Regine Gläser

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi The role and potential therapeutical applications of antimicrobial proteins in infectious and inflammatory diseases
    Jurgen Harder
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    Endocr Metab Immune Disord Drug Targets 7:75-82. 2007
  2. doi The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption
    Regine Gläser
    Department of Dermatology, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    J Invest Dermatol 129:641-9. 2009
  3. doi Research in practice: Antimicrobial peptides of the skin
    Regine Gläser
    Department of Dermatology, Venereology and Allergy, University Clinic Schleswig Holstein, Campus Kiel, Germany
    J Dtsch Dermatol Ges 9:678-80. 2011
  4. doi Psoriasin: key molecule of the cutaneous barrier?
    Regine Gläser
    Department of Dermatology, Venereology and Allergy, University Clinic Schleswig Holstein, Campus Kiel, Germany
    J Dtsch Dermatol Ges 9:897-902. 2011
  5. doi Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin
    Zhihong Wu
    Department of Dermatology, University Hospital of Schleswig Holstein, Kiel, Germany
    J Invest Dermatol 129:1446-58. 2009
  6. doi Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury
    Jurgen Harder
    Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Invest Dermatol 130:1355-64. 2010
  7. doi Differential expression of antimicrobial peptides in margins of chronic wounds
    Stefanie Dressel
    Department of Dermatology, University Hospital Schleswig Holstein, Germany
    Exp Dermatol 19:628-32. 2010
  8. pmc Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, D 24105 Kiel, Germany
    J Biol Chem 285:32174-81. 2010
  9. doi Susceptibility of Staphylococcus aureus bacteremia strains to different skin-derived antimicrobial proteins
    Bente Köten
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Arch Dermatol Res 304:633-7. 2012
  10. doi Antimicrobial RNases in cutaneous defense
    Maren Simanski
    Department of Dermatology, University Hospital Schleswig Holstein, Kiel Campus, Kiel, Germany
    J Innate Immun 4:241-7. 2012

Collaborators

Detail Information

Publications32

  1. ncbi The role and potential therapeutical applications of antimicrobial proteins in infectious and inflammatory diseases
    Jurgen Harder
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    Endocr Metab Immune Disord Drug Targets 7:75-82. 2007
    ..The benefits and possible restrictions of AMP utilization as a new class of antibiotic compounds are discussed...
  2. doi The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption
    Regine Gläser
    Department of Dermatology, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    J Invest Dermatol 129:641-9. 2009
    ..coli. This indicates that the antimicrobial response in AD is not generally impaired, but greatly differs according to the type of AMP produced by the skin...
  3. doi Research in practice: Antimicrobial peptides of the skin
    Regine Gläser
    Department of Dermatology, Venereology and Allergy, University Clinic Schleswig Holstein, Campus Kiel, Germany
    J Dtsch Dermatol Ges 9:678-80. 2011
    ..Everyday clinical observations formed the background for several interesting hypotheses and findings...
  4. doi Psoriasin: key molecule of the cutaneous barrier?
    Regine Gläser
    Department of Dermatology, Venereology and Allergy, University Clinic Schleswig Holstein, Campus Kiel, Germany
    J Dtsch Dermatol Ges 9:897-902. 2011
    ..In this review, we provide an overview of the major findings in psoriasin research and discuss novel studies highlighting the role of psoriasin as an important effector molecule of the cutaneous barrier...
  5. doi Highly complex peptide aggregates of the S100 fused-type protein hornerin are present in human skin
    Zhihong Wu
    Department of Dermatology, University Hospital of Schleswig Holstein, Kiel, Germany
    J Invest Dermatol 129:1446-58. 2009
    ..Our findings suggest that HRNR is expressed in healthy skin and give insight into the complex biology of this protein. HRNR and its degradation products might contribute to the barrier function of healthy human skin...
  6. doi Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury
    Jurgen Harder
    Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Invest Dermatol 130:1355-64. 2010
    ..Thus, a disturbed skin barrier may trigger AMP induction in AD and psoriasis. The functional role of AMP in AD, especially with regard to the control of S. aureus colonization, needs further analysis...
  7. doi Differential expression of antimicrobial peptides in margins of chronic wounds
    Stefanie Dressel
    Department of Dermatology, University Hospital Schleswig Holstein, Germany
    Exp Dermatol 19:628-32. 2010
    ..Clinically, supplementation of AMP with the capability to enhance wound healing besides restricting bacterial overgrowth could present a physiological support for treatment of disturbed wound healing...
  8. pmc Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, D 24105 Kiel, Germany
    J Biol Chem 285:32174-81. 2010
    ..Our findings suggest that SPINK6 plays a role in modulating the activity of KLKs in human skin. A selective inhibition of KLKs by SPINK6 might have therapeutic potential when KLK activity is elevated...
  9. doi Susceptibility of Staphylococcus aureus bacteremia strains to different skin-derived antimicrobial proteins
    Bente Köten
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Arch Dermatol Res 304:633-7. 2012
    ..No differences in the AMP-killing activity against bacteremia-derived S. aureus and control strains were detected suggesting that the onset of S. aureus bacteremia is not based on the varying susceptibilities against skin-derived AMP...
  10. doi Antimicrobial RNases in cutaneous defense
    Maren Simanski
    Department of Dermatology, University Hospital Schleswig Holstein, Kiel Campus, Kiel, Germany
    J Innate Immun 4:241-7. 2012
    ..Of these, two members, RNase 7 and RNase 5, have been implicated in cutaneous defense. This review gives an overview about our current knowledge on the potential role of RNase 7 and RNase 5 in protecting human skin from infection...
  11. doi The skin surface as antimicrobial barrier: present concepts and future outlooks
    Jurgen Harder
    Department of Dermatology, University Hospital of Schleswig Holstein, Kiel, Germany
    Exp Dermatol 22:1-5. 2013
    ..We place special emphasis on the role of antimicrobial peptides and the microbiota. In addition, we discuss and try to provide answers to some emerging issues concerning the various defense strategies of the epidermis...
  12. pmc IL-17A and IFN-γ synergistically induce RNase 7 expression via STAT3 in primary keratinocytes
    Maren Simanski
    Department of Dermatology, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 8:e59531. 2013
    ..This was also reflected by an increase of the Staphylococcus aureus-killing activity of IL-17A/IFN-γ -treated keratinocytes...
  13. ncbi Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection
    Regine Gläser
    Clinical Research Unit of the Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Nat Immunol 6:57-64. 2005
    ..Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli...
  14. pmc Flagellin delivery by Pseudomonas aeruginosa rhamnolipids induces the antimicrobial protein psoriasin in human skin
    Ulf Meyer-Hoffert
    Department of Dermatology, University Hospital Schleswig Holstein, Kiel, Germany
    PLoS ONE 6:e16433. 2011
    ..Hereby, human skin might control the microflora to prevent colonization of unwanted microbes in the earliest steps before potential pathogens can develop strategies to subvert the immune response...
  15. pmc Molecular identification and expression analysis of filaggrin-2, a member of the S100 fused-type protein family
    Zhihong Wu
    Department of Dermatology, University Hospital of Schleswig Holstein, Kiel, Germany
    PLoS ONE 4:e5227. 2009
    ....
  16. ncbi Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours
    Noemi Moubayed
    Department of Dermatology, Allergology and Venerology, University Hospital of Schleswig Holstein, Campus Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    J Cancer Res Clin Oncol 133:253-61. 2007
    ..As psoriasin was found to be overexpressed in human breast and bladder cancer suggesting a role in tumour progression, we investigated the expression of psoriasin in human epithelial skin tumours...
  17. doi Expression of antimicrobial peptides in different subtypes of cutaneous lupus erythematosus
    Alexander Kreuter
    Department of Dermatology, Venereology, and Allergology, Ruhr University, Bochum, Germany
    J Am Acad Dermatol 65:125-33. 2011
    ..Skin infections rarely occur in patients with cutaneous lupus erythematosus (CLE), and AMP expression in CLE has not been previously evaluated...
  18. pmc The Inflammasome and the Epidermal Growth Factor Receptor (EGFR) Are Involved in the Staphylococcus aureus-Mediated Induction of IL-1alpha and IL-1beta in Human Keratinocytes
    Maren Simanski
    Department of Dermatology, University of Kiel, Kiel, Germany
    PLoS ONE 11:e0147118. 2016
    ..aureus. A failure of keratinocytes to adequately upregulate IL-1alpha and IL-1beta may promote S. aureus skin infections. ..
  19. doi Decreased susceptibility of Staphylococcus aureus small-colony variants toward human antimicrobial peptides
    Regine Gläser
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 134:2347-50. 2014
    ..Switching into the SCV phenotype may help S. aureus to subvert cutaneous innate defense, thus contributing to the establishment and persistence of infection...
  20. doi Human antimicrobial proteins effectors of innate immunity
    Jurgen Harder
    Clinical Research Unit, Department of Dermatology, University Hospital Schleswig Holstein, Kiel, Germany
    J Endotoxin Res 13:317-38. 2007
    ..In this review, we provide an overview of the characteristics of human AMPs and discuss examples where AMPs may be involved in the pathogenesis of infectious and inflammatory diseases...
  21. doi Staphylococcus aureus subverts cutaneous defense by d-alanylation of teichoic acids
    Maren Simanski
    Department of Dermatology, University Hospital of Schleswig Holstein, Kiel, Germany
    Exp Dermatol 22:294-6. 2013
    ..We conclude that modulation of cell envelope d-alanylation may help S. aureus to persist on human skin through evasion of cutaneous innate defense provided by cationic skin-derived AMPs...
  22. doi Differential suppression of epidermal antimicrobial protein expression in atopic dermatitis and in EFAD mice by pimecrolimus compared to corticosteroids
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Kiel, Germany
    Exp Dermatol 20:783-8. 2011
    ..This result may explain the clinical observation that prolonged treatment with topical corticosteroids sometimes leads to bacterial infection...
  23. pmc RNase 7 contributes to the cutaneous defense against Enterococcus faecium
    Bente Köten
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    PLoS ONE 4:e6424. 2009
    ..Because RNase 7 exhibits high activity against Enterococcus faecium the aim of this study was to further explore the role of RNase 7 in the cutaneous innate defense system against E. faecium...
  24. pmc Elafin is specifically inactivated by RgpB from Porphyromonas gingivalis by distinct proteolytic cleavage
    Tomasz Kantyka
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, D 24105 Kiel, Germany
    Biol Chem 390:1313-20. 2009
    ..This contributes to enhanced degradation of host proteins and generation of a pool of peptides serving as nutrients for this asaccharolytic pathogen...
  25. doi Differential expression pattern of antimicrobial peptides in nasal mucosa and secretion
    Martin Laudien
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Kiel, Kiel, Germany
    Rhinology 49:107-11. 2011
    ..This study is addressed to gain further insight into the differential AMP expression and secretion pattern according to defined anatomical regions of the vestibulum nasi and turbinates...
  26. doi Successful Treatment of Refractory Alopecia Areata Universalis and Psoriatic Arthritis, But Not of Plaque Psoriasis with Tofacitinib in a Young Woman
    Ulrich Mrowietz
    Psoriasis Center, Department of Dermatology, University Medical Center Schleswig Holstein, Campus Kiel, D 24105 Kiel, Germany
    Acta Derm Venereol . 2016
    ..is missing (Short communication)...
  27. doi Bacterial soft tissue infection in psoriasis despite induction of epidermal antimicrobial peptides
    Kirsten Steinz
    Department of Dermatology, University Hospital Schleswig Holstein, Kiel, Germany
    Exp Dermatol 23:862-4. 2014
    ..Therefore, other factors, for example deep penetrating injuries bypassing the keratinocyte innate defense system, must have caused the soft tissue infection. ..
  28. doi Human skin engages different epidermal layers to provide distinct innate defense mechanisms
    Maren Simanski
    Department of Dermatology, University Hospital of Schleswig Holstein, Kiel, Germany
    Exp Dermatol 23:230-1. 2014
    ....
  29. ncbi Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption
    Lilia Westermann
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    J Dermatol 39:168-71. 2012
    ..5% allowing the reduction of prednisolone to 7.5 mg/day. We conclude that immunoadsorption is an effective and safe adjuvant therapeutic option for severe pemphigoid gestationis...
  30. ncbi Dimethylfumarate is a potent inducer of apoptosis in human T cells
    Felix Treumer
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 121:1383-8. 2003
    ..The data provide evidence that the effect of FAE treatment of psoriasis may at least in part be due to induction of apoptosis in activated T cells...
  31. doi Photoprovocation in cutaneous lupus erythematosus: a multicenter study evaluating a standardized protocol
    Annegret Kuhn
    Department of Dermatology, University of Munster, Munster, Germany
    J Invest Dermatol 131:1622-30. 2011
    ..This method may therefore be used for future diagnostic testing and clinical trials...
  32. ncbi Vitamin D(3) and analogues modulate the expression of CSF-1 and its receptor in human dendritic cells
    Kejian Zhu
    Department of Dermatology, University of Kiel, Kiel, Germany
    Biochem Biophys Res Commun 297:1211-7. 2002
    ....