ultrasound imaging and transcutaneous nerve stimulation
    Saskia Christ
    Department of Anesthesiology, Bogenhausen Hospital, Academic Hospital of the Technical University Munich, Englschalkinger Str 77, 81925 Munich, Germany
    Anesth Analg 114:1128-30. 2012

Detail Information

Publications35

  1. ncbi request reprint Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A
    P Friederich
    Department of Anaesthesiology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20251 Hamburg, Germany
    Br J Anaesth 92:93-101. 2004
    ..This may suggest the presence of genetic risk factors for local-anaesthetic-induced cardiac arrhythmia...
  2. ncbi request reprint Interaction of ropivacaine with cloned cardiac Kv4.3/KChIP2.2 complexes
    Patrick Friederich
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Germany
    Anesthesiology 101:1347-56. 2004
    ..In human ventricular myocardium, Ito is formed by Kv4.3 and KChIP2.2 subunits. Therefore, the aim of this study was to establish the effects of S(-)-ropivacaine on human Kv4.3/KChIP2.2 channels...
  3. ncbi request reprint Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations
    P Friederich
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany
    Anesthesiology 95:954-8. 2001
    ..To obtain an indication whether these findings may be specific to Kv3 channels, the effects of enflurane and isoflurane on human Kv1.1 channels were also investigated...
  4. ncbi request reprint Retigabine stimulates human KCNQ2/Q3 channels in the presence of bupivacaine
    Mark A Punke
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, 52, 20246 Hamburg, Germany
    Anesthesiology 101:430-8. 2004
    ..The aim of this study was to characterize bupivacaine effects on KCNQ2/Q3 channels and to investigate whether retigabine reverses the effects of the local anesthetic...
  5. ncbi request reprint Basic concepts of ion channel physiology and anaesthetic drug effects
    P Friederich
    University of Hamburg, Department of Anaesthesiology, Hamburg, Germany
    Eur J Anaesthesiol 20:343-53. 2003
    ..Pharmacological action on ion channels is thus fundamental to effects as well as side-effects of anaesthetic agents. The alteration of ion channel function by anaesthetic agents consequently determines their clinical effects...
  6. ncbi request reprint Lidocaine-induced cell death in a human model of neuronal apoptosis
    P Friederich
    Universitätsklinik Eppendorf, Department of Anaesthesiology, Centre for Molecular Neurobiology, Hamburg, Germany
    Eur J Anaesthesiol 19:564-70. 2002
    ..This is important to know as it may help one to judge on possible neurotoxic risks imposed by the spinal application of lidocaine...
  7. ncbi request reprint Inhibition of human TREK-1 channels by bupivacaine
    Mark A Punke
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Germany
    Anesth Analg 96:1665-73, table of contents. 2003
    ..Inhibition of TREK-1 channels and consecutive depolarization of the cell membrane by bupivacaine may contribute to blockade of neuronal signal conduction during regional anesthesia...
  8. doi request reprint The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome
    Alexander P Schwoerer
    Department of Vegetative Physiology and Pathophysiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anesth Analg 111:638-46. 2010
    ..In this study, we investigated whether droperidol has subtype-specific effects in cellular and computational models of LQT syndrome...
  9. ncbi request reprint Bupivacaine inhibits human neuronal Kv3 channels in SH-SY5Y human neuroblastoma cells
    P Friederich
    Clinic of Anaesthesiology, University Hospital Eppendorf, Institute of Neural Signal Transduction, Centre for Molecular Neurobiology, University of Hamburg, Germany
    Br J Anaesth 88:864-6. 2002
    ..Data on the effects of bupivacaine on these potassium channels are lacking. We therefore characterized the effects of bupivacaine on human Kv3 channels natively expressed in SH-SY5Y cells...
  10. doi request reprint Brief report: identification of the great auricular nerve by ultrasound imaging and transcutaneous nerve stimulation
    Saskia Christ
    Department of Anesthesiology, Bogenhausen Hospital, Academic Hospital of the Technical University Munich, Englschalkinger Str 77, 81925 Munich, Germany
    Anesth Analg 114:1128-30. 2012
    ..Further studies will allow determination of whether this information will help to reduce the incidence of superficial cervical plexus neuropathy...
  11. doi request reprint Bupivacaine destabilizes action potential duration in cellular and computational models of long QT syndrome 1
    Alexander P Schwoerer
    Department of Cellular and Integrative Physiology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Anesth Analg 113:1365-73. 2011
    ..We investigated whether this interaction may functionally become more significant in cellular and computational models of long (L)QT syndromes...
  12. ncbi request reprint Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics
    Dirk Isbrandt
    Institute for Neural Signal Transduction, Centre for Molecular Neurobiology Hamburg, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    J Mol Med (Berl) 80:524-32. 2002
    ....
  13. ncbi request reprint Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization
    Alexander P Schwoerer
    Department of Vegetative Physiology and Pathophysiology, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 106:967-76. 2007
    ..It is furthermore unresolved whether droperidol at antiemetic concentrations induces action potential prolongation and arrhythmogenic early afterdepolarizations in cardiac myocytes...
  14. ncbi request reprint Differential lidocaine sensitivity of human voltage-gated potassium channels relevant to the auditory system
    Sokratis Trellakis
    Department of Otorhinolaryngology, University of Essen, University of Bonn, Hamburg, Germany
    Otol Neurotol 27:117-23. 2006
    ..Lidocaine may lead to an alteration in the processing of hearing as observed during tinnitus by inhibiting voltage-gated potassium channels at clinically relevant concentrations...
  15. ncbi request reprint Inhibition of HERG channels by the local anaesthetic articaine
    C C Siebrands
    University Medical Center Hamburg Eppendorf, Department of Anaesthesiology, Martinistrasse 52, 20251 Hamburg, Germany
    Eur J Anaesthesiol 24:148-53. 2007
    ....
  16. ncbi request reprint Local anesthetic interaction with human ether-a-go-go-related gene (HERG) channels: role of aromatic amino acids Y652 and F656
    Cornelia C Siebrands
    Department of Anesthesiology and Institute for Neural Signal Transduction, Hamburg, Germany
    Anesthesiology 103:102-12. 2005
    ..The aim of this study was to determine the effect of the mutations Y652A and F656A in the putative drug binding region of HERG on the inhibition by bupivacaine, ropivacaine, and mepivacaine...
  17. doi request reprint Lipophilic and stereospecific interactions of amino-amide local anesthetics with human Kv1.1 channels
    Mark A Punke
    Department of Anesthesiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anesthesiology 109:895-904. 2008
    ..1. The use of stereoisomers allowed testing of the role of polar drug actions...
  18. ncbi request reprint Long QT 1 mutation KCNQ1A344V increases local anesthetic sensitivity of the slowly activating delayed rectifier potassium current
    Cornelia C Siebrands
    Department of Anesthesiology, University Medical Center Hamburg Eppendorf, Germany
    Anesthesiology 105:511-20. 2006
    ..CONCLUSIONS: The results indicate that certain forms of the LQTS may constitute a specific pharmacogenetic risk factor for regional anesthesia...
  19. ncbi request reprint Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels
    Mark A Punke
    Department of Anesthesiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Anesth Analg 104:1256-64, tables of contents. 2007
    ..1 and Kv7.2/7.3 channels. We also intended to establish the interaction of amitriptyline with the Kv7.2/7.3 channel opener, retigabine...
  20. doi request reprint [Perioperative pharmacological myocardial protection. Systematic literature-based process optimization]
    M Petzoldt
    Zentrum für Anästhesiologie und Intensivmedizin, Universitätskrankenhaus Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Deutschland
    Anaesthesist 57:655-69. 2008
    ..So far evidence from relevant trials about how to best implement perioperative beta-blockade is lacking. This article offers a simple clinical concept for this purpose...
  21. ncbi request reprint [Epileptic seizures from etomidate? The human Kv1.1 potassium channel in humans]
    P Friederich
    Klinik und Poliklinik für Anästhesiologie, Universitätsklinik Eppendorf, Hamburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 36:100-4. 2001
    ..Suppression of Kv1.1 channels may be associated with epilepsy in men. Inhibition of Kv1.1 channels by etomidate at clinically relevant concentrations would, thus, argue in favour of an epileptogenic action of etomidate...
  22. doi request reprint [Improved survival by guideline compliant cardiopulmonary resuscitation: analysis of primary survival rates in the Hamburg emergency medical service]
    S Maisch
    Klinik fur Anasthesiologie, Universitatsklinikum Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Deutschland
    Anaesthesist 59:994-6, 998-1002. 2010
    ..The aim of this study was to test the compliance with valid guidelines and to establish the quality of pre-hospital CPR provided by paramedics over a period of 38 months...
  23. ncbi request reprint [Severe accidental hypothermia with cardiac arrest and extracorporeal rewarming. A case report of a 2-year-old child]
    S Maisch
    Klinik fur Anasthesiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg
    Anaesthesist 56:25-9. 2007
    ..On the third day after the accident the patient was extubated and after a further 9 days was discharged without any sequelae...
  24. ncbi request reprint [Public access defibrillation. Limited use by trained first responders and laymen]
    S Maisch
    Klinik fur Anasthesiologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg
    Anaesthesist 55:1281-90. 2006
    ....
  25. ncbi request reprint [Fast-track surgery in radical retropubic prostatectomy. First experiences with a comprehensive program to enhance postoperative convalescence]
    H Heinzer
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Hamburg Eppendorf
    Urologe A 44:1287-93. 2005
    ..Our initial results in radical retropubic prostatectomy fast-track surgery have been encouraging. Fast-track surgery in major urological operations needs validation using randomized trials...
  26. ncbi request reprint Ketamine and propofol differentially inhibit human neuronal K(+) channels
    P Friederich
    Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Germany
    Eur J Anaesthesiol 18:177-83. 2001
    ..This provides additional evidence for the hypothesis that voltage-dependent potassium channels play an important role in anaesthesia...
  27. ncbi request reprint Ketamine effects on human neuronal Na+ channels
    G Reckziegel
    University of Bonn, Department of Anaesthesiology and Intensive Care Medicine, Germany
    Eur J Anaesthesiol 19:634-40. 2002
    ..This information--that has, so far, not been published--will help to characterize further local anaesthetic properties of ketamine...
  28. doi request reprint A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels
    Alexander P Schwoerer
    From the Department of Cellular and Integrative Physiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, DZHK German Centre for Cardiovascular Research Hamburg Kiel Luebeck, Hamburg, Germany Department of Anesthesiology, German Armed Forces Hospital Hamburg, Academic Hospital of University Medical Center Hamburg Eppendorf, Hamburg, Germany and Department of Anaesthesiology, Bogenhausen Hospital, Academic Hospital of Technische Universitaet Muenchen, Munich, Germany
    Anesth Analg 120:1226-34. 2015
    ..We conducted this study to test this hypothesis and to provide experimental basis for the ongoing discussion regarding the cardiotoxic profiles of these local anesthetics...
  29. doi request reprint Superficial cervical plexus neuropathy after single-injection interscalene brachial plexus block
    Saskia Christ
    Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Bogenhausen Hospital, Academic Hospital of the Technical University Munich, Englschalkinger Str 77, Munich 81925, Germany
    Anesth Analg 109:2008-11. 2009
    ..Considering the neural anatomy at the site of injection, the superficial cervical plexus may be at risk of injury. We evaluated the incidence and characteristics of superficial cervical plexus neuropathy...
  30. pmc Pacemaker channel dysfunction in a patient with sinus node disease
    Eric Schulze-Bahr
    Genetics of Arrhythmias, Molecular Cardiology Section, Institute for Arteriosclerosis Research, University of Munster, Munster, Germany
    J Clin Invest 111:1537-45. 2003
    ..Taken together, the clinical, genetic, and in vitro data provide a likely explanation for the patient's sinus bradycardia and the chronotropic incompetence...
  31. ncbi request reprint Molecular site of action of the antiarrhythmic drug propafenone at the voltage-operated potassium channel Kv2.1
    Michael Madeja
    Institute of Physiology, University of Munster, Munster, Germany
    Mol Pharmacol 63:547-56. 2003
    ..These results are consistent with a direct interaction of propafenone with the lower part of the pore helix and/or residues of segment S6...
  32. ncbi request reprint Inhibition of Kv4.3/KChIP2.2 channels by bupivacaine and its modulation by the pore mutation Kv4.3V401I
    Anna Solth
    Department of Anesthesiology and Institute for Neural Signal Transduction, University Medical Center Hamburg Eppendorf, Germany
    Anesthesiology 103:796-804. 2005
    ..3 and KChIP2.2 as well as the modulatory effect of KChIP2.2. For this purpose, the pharmacologic effects of bupivacaine on Kv4.3wt/KChIP2.2 channels and on the pore mutant Kv4.3V401I were investigated...
  33. ncbi request reprint Structural requirements of human ether-a-go-go-related gene channels for block by bupivacaine
    Cornelia C Siebrands
    Department of Anesthesiology and Institute for Neural Signal Transduction, University Medical Center Hamburg Eppendorf, Germany
    Anesthesiology 106:523-31. 2007
    ..In addition, the study aimed to further define the role of the aromatic residues Y652 and F656 in bupivacaine inhibition by mutating these residues to threonine...
  34. ncbi request reprint Hesitant to follow the conclusion drawn
    Patrick Friederich
    Anesthesiology 101:552-3. 2004
  35. ncbi request reprint Sudden infant death syndrome and long QT syndrome: an epidemiological and genetic study
    Horst Wedekind
    Department of Cardiology and Angiology, University of Munster, Munster, Germany
    Int J Legal Med 120:129-37. 2006
    ....